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Cancer Research, ISSN 0008-5472, 04/2012, Volume 72, Issue 8 Supplement, pp. 2226 - 2226
Journal Article
Nature Genetics, ISSN 1061-4036, 04/2015, Volume 47, Issue 4, pp. 330 - 337
Journal Article
Cancer Cell, ISSN 1535-6108, 11/2012, Volume 22, Issue 5, pp. 683 - 697
To define the mutation spectrum in non-Down syndrome acute megakaryoblastic leukemia (non-DS-AMKL), we performed transcriptome sequencing on diagnostic blasts... 
ONCOLOGY-GROUP | ONCOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | ZINC-FINGER PROTEIN | GLI PROTEINS | FUNCTIONAL-CHARACTERIZATION | ACUTE MYELOID-LEUKEMIA | DIFFERENTIATION | ACUTE MEGAKARYOCYTIC LEUKEMIA | CELL-LINE | GENETIC ALTERATIONS | CELL BIOLOGY | Oncogene Proteins, Fusion - metabolism | Prognosis | Humans | Leukemia, Megakaryoblastic, Acute - classification | Recombinant Fusion Proteins - physiology | Gene Expression Profiling | Chromosome Inversion | Recombinant Fusion Proteins - metabolism | Oncogene Proteins, Fusion - physiology | Bone Morphogenetic Proteins - metabolism | Tumor Suppressor Proteins - genetics | Leukemia, Megakaryoblastic, Acute - genetics | Child | Drosophila - genetics | Leukemia, Megakaryoblastic, Acute - diagnosis | Signal Transduction | Repressor Proteins - genetics | Animals | Sequence Analysis, RNA | Oncogene Proteins, Fusion - genetics | Chromosomes, Human, Pair 16 | Recombinant Fusion Proteins - genetics | Drosophila - growth & development | Mice | Kruppel-Like Transcription Factors - genetics | Pediatrics | Medical colleges | Oncology, Experimental | Analysis | Bone marrow | Transplantation | Research | Children | Health aspects | Biometry | Cancer | Leukemia, Megakaryoblastic, Acute/classification | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin | Drosophila/genetics | Bone Morphogenetic Proteins/metabolism | Kruppel-Like Transcription Factors/genetics | Oncogene Proteins, Fusion/genetics | Recombinant Fusion Proteins/genetics | Basic Medicine | Repressor Proteins/genetics | Tumor Suppressor Proteins/genetics | Clinical Medicine | Medicinska och farmaceutiska grundvetenskaper | Cancer and Oncology | Cancer och onkologi
Journal Article
Journal Article
Nature Genetics, ISSN 1061-4036, 12/2016, Volume 48, Issue 12, pp. 1551 - 1556
Journal Article
Leukemia, ISSN 0887-6924, 08/2009, Volume 23, Issue 8, pp. 1417 - 1425
We explored the impact of mutations in the NOTCH1, FBW7 and PTEN genes on prognosis and downstream signaling in a well-defined cohort of 47 patients with... 
NOTCH1 | T-cell | PROTEOLYTIC ACTIVATION | PTEN | RECEPTOR | HETERODIMERIZATION | INDUCTION | chemotherapy | DROSOPHILA | ONCOLOGY | acute lymphoblastic leukemia | PATHWAY | GENE-EXPRESSION | RESISTANCE | TUMOR-SUPPRESSOR | FBW7 | HEMATOLOGY | INTRACELLULAR DOMAIN | F-Box-WD Repeat-Containing Protein 7 | Transcription Factor HES-1 | Prognosis | Humans | Neoplasm Proteins - physiology | PTEN Phosphohydrolase - physiology | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Child, Preschool | Infant | Male | Ubiquitin-Protein Ligases - physiology | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - mortality | Gene Expression Regulation, Leukemic - genetics | Young Adult | DNA Mutational Analysis | Basic Helix-Loop-Helix Transcription Factors - biosynthesis | Cell Cycle Proteins - genetics | Female | Neoplasm Proteins - genetics | Child | Genes, Reporter | PTEN Phosphohydrolase - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Basic Helix-Loop-Helix Transcription Factors - genetics | Homeodomain Proteins - biosynthesis | Treatment Outcome | Signal Transduction - genetics | Homeodomain Proteins - genetics | F-Box Proteins - physiology | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Adolescent | DNA, Neoplasm - genetics | Mutation | Receptor, Notch1 - genetics | Ubiquitin-Protein Ligases - genetics | Cell Cycle Proteins - physiology | F-Box Proteins - genetics | Receptor, Notch1 - physiology | Cohort Studies | Gene mutations | Physiological aspects | Genetic aspects | Research | Acute lymphocytic leukemia | Children | T cells | Diseases | DELTEX1 | HES1 | cMYC
Journal Article
Leukemia, ISSN 0887-6924, 10/2017, Volume 31, Issue 10, pp. 2228 - 2234
Acute megakaryoblastic leukemia in patients without Down syndrome is a rare malignancy with a poor prognosis. RNA sequencing of fourteen pediatric cases... 
ONCOLOGY | FLT3 | ACUTE LYMPHOBLASTIC-LEUKEMIA | DOWN-SYNDROME | ACUTE MEGAKARYOBLASTIC LEUKEMIA | GENOME-WIDE ANALYSIS | GENE-EXPRESSION | ACUTE MYELOID-LEUKEMIA | MUTATIONS | HEMATOLOGY | CHILDRENS ONCOLOGY GROUP | ACUTE PROMYELOCYTIC LEUKEMIA | Neoplasm Transplantation | RNA, Small Interfering - genetics | Humans | Hematopoietic Stem Cells - pathology | Gene Expression Profiling | Gene Expression Regulation, Leukemic - genetics | Oncogene Proteins, Fusion - physiology | Thrombopoiesis - genetics | Cell Self Renewal | Neoplastic Stem Cells - metabolism | Cell Transformation, Neoplastic - genetics | Neoplastic Stem Cells - pathology | Female | Leukemia, Megakaryoblastic, Acute - genetics | Transcription Factors - physiology | Mice, Inbred C57BL | Hematopoietic Stem Cells - metabolism | Radiation Chimera | Transcription Factors - genetics | Phenotype | Animals | Oncogene Proteins, Fusion - genetics | Bone Marrow - pathology | Mice | Models, Genetic | Myeloid Cells - pathology | Transcription factors | Care and treatment | Leukemia | Development and progression | Genetic aspects | Gene expression | Health aspects | Transformation | Animal models | Syngeneic grafts | Genes | Bone marrow transplantation | Pharmacology | Malignancy | Ribonucleic acid--RNA | Chemical compounds | Gene sequencing | Down's syndrome | Bone marrow | Mutation | Inducers | Tumors
Journal Article
Blood, ISSN 0006-4971, 02/2010, Volume 115, Issue 6, pp. 1175 - 1184
Journal Article
Cancer Research, ISSN 0008-5472, 04/2011, Volume 71, Issue 8 Supplement, pp. 2881 - 2881
Journal Article
Blood, ISSN 0006-4971, 12/2014, Volume 124, Issue 21, pp. 127 - 127
Abstract Pathologic germ line mutations that predispose patients to cancer are estimated to occur in 4-30% of all pediatric oncology cases. In addition to... 
Journal Article
Blood, ISSN 0006-4971, 11/2009, Volume 114, Issue 22, pp. 8 - 8
Abstract Abstract 8 T-cell acute lymphoblastic leukemia (T-ALL) is a malignancy of immature T cell progenitors in which activating mutations of NOTCH1 occur in... 
Journal Article