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1. Full Text Backbone modification of a polypeptide drug alters duration of action in vivo
by Cheloha, Ross W and Maeda, Akira and Dean, Thomas and Gardella, Thomas J and Gellman, Samuel H
Nature biotechnology, ISSN 1087-0156, 2014, Volume 32, Issue 7, pp. 653 - 655
Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Receptor, Parathyroid Hormone, Type 1 - antagonists & inhibitors | Mice, Inbred C57BL | Peptide Hormones - blood | Amino Acids - chemistry | Male | Metabolic Clearance Rate | Structure-Activity Relationship | Peptide Hormones - pharmacokinetics | Tissue Distribution | Animals | Amino Acids - pharmacokinetics | Peptide Hormones - chemistry | Amino Acid Substitution | Pharmaceutical research | Protein research | Polypeptides | Drug interactions | Physiological aspects | G proteins | Research | Pharmacology | Biological activity | Index Medicus
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2. Full Text Binding Selectivity of Abaloparatide for PTH-Type-1-Receptor Conformations and Effects on Downstream Signaling
by Hattersley, Gary and Dean, Thomas and Corbin, Braden A and Bahar, Hila and Gardella, Thomas J
Endocrinology (Philadelphia), ISSN 0013-7227, 01/2016, Volume 157, Issue 1, pp. 141 - 149
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Receptor, Parathyroid Hormone, Type 1 - chemistry | Receptor, Parathyroid Hormone, Type 1 - metabolism | Humans | Peptide Fragments - pharmacology | Guanosine 5'-O-(3-Thiotriphosphate) - chemistry | HEK293 Cells | Cell Membrane - metabolism | Bone Density Conservation Agents - metabolism | Cyclic AMP - metabolism | Binding Sites - drug effects | Cell Membrane - drug effects | Bone Density Conservation Agents - chemistry | Recombinant Proteins - metabolism | Peptide Fragments - metabolism | Second Messenger Systems - drug effects | Models, Molecular | Recombinant Proteins - chemistry | Parathyroid Hormone-Related Protein - chemistry | Parathyroid Hormone-Related Protein - metabolism | Bone Density Conservation Agents - pharmacology | Parathyroid Hormone-Related Protein - pharmacology | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Peptide Fragments - chemistry | MAP Kinase Signaling System - drug effects | Receptor, Parathyroid Hormone, Type 1 - genetics | Genes, Reporter - drug effects | Ligands | Protein Conformation | Kinetics | GTP-Binding Proteins - metabolism | Index Medicus | Abridged Index Medicus | Original Research
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3. Full Text SIKs control osteocyte responses to parathyroid hormone
by Wein, Marc N and Liang, Yanke and Goransson, Olga and Sundberg, Thomas B and Wang, Jinhua and Williams, Elizabeth A and O'Meara, Maureen J and Govea, Nicolas and Beqo, Belinda and Nishimori, Shigeki and Nagano, Kenichi and Brooks, Daniel J and Martins, Janaina S and Corbin, Braden and Anselmo, Anthony and Sadreyev, Ruslan and Wu, Joy Y and Sakamoto, Kei and Foretz, Marc and Xavier, Ramnik J and Baron, Roland and Bouxsein, Mary L and Gardella, Thomas J and Divieti-Pajevic, Paola and Gray, Nathanael S and Kronenberg, Henry M
Nature communications, ISSN 2041-1723, 10/2016, Volume 7, Issue 1, pp. 13176 - 13176
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Osteocytes - drug effects | RNA, Small Interfering - genetics | RANK Ligand - metabolism | Humans | Glycoproteins - metabolism | Parathyroid Hormone - pharmacology | Bone and Bones - drug effects | Protein Isoforms - metabolism | Parathyroid Hormone - metabolism | Bone and Bones - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Phosphorylation - drug effects | Osteogenesis - genetics | Protein-Serine-Threonine Kinases - metabolism | Bone and Bones - cytology | Glycoproteins - genetics | Histone Deacetylases - genetics | Osteocytes - metabolism | Signal Transduction | Intercellular Signaling Peptides and Proteins | Osteocytes - cytology | Osteogenesis - drug effects | Gene Expression Regulation | Glycoproteins - antagonists & inhibitors | Protein-Serine-Threonine Kinases - genetics | Histone Deacetylases - metabolism | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Mice, Knockout | RANK Ligand - genetics | Transcription Factors - metabolism | Animals | RANK Ligand - antagonists & inhibitors | Active Transport, Cell Nucleus - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Primary Cell Culture | Protein Isoforms - antagonists & inhibitors | Protein Isoforms - genetics | RNA, Small Interfering - metabolism | Index Medicus | Cell and Molecular Biology | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Cell- och molekylärbiologi | Medicinska och farmaceutiska grundvetenskaper
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4. Full Text Genetic and phenotypic heterogeneity suggest therapeutic implications in SCN2A-related disorders
by Wolff, M and Johannesen, K.M and Heich, U.B.S and Masnada, S and Rubboli, G and Gardella, E and Lesca, G and Ville, D and Milh, M and Villard, Laurent and Afenjar, Alexana and Chantot-Bastaraud, S and Mignot, A and Lardennois, C and Nava, Caroline and Schwarz, N and Gérard, M and Perrin, L and Doummar, Diane and Auvin, S and Miranda, M.J and Hempel, M and Brilstra, Eva and Knoers, Nine and Verbeek, Nienke and Kempen, M. J A and Braun, K.P and Mancini, Grazia and Biskup, S and Hörtnagel, K and Döcker, M and Bast, T and Loddenkemper, T and Wong-Kisiel, L and Baumeister, F.M and Fazeli, W and Striano, Pasquale and Dilena, R and Fontana, E and Zara, Federico and Kurlemann, Gerhard and Klepper, Joerg and Thoene, J.G and Arndt, D.H and Deconinck, N and Schmitt-Mechelke, T and Maier, O and Muhle, Hiltrud and Wical, B and Finetti, C and Brückner, R and Pietz, J and Golla, G and Jillella, D and Linnet, K.M and Charles, Perrine and Moog, U and Õiglane-Shlik, E and Mantovani, J.F and Park, K and Deprez, M and Lederer, Damien and Mary, S and Scalais, E and Selim, L and Coster, R. N A and Lagae, Lieven and Nikanorova, M and Hjalgrim, H and Korenke, Christoph and Trivisano, M and Specchio, N and Ceulemans, B and Dorn, T and Helbig, K.L and Hardies, K and Stamberger, H and Jonghe, P and Weckhuysen, S and Lemke, Johannes R and Krägeloh-Mann, I and Helbig, Ingo and Kluger, G and Lerche, Holger and Møller, Rikke
Brain (London, England : 1878), ISSN 0006-8950, 05/2017, Volume 140, Issue 5, pp. 1316 - 1336
epilepsy | epilepsy genetics | SCN2A | treatment response | sodium channel blockers | Neurosciences | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | NAV1.2 Voltage-Gated Sodium Channel - physiology | Humans | NAV1.2 Voltage-Gated Sodium Channel - genetics | Child, Preschool | Infant | Male | Neurodevelopmental Disorders - genetics | Epilepsy - physiopathology | Epilepsy - epidemiology | Young Adult | Phenotype | Adolescent | Age of Onset | Denmark - epidemiology | Sodium Channel Blockers - therapeutic use | Adult | Epilepsy - drug therapy | Epilepsy - genetics | Female | Mutation | Child | Index Medicus | Abridged Index Medicus | Life Sciences | Genetics | Neurons and Cognition | Human genetics | Neurobiology
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5. Full Text G-Protein-coupled receptors: Decoding mixed signals
by Gardella, Thomas J
Nature chemical biology, ISSN 1552-4450, 02/2017, Volume 13, Issue 3, pp. 247 - 248
Proteins | Eukaryotes | ABC transporters | Hormones | Adrenal glands | Index Medicus
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6. Full Text A Homozygous [Cys25]PTH(1‐84) Mutation That Impairs PTH/PTHrP Receptor Activation Defines a Novel Form of Hypoparathyroidism
by Lee, Sihoon and Mannstadt, Michael and Guo, Jun and Kim, Seul Min and Yi, Hyon‐Seung and Khatri, Ashok and Dean, Thomas and Okazaki, Makoto and Gardella, Thomas J and Jüppner, Harald
Journal of bone and mineral research, ISSN 0884-0431, 10/2015, Volume 30, Issue 10, pp. 1803 - 1813
IDIOPATHIC HYPOPARATHYROIDISM | PSEUDOHYPOPARATHYROIDISM TYPE IB | PTH(1‐84) MUTATION | PTH(1-84) mutation | idiopathic hypoparathyroidism | pseudohypoparathyroidism type IB | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Humans | Parathyroid Hormone-Related Protein - genetics | Cercopithecus aethiops | Hypoparathyroidism - genetics | Mutation, Missense | Parathyroid Hormone-Related Protein - metabolism | Hypoparathyroidism - metabolism | Parathyroid Hormone - genetics | Homozygote | Animals | Parathyroid Hormone - metabolism | COS Cells | Amino Acid Substitution | Cysteine | Chronic kidney failure | Vitamin D | Parathyroid hormone | Hypoparathyroidism | Calcifediol | Genetic aspects | Alfacalcidol | Methylation | Calcium | Secretion | Homeostasis | Biological activity | Parathyroid hormone-related protein | Genetic counseling | Arginine | Calcinosis | Pseudohypoparathyroidism | Hyperphosphatemia | Mutation | Receptor mechanisms | Kidney diseases | Parathyroid | Hypocalcemia | Siblings | Kidney transplantation | Index Medicus | PTH(1-84) MUTATION
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7. Full Text An Inverse Agonist Ligand of the PTH Receptor Partially Rescues Skeletal Defects in a Mouse Model of Jansen's Metaphyseal Chondrodysplasia
by Noda, Hiroshi and Guo, Jun and Khatri, Ashok and Dean, Thomas and Reyes, Monica and Armanini, Michael and Brooks, Daniel J and Martins, Janaina S and Schipani, Ernestina and Bouxsein, Mary L and Demay, Marie B and Potts, John T and Jüppner, Harald and Gardella, Thomas J
Journal of bone and mineral research, ISSN 0884-0431, 03/2020, Volume 35, Issue 3, pp. 540 - 549
THERAPEUTICS | CELL/TISSUE SIGNALING ‐ ENDOCRINE PATHWAYS | GENETIC ANIMAL MODELS | PTH/VIT D/FGF23 | ANIMAL MODELS | HORMONE REPLACEMENT/RECEPTOR MODULATORS | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Kidneys | Transgenic mice | Bone turnover | Bone (trabecular) | Osteoblasts | Chondrodystrophy | Parathyroid hormone-related protein | Mutants | Hypercalcemia | Bone growth | Bone mass | Parathyroid hormone | Calcinosis | Collagen | Inverse agonists | Fibrosis | Bone marrow | Ligands | Kidney diseases | Index Medicus
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8. Full Text Decoding mixed signals
by Gardella, Thomas J
Nature chemical biology, ISSN 1552-4450, 02/2017, Volume 13, Issue 3, pp. 247 - 248
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9. Full Text Endosomal generation of cAMP in GPCR signaling
by Vilardaga, Jean-Pierre and Jean-Alphonse, Frederic G and Gardella, Thomas J
Nature chemical biology, ISSN 1552-4450, 2014, Volume 10, Issue 9, pp. 700 - 706
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Animals | Cyclic AMP - biosynthesis | Receptors, G-Protein-Coupled - metabolism | Humans | Receptors, Cell Surface - metabolism | Signal Transduction - physiology | Cell Membrane - metabolism | Endosomes - metabolism | Proteins | Signal transduction | Plasma | Ligands | Binding sites | Index Medicus
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10. Full Text PTH receptor-1 signalling - Mechanistic insights and therapeutic prospects
by Cheloha, Ross W and Gellman, Samuel H and Vilardaga, Jean-Pierre and Gardella, Thomas J
Nature reviews. Endocrinology, ISSN 1759-5029, 12/2015, Volume 11, Issue 12, pp. 712 - 724
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Parathyroid Hormone - physiology | Signal Transduction - drug effects | Parathyroid Hormone - metabolism | Humans | Ligands | Osteoporosis - drug therapy | Osteoporosis - genetics | Receptor, Parathyroid Hormone, Type 1 - drug effects | Receptor, Parathyroid Hormone, Type 1 - physiology | Receptor, Parathyroid Hormone, Type 1 - deficiency | Medicine, Experimental | Hormone receptors | Medical research | Cellular signal transduction | Genetic aspects | Health aspects | Index Medicus
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