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1. Full Text Comment on: Tenofovir DF/emtricitabine/rilpivirine as HIV post-exposure prophylaxis: results from a multicentre prospective study
by Gatanaga, Hiroyuki and Oka, Shinichi
The Journal of antimicrobial chemotherapy, ISSN 0305-7453, 07/2019
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2. Full Text Prophylactic Effect of Antiretroviral Therapy on Hepatitis B Virus Infection
by Hiroyuki Gatanaga and Tsunefusa Hayashida and Junko Tanuma and Shinichi Oka
Clinical Infectious Diseases, ISSN 1058-4838, 6/2013, Volume 56, Issue 12, pp. 1812 - 1819
Background. Hepatitis B virus (HBV) infection is common in individuals infected with human immunodeficiency virus, especially in men who have sex with men... 
HIV/AIDS | Hepatitis | Antiretrovirals | HIV | Hepatitis antigens | Vaccination | Viruses | Infections | Hepatitis B virus | Art periods | Genotypes | resistant | tenofovir disoproxil fumarate | chronic infection | lamivudine | INFECTIOUS DISEASES | GENOTYPE | VACCINE | RANDOMIZED-TRIAL | COINFECTION | MICROBIOLOGY | IMMUNOLOGY | CORE ANTIGEN | ISOLATED ANTIBODY | HIV-INFECTION | HOMOSEXUAL-MEN | JAPAN | VIRAL-HEPATITIS | Humans | Drug Resistance, Viral | Hepatitis B - virology | Male | Alanine Transaminase - blood | Antibiotic Prophylaxis | Hepatitis B - blood | Hepatitis B Surface Antigens - blood | Tenofovir | Hepatitis B - immunology | Hepatitis B Antibodies - blood | Adenine - therapeutic use | Lamivudine - therapeutic use | Adult | Female | Retrospective Studies | HIV Infections - blood | Hepatitis B Core Antigens - blood | Anti-Retroviral Agents - therapeutic use | Adenine - analogs & derivatives | Organophosphonates - therapeutic use | HIV Infections - virology | Kaplan-Meier Estimate | Hepatitis B Surface Antigens - immunology | Hepatitis B Core Antigens - immunology | HIV Infections - drug therapy | Hepatitis B - prevention & control | Hepatitis B Antibodies - immunology | Complications and side effects | Highly active antiretroviral therapy | Patient outcomes | Drug therapy | HIV infection | Health aspects | Risk factors | Hepatitis B | Index Medicus
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3. Full Text Short Communication: A Quantitative System for Monitoring Blood-Circulating Viral Protein R of Human Immunodeficiency Virus-1 Detected a Possible Link with Pathogenic Indices
by Matsunaga, Akihiro and Oka, Masako and Iijima, Kenta and Shimura, Mari and Gatanaga, Hiroyuki and Oka, Shinichi and Ishizaka, Yukihito
AIDS Research and Human Retroviruses, ISSN 0889-2229, 07/2019, Volume 35, Issue 7, pp. 66 - 663
We developed a detergent-free enzyme-linked immunosorbent assay (ELISA) for HIV-1 viral protein R (Vpr), an accessory protein of human immunodeficiency virus... 
Virology | Carbon-carbon composites | Antiretroviral drugs | Intercellular adhesion molecule 1 | Complications | CD8 antigen | Health risks | Viruses | Cognition | Ribonucleic acid--RNA | Antiretroviral therapy | Proteins | Communications systems | Vpr protein | Blood circulation | Antiretroviral agents | Human immunodeficiency virus--HIV | Cell adhesion | Monocyte chemoattractant protein 1 | Monitoring | Enzyme-linked immunosorbent assay
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4. Full Text High Incidence of Renal Stones Among HIV-Infected Patients on Ritonavir-Boosted Atazanavir Than in Those Receiving Other Protease Inhibitor—Containing Antiretroviral Therapy
by Yohei Hamada and Takeshi Nishijima and Koji Watanabe and Hirokazu Komatsu and Kunihisa Tsukada and Katsuji Teruya and Hiroyuki Gatanaga and Yoshimi Kikuchi and Shinichi Oka
Clinical Infectious Diseases, ISSN 1058-4838, 11/2012, Volume 55, Issue 9, pp. 1262 - 1269
Background. Little information is available on the incidence of renal stones with ritonavir-boosted atazanavir (ATV/r) use. Methods. In a single-center study,... 
HIV/AIDS | Antiretrovirals | Body mass index | HIV | Protease inhibitors | Predisposing factors | AIDS | Uric acid | Hepatitis B virus | Kidney stones | Arts | NEPHROLITHIASIS | INFECTIOUS DISEASES | MANAGEMENT | POSITIVE PATIENTS | MICROBIOLOGY | IMMUNOLOGY | COMBINATION | LOPINAVIR | GLOMERULAR-FILTRATION-RATE | EFAVIRENZ | CREATININE | UROLITHIASIS | CHRONIC KIDNEY-DISEASE | HIV Protease Inhibitors - adverse effects | Kidney Calculi - chemically induced | Pyridines - administration & dosage | Ritonavir - administration & dosage | Anti-HIV Agents - adverse effects | Humans | Middle Aged | Antiretroviral Therapy, Highly Active - adverse effects | Male | HIV Protease Inhibitors - administration & dosage | Oligopeptides - adverse effects | Incidence | Anti-HIV Agents - administration & dosage | Pyridines - adverse effects | Ritonavir - adverse effects | HIV Infections - complications | Atazanavir Sulfate | Adult | Female | HIV Infections - drug therapy | Oligopeptides - administration & dosage | Retrospective Studies | Antiretroviral Therapy, Highly Active - methods | Cohort Studies | Complications and side effects | Demographic aspects | Distribution | Dosage and administration | Research | Drug therapy | HIV infection
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5. Full Text Adaptation of HIV-1 to human leukocyte antigen class I
by Kawashima, Yuka and Pfafferott, Katja and Frater, John and Matthews, Philippa and Payne, Rebecca and Addo, Marylyn and Gatanaga, Hiroyuki and Fujiwara, Mamoru and Hachiya, Atsuko and Koizumi, Hirokazu and Kuse, Nozomi and Oka, Shinichi and Duda, Anna and Prendergast, Andrew and Crawford, Hayley and Leslie, Alasdair and Brumme, Zabrina and Brumme, Chanson and Allen, Todd and Brander, Christian and Kaslow, Richard and Tang, James and Hunter, Eric and Allen, Susan and Mulenga, Joseph and Branch, Songee and Roach, Tim and John, Mina and Mallal, Simon and Ogwu, Anthony and Shapiro, Roger and Prado, Julia G and Fidler, Sarah and Weber, Jonathan and Pybus, Oliver G and Klenerman, Paul and Ndungu, Thumbi and Phillips, Rodney and Heckerman, David and Harrigan, P. Richard and Walker, Bruce D and Takiguchi, Masafumi and Goulder, Philip
Nature, ISSN 0028-0836, 04/2009, Volume 458, Issue 7238, pp. 641 - 645
The rapid and extensive spread of the human immunodeficiency virus (HIV) epidemic provides a rare opportunity to witness host-pathogen co-evolution involving... 
VIRAL LOAD | TRANSMISSION | MHC-CLASS-I | CELL RESPONSES | MULTIDISCIPLINARY SCIENCES | ESCAPE MUTATIONS | IMMUNODEFICIENCY-VIRUS TYPE-1 | T-LYMPHOCYTE RESPONSE | HLA-B | INFECTION | GAG | Humans | HLA-B Antigens - immunology | Epitopes, T-Lymphocyte - genetics | gag Gene Products, Human Immunodeficiency Virus - chemistry | HIV-1 - genetics | Polymorphism, Genetic | Epitopes, T-Lymphocyte - chemistry | Leukocytes - immunology | HIV-1 - immunology | HIV-1 - physiology | HIV Antigens - genetics | HIV Antigens - immunology | Internationality | Alleles | HIV Antigens - chemistry | Epitopes, T-Lymphocyte - immunology | gag Gene Products, Human Immunodeficiency Virus - genetics | CD8-Positive T-Lymphocytes - immunology | gag Gene Products, Human Immunodeficiency Virus - immunology | HLA-B Antigens - genetics | Cohort Studies | HIV antigens | Antigen receptors, T cell | Receptors | Histocompatibility antigens | Analysis | HLA histocompatibility antigens | Research | T cells | Medical research | Leucocytes | Antigens | Mutation | Human immunodeficiency virus--HIV
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6. Full Text Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection
by Ondondo, Beatrice and Murakoshi, Hayato and Clutton, Genevieve and Abdul-Jawad, Sultan and Wee, Edmund G-T and Gatanaga, Hiroyuki and Oka, Shinichi and McMichael, Andrew J and Takiguchi, Masafumi and Korber, Bette and Hanke, Tomáš
Molecular Therapy, ISSN 1525-0016, 04/2016, Volume 24, Issue 4, pp. 832 - 842
An effective human immunodeficiency virus type 1 (HIV-1) vaccine is the best solution for halting the acquired immune deficiency syndrome epidemic. Here, we... 
MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNITY | FITNESS | DOMINANCE | SEQUENCES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | TARGETS | BROAD | PROTEINS | PATHOGENIC SIV | Adenoviruses, Simian - immunology | Humans | AIDS Vaccines - immunology | CD4 Lymphocyte Count | Vaccinia virus - immunology | Viral Load | HIV Infections - immunology | Animals | HIV-1 - physiology | HIV Infections - therapy | Mice | HeLa Cells | AIDS Vaccines - administration & dosage | CD8-Positive T-Lymphocytes - immunology | Original
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7. Full Text Reply to Sheng et al
by Hiroyuki Gatanaga and Shinichi Oka
Clinical Infectious Diseases, ISSN 1058-4838, 11/2013, Volume 57, Issue 10, pp. 1506 - 1506
Shengs | Pharmaceutical preparations | HIV | AIDS | Correspondence | Infections | Hepatitis B virus | Art periods | Honoraria | Arts | Female | Influenza, Human - epidemiology | Influenza, Human - virology | Male | Influenza A Virus, H7N9 Subtype - isolation & purification | Humans
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8. Full Text Single Nucleotide Polymorphisms in ABCC2 Associate With Tenofovir-Induced Kidney Tubular Dysfunction in Japanese Patients With HIV-1 Infection: A Pharmacogenetic Study
by Takeshi Nishijima and Hirokazu Komatsu and Koichiro Higasa and Misao Takano and Kiyoto Tsuchiya and Tsunefusa Hayashida and Shinichi Oka and Hiroyuki Gatanaga
Clinical Infectious Diseases, ISSN 1058-4838, 12/2012, Volume 55, Issue 11, pp. 1558 - 1567
Background. Tenofovir is a widely used antiretroviral drug although it can cause kidney tubular dysfunction (KTD). The aim of this study was to determine the... 
Haplotypes | Phosphates | Urine | HIV/AIDS | Excretion | Kidneys | Antivirals | Infections | Uric acid | Operating rooms | Genotypes | ANTIRETROVIRAL-NAIVE | INFECTIOUS DISEASES | TRANSPORTER | ELIMINATION | MICROBIOLOGY | IMMUNOLOGY | DISPOSITION | P-GLYCOPROTEIN | RENAL SAFETY | THERAPY | GENE | DISOPROXIL FUMARATE | ABACAVIR/LAMIVUDINE | HIV-1 | Genetic Predisposition to Disease | Adenine - analogs & derivatives | Cross-Sectional Studies | Kidney Tubules - drug effects | Humans | Japan | Middle Aged | Organophosphonates - adverse effects | Male | Kidney Diseases - genetics | Tenofovir | Adenine - adverse effects | HIV Infections - complications | Kidney Diseases - chemically induced | Polymorphism, Single Nucleotide - genetics | Adult | Female | Multidrug Resistance-Associated Proteins - genetics | Kidney Diseases - complications | Multidrug Resistance-Associated Proteins - metabolism | Cohort Studies | Index Medicus
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9. Full Text Emergence of CXCR4-Tropic HIV-1 variants followed by rapid disease progression in hemophiliac slow progressors
by Hayashida, Tsunefusa and Tsuchiya, Kiyoto and Kikuchi, Yoshimi and Oka, Shinichi and Gatanaga, Hiroyuki
PLoS ONE, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, p. e0177033
Objective The association between emergence of CXCR4-tropic HIV-1 variants (X4 variants) and disease progression of HIV-1 infection has been reported. However,... 
POPULATION | MULTIDISCIPLINARY SCIENCES | REVERSE-TRANSCRIPTASE | ULTRA-DEEP | IN-VIVO | TYPE-1 TROPISM | AIDS | CORECEPTOR USAGE | MUTATIONS | V3 REGION | TREATMENT-NAIVE PATIENTS | HIV-1 - metabolism | Humans | Phylogeny | HIV-1 - genetics | Disease Progression | Viral Load | HIV-1 - classification | Hemophilia A - complications | Receptors, CXCR4 - metabolism | HIV-1 - physiology | HIV Infections - pathology | HIV Infections - complications | CD4-Positive T-Lymphocytes | High-Throughput Nucleotide Sequencing | Viral Tropism | Development and progression | Genetic aspects | Research | HIV (Viruses) | Genetic variation | Risk factors | Tropism | Viruses | Lymphocytes T | Infections | Drug resistance | Antiretroviral therapy | Medicine | Studies | Acquired immune deficiency syndrome--AIDS | Antiretroviral agents | Human immunodeficiency virus--HIV | Hemophilia | Emergence | Mutation | Deoxyribonucleic acid--DNA | HIV | Acquired immune deficiency syndrome | Deoxyribonucleic acid | DNA | Human immunodeficiency virus
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10. New anti-HIV agents
by Gatanaga, Hiroyuki
Nihon rinsho. Japanese journal of clinical medicine, ISSN 0047-1852, 04/2012, Volume 70, Issue 4, p. 655
Since the introduction of zidovudine into HIV clinical practice in 1985, the history of antiretroviral treatment has been started. Even in well controlled... 
Anti-HIV Agents - administration & dosage | Drug Administration Schedule | Humans | Reverse Transcriptase Inhibitors | CCR5 Receptor Antagonists | HIV Integrase Inhibitors
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11. Full Text Routine eye screening by an ophthalmologist is clinically useful for HIV-1-infected patients with CD4 count less than 200/μL
by Nishijima, Takeshi and Yashiro, Shigeko and Teruya, Katsuji and Kikuchi, Yoshimi and Katai, Naomichi and Oka, Shinichi and Gatanaga, Hiroyuki
PLoS ONE, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, p. e0136747
To investigate whether routine eye screening by an ophthalmologist in patients with HIV-1 infection is clinically useful. A single-center, retrospective study... 
Multivariate Analysis | Vision Screening | Cytomegalovirus Retinitis - epidemiology | Prevalence | Eye Diseases - complications | Cytomegalovirus Retinitis - diagnosis | Humans | Middle Aged | Male | CD4 Lymphocyte Count | Eye Diseases - diagnosis | HIV Infections - immunology | HIV-1 - physiology | HIV Infections - complications | Eye Diseases - epidemiology | Adult | Female | Aged | Retrospective Studies | Ophthalmology | Cytomegalovirus Retinitis - complications | Antiretroviral drugs | Cytomegalovirus | Retinopathy | Retina | Medical screening | Patients | CD4 antigen | Screening | Sexually transmitted diseases | Acquired immune deficiency syndrome--AIDS | Syphilis | Human immunodeficiency virus--HIV | Uveitis | Eye diseases | Retinitis | AIDS | HIV | Acquired immune deficiency syndrome | Human immunodeficiency virus
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12. Full Text Brief Report: High Peak Level of Plasma Raltegravir Concentration in Patients With ABCB1 and ABCG2 Genetic Variants
by Tsuchiya, Kiyoto and Hayashida, Tsunefusa and Hamada, Akinobu and Oka, Shinichi and Gatanaga, Hiroyuki
JAIDS Journal of Acquired Immune Deficiency Syndromes, ISSN 1525-4135, 05/2016, Volume 72, Issue 1, pp. 11 - 14
Raltegravir was recently identified to be a substrate of ATP-binding cassette transporter B1 (ABCB1) and G2 (ABCG2), which are efflux transporters and... 
Plasma concentrations | ATP-binding cassette transporter B1 | ATP-binding cassette transporter G2 | Antiretroviral therapy | Raltegravir | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Humans | Japan | Middle Aged | Raltegravir Potassium - therapeutic use | Male | ATP-Binding Cassette Transporters - genetics | HIV Integrase Inhibitors - therapeutic use | Polymorphism, Single Nucleotide - genetics | Raltegravir Potassium - blood | Female | HIV Infections - drug therapy | HIV Integrase Inhibitors - blood | Reverse Transcriptase Inhibitors - therapeutic use | Drug Therapy, Combination | Neoplasm Proteins - genetics | ATP Binding Cassette Transporter, Sub-Family B - genetics
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13. New anti-HIV agents
by Gatanaga, Hiroyuki
Nihon rinsho. Japanese journal of clinical medicine, ISSN 0047-1852, 2012, Volume 70, Issue 4, pp. 655 - 659
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14. Full Text Cerebral syphilitic gumma within 5 months of syphilis in HIV-infected patient
by Tsuboi, Motoyuki and Nishijima, Takeshi and Teruya, Katsuji and Kikuchi, Yoshimi and Gatanaga, Hiroyuki and Oka, Shinichi
Emerging Infectious Diseases, ISSN 1080-6040, 10/2016, Volume 22, Issue 10, pp. 1846 - 1848
INFECTIOUS DISEASES | IMMUNOLOGY | Brain - diagnostic imaging | Brain - microbiology | Coinfection | HIV Infections - virology | Humans | Symptom Assessment | Magnetic Resonance Imaging - methods | Male | Young Adult | HIV Infections - immunology | Syphilis - microbiology | Syphilis - diagnosis | HIV Infections - diagnosis | Biomarkers | Brain - pathology | HIV patients | Health aspects | Syphilis | computed tomography | viruses | magnetic resonance imaging | bacteria | syphilis | neurosyphilis | Letter | HIV | Letters to the Editor | AIDS and other retroviruses | Cerebral Syphilitic Gumma within 5 Months of Syphilis in HIV-Infected Patient | cerebral syphilitic gumma | Treponema pallidum
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15. Full Text Full-Genome Analysis of Hepatitis C Virus in Japanese and Non-Japanese Patients Coinfected With HIV-1 in Tokyo
by Ishida, Yuki and Hayashida, Tsunefusa and Sugiyama, Masaya and Tsuchiya, Kiyoto and Kikuchi, Yoshimi and Mizokami, Masashi and Oka, Shinichi and Gatanaga, Hiroyuki
JAIDS Journal of Acquired Immune Deficiency Syndromes, ISSN 1525-4135, 03/2019, Volume 80, Issue 3, pp. 350 - 357
BACKGROUND:Acute hepatitis C virus (HCV) infection is increasing among HIV-1–infected individuals in Tokyo. Appropriate clinical management is needed.... 
INFECTIOUS DISEASES | NS5A INHIBITOR BMS-790052 | DRUG-RESISTANT HIV-1 | SEX | IMMUNOLOGY | LIVER-DISEASE | men who have sex with men | HCV INFECTION | NS3 | injection drug users | epidemiology | phylogenetic analysis | IN-VITRO | HIV | MEN | DIRECT-ACTING ANTIVIRALS | HCV | VARIANTS RESISTANT | Epidemics | Drug abuse | Sexually transmitted diseases--STD | RNA-directed DNA polymerase | Viruses | Infections | Genomes | Phylogeny | Cases (containers) | Epidemiology | Gene sequencing | Hepatitis | Next-generation sequencing | Human immunodeficiency virus--HIV | Phylogenetics | Clusters | Drug use | Population growth | Risk groups | Patients | Disease transmission | Genotyping | Hepatitis C virus | Hepatitis C | Sexual partners
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16. Full Text Colonic cytomegalovirus detection by mucosal PCR and antiviral therapy in ulcerative colitis
by Okahara, Koki and Nagata, Naoyoshi and Shimada, Takayuki and Joya, Akane and Hayashida, Tsunefusa and Gatanaga, Hiroyuki and Oka, Shinichi and Sakurai, Toshiyuki and Uemura, Naomi and Akiyama, Junichi
PLoS ONE, ISSN 1932-6203, 09/2017, Volume 12, Issue 9, p. e0183951
Background We aimed to identify the risk factors associated with colonic cytomegalovirus (CMV) infection in ulcerative colitis (UC) and to compare the clinical... 
REAL-TIME PCR | CELLS | DIAGNOSIS | INFLAMMATORY-BOWEL-DISEASE | MANAGEMENT | MULTIDISCIPLINARY SCIENCES | BIOPSY | TISSUE | INFECTION | CMV | TRANSPLANTATION | Humans | Middle Aged | Male | Cytomegalovirus Infections - complications | Viral Load | Young Adult | Polymerase Chain Reaction | Aged, 80 and over | Colitis, Ulcerative - therapy | Cytomegalovirus Infections - virology | Adult | Female | Retrospective Studies | Severity of Illness Index | Cytomegalovirus - genetics | Treatment Outcome | Antiviral Agents | Intestinal Mucosa - virology | Cytomegalovirus Infections - diagnosis | Colitis, Ulcerative - etiology | Colitis, Ulcerative - diagnosis | Cytomegalovirus Infections - drug therapy | Adolescent | Biomarkers | Aged | DNA, Viral - genetics | Cytomegalovirus - drug effects | Intestinal Mucosa - pathology | Drugs | Therapy | Mucosa | Infections | Risk factors | Endoscopes | Infliximab | Hepatology | Colonoscopy | Surgery | Gastroenterology | Aging | Remission | Colon | Endoscopy | Drug dosages | Deoxyribonucleic acid--DNA | Cytomegalovirus | Health risks | Inflammation | Tumor necrosis factor-α | Risk analysis | Patients | Inflammatory bowel disease | Polymerase chain reaction | Medicine | Biopsy | Monoclonal antibodies | Azathioprine | Ulcerative colitis | Deoxyribonucleic acid | DNA
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17. Full Text Case Report: Hemophagocytic Lymphohistiocytosis Caused by Disseminated Histoplasmosis in a Venezuelan Patient with HIV and Epstein-Barr Virus Reactivation Who Traveled to Japan
by Tsuboi, Motoyuki and Nishijima, Takeshi and Nagi, Minoru and Miyazaki, Yoshitsugu and Teruya, Katsuji and Kikuchi, Yoshimi and Gatanaga, Hiroyuki and Oka, Shinichi
The American journal of tropical medicine and hygiene, ISSN 0002-9637, 02/2019, Volume 100, Issue 2, pp. 365 - 367
We describe a Venezuelan visitor to Japan who was diagnosed with hemophagocytic lymphohistiocytosis (HLH). The patient was also diagnosed with human... 
AIDS | BOLIVAR STATE | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | TROPICAL MEDICINE | FEATURES
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18. Full Text Antiretroviral Therapy Containing HIV Protease Inhibitors Enhances Fracture Risk by Impairing Osteoblast Differentiation and Bone Quality
by Hirakawa, Hiroyuki and Gatanaga, Hiroyuki and Ochi, Hiroki and Fukuda, Toru and Sunamura, Satoko and Oka, Shinichi and Takeda, Shu and Sato, Shingo
The Journal of Infectious Diseases, ISSN 0022-1899, 06/2017, Volume 215, Issue 12, pp. 1893 - 1897
Abstract Long-term antiretroviral therapy is associated with increased fracture risk, but the mechanism remains elusive. We measured serum undercarboxylated... 
HIV | bone quality | integrase strand transfer inhibitor (INSTI) | osteoblast differentiation | protease inhibitor (PI) | INFECTIOUS DISEASES | MINERAL DENSITY | MICROBIOLOGY | IMMUNOLOGY | Lysine - analogs & derivatives | HIV-1 - drug effects | Humans | Antiretroviral Therapy, Highly Active - adverse effects | Male | Biomarkers - blood | Arginine - analogs & derivatives | Osteocalcin - blood | Bone Density - drug effects | Animals | Arginine - blood | Protease Inhibitors - adverse effects | Female | Integrase Inhibitors | Mice | Retrospective Studies | Reverse Transcriptase Inhibitors | Lysine - blood | Antiviral agents | Usage | Care and treatment | Fractures | Protease inhibitors | Bones |