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Expert Opinion on Drug Discovery, ISSN 1746-0441, 12/2019, Volume 14, Issue 12, pp. 1221 - 1225
Journal Article
Journal Article
Expert opinion on drug discovery, 09/2019, p. 1
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2015, Volume 58, Issue 16, pp. 6321 - 6335
Journal Article
Nature, ISSN 0028-0836, 05/2017, Volume 545, Issue 7652, pp. 112 - 115
Protease-activated receptors ( PARs) are a family of G-proteincoupled receptors ( GPCRs) that are irreversibly activated by proteolytic cleavage of the N... 
PHENIX | THROMBIN | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | Allosteric Regulation - drug effects | Benzyl Alcohols - chemistry | Allosteric Site - drug effects | Humans | Receptor, PAR-2 - metabolism | Imidazoles - chemistry | Models, Molecular | Crystallography, X-Ray | Antibodies, Blocking - pharmacology | Imidazoles - pharmacology | Benzimidazoles - chemistry | Receptor, PAR-2 - chemistry | Immunoglobulin Fab Fragments - pharmacology | Receptor, PAR-2 - antagonists & inhibitors | Signal Transduction - drug effects | Antibodies, Blocking - chemistry | Immunoglobulin Fab Fragments - chemistry | Benzyl Alcohols - pharmacology | Benzimidazoles - pharmacology | Ligands | Benzodioxoles - chemistry | Kinetics | Benzodioxoles - pharmacology | Physiological aspects | Cell receptors | Allosteric proteins | Cytochrome | Residues | G protein-coupled receptors | Peptides | Molecular structure | Hydrogen | Homology | Antagonists | Hydrophobicity | Hydrogen bonding | Optimization | Proteins | Lipophilic | Allosteric properties | Imidazole | Cleavage | Inhibition | Thromboembolism | Lysozyme | Hydrogen ion concentration | Deoxyribonucleic acid--DNA | Cultivation | Architecture | Fab | Crystals | Crystallization | Pharmacology | Inflammation | Glycosylation | Computer programs | Chemistry | Diffraction | Antagonist drugs | Lysine | Isoforms | Computer applications | Mutation | Internet | Receptor mechanisms | Binding sites | Glutamine | Cancer
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2015, Volume 466, Issue 1, pp. 55 - 68
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2018, Volume 13, Issue 2, p. e0193380
Excess mineralocorticoid receptor (MR) activation promotes target organ dysfunction, vascular injury and fibrosis. MR antagonists like eplerenone are used for... 
ACTIVATION | LIGAND-BINDING | ANTAGONIST | MULTIDISCIPLINARY SCIENCES | HEART-FAILURE | BAY 94-8862 | DIABETIC-NEPHROPATHY | ALDOSTERONE | CHRONIC KIDNEY-DISEASE | CARDIORENAL INJURY | HYPERTENSIVE-RATS | Receptors, Mineralocorticoid - genetics | Sodium, Dietary | Kidney - pathology | Receptors, Mineralocorticoid - metabolism | Humans | Male | Aldosterone | Renal Insufficiency, Chronic - drug therapy | Dose-Response Relationship, Drug | Renal Insufficiency, Chronic - metabolism | Kidney - metabolism | Spironolactone - pharmacology | Sodium - urine | Mice, Mutant Strains | Mineralocorticoid Receptor Antagonists - pharmacology | Molecular Structure | Spironolactone - analogs & derivatives | Drug Evaluation, Preclinical | Mineralocorticoid Receptor Antagonists - chemistry | Kidney - drug effects | Administration, Oral | Spironolactone - chemistry | Rats, Sprague-Dawley | Spironolactone - pharmacokinetics | Renal Insufficiency, Chronic - pathology | Animals | Potassium - urine | Cell Line, Tumor | Mineralocorticoid Receptor Antagonists - pharmacokinetics | Complications and side effects | Hyperkalemia | Corticosteroids | Genetic aspects | Dosage and administration | Research | Drug therapy | Heart | Salts | Peptides | Cardiovascular disease | Systematic review | Antagonists | Hormones | Recruitment | Reporter gene | Histopathology | Rodents | Acute effects | Heart diseases | Binding | Heart failure | Hypertension | Excretion | Nutrient deficiency | Kidneys | Rats | Pharmacology | Gene expression | Liability | Fibrosis | Electrolytes | Ligands | Mice | Kidney diseases | Diabetes | Metabolic disorders
Journal Article
Expert Opinion on Drug Discovery, ISSN 1746-0441, 11/2017, Volume 12, Issue 11, pp. 1083 - 1086
Journal Article
Journal Article
Analytical Chemistry, ISSN 0003-2700, 04/2015, Volume 87, Issue 8, p. 4100
  Inhibition-in-solution assays (ISA) employing surface-based biosensors such as surface plasmon resonance (SPR) are an effective screening approach in drug... 
Proteins | Microscopy | Research & development--R&D | Biosensors | Biological assays
Journal Article