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PLoS ONE, ISSN 1932-6203, 12/2011, Volume 6, Issue 12, p. e29713
Rational engineering to produce biologically active plant compounds has been greatly impeded by our poor understanding of the regulatory and metabolic pathways... 
CELL-SUSPENSION CULTURES | VITAMIN-E | SECONDARY METABOLISM | COLEUS-BLUMEI | MULTIDISCIPLINARY SCIENCES | CINNAMATE 4-HYDROXYLASE | ACCUMULATION | PHENYLALANINE AMMONIA-LYASE | 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE | JASMONIC ACID | EXPRESSION | Transformation, Genetic | Metabolic Engineering - methods | Reproducibility of Results | Depsides - metabolism | RNA, Messenger - genetics | Plant Roots - genetics | Depsides - chemistry | Salvia miltiorrhiza - growth & development | Salvia miltiorrhiza - anatomy & histology | RNA, Messenger - metabolism | Plant Proteins - genetics | Biosynthetic Pathways - genetics | Genes, Plant - genetics | Plants, Genetically Modified | Gene Expression Regulation, Plant | Plasmids - genetics | Cinnamates - metabolism | Salvia miltiorrhiza - genetics | Plant Proteins - metabolism | Cinnamates - chemistry | Tissue Culture Techniques - methods | Plant Roots - growth & development | Tyrosine | Physiological aspects | Genetic engineering | Hydroxylases | Metabolites | Genes | Hairy root | Laboratories | Cinnamic acid | Biosynthesis | Optimization | 4-Hydroxyphenylpyruvate dioxygenase | Engineering | Chinese medicine | Plant sciences | Enzymes | Hydroxylase | Lithospermic acid B | Cultures | Metabolism | Hydroxyphenylpyruvate dioxygenase | Biological activity | Studies | Hydroxyphenylpyruvate reductase | Salvia miltiorrhiza | Flavonoids | Acids | Bioreactors | Plasmids | Pharmacy | Rosmarinic acid | Metabolic pathways | Reductase
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, p. 1595
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 14688 - 10
Few literatures have evaluated the exact role of metabolomics in the identification process of potential biomarkers for acute kidney injury among the patients... 
KYNURENINE | CITRULLINE | METABOLISM | AMINO-ACIDS | MULTIDISCIPLINARY SCIENCES | INDOLEAMINE 2,3-DIOXYGENASE | L-ARGININE | DISEASE | RENAL-FUNCTION | SERUM | DEFICIENCY | Creatinine | Metabolomics | Kidneys | Transplants & implants | Metabolites | Arginine | Tacrolimus | Tryptophan | Biomarkers | Amino acids | Metabolism | Kidney transplantation
Journal Article
Molecules, ISSN 1420-3049, 08/2017, Volume 22, Issue 8, p. 1298
The traditional Chinese medicine Schisandra chinensis has remarkable protective effects against chemical-induced toxicity. Cyclophosphamide (CTX), in spite... 
Cyclophosphamide | Gomisin A | Time-dependent inhibition | Drug-drug interaction | Pharmacokinetics | time-dependent inhibition | CHEMISTRY, ORGANIC | TOXICITY | DRUG-METABOLIZING-ENZYMES | IFOSFAMIDE | gomisin A | CHLOROACETALDEHYDE | IN-VITRO | KIDNEY-TUBULES | CYTOCHROME-P450 ENZYMES | LIVER | pharmacokinetics | cyclophosphamide | SCHISANDRA-CHINENSIS | drug-drug interaction | CELL | Cytochrome P-450 CYP3A Inhibitors - pharmacology | Humans | Microsomes, Liver - metabolism | Cytochrome P-450 CYP3A Inhibitors - pharmacokinetics | Male | Lignans - pharmacology | Drug Interactions | Liver - drug effects | Microsomes, Liver - drug effects | Cytochrome P-450 CYP3A Inhibitors - chemistry | Dioxoles - pharmacology | Inhibitory Concentration 50 | Cyclooctanes - pharmacology | Molecular Structure | NADP - metabolism | Cyclooctanes - pharmacokinetics | Dioxoles - pharmacokinetics | Lignans - chemistry | Liver - metabolism | Rats | Enzyme Activation - drug effects | Dioxoles - chemistry | Lignans - pharmacokinetics | Animals | Cytochrome P-450 CYP3A - metabolism | Cyclophosphamide - pharmacology | Cyclooctanes - chemistry | Intervention | Drugs | Brain | Toxicity | Syngeneic grafts | Liver | Lignans | Immunosuppressive agents | Chloroacetaldehyde | Chinese medicine | Head injuries | Metabolites | Rodents | Biocompatibility | NADP | Inhibition | Pretreatment | Kidneys | Traditional Chinese medicine | Pharmacology | Metabolism | Gene expression | Microsomes | Chemotherapy | In vivo methods and tests | In vitro methods and tests | Brain injury | Kidney transplantation | Index Medicus
Journal Article
Bioscience Reports, ISSN 0144-8463, 10/2018, Volume 38, Issue 5
Clearance of protein-bound uremic toxins (PBUTs) by dialysis is a challenge in the treatment of uremic patients. Shen-Shuai-Ning (SSN), a traditional Chinese... 
Medical research | Kidneys | Clinical trials | Traditional Chinese medicine | Liquid chromatography | High-performance liquid chromatography | Sulfates | Patients | Peritoneal dialysis | Proteins | Cresol | Herbal medicine | p-Cresol | Granular materials | Toxins | Dialysis | Kidney diseases | Peritoneum
Journal Article