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European Heart Journal, ISSN 0195-668X, 11/2018, Volume 39, Issue 44, pp. 3925 - 3931
Abstract Genetic conditions, even those associated with identical gene mutations, can present with variable clinical manifestations. One widely accepted... 
Long QT syndrome | Genetic modifiers | Genetics | Acute myocardial infarction | Genetic variants | 3' UNTRANSLATED REGION | COMMON VARIANTS | CARDIAC & CARDIOVASCULAR SYSTEMS | VENTRICULAR-FIBRILLATION | DISEASE SEVERITY | COMPOUND MUTATIONS | LONG-QT SYNDROME | INTERVAL DURATION | ACUTE MYOCARDIAL-INFARCTION | NOS1AP GENE | HEART-RATE | Clinical Review
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 08/2019, Volume 74, Issue 6, pp. 759 - 770
Journal Article
PloS one, 2019, Volume 14, Issue 9, p. e0220415
The voltage-gated potassium channel KCNQ1 (KV7.1) assembles with the KCNE1 accessory protein to generate the slow delayed rectifier current, IKS, which is... 
Journal Article
The Journal of physiology, ISSN 0022-3751, 05/2019, Volume 597, Issue 16, pp. 4293 - 4307
Dravet syndrome mice (Scn1a ) demonstrate a marked strain dependence for the severity of seizures which is correlated with GABA receptor α subunit expression.... 
Journal Article
Circulation, ISSN 0009-7322, 11/2007, Volume 116, Issue 20, pp. 2325 - 2345
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2016, Volume 110, Issue 3, pp. 447a - 447a
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2012, Volume 122, Issue 12, pp. 4333 - 4333
Mutations in the skeletal muscle voltage-gated calcium channel (Ca sub( v)1.1) have been associated with hypokalemic periodic paralysis, but how the... 
Channel pores | Animal models | Molecular modelling | Channel gating | Channelopathy | Calcium channels (voltage-gated) | Action potential | Mutation | Paralysis | Skeletal muscle
Journal Article
Heart rhythm, 09/2018
Journal Article
Cell Calcium, ISSN 0143-4160, 09/2019, Volume 82, p. 102063
Here we report the structure of the widely utilized calmodulin (CaM)-dependent protein kinase II (CaMKII) inhibitor KN93 bound to the Ca -sensing protein CaM.... 
Calcium calmodulin dependent kinase type II (CaMKII) | Calcium signaling | CaMKII inhibition | autocamtide-2-inhibitor peptide | KN93 | KN92
Journal Article
Biophysical Journal, ISSN 0006-3495, 01/2015, Volume 108, Issue 2, pp. 576a - 576a
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 02/2017, Volume 114, Issue 7, pp. 1696 - 1696
Monogenic epilepsies with wide-ranging clinical severity have been associated with mutations in voltage-gated sodium channel genes. In the Scn2a super( Q54)... 
Journal Article
Analytical Chemistry (Washington), ISSN 0003-2700, 09/2016, Volume 88, Issue 17, pp. 8604 - 8604
The competition of two drugs for the same metabolizing enzyme is a common mechanism for drug-drug interactions that can lead to altered kinetics in drug... 
Drugs | Platforms | Self-assembled monolayers | Lasers | Reaction kinetics | Inhibition | Metabolism | Mass spectrometry
Journal Article
Analytical Chemistry (Washington), ISSN 0003-2700, 09/2016, Volume 88, Issue 17, pp. 8604 - 8604
The competition of two drugs for the same metabolizing enzyme is a common mechanism for drug-drug interactions that can lead to altered kinetics in drug... 
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2017, Volume 127, Issue 7, p. 2805
Voltage-gated sodium channel ([Na.sub.v]) mutations cause genetic pain disorders that range from severe paroxysmal pain to a congenital inability to sense... 
Research | Gene mutations | Neurons | Analysis
Journal Article