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Nature Protocols, ISSN 1754-2189, 10/2016, Volume 11, Issue 10, pp. 1782 - 1787
Journal Article
Nature, ISSN 0028-0836, 10/2018, Volume 562, Issue 7726, pp. 217 - 222
Journal Article
Nature Methods, ISSN 1548-7091, 04/2018, Volume 15, Issue 4, pp. 271 - 274
Several groups recently coupled CRISPR perturbations and single-cell RNA-seq for pooled genetic screens. We demonstrate that vector designs of these studies... 
CIRCUITS | GENETIC SCREENS | BIOCHEMICAL RESEARCH METHODS | EXPRESSION | GENOME | SEQ | P53 | RNA sequencing | Usage | Restriction enzymes, DNA | Physiological aspects | Genetic aspects | Genetic screening | Methods | CRISPR | Molecular biology | Ribonucleic acid--RNA | Cells
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2014, Volume 124, Issue 6, pp. 2651 - 2667
Journal Article
01/2019, ISBN 1085799700
A single 3 billion letter genome contains the instructions for the 37 trillion diverse cells that make up one human. To accomplish this, the ~21,000 human... 
Bioengineering | Health sciences | Genetics | Biology | Histology | Physiology | Epidemiology
Dissertation
Journal Article
HUMAN MOLECULAR GENETICS, ISSN 0964-6906, 08/2015, Volume 24, Issue 15, pp. 4480 - 4481
Journal Article
Cell, ISSN 0092-8674, 01/2019, Volume 176, Issue 1-2, pp. 377 - 390.e19
Over one million candidate regulatory elements have been identified across the human genome, but nearly all are unvalidated and their target genes uncertain.... 
CRISPR | human genetics | enhancer | single cell | CRISPRi | genetic screen | RNA-seq | gene regulation | crisprQTL | eQTL | ELEMENTS | DIFFERENTIAL ANALYSIS | DISSECTION | QUANTIFICATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | REGIONS | ENHANCERS | EXPRESSION | CELL BIOLOGY | RNA sequencing | Computer science | Anopheles | RNA | Analysis | Genes | Genomics | Genomes | DNA binding proteins | Genetic transcription | Genetic regulation | Genetic screening
Journal Article
Human molecular genetics, ISSN 0964-6906, 08/2015, Volume 24, Issue 15, pp. 4480 - 4481
Journal Article
American Journal of Human Genetics, ISSN 0002-9297, 10/2013, Volume 93, Issue 4, p. 697
  Chimeric genes can be caused by structural genomic rearrangements that fuse together portions of two different genes to create a novel gene. We hypothesize... 
Brain | Cell culture | Genes | Genomes | Gene expression | Deoxyribonucleic acid--DNA
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2014, Volume 124, Issue 6, pp. 2651 - 2651
Duchenne muscular dystrophy (DMD) is caused by mutations in the gene encoding dystrophin, which results in dysfunctional signaling pathways within muscle.... 
Journal Article
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