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Nature Chemical Biology, ISSN 1552-4450, 02/2018, Volume 14, Issue 2, pp. 118 - 125
Given the importance of ubiquitin-specific protease 7 (USP7) in oncogenic pathways, identification of USP7 inhibitors has attracted considerable interest.... 
INACTIVATION | DUBS | STABILIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | HAUSP | ACTIVATES P53 | PROTEASES | Ubiquitin | Cell culture | MDM2 protein | Allosteric properties | Ubiquitin-specific proteinase | Inhibitors | Antagonists | Tumor cell lines | Binding sites | Optimization | Crystal structure | Cancer
Journal Article
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 1181 - 1181
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. LB-159 - LB-159
Wee1 is a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDK1CDC2) to inactive the CDC2cyclinB complex. Wee1 is therefore a key regulator of... 
Journal Article
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. LB-257 - LB-257
Journal Article
Molecular Cancer Research, ISSN 1541-7786, 04/2017, Volume 15, Issue 4 Supplement, pp. B17 - B17
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 03/2018, Volume 9, Issue 3, pp. 238 - 243
Ubiquitin specific protease 7 (USP7, HAUSP) has become an attractive target in drug discovery due to the role it plays in modulating Mdm2 levels and... 
proteasome | USP7 | ubiquitination | Mdm2 | HAUSP | deubiquitinase | ubiquitin | p53 | CHEMISTRY, MEDICINAL | CANCER | DISCOVERY | POTENT | SMALL-MOLECULE INHIBITORS | USP7/HAUSP
Journal Article
Biochemistry, ISSN 0006-2960, 11/2006, Volume 45, Issue 44, pp. 13304 - 13311
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 11/2003, Volume 31, Issue 22, pp. 6509 - 6515
The enzyme telomerase is a ribonucleoprotein that has a critical role in the maintenance of stable telomeres in organisms that possess linear chromosomes.... 
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 11/2003, Volume 31, Issue 22, pp. 6509 - 6515
The enzyme telomerase is a ribonucleoprotein that has a critical role in the maintenance of stable telomeres in organisms that possess linear chromosomes.... 
Journal Article
Chemical Communications, ISSN 1359-7345, 2003, Volume 9, Issue 1, pp. 36 - 37
Journal Article
Nucleic acids research, ISSN 0305-1048, 10/2002, Volume 30, Issue 20, pp. 4470 - 4480
Telomeres are essential for genomic stability and cell viability. Telomerase, the enzyme responsible for telomere maintenance, is composed of a reverse... 
Consensus Sequence | Sequence Deletion | Humans | Templates, Genetic | Ribonucleoproteins - metabolism | RNA - chemistry | RNA - genetics | Sequence Alignment | Animals | Telomerase - genetics | Base Sequence | Telomerase - chemistry | DNA - biosynthesis | Telomerase - metabolism | Models, Genetic | Telomere - metabolism | Catalysis | Mutation
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 10/2002, Volume 30, Issue 20, pp. 4470 - 4480
Telomeres are essential for genomic stability and cell viability. Telomerase, the enzyme responsible for telomere maintenance, is composed of a reverse... 
PROTEIN INTERACTIONS | TETRAHYMENA TELOMERASE | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | REVERSE-TRANSCRIPTASE | YEAST TELOMERASE | ACTIVITY IN-VITRO | TERMINAL TRANSFERASE | PRIMER SPECIFICITY | IDENTIFICATION | SUBUNIT
Journal Article
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