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Nature Medicine, ISSN 1078-8956, 12/2014, Volume 21, Issue 1, pp. 27 - 36
Journal Article
Nature Medicine, ISSN 1078-8956, 12/2012, Volume 18, Issue 12, pp. 1847 - 1856
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 10/2009, Volume 5, Issue 10, pp. 749 - 757
Journal Article
Diabetes, ISSN 0012-1797, 05/2013, Volume 62, Issue 5, pp. 1453 - 1463
Glucagon, an essential regulator of glucose homeostasis, also modulates lipid metabolism and promotes weight loss, as reflected by the wasting observed in... 
PPAR-ALPHA | BODY-WEIGHT | METABOLISM | FIBROBLAST-GROWTH-FACTOR-21 | PHARMACOLOGY | INCREASES ENERGY-EXPENDITURE | ENDOCRINOLOGY & METABOLISM | DEGRADATION | MICE | INSULIN SENSITIVITY | FGF21 | Obesity - drug therapy | Humans | Peptides - pharmacokinetics | Fibroblast Growth Factors - genetics | Male | Fibroblast Growth Factors - secretion | Obesity - blood | Anti-Obesity Agents - therapeutic use | Glucagon - agonists | Fibroblast Growth Factors - metabolism | Anti-Obesity Agents - pharmacokinetics | Peptides - chemical synthesis | Hepatocytes - secretion | Hypoglycemic Agents - therapeutic use | Receptors, Glucagon - agonists | Receptors, Glucagon - genetics | Hypoglycemic Agents - pharmacokinetics | Peptides - physiology | Rats | Hypoglycemic Agents - pharmacology | Mice, Knockout | Cross-Over Studies | Anti-Obesity Agents - chemical synthesis | Mice | Anti-Obesity Agents - pharmacology | Hepatocytes - pathology | Diabetes Mellitus, Type 2 - metabolism | Hepatocytes - metabolism | Molecular Targeted Therapy | Mice, Mutant Strains | HEK293 Cells | Adult | Female | Hepatocytes - drug effects | Recombinant Proteins - metabolism | Double-Blind Method | Cells, Cultured | Insulin Resistance | Receptors, Glucagon - metabolism | Recombinant Proteins - agonists | Glucagon - pharmacology | Obesity - metabolism | Diabetes Mellitus, Type 2 - blood | Animals | Fibroblast Growth Factors - blood | Hypoglycemic Agents - chemical synthesis | Glucagon - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Peptides - therapeutic use | Physiological aspects | Fibroblast growth factors | Research | Glucagon | Analysis | Original Research
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 03/2019, Volume 316, Issue 3, pp. E397 - E409
Journal Article
Organic Letters, ISSN 1523-7060, 11/2016, Volume 18, Issue 21, pp. 5516 - 5519
A new synthetic route to human telaxin-2 has been established through a sequential disulfide bond formation process in the absence of iodine. It is enabled by... 
DIFFICULT | IN-VITRO | CHAIN COMBINATION | PROTECTING GROUP | ANALOG | AFFINITY | CHEMISTRY, ORGANIC | CHEMICAL-SYNTHESIS | PHACM | PHASE PEPTIDE-SYNTHESIS
Journal Article
ChemMedChem, ISSN 1860-7179, 04/2018, Volume 13, Issue 8, pp. 852 - 859
Journal Article
Accounts of Chemical Research, ISSN 0001-4842, 08/2017, Volume 50, Issue 8, pp. 1855 - 1865
Insulin is a miraculous hormone that has served a seminal role in the treatment of insulin-dependent diabetes for nearly a century. Insulin resides within in a... 
BIOMIMETIC SYNTHESIS | DISULFIDE BOND FORMATION | HUMAN RELAXIN-2 | IN-VITRO | BOVINE INSULIN | IODINE-FREE | RECEPTOR-BINDING ACTIVITY | SOLID-PHASE SYNTHESIS | MINI-PROINSULIN | CHEMICAL-SYNTHESIS | CHEMISTRY, MULTIDISCIPLINARY | Insulin - physiology | Peptides - physiology | Humans
Journal Article
Peptides, ISSN 0196-9781, 10/2019, Volume 120, p. 170116
Insulin-like peptide 5 (INSL5) is a member of the insulin-like family of peptides. It has been reported to be orexigenic in rodent models of obesity with... 
Obesity | Glucose sensitivity | Metabolism | INSL5
Journal Article
Protein and peptide letters, ISSN 0929-8665, 2018, Volume 25, Issue 12, pp. 1149 - 1154
Background: Research has been directed at the optimization of insulin for medicinal purposes. An insulin analog that could be reversibly activated might... 
Insulin analogs | reversible tethering | amide bond | peptide hormone | bioactivity | biological potency | HALF-LIFE EXTENSION | PEPTIDES | ACETYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEINS
Journal Article
Organic Letters, ISSN 1523-7060, 02/2017, Volume 19, Issue 3, pp. 706 - 709
Journal Article
Molecular Metabolism, ISSN 2212-8778, 02/2019, Volume 20, pp. 51 - 62
Structurally-improved GIP analogs were developed to determine precisely whether GIP receptor (GIPR) agonism or antagonism lowers body weight in obese mice. A... 
Obesity | Agonism | Pharmacology | Diet-induced obese (DIO) mice | Glucose-dependent insulinotropic polypeptide (GIP) | HIGH-FAT | GLUCOSE-INTOLERANCE | COMPETITIVE ANTAGONIST | GLUCAGON-LIKE PEPTIDE-1 | GIP(3-30)NH2 | ENDOCRINOLOGY & METABOLISM | IMPROVES | DEPENDENT INSULINOTROPIC POLYPEPTIDE | GASTRIC-INHIBITORY POLYPEPTIDE | RECEPTOR AGONIST
Journal Article
Organic Letters, ISSN 1523-7060, 06/2018, Volume 20, Issue 12, pp. 3695 - 3699
A simplified route to synthesis of INSL5 is reported, where the elimination of intermediate purification steps and nonconventional disulfide pairing results in... 
ROUTE | MECHANISM | RXFP4 | CHEMISTRY, ORGANIC | SUPERFAMILY | ACYL ISOPEPTIDE METHOD | CHEMICAL-SYNTHESIS | PROTECTING GROUPS | IDENTIFICATION | INSL5 | AGONIST
Journal Article