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Addiction biology, ISSN 1355-6215, 05/2019, pp. e12765 - e12765
The purpose of this study was to explore the effects of cannabidiol (CBD) on binge drinking and evaluate potential gender-related differences. To this aim,... 
Journal Article
ISSN 0006-2952, 2018
Drug addiction is a chronic relapsing disorder that produces a dramaticglobal health burden worldwide. Not effective treatment of drug addiction is currently... 
Drogoaddicció | Sistema endocannabinoide
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 02/2012, Volume 165, Issue 4, pp. 951 - 964
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 08/2018, Volume 175, Issue 16, pp. 3369 - 3378
Journal Article
Journal Article
Addiction Biology, ISSN 1355-6215, 01/2018, Volume 23, Issue 1, pp. 154 - 164
This study evaluated the effects of cannabidiol (CBD) on ethanol reinforcement, motivation and relapse in C57BL/6 J mice. The effects of CBD (60 mg/kg, i.p.)... 
AUD | cannabidiol | gene expression | ANTIDEPRESSANT-LIKE | 5-HT1A RECEPTORS | PREPULSE INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SCHIZOPHRENIA | SUBSTANCE ABUSE | ADDICTION | ALLOSTERIC MODULATOR | IN-VITRO | CANNABINOID CB1 RECEPTOR | ANIMAL-MODEL | WITHDRAWAL | Recurrence | Tyrosine 3-Monooxygenase - metabolism | Gene Expression - drug effects | Nucleus Accumbens - metabolism | Ethanol - administration & dosage | Alcohol Drinking | Receptor, Cannabinoid, CB2 - genetics | Motivation - drug effects | Receptors, Cannabinoid - drug effects | Receptors, Cannabinoid - metabolism | Self Administration | Behavior, Animal - drug effects | Receptors, Cannabinoid - genetics | Ventral Tegmental Area - drug effects | Receptors, Opioid, mu - drug effects | Receptors, Opioid, mu - metabolism | Mice, Inbred C57BL | Receptor, Cannabinoid, CB2 - drug effects | Reinforcement (Psychology) | Cannabidiol - pharmacology | Tyrosine 3-Monooxygenase - drug effects | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Tyrosine 3-Monooxygenase - genetics | Animals | Receptor, Cannabinoid, CB1 - genetics | Ventral Tegmental Area - metabolism | Central Nervous System Depressants - administration & dosage | Receptor, Cannabinoid, CB1 - drug effects | Mice | Receptors, Opioid, mu - genetics | Nucleus Accumbens - drug effects | Tyrosine | Alcohol, Denatured | Analysis | Genes | Alcohol | Hydroxylases | Gene expression | Hypothermia | Ventral tegmentum | Ethanol | Opioid receptors | Hydroxylase | Tyrosine 3-monooxygenase | Blood levels | Nucleus accumbens | Polymerase chain reaction | Drug self-administration | Motivation | Rodents | Reinforcement | Convulsions | Controlled release | Index Medicus
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 06/2011, Volume 36, Issue 7, pp. 1489 - 1504
The possible role of the CB2 receptor (CB(2)r) in psychiatric disorders has been considered. Several animal models use knockout (KO) mice that display... 
cannabinoid; CB | receptor; schizophrenia; risperidone; pre-pulse inhibition; gene expression | CB2 receptor | pre-pulse inhibition | NERVOUS-SYSTEM | PSYCHIATRY | cannabinoid | PREPULSE INHIBITION DEFICITS | risperidone | schizophrenia | NEUROSCIENCES | STARTLE REFLEX | MUTANT MICE | SWEDISH CONSCRIPTS | IN-VIVO | ANTIPSYCHOTIC-DRUGS | SUSCEPTIBILITY GENE | PHARMACOLOGY & PHARMACY | TRANSPORTER KNOCKOUT MICE | RAT-BRAIN | gene expression | Memory Disorders - genetics | Dark Adaptation - genetics | Male | Schizophrenia - complications | Depression - genetics | Hindlimb Suspension - physiology | Receptors, Catecholamine - metabolism | Acoustic Stimulation - methods | Depression - etiology | Exploratory Behavior - physiology | Schizophrenia - genetics | Risperidone - therapeutic use | Time Factors | Cognition Disorders - etiology | Sensory Gating - genetics | Receptors, Catecholamine - genetics | Disease Models, Animal | Inhibition (Psychology) | Maze Learning - physiology | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Risperidone - pharmacology | Cognition Disorders - genetics | Receptors, Catecholamine - classification | Avoidance Learning - physiology | Cognition Disorders - drug therapy | Mice, Knockout | Gene Expression Regulation - drug effects | Anxiety - genetics | Animals | Memory Disorders - etiology | Analysis of Variance | Avoidance Learning - drug effects | Mice | Antipsychotic Agents - pharmacology | Schizophrenia - drug therapy | Anxiety - etiology | Receptor, Cannabinoid, CB2 - deficiency | Index Medicus | animal models | behavioral science | antipsychotics | cannabinoids | Original
Journal Article
Pain, ISSN 0304-3959, 10/2015, Volume 156, Issue 10, pp. 2001 - 2012
In this study, we investigated the role of the endocannabinoid system (ECS) in the emotional and cognitive alterations associated with osteoarthritis pain. The... 
Animal model | 2-Arachidonoylglycerol | Anxiety | Cannabinoid receptor 1 | Cannabinoid receptor 2 | Anandamide | DEPRESSION | BEHAVIOR | ADRENAL AXIS | CHRONIC STRESS | KNOCKOUT MICE | NEUROSCIENCES | 2-arachidonoylglycerol | PREFRONTAL CORTEX | RAT MODEL | CLINICAL NEUROLOGY | CB2 CANNABINOID RECEPTORS | NEUROPATHIC PAIN | ANESTHESIOLOGY | Endocannabinoids - metabolism | Mood Disorders - drug therapy | Mood Disorders - genetics | Humans | Middle Aged | Male | Receptors, Glucocorticoid - metabolism | Receptor, Cannabinoid, CB2 - genetics | Iodoacetates - toxicity | Mood Disorders - etiology | Arachidonic Acids - metabolism | Osteoarthritis - chemically induced | Prefrontal Cortex - drug effects | Cognition Disorders - etiology | Enzyme Inhibitors - toxicity | Female | Corticotropin-Releasing Hormone - genetics | Endocannabinoids - genetics | Endocannabinoids - therapeutic use | Osteoarthritis - complications | Maze Learning - physiology | Mice, Inbred C57BL | Cognition Disorders - drug therapy | Glycerides - metabolism | Maze Learning - drug effects | Corticotropin-Releasing Hormone - metabolism | Osteoarthritis - genetics | Mice, Knockout | Animals | Arachidonic Acids - therapeutic use | Receptor, Cannabinoid, CB1 - genetics | Mood Disorders - diagnosis | Prefrontal Cortex - metabolism | Receptors, Glucocorticoid - genetics | Glycerides - therapeutic use | Aged | Mice | Receptor, Cannabinoid, CB1 - deficiency | Receptor, Cannabinoid, CB2 - deficiency | Index Medicus | Receptors | Cannabinoides | Ansietat | Research Paper
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 11/2013, Volume 38, Issue 12, pp. 2515 - 2524
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2015, Volume 10, Issue 11, pp. e0142978 - e0142978
The recreational drugs, alcohol and 3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") have both been shown to cause immune activation in vivo, and they are... 
MOUSE-BRAIN | PATTERN SEPARATION | NEURONAL DEVELOPMENT | ETHANOL DRINKING | MESSENGER-RNA EXPRESSION | ADULT NEUROGENESIS | MULTIDISCIPLINARY SCIENCES | 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA | RAT-BRAIN | HIPPOCAMPAL NEUROGENESIS | CELL-DEATH | Immunohistochemistry | N-Methyl-3,4-methylenedioxyamphetamine - adverse effects | Fear - drug effects | Motor Activity - drug effects | Male | Anxiety - drug therapy | Gene Expression Profiling | Inflammation | Hippocampus - drug effects | Alcohol Drinking | Cognition - drug effects | Gene Expression Regulation - drug effects | Animals | Discrimination Learning - drug effects | Maze Learning | Interleukin-1beta - metabolism | Polymerase Chain Reaction | Behavior, Animal - drug effects | Brain-Derived Neurotrophic Factor - metabolism | Mice | Neurons - drug effects | Hallucinogens - adverse effects | Street Drugs - chemistry | Research | Drinking of alcoholic beverages | Health aspects | Ecstasy (Drug) | Drugs | Brain | Drug abuse | Neurosciences | Biomedical research | Memory | Interleukin | Cognitive ability | Neurobiology | Disorders | Alcohol | Neurogenesis | Immunosuppressive agents | MDMA | Rodents | Anxiety | Behavior | Drug dosages | Consumption | Medical research | Immune response | Panic attacks | Cytokines | IL-1β | Gene expression | Fear | Brain research | Brain-derived neurotrophic factor | Discrimination | Anxieties | In vivo methods and tests | Hippocampus | Index Medicus | Efectes secundaris | Rates (Animals de laboratori) | Drogues
Journal Article