Lancet Infectious Diseases, The, ISSN 1473-3099, 2011, Volume 11, Issue 5, pp. 394 - 407
Summary Viral tropism is the ability of viruses to enter and infect specific host cells and is based on the ability of viruses to bind to receptors on those...
Infectious Disease | INFECTIOUS DISEASES | PHENOTYPIC ASSAY | CORECEPTOR USE | TREATMENT-EXPERIENCED PATIENTS | IMMUNODEFICIENCY-VIRUS TYPE-1 | LARGE POPULATION | GENOTYPIC PREDICTION | ANTIRETROVIRAL THERAPY | CCR5 ANTAGONISTS | TREATED PATIENTS | CCR5-TROPIC HIV-1 | HIV-1 - physiology | Humans | Anti-HIV Agents - therapeutic use | HIV Infections - drug therapy | HIV-1 - genetics | Practice Guidelines as Topic | Viral Tropism - genetics | Viral Tropism - physiology
Infectious Disease | INFECTIOUS DISEASES | PHENOTYPIC ASSAY | CORECEPTOR USE | TREATMENT-EXPERIENCED PATIENTS | IMMUNODEFICIENCY-VIRUS TYPE-1 | LARGE POPULATION | GENOTYPIC PREDICTION | ANTIRETROVIRAL THERAPY | CCR5 ANTAGONISTS | TREATED PATIENTS | CCR5-TROPIC HIV-1 | HIV-1 - physiology | Humans | Anti-HIV Agents - therapeutic use | HIV Infections - drug therapy | HIV-1 - genetics | Practice Guidelines as Topic | Viral Tropism - genetics | Viral Tropism - physiology
Journal Article
JAMA, ISSN 0098-7484, 04/2011, Volume 305, Issue 13, pp. 1327 - 1335
CONTEXT Presence of low-frequency, or minority, human immunodeficiency virus type 1 (HIV-1) drug resistance mutations may adversely affect response to...
MEDICINE, GENERAL & INTERNAL | MINORITY VARIANTS | IMPACT | TRANSMISSION | THERAPY | REVERSE-TRANSCRIPTASE | EFAVIRENZ | POPULATIONS | INFECTED PATIENTS | TREATMENT-NAIVE PATIENTS | ADHERENCE | Drug Resistance, Viral - genetics | Humans | Treatment Failure | Anti-Retroviral Agents - pharmacology | HIV Infections - drug therapy | Risk | Mutation | HIV-1 - genetics | Case-Control Studies | Cohort Studies | Antiretroviral drugs | Systematic review | Drug resistance | Human immunodeficiency virus--HIV | Risk factors
MEDICINE, GENERAL & INTERNAL | MINORITY VARIANTS | IMPACT | TRANSMISSION | THERAPY | REVERSE-TRANSCRIPTASE | EFAVIRENZ | POPULATIONS | INFECTED PATIENTS | TREATMENT-NAIVE PATIENTS | ADHERENCE | Drug Resistance, Viral - genetics | Humans | Treatment Failure | Anti-Retroviral Agents - pharmacology | HIV Infections - drug therapy | Risk | Mutation | HIV-1 - genetics | Case-Control Studies | Cohort Studies | Antiretroviral drugs | Systematic review | Drug resistance | Human immunodeficiency virus--HIV | Risk factors
Journal Article
The Journal of Infectious Diseases, ISSN 0022-1899, 3/2013, Volume 207, Issue 6, pp. 893 - 897
Drug-resistant human immunodeficiency virus type 1 (HIV-1) minority variants increase the risk of virologic failure for first-line nonnucleoside reverse...
HIV/AIDS | Antiretrovirals | HIV | Drug evaluation | AIDS | Reverse transcriptase inhibitors | Drug resistance | Genetic mutation | Disease risks | Virology | HIV 1 | virologic failure | resistance genotyping | HIV-1 drug resistance | minority variants | HIV-1 | INFECTIOUS DISEASES | VARIANTS | MICROBIOLOGY | DRUG-RESISTANCE | IMMUNOLOGY | NEVIRAPINE | ESCAPE | TREATMENT-NAIVE | ACTIVE ANTIRETROVIRAL THERAPY | EFAVIRENZ | Viral drug resistance | Care and treatment | Gene mutations | Genetic aspects | Dosage and administration | Research | HIV infection | Major and Brief Reports
HIV/AIDS | Antiretrovirals | HIV | Drug evaluation | AIDS | Reverse transcriptase inhibitors | Drug resistance | Genetic mutation | Disease risks | Virology | HIV 1 | virologic failure | resistance genotyping | HIV-1 drug resistance | minority variants | HIV-1 | INFECTIOUS DISEASES | VARIANTS | MICROBIOLOGY | DRUG-RESISTANCE | IMMUNOLOGY | NEVIRAPINE | ESCAPE | TREATMENT-NAIVE | ACTIVE ANTIRETROVIRAL THERAPY | EFAVIRENZ | Viral drug resistance | Care and treatment | Gene mutations | Genetic aspects | Dosage and administration | Research | HIV infection | Major and Brief Reports
Journal Article
The Lancet, ISSN 0140-6736, 06/2019, Volume 393, Issue 10189, pp. 2428 - 2438
The level of evidence for HIV transmission risk through condomless sex in serodifferent gay couples with the HIV-positive partner taking virally suppressive...
VIRAL LOAD | MEDICINE, GENERAL & INTERNAL | RNA | HETEROSEXUAL TRANSMISSION | BLOOD-PLASMA | SEMEN | PREVENTION | INFECTION | SERODISCORDANT COUPLES | HIV patients | Disease transmission | HIV (Viruses) | Gay couples | Risk factors | Therapy | Sexually transmitted diseases--STD | Prophylaxis | Sex | Risk | Partnerships | Infections | Phylogeny | Incidence | Mathematical analysis | Antiretroviral agents | Human immunodeficiency virus--HIV | Drug therapy | Anal sex | Antiretroviral drugs | Sexual behavior | Health risks | Exposure | Ribonucleic acid--RNA | Seroconversion | Antiretroviral therapy | Studies | Data collection | Gays & lesbians | Condoms
VIRAL LOAD | MEDICINE, GENERAL & INTERNAL | RNA | HETEROSEXUAL TRANSMISSION | BLOOD-PLASMA | SEMEN | PREVENTION | INFECTION | SERODISCORDANT COUPLES | HIV patients | Disease transmission | HIV (Viruses) | Gay couples | Risk factors | Therapy | Sexually transmitted diseases--STD | Prophylaxis | Sex | Risk | Partnerships | Infections | Phylogeny | Incidence | Mathematical analysis | Antiretroviral agents | Human immunodeficiency virus--HIV | Drug therapy | Anal sex | Antiretroviral drugs | Sexual behavior | Health risks | Exposure | Ribonucleic acid--RNA | Seroconversion | Antiretroviral therapy | Studies | Data collection | Gays & lesbians | Condoms
Journal Article
The Lancet Public Health, ISSN 2468-2667, 11/2016, Volume 1, Issue 1, pp. e26 - e36
Few studies have assessed the effect of socioeconomic status on HIV treatment outcomes in settings with universal access to health care. Here we aimed to...
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Journal Article
The Lancet Infectious Diseases, ISSN 1473-3099, 09/2018, Volume 18, Issue 9, pp. 992 - 1003
Viral meningitis is increasingly recognised, but little is known about the frequency with which it occurs, or the causes and outcomes in the UK. We aimed to...
IMMUNOCOMPETENT ADULTS | DIAGNOSIS | INFECTIOUS DISEASES | POLYMERASE-CHAIN-REACTION | MANAGEMENT | ACUTE BACTERIAL-MENINGITIS | ENTEROVIRAL MENINGITIS | ASEPTIC-MENINGITIS | CENTRAL-NERVOUS-SYSTEM | CEREBROSPINAL-FLUID | CONSENSUS STATEMENT | Viral meningitis | Pathogens | Encephalitis | Aseptic meningitis | Laboratories | Health | Complications | Chicken pox | Viruses | Patients | Epidemiology | Blood | Morbidity | Incidence | Streptococcus infections | Proteins | Studies | Antibiotics | Herpes viruses | Population | Meningitis | Adults | Ventricle | Blood culture | Viral infections
IMMUNOCOMPETENT ADULTS | DIAGNOSIS | INFECTIOUS DISEASES | POLYMERASE-CHAIN-REACTION | MANAGEMENT | ACUTE BACTERIAL-MENINGITIS | ENTEROVIRAL MENINGITIS | ASEPTIC-MENINGITIS | CENTRAL-NERVOUS-SYSTEM | CEREBROSPINAL-FLUID | CONSENSUS STATEMENT | Viral meningitis | Pathogens | Encephalitis | Aseptic meningitis | Laboratories | Health | Complications | Chicken pox | Viruses | Patients | Epidemiology | Blood | Morbidity | Incidence | Streptococcus infections | Proteins | Studies | Antibiotics | Herpes viruses | Population | Meningitis | Adults | Ventricle | Blood culture | Viral infections
Journal Article
American Journal of Pathology, The, ISSN 0002-9440, 2013, Volume 183, Issue 5, pp. 1446 - 1460
Human epidermal growth factor receptor 2 (HER2) is an important biomarker for breast and gastric cancer prognosis and patient treatment decisions. HER2...
Pathology | BREAST-CANCER | INDUCED ACTIVATION | TRASTUZUMAB | PROTEIN EXPRESSION | POLYSOMY 17 | IN-SITU HYBRIDIZATION | GENE AMPLIFICATION | HER-2/NEU | ANTIBODY | PATHOLOGY | CARCINOMA | Neoplasms - metabolism | Urinary Bladder Neoplasms - classification | Tissue Array Analysis | Humans | Receptor, ErbB-2 - metabolism | Stomach Neoplasms - metabolism | Stomach Neoplasms - pathology | Breast Neoplasms - metabolism | Reference Standards | Single-Cell Analysis - methods | Urinary Bladder Neoplasms - pathology | Female | Stomach Neoplasms - classification | Urinary Bladder Neoplasms - metabolism | Breast Neoplasms - classification | Reproducibility of Results | Neoplasms - classification | Genetic Heterogeneity | Animals | Breast Neoplasms - pathology | Mice, Nude | Fluorescent Antibody Technique | Cell Line, Tumor | Mice | Neoplasms - pathology | Cluster Analysis
Pathology | BREAST-CANCER | INDUCED ACTIVATION | TRASTUZUMAB | PROTEIN EXPRESSION | POLYSOMY 17 | IN-SITU HYBRIDIZATION | GENE AMPLIFICATION | HER-2/NEU | ANTIBODY | PATHOLOGY | CARCINOMA | Neoplasms - metabolism | Urinary Bladder Neoplasms - classification | Tissue Array Analysis | Humans | Receptor, ErbB-2 - metabolism | Stomach Neoplasms - metabolism | Stomach Neoplasms - pathology | Breast Neoplasms - metabolism | Reference Standards | Single-Cell Analysis - methods | Urinary Bladder Neoplasms - pathology | Female | Stomach Neoplasms - classification | Urinary Bladder Neoplasms - metabolism | Breast Neoplasms - classification | Reproducibility of Results | Neoplasms - classification | Genetic Heterogeneity | Animals | Breast Neoplasms - pathology | Mice, Nude | Fluorescent Antibody Technique | Cell Line, Tumor | Mice | Neoplasms - pathology | Cluster Analysis
Journal Article
Lancet HIV, The, ISSN 2352-3018, 2014, Volume 1, Issue 1, pp. e32 - e40
Summary Background Combination antiretroviral therapy has substantially increased life-expectancy in people living with HIV, but the effects of chronic...
Infectious Disease | INFECTIOUS DISEASES | INFECTION | IMMUNOLOGY | BURDEN
Infectious Disease | INFECTIOUS DISEASES | INFECTION | IMMUNOLOGY | BURDEN
Journal Article
Hepatology, ISSN 0270-9139, 05/2011, Volume 53, Issue 5, pp. 1494 - 1503
An excess of coinhibitory signals has been proposed to drive the T‐cell exhaustion characteristic of persistent viral infections. In this study we examined the...
POPULATION | RESPONSES | LIVER | CTLA-4 | DEFINES | GASTROENTEROLOGY & HEPATOLOGY | DELETION | Hepatitis B, Chronic - immunology | Humans | Middle Aged | Cells, Cultured | Male | CD8-Positive T-Lymphocytes - physiology | CTLA-4 Antigen | Young Adult | Adult | Antigens, CD - physiology | Female | Aged | Apoptosis - physiology | Hepatitis | Antigens | Cytotoxicity | Interferon | Lymphocytes | Viral infections
POPULATION | RESPONSES | LIVER | CTLA-4 | DEFINES | GASTROENTEROLOGY & HEPATOLOGY | DELETION | Hepatitis B, Chronic - immunology | Humans | Middle Aged | Cells, Cultured | Male | CD8-Positive T-Lymphocytes - physiology | CTLA-4 Antigen | Young Adult | Adult | Antigens, CD - physiology | Female | Aged | Apoptosis - physiology | Hepatitis | Antigens | Cytotoxicity | Interferon | Lymphocytes | Viral infections
Journal Article
Lancet HIV, The, ISSN 2352-3018, 2014, Volume 1, Issue 1, pp. e22 - e31
Summary Background Recreational drug use in men who have sex with men (MSM) is of concern because it might be linked to the transmission of HIV and other...
Infectious Disease | BISEXUAL MEN | CRYSTAL METHAMPHETAMINE | CLUB DRUGS | INFECTIOUS DISEASES | TRANSMISSION | SUBSTANCE USE | IMMUNOLOGY | GAY MEN | RISK BEHAVIOR | POSITIVE MEN
Infectious Disease | BISEXUAL MEN | CRYSTAL METHAMPHETAMINE | CLUB DRUGS | INFECTIOUS DISEASES | TRANSMISSION | SUBSTANCE USE | IMMUNOLOGY | GAY MEN | RISK BEHAVIOR | POSITIVE MEN
Journal Article
Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 06/2007, Volume 59, Issue 6, pp. 1047 - 1056
Transmission of drug-resistant HIV-1 variants from antiretroviral treatment-experienced persons has been documented to occur through multiple routes, including...
Primary resistance | Newly diagnosed | HAART | Anti-HIV Agents - pharmacology | Drug Resistance, Viral - genetics | Guidelines as Topic | HIV-1 - drug effects | HIV Infections - diagnosis | HIV Infections - epidemiology | HIV Infections - genetics | HIV Infections - virology | Humans | CD4 Lymphocyte Count | HIV-1 - genetics | INFECTIOUS DISEASES | MULTIDRUG-RESISTANT | primary resistance | MICROBIOLOGY | HUMAN-IMMUNODEFICIENCY-VIRUS | NATURAL-HISTORY | newly diagnosed | NAIVE INDIVIDUALS | REVERSE-TRANSCRIPTASE INHIBITORS | PRIMARY GENOTYPIC RESISTANCE | SURVEILLANCE PROGRAM | NON-B SUBTYPES | HIV-1-INFECTED PERSONS | PHARMACOLOGY & PHARMACY | REPLICATIVE FITNESS | Antiretroviral drugs | Disease transmission | HIV | Pharmacology | Human immunodeficiency virus | Drug resistance | Virology
Primary resistance | Newly diagnosed | HAART | Anti-HIV Agents - pharmacology | Drug Resistance, Viral - genetics | Guidelines as Topic | HIV-1 - drug effects | HIV Infections - diagnosis | HIV Infections - epidemiology | HIV Infections - genetics | HIV Infections - virology | Humans | CD4 Lymphocyte Count | HIV-1 - genetics | INFECTIOUS DISEASES | MULTIDRUG-RESISTANT | primary resistance | MICROBIOLOGY | HUMAN-IMMUNODEFICIENCY-VIRUS | NATURAL-HISTORY | newly diagnosed | NAIVE INDIVIDUALS | REVERSE-TRANSCRIPTASE INHIBITORS | PRIMARY GENOTYPIC RESISTANCE | SURVEILLANCE PROGRAM | NON-B SUBTYPES | HIV-1-INFECTED PERSONS | PHARMACOLOGY & PHARMACY | REPLICATIVE FITNESS | Antiretroviral drugs | Disease transmission | HIV | Pharmacology | Human immunodeficiency virus | Drug resistance | Virology
Journal Article