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Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 09/2019, Volume 9, Issue 1, pp. 1 - 11
For cancers, such as common solid tumours, variants in the genome give a selective growth advantage to certain cells. It has recently been argued that the mean... 
TERT PROMOTER MUTATIONS | IMPACT | PATHOGENICITY | GENE | MULTIDISCIPLINARY SCIENCES | SELECTION | CANCER | Learning algorithms | Genomes | Solid tumors | Cancer | Tumors
Journal Article
Epigenetics and Chromatin, ISSN 1756-8935, 05/2018, Volume 11, Issue 1, pp. 25 - 11
Background: The well-established association of chronological age with changes in DNA methylation is primarily founded on the analysis of large sets of blood... 
DNA methylation | Ageing | 450 k | Tissue-specific | STEM-CELLS | HYPERMETHYLATION | POPULATIONS | CANCER | INTEGRATIVE ANALYSIS | CPG SITES | GENETICS & HEREDITY | GENE-EXPRESSION | EPIGENOME | WIDE | BLOOD | Aging | Genomes | Research | Methylation | Biological markers | Chromatin | Senescence | Segmentation | Liver | Helper cells | Cell division | Studies | Polycomb group proteins | Monocytes | Stem cells | Bioinformatics | Age | Binding sites | Deoxyribonucleic acid--DNA | Cancer | CpG islands | 450 k
Journal Article
Translational Psychiatry, ISSN 2158-3188, 12/2019, Volume 9, Issue 1, pp. 105 - 10
Integrative approaches that harness large-scale molecular datasets can help develop mechanistic insight into findings from genome-wide association studies... 
GWAS | DNA METHYLATION | EQTL | PSYCHIATRY | SCHIZOPHRENIA | LOCI | GENOME-WIDE ASSOCIATION | DNA methylation | Schizophrenia | Epigenetics | Genomes | Gene expression | Deoxyribonucleic acid--DNA
Journal Article
PLoS Genetics, ISSN 1553-7390, 02/2019, Volume 15, Issue 2, p. e1007951
Mendelian randomization (MR) has been used to estimate the causal effect of body mass index (BMI) on particular traits thought to be affected by BMI. However,... 
DEPRESSION | OBESITY | FTO GENE | RISK-FACTOR | OVERWEIGHT | DISEASE | GENETICS & HEREDITY | ADIPOSITY | ANXIETY DISORDERS | ASSOCIATION | CANCER | Causal inference | Body mass index | Usage | Analysis | Genetic research | Influence | Genetic aspects | Gene banks | Obesity | Health sciences | Phenotypes | Diabetes mellitus | Bias | Cardiovascular disease | Genomes | Epidemiology | Risk factors | Medical schools | Studies | Genotype & phenotype | Hypotheses | Population
Journal Article
Human molecular genetics, ISSN 0964-6906, 07/2019
Immune mediated diseases (IMDs) arise when tolerance is lost and chronic inflammation is targeted towards healthy tissues. Despite their growing prevalence,... 
Journal Article
International Journal of Epidemiology, ISSN 0300-5771, 04/2018, Volume 47, Issue 2, pp. 369 - 379
Background: The scientific literature contains a wealth of information from different fields on potential disease mechanisms. However, identifying and... 
Publications | Data mining | Risk factors | SYSTEMIC CARNITINE DEFICIENCY | risk factors | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | FUSION | PROSTATE-CANCER | DISEASE | MENDELIAN RANDOMIZATION | EPIDEMIOLOGY | publications | Software Application Profile
Journal Article
Journal Article
International Journal of Epidemiology, ISSN 0300-5771, 12/2017, Volume 46, Issue 6, pp. 1857 - 1870
Journal Article
Nature genetics, ISSN 1061-4036, 2/2019, Volume 51, Issue 2, pp. 230 - 236
Osteoarthritis is the most common musculoskeletal disease and the leading cause of disability globally. Here, we perform a genome-wide association study for... 
Journal Article
by Swerdlow, Daniel I, Dr and Preiss, David, Dr and Kuchenbaecker, Karoline B, MSc and Holmes, Michael V, PhD and Engmann, Jorgen E L, MSc and Shah, Tina, PhD and Sofat, Reecha, MD and Stender, Stefan, MD and Johnson, Paul C D, PhD and Scott, Robert A, PhD and Leusink, Maarten, MSc and Verweij, Niek, MD and Sharp, Stephen J, MSc and Guo, Yiran, PhD and Giambartolomei, Claudia, MSc and Chung, Christina, MSc and Peasey, Anne, PhD and Amuzu, Antoinette, MSc and Li, KaWah, MSc and Palmen, Jutta, MSc and Howard, Philip, MSc and Cooper, Jackie A, MSc and Drenos, Fotios, PhD and Li, Yun R, BSc and Lowe, Gordon, Prof and Gallacher, John, PhD and Stewart, Marlene C W, PhD and Tzoulaki, Ioanna, PhD and Buxbaum, Sarah G, PhD and van der A, Daphne L, PhD and Forouhi, Nita G, MRCP and Onland-Moret, N Charlotte, PhD and van der Schouw, Yvonne T, Prof and Schnabel, Renate B, MD and Hubacek, Jaroslav A, PhD and Kubinova, Ruzena, MD and Baceviciene, Migle, MD and Tamosiunas, Abdonas, Prof and Pajak, Andrzej, Prof and Topor-Madry, Romanvan, MD and Stepaniak, Urszula, PhD and Malyutina, Sofia, Prof and Baldassarre, Damiano, PhD and Sennblad, Bengt, PhD and Tremoli, Elena, Prof and de Faire, Ulf, Prof and Veglia, Fabrizio, PhD and Ford, Ian, Prof and Jukema, J Wouter, Prof and Westendorp, Rudi G J, Prof and de Borst, Gert Jan, MD and de Jong, Pim A, MD and Algra, Ale, Prof and Spiering, Wilko, MD and der Zee, Anke H Maitland-van, PhD and Klungel, Olaf H, PharmD and de Boer, Anthonius, Prof and Doevendans, Pieter A, Prof and Eaton, Charles B, Prof and Robinson, Jennifer G, Prof and Duggan, David, PhD and Kjekshus, John, Prof and Downs, John R, MD and Gotto, Antonio M, MD and Keech, Anthony C, MD and Marchioli, Roberto, MD and Tognoni, Gianni, MD and Sever, Peter S, Prof and Poulter, Neil R, Prof and Waters, David D, MD and Pedersen, Terje R, MD and Amarenco, Pierre, MD and Nakamura, Haruo, MD and McMurray, John J V, Prof and Lewsey, James D, PhD and Chasman, Daniel I, PhD and Ridker, Paul M, MD and Maggioni, Aldo P, Prof and Tavazzi, Luigi, Prof and Ray, Kausik K, Prof and Seshasai, Sreenivasa Rao Kondapally, MD and Manson, JoAnn E, Prof and Price, Jackie F, MD and Whincup, Peter H, Prof and Morris, Richard W, Prof and Lawlor, Debbie A, Prof and Smith, George Davey, Prof and Ben-Shlomo, Yoav, Prof and Schreiner, Pamela J, Prof and Fornage, Myriam, Prof and Siscovick, David S, Prof and Cushman, Mary, MD and Kumari, Meena, PhD and Wareham, Nick J, Prof and Verschuren, W M Monique, PhD and Redline, Susan, Prof and Patel, Sanjay R, MD and Whittaker, John C, Prof and Hamsten, Anders, Prof and Delaney, Joseph A, PhD and ... and MAGIC Consortium and InterAct Consortium and DIAGRAM Consortium
The Lancet, ISSN 0140-6736, 01/2015, Volume 385, Issue 9965, pp. 351 - 361
Journal Article