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Oncogene, ISSN 0950-9232, 03/2017, Volume 36, Issue 9, pp. 1232 - 1244
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a high degree of inflammation and profound immune suppression. Here we identify Yes-associated... 
COLONY-STIMULATING FACTOR | TUMOR PROGRESSION | ONCOGENIC KRAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BONE-MARROW | PROMOTES RESISTANCE | CELL BIOLOGY | LUNG-CANCER | ONCOLOGY | GM-CSF | GENETICS & HEREDITY | SUPPRESSOR-CELLS | TRANSGENIC MICE | PHASE-2 TRIAL | Inflammation - pathology | Adenocarcinoma - pathology | Cell Proliferation | Pancreatic Neoplasms - metabolism | Prognosis | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Carcinoma, Pancreatic Ductal - metabolism | Phosphoproteins - metabolism | Inflammation - metabolism | Adenocarcinoma - metabolism | T-Lymphocytes - metabolism | Biomarkers, Tumor - metabolism | Pancreatitis - immunology | Cell Differentiation | Phosphoproteins - physiology | T-Lymphocytes - pathology | Tumor Cells, Cultured | Carcinoma, Pancreatic Ductal - immunology | Macrophages - immunology | Myeloid-Derived Suppressor Cells - metabolism | Myeloid-Derived Suppressor Cells - pathology | Acute Disease | Myeloid-Derived Suppressor Cells - immunology | Cytokines - metabolism | Macrophages - pathology | Adenocarcinoma - immunology | Pancreatic Neoplasms - pathology | Survival Rate | Inflammation - immunology | Phosphoproteins - genetics | Mutation - genetics | Carcinoma, Pancreatic Ductal - pathology | Xenograft Model Antitumor Assays | Adaptor Proteins, Signal Transducing - physiology | Macrophages - metabolism | Animals | Pancreatic Neoplasms - immunology | Adaptor Proteins, Signal Transducing - genetics | Pancreatitis - pathology | T-Lymphocytes - immunology | Mice | Pancreatitis - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Neoplasm Staging | Apoptosis | Proteins | Inflammation | Cytokines | Pancreatic cancer | PDAC | MDSC | inflammation | acute pancreatitis | YAP | T cells | Macrophages
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2015, Volume 112, Issue 11, pp. E1307 - E1316
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2015, Volume 112, Issue 11, p. E1307
  The synthesis and processing of mRNA, from transcription to translation initiation, often requires splicing of intragenic material. The final mRNA... 
Proteins | Genes | Stem cells | Tumorigenesis | Ribonucleic acid--RNA | Telomerase
Journal Article
Molecular cancer therapeutics, ISSN 1535-7163, 08/2019, p. molcanther.0231.2019
CDK4/6 inhibitors are used in the treatment of advanced estrogen receptor (ER)(+) breast cancer (BC). Their efficacy in ER(-) and early stage BC is currently... 
Journal Article
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 694 - 694
Journal Article
Developmental Cell, ISSN 1534-5807, 11/2016, Volume 39, Issue 4, pp. 452 - 465
Journal Article
Developmental Cell, ISSN 1534-5807, 10/2019, Volume 51, Issue 1, pp. 113 - 128.e9
Employing inducible genetically engineered and orthotopic mouse models, we demonstrate a key role for transcriptional regulator Yap in maintenance of... 
Sox2 | pancreatic cancer | tumor maintenance | Myc | Yap | Kras | p53 | SOX2 | TRANSFORMATION | INHIBITION | YAP/TAZ | ONCOGENIC KRAS | MYC | HIPPO PATHWAY ACTIVITY | YAP | DEVELOPMENTAL BIOLOGY | FEEDBACK MECHANISM | CANCER | CELL BIOLOGY
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 10/2019, Volume 47, Issue 18, pp. 9619 - 9636
Abstract Connections between epigenetic reprogramming and transcription or splicing create novel mechanistic networks that can be targeted with tailored... 
EWINGS-SARCOMA | CHROMATIN | RNA HELICASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN EWS-FLI1 | EWS/FLI-1 FUSION | GENE-REGULATION | BLOCKING | BINDING | CANCER | PREDICTION | Index Medicus
Journal Article
Science, ISSN 0036-8075, 08/2018, Volume 361, Issue 6405, p. eaam8419
Journal Article
Science Signaling, ISSN 1945-0877, 10/2017, Volume 10, Issue 499
Ewing's sarcoma (ES) is a rare and highly malignant cancer that grows in the bones or surrounding tissues mostly affecting adolescents and young adults. A... 
Journal Article
Journal Article
Cancer Genetics, ISSN 2210-7762, 12/2018, Volume 228-229, pp. 131 - 142
Cancer is a heterogeneous disease harboring diverse subclonal populations that can be discriminated by their DNA mutations. Environmental pressure selects... 
Liquid biopsies | pancreatic cancer | clonal evolution | colon cancer | circulating cell-free DNA (ccfDNA) | circulating tumor DNA | Colon cancer | Gene mutations | Analysis | Pancreatic cancer | DNA | Development and progression | Genetic aspects | Metastasis | Cancer
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2016, Volume 291, Issue 25, pp. 13257 - 13270
Journal Article