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Clinical Journal of the American Society of Nephrology, ISSN 1555-9041, 2016, Volume 11, Issue 8, pp. 1472 - 1483
Journal Article
American Journal of Kidney Diseases, ISSN 0272-6386, 2016, Volume 67, Issue 1, pp. 20 - 30
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 08/2019, Volume 381, Issue 8, pp. 693 - 696
Chronic kidney disease of unknown origin, which is exacting a rising death toll globally, is related to heat exposure and dehydration and is a sentinel disease... 
MEDICINE, GENERAL & INTERNAL | Climate change | Heat | Poverty | Personal health | Humidity | Mental health | Immigration | Kidney diseases | Dehydration | Sugarcane | Emergency communications systems | Public health | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Seminars in Nephrology, ISSN 0270-9295, 05/2019, Volume 39, Issue 3, pp. 263 - 271
Mesoamerican endemic nephropathy is a type of chronic kidney disease of unknown origin, present in pockets of high prevalence along the Pacific Ocean coast of... 
toxicity | chronic kidney disease | hydration | Mesoamerica | ETIOLOGY | RISK-FACTORS | WORKERS | AGRICULTURAL COMMUNITIES | NONTRADITIONAL CAUSES | CLINICAL CHARACTERISTICS | CENTRAL-AMERICA | UROLOGY & NEPHROLOGY | CHRONIC KIDNEY-DISEASE | EPIDEMIC | CKD
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 09/2018, Volume 315, Issue 3, pp. F726 - F733
An epidemic of chronic kidney disease (CKD) has been observed in Central America among workers in the sugarcane fields. One hypothesis is that the CKD may be... 
Chronic kidney disease of unknown etiology | Heat stress | Uric acid | Mesoamerican nephropathy | Heat shock | TUBULAR CELLS | PHYSIOLOGY | heat shock | chronic kidney disease of unknown etiology | STROKE | heat stress | HEATSTROKE | CENTRAL-AMERICA | DEHYDRATION | UROLOGY & NEPHROLOGY | CHRONIC KIDNEY-DISEASE | HYPERTENSION | uric acid | RENAL INJURY | URIC-ACID | Liver - pathology | Kidney - pathology | Liver Diseases - pathology | Male | Heat Stress Disorders - etiology | Kidney - metabolism | Liver - drug effects | Liver Diseases - etiology | Hyperthermia, Induced | Xanthine Oxidase - antagonists & inhibitors | Disease Models, Animal | Heat Stress Disorders - pathology | Kidney Diseases - metabolism | Xanthine Oxidase - metabolism | Kidney - drug effects | Uric Acid - metabolism | Kidney Diseases - pathology | Kidney Diseases - prevention & control | Liver - metabolism | Liver Diseases - prevention & control | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Heat Stress Disorders - metabolism | Hot Temperature | HSP70 Heat-Shock Proteins - metabolism | Heat Stress Disorders - prevention & control | Collagen - metabolism | Animals | Allopurinol - pharmacology | Kidney Diseases - etiology | Liver Diseases - metabolism | Heat stress disorders | Dosage and administration | Kidney diseases | Drug therapy | Allopurinol
Journal Article
American Journal of Tropical Medicine and Hygiene, ISSN 0002-9637, 2017, Volume 97, Issue 4, pp. 1247 - 1256
Mesoamerican nephropathy (MeN), an epidemic of unexplained kidney disease in Central America, affects mostly young, healthy individuals. Its etiology is a... 
SERUM CREATININE | MORTALITY | RECOVERY | ETIOLOGY | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | RISK | CHRONIC KIDNEY-DISEASE | EQUATION | EPIDEMIOLOGY | TROPICAL MEDICINE | PREDICTION | SALVADOR | Inflammation - pathology | Acute Kidney Injury - pathology | Humans | Middle Aged | Male | Nicaragua - epidemiology | Young Adult | Rural Population | Adolescent | Adult | Female | Aged | Acute Kidney Injury - epidemiology
Journal Article
Occupational and Environmental Medicine, ISSN 1351-0711, 06/2016, Volume 73, Issue 6, pp. 409 - 416
Journal Article
Journal Article
Kidney International, ISSN 0085-2538, 03/2018, Volume 93, Issue 3, pp. 681 - 690
Mesoamerican nephropathy is a devastating disease of unknown etiology that affects mostly young agricultural workers in Central America. An understanding of... 
acute kidney injury | chronic kidney disease of unknown etiology | chronic interstitial nephritis in agricultural communities | Mesoamerican nephropathy | acute interstitial nephritis | RISK-FACTORS | SERUM CREATININE | CENTRAL-AMERICA | UROLOGY & NEPHROLOGY | CHRONIC KIDNEY-DISEASE | EPIDEMIC | CKD | PROGRESSION | Predictive Value of Tests | Biomarkers - urine | Prognosis | Prospective Studies | Kidney - pathology | Nephritis, Interstitial - diagnosis | Humans | Agricultural Workers' Diseases - epidemiology | Male | Nicaragua - epidemiology | Nephritis, Interstitial - epidemiology | Atrophy | Young Adult | Nephritis, Interstitial - pathology | Edema - epidemiology | Adult | Agricultural Workers' Diseases - diagnosis | Risk Factors | Biomarkers - blood | Microscopy, Electron | Agricultural Workers' Diseases - pathology | Kidney - ultrastructure | Edema - diagnosis | Biopsy | Fibrosis | Fluorescent Antibody Technique | Early Diagnosis | Edema - pathology | Nephritis | Lymphocytes T | Proteins | Ischemia | Analgesics | Etiology | Agriculture | Ultrasound | Chronic illnesses | Urine | Creatinine | Hypertension | Edema | Kidneys | Neutrophils | Tubular basement membrane | Leukocytes (neutrophilic) | Uric acid | Electron microscopy | Patients | Pathology | Monocytes | Leukocytosis | Cell injury | Nephropathy | Antibiotics | Workers | Neutrophilia | Diabetes | Immunofluorescence
Journal Article
Occupational and Environmental Medicine, ISSN 1351-0711, 09/2011, Volume 68, Issue Suppl 1, pp. A119 - A119
Objectives Chronic kidney disease (CKD) unrelated to conventional risk factors occurs in Central America, mostly in younger, male agricultural workers. We... 
Journal Article
ENVIRONMENTAL RESEARCH, ISSN 0013-9351, 10/2015, Volume 142, pp. 746 - 755
Background: An epidemic of progressive kidney failure afflicts sugarcane workers in Central America. Repeated high-intensity work in hot environments is a... 
eGFR | Specific gravity | PERFORMANCE | EQUATIONS | Chronic kidney disease | Uric acid | Dehydration | Sugarcane work | EXERCISE | GLOMERULAR-FILTRATION-RATE | ENVIRONMENTAL SCIENCES | CENTRAL-AMERICA | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | Mesoamerican nephropathy | DISEASE | Heat stress | HYPERTENSION | EPIDEMIC | CKD | URIC-ACID
Journal Article
Transplantation Proceedings, ISSN 0041-1345, 2003, Volume 35, Issue 5, pp. 1767 - 1768
The purpose of this work was to determine the necessity for rhuEPO for 50 kidney transplant patients with stable graft function. We analyzed the red cell... 
SURGERY | RENAL-TRANSPLANTATION | ANEMIA | IMMUNOLOGY | RECIPIENTS | TRANSPLANTATION | Kidney Transplantation - physiology | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Follow-Up Studies | Time Factors | Erythropoietin - therapeutic use | Humans | Creatinine - blood | Recombinant Proteins | Erythrocyte Count | Proteinuria
Journal Article
Blood Purification, ISSN 0253-5068, 03/2016, Volume 41, Issue 1-3, pp. 135 - 138
Background: An epidemic of chronic kidney disease (CKD) of unknown cause has emerged along the Pacific Coast of Cen