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1. Full Text Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity
by Gross, Olaf and Gewies, Andreas and Finger, Katrin and Schäfer, Martin and Sparwasser, Tim and Peschel, Christian and Förster, Irmgard and Ruland, Jürgen
Nature, ISSN 0028-0836, 08/2006, Volume 442, Issue 7103, pp. 651 - 656
Fungal infections are increasing worldwide due to the marked rise in immunodeficiencies including AIDS; however, immune responses to fungi are poorly... 
BETA-GLUCANS | MYD88-DEFICIENT MICE | TOLL-LIKE RECEPTOR-2 | ACTIVATION | RECOGNITION | CARMA1 | MULTIDISCIPLINARY SCIENCES | T-CELL | INDUCTION | NF-KAPPA-B | MALT1 | Protein-Tyrosine Kinases - metabolism | NF-kappa B - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Neoplasm Proteins - metabolism | Fungi - immunology | Toll-Like Receptors | Lymphocyte Activation - immunology | Caspases - metabolism | Adaptor Proteins, Signal Transducing - immunology | Membrane Proteins - metabolism | Syk Kinase | Cytokines - immunology | Signal Transduction | Lectins, C-Type | Antigens, Fungal - immunology | Candida albicans - immunology | Zymosan - immunology | Nerve Tissue Proteins - metabolism | Immunity, Innate - immunology | Animals | Adaptor Proteins, Signal Transducing - deficiency | B-Cell CLL-Lymphoma 10 Protein | CARD Signaling Adaptor Proteins | Adaptor Proteins, Signal Transducing - genetics | Mice | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein | Adaptor Proteins, Signal Transducing - metabolism | Cytokines - biosynthesis | Proteins | Signal transduction | Fungal infections | Cytokines | Immune system
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2. Full Text A homozygous mucosa-associated lymphoid tissue 1 ( MALT1 ) mutation in a family with combined immunodeficiency
by Jabara, Haifa H., BSc and Ohsumi, Toshiro, PhD and Chou, Janet, MD and Massaad, Michel J., PhD and Benson, Halli, BSc and Megarbane, Andre, MD, PhD and Chouery, Eliane, PhD and Mikhael, Raymond, MD and Gorka, Oliver, MD and Gewies, Andreas, PhD and Portales, Pierre, MD and Nakayama, Toshinori, MD, PhD and Hosokawa, Hiroyuki, PhD and Revy, Patrick, PhD and Herrod, Henry, MD and Le Deist, Francoise, MD, PhD and Lefranc, Gerard, PhD and Ruland, Jürgen, MD and Geha, Raif S., MD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2013, Volume 132, Issue 1, pp. 151 - 158
Background Combined immunodeficiency (CID) is characterized by severe recurrent infections with normal numbers of T and B lymphocytes but with deficient... 
Allergy and Immunology | NF-κB | combined immunodeficiency (CID) | MALT1 | Combined immunodeficiency (CID) | NF-kappa B | ALLERGY | T-CELL | IMMUNOLOGY | DEFICIENCY | CARD11 | Amino Acid Sequence | Caspases - genetics | Lymphocyte Activation | Humans | Cells, Cultured | Child, Preschool | Molecular Sequence Data | Severe Combined Immunodeficiency - immunology | Caspases - analysis | Severe Combined Immunodeficiency - genetics | Animals | I-kappa B Kinase - metabolism | T-Lymphocytes - metabolism | Neoplasm Proteins - analysis | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein | Mutation | Neoplasm Proteins - genetics | Child | Medical colleges | Genetic aspects | Immunodeficiency | Medical genetics | T cell receptors | Kinases | Genes
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3. Full Text Clec12a Is an Inhibitory Receptor for Uric Acid Crystals that Regulates Inflammation in Response to Cell Death
by Neumann, Konstantin and Castiñeiras-Vilariño, Mercedes and Höckendorf, Ulrike and Hannesschläger, Nicole and Lemeer, Simone and Kupka, Danny and Meyermann, Svenia and Lech, Maciej and Anders, Hans-Joachim and Kuster, Bernhard and Busch, Dirk H and Gewies, Andreas and Naumann, Ronald and Groß, Olaf and Ruland, Jürgen
Immunity, ISSN 1074-7613, 03/2014, Volume 40, Issue 3, pp. 389 - 399
Recognition of cell death by the innate immune system triggers inflammatory responses. However, how these reactions are regulated is not well understood. Here,... 
MONOSODIUM URATE CRYSTALS | DAMAGED CELLS | ORCHESTRATE ANTIFUNGAL IMMUNITY | DENDRITIC CELLS | IMMUNOLOGY | MICL CLEC12A | IDENTIFICATION | PROTEINS | LECTIN RECEPTORS | INDUCED NEUTROPHIL ACTIVATION | NALP3 INFLAMMASOME | Neutrophil Activation - genetics | Cell Line | Neutrophil Activation - immunology | Uric Acid - metabolism | Cell Death - immunology | Neutrophils - immunology | Receptors, Mitogen - metabolism | Inflammation - immunology | Lectins, C-Type - genetics | Uric Acid - immunology | Mice, Knockout | Lectins, C-Type - metabolism | Inflammation - metabolism | Animals | Cell Death - genetics | Models, Biological | Inflammation - genetics | Mice | Neutrophils - metabolism | Receptors, Mitogen - genetics | Autoimmunity | Nuclear radiation | Cell death | Lectins | Biochemistry | Inflammation | Uric acid | Cells | Proteins | Flow cytometry | Ligands | Kidneys | Immune system | Apoptosis
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4. Full Text Uncoupling Malt1 Threshold Function from Paracaspase Activity Results in Destructive Autoimmune Inflammation
by Gewies, Andreas and Gorka, Oliver and Bergmann, Hanna and Pechloff, Konstanze and Petermann, Franziska and Jeltsch, Katharina M and Rudelius, Martina and Kriegsmann, Mark and Weichert, Wilko and Horsch, Marion and Beckers, Johannes and Wurst, Wolfgang and Heikenwalder, Mathias and Korn, Thomas and Heissmeyer, Vigo and Ruland, Jürgen
Cell Reports, ISSN 2211-1247, 11/2014, Volume 9, Issue 4, pp. 1292 - 1305
The paracaspase Malt1 is a central regulator of antigen receptor signaling that is frequently mutated in human lymphoma. As a scaffold, it assembles protein... 
ACTIVATION | COMBINED IMMUNODEFICIENCY | MESSENGER-RNA | LYMPHOID-TISSUE | ROQUIN | MICE | MUTATIONS | CLEAVAGE | NF-KAPPA-B | HELPER T-CELLS | CELL BIOLOGY | Autoimmunity | Immunity, Mucosal - immunology | Inflammation - pathology | Humans | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | T-Lymphocytes, Regulatory - immunology | Signal Transduction - immunology | Lymphocyte Activation - immunology | Caspases - metabolism | Mice, Mutant Strains | Caspases - deficiency | Receptors, Antigen, T-Cell - metabolism | RNA, Messenger - genetics | Gene Expression Regulation | Homeostasis - immunology | Nerve Degeneration - immunology | Inflammation - immunology | Nerve Degeneration - pathology | Cell Differentiation - immunology | Animals | B-Lymphocytes - immunology | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein | Neoplasm Proteins - deficiency | Interferon-gamma - biosynthesis
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5. Full Text Alternative splicing of MALT1 controls signalling and activation of CD4 + T cells
by Meininger, Isabel and Griesbach, Richard A and Hu, Desheng and Gehring, Torben and Seeholzer, Thomas and Bertossi, Arianna and Kranich, Jan and Oeckinghaus, Andrea and Eitelhuber, Andrea C and Greczmiel, Ute and Gewies, Andreas and Schmidt-Supprian, Marc and Ruland, Jürgen and Brocker, Thomas and Heissmeyer, Vigo and Heyd, Florian and Krappmann, Daniel
Nature Communications, ISSN 2041-1723, 04/2016, Volume 7, Issue 1, p. 11292
MALT1 channels proximal T-cell receptor (TCR) signalling to downstream signalling pathways. With MALT1A and MALT1B two conserved splice variants exist and we... 
PARACASPASE MALT1 | REGULATOR | UBIQUITIN CHAINS | IMMUNE CELLS | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | HNRNP L | INFECTION | CLEAVAGE | NF-KAPPA-B | LYMPHOCYTES | Up-Regulation | Humans | JNK Mitogen-Activated Protein Kinases - metabolism | NF-kappa B - metabolism | Neoplasm Proteins - metabolism | CD4-Positive T-Lymphocytes - immunology | Lymphocyte Activation - immunology | Caspases - metabolism | HEK293 Cells | Neoplasm Proteins - genetics | Heterogeneous-Nuclear Ribonucleoprotein U - metabolism | Receptors, Antigen, T-Cell - metabolism | Signal Transduction | Caspases - genetics | Jurkat Cells | Alternative Splicing - genetics | Down-Regulation | Mice, Inbred C57BL | Exons - genetics | Animals | TNF Receptor-Associated Factor 6 - metabolism | Th17 Cells - immunology | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein | Enzyme Activation | Interleukin-2 - biosynthesis
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6. Full Text Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells
by Rosenbaum, Marc and Gewies, Andreas and Pechloff, Konstanze and Heuser, Christoph and Engleitner, Thomas and Gehring, Torben and Hartjes, Lara and Krebs, Sabrina and Krappmann, Daniel and Kriegsmann, Mark and Weichert, Wilko and Rad, Roland and Kurts, Christian and Ruland, Jürgen
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 2352 - 15
Regulatory T cells (Tregs) have crucial functions in the inhibition of immune responses. Their development and suppressive functions are controlled by the T... 
T-Lymphocyte Subsets - immunology | B-Cell CLL-Lymphoma 10 Protein - metabolism | CARD Signaling Adaptor Proteins - immunology | T-Lymphocytes, Regulatory - metabolism | Receptors, Antigen, T-Cell - metabolism | Signal Transduction | NF-kappa B - immunology | B-Cell CLL-Lymphoma 10 Protein - immunology | T-Lymphocytes, Regulatory - immunology | CARD Signaling Adaptor Proteins - metabolism | Animals | Melanoma, Experimental | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein - immunology | T-Lymphocyte Subsets - metabolism | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein - metabolism | Cell Differentiation | Mice | Cytokines - immunology | NF-κB protein | Cytokines | Immunoregulation | Melanoma | T cell receptors | Lymphocytes T | Pharmacology | Inflammation | T-cell receptor | Signaling | Lymphocytes | Immunotherapy | Bcl-10 protein | Inhibition | Differentiation
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7. Full Text The CARD11-BCL10-MALT1 ( CBM ) signalosome complex: Stepping into the limelight of human primary immunodeficiency
by Turvey, Stuart E., MBBS, DPhil, FRCPC and Durandy, Anne, MD, PhD and Fischer, Alain, MD, PhD and Fung, Shan-Yu, PhD and Geha, Raif S., MD and Gewies, Andreas, PhD and Giese, Thomas, MD and Greil, Johann, MD and Keller, Bärbel, MSc and McKinnon, Margaret L., MD and Neven, Bénédicte, MD and Rozmus, Jacob, MD and Ruland, Jürgen, MD and Snow, Andrew L., PhD and Stepensky, Polina, MD and Warnatz, Klaus, MD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 134, Issue 2, pp. 276 - 284
Next-generation DNA sequencing has accelerated the genetic characterization of many human primary immunodeficiency diseases (PIDs). These discoveries can be... 
Allergy and Immunology | nuclear factor κB | next-generation sequencing | CARMA1 | primary immunodeficiency diseases | CARD11-BCL10-MALT1 signalosome complex | paracaspase | congenital B-cell lymphocytosis | combined immunodeficiency | nuclear factor kappa B | IMMUNE-DEFICIENCY | T-CELL | BCL10 | IMMUNOLOGY | CLEAVAGE | MALT LYMPHOMA | JNK ACTIVATION | ALLERGY | ECTODERMAL DYSPLASIA | CARD11 MUTATIONS | NF-KAPPA-B | Immunologic Deficiency Syndromes - pathology | Caspases - immunology | Humans | NF-kappa B - immunology | Neoplasm Proteins - immunology | CARD Signaling Adaptor Proteins - genetics | Adaptor Proteins, Signal Transducing - immunology | Germ-Line Mutation | B-Lymphocytes - pathology | Immunologic Deficiency Syndromes - diagnosis | Immunologic Deficiency Syndromes - immunology | Neoplasm Proteins - genetics | CARD Signaling Adaptor Proteins - immunology | Guanylate Cyclase - immunology | Signal Transduction | Caspases - genetics | Gene Expression Regulation | Receptors, Antigen, B-Cell - immunology | B-Lymphocytes - immunology | NF-kappa B - genetics | B-Cell CLL-Lymphoma 10 Protein | Adaptor Proteins, Signal Transducing - genetics | Immunologic Deficiency Syndromes - genetics | Guanylate Cyclase - genetics | Receptors, Antigen, B-Cell - genetics | High-Throughput Nucleotide Sequencing | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein | Lymphomas | Immunodeficiency | Primary immunodeficiency diseases | Congenital B cell lymphocytosis | NF-κB | Combined immunodeficiency | CARD11–BCL10–MALT1 (CBM) signalosome complex | Paracaspase | Next generation sequencing
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8. Full Text Dynamic landscape of pancreatic carcinogenesis reveals early molecular networks of malignancy
by Kong, Bo and Bruns, Philipp and Behler, Nora A and Chang, Ligong and Schlitter, Anna Melissa and Cao, Jing and Gewies, Andreas and Ruland, Jürgen and Fritzsche, Sina and Valkovskaya, Nataliya and Jian, Ziying and Regel, Ivonne and Raulefs, Susanne and Irmler, Martin and Beckers, Johannes and Friess, Helmut and Erkan, Mert and Mueller, Nikola S and Roth, Susanne and Hackert, Thilo and Esposito, Irene and Theis, Fabian J and Kleeff, Jörg and Michalski, Christoph W
Gut, ISSN 0017-5749, 01/2018, Volume 67, Issue 1, pp. 146 - 156
Objective The initial steps of pancreatic regeneration versus carcinogenesis are insufficiently understood. Although a combination of oncogenic Kras and... 
PANCREATIC CANCER | SIGNAL TRANSDUCTION | SIGNALING PATHWAYS | DUCTAL ADENOCARCINOMA | ONCOGENIC KRAS | REGENERATION | GENE-EXPRESSION | ADULT MICE | MOSAIC ANALYSIS | DOUBLE MARKERS | CANCER PROGRESSION | GASTROENTEROLOGY & HEPATOLOGY | CELL | Complications and side effects | Research | Gene mutations | Pancreatic cancer | Risk factors | Pancreatitis | Cell proliferation | Adenocarcinoma | Acinar cells | Intercellular signalling | Statistical analysis | Mesenchyme | Transcription | Laboratories | Homeostasis | Data processing | Inflammation | Malignancy | Gene expression | Cancer therapies | Carcinogenesis | Rodents | Gastroenterology | Mutation | Pancreas | Index Medicus | Abridged Index Medicus
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9. Full Text Loss of ifnar1 in pancreatic acinar cells ameliorates the disease course of acute pancreatitis
by Miller, Katharina J and Raulefs, Susanne and Kong, Bo and Steiger, Katja and Regel, Ivonne and Gewies, Andreas and Kleeff, Jörg and Michalski, Christoph W
PLoS ONE, ISSN 1932-6203, 11/2015, Volume 10, Issue 11, p. e0143735
Type I interferon constitutes an essential component of the combinational therapy against viral disease. Acute pancreatitis is one side effect of type I... 
RESPOND | INTERFERON-ALPHA | CYTOKINE PRODUCTION | STIMULATION | THERAPY | MACROPHAGES | REGENERATION | CHEMOKINES | MULTIDISCIPLINARY SCIENCES | MONOCYTES | EXPRESSION | Acinar Cells - metabolism | Pancreatitis, Acute Necrotizing - genetics | Mice, Inbred C57BL | Chemokine CCL2 - genetics | Macrophages - metabolism | Animals | Pancreatitis, Acute Necrotizing - metabolism | Chemokine CCL2 - metabolism | Mice | Receptor, Interferon alpha-beta - genetics | Macrophages - immunology | Pancreatitis, Acute Necrotizing - pathology | Receptor, Interferon alpha-beta - metabolism | Complications and side effects | Care and treatment | Pancreatitis | Influence | Interferon | Research | Biological response modifiers | Therapy | Animal models | Disease | Homeostasis | Inflammatory response | Macrophages | Experiments | α-Interferon | Rodents | Surgery | Gastroenterology | Tumor necrosis factor-TNF | Physiology | Pancreas | Protected animals | Immune system | Carbon-carbon composites | Acinar cells | Cytokines | Pharmacology | Inflammation | Ablation | Signaling | Laboratory animals | Chemokines | Monocyte chemoattractant protein 1
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10. Full Text Inhibition of MALT1 protease activity is selectively toxic for activated B cell-like diffuse large B cell lymphoma cells
by Ferch, Uta and Kloo, Bernhard and Gewies, Andreas and Pfänder, Vera and Düwel, Michael and Peschel, Christian and Krappmann, Daniel and Ruland, Jürgen
Journal of Experimental Medicine, ISSN 0022-1007, 10/2009, Volume 206, Issue 11, pp. 2313 - 2320
Diffuse large B cell lymphoma (DLBCL) is the most common type of lymphoma in humans. The aggressive activated B cell-like (ABC) subtype of DLBCL is... 
MEDICINE, RESEARCH & EXPERIMENTAL | PARACASPASE | APOPTOSIS | UBIQUITIN | GENE-EXPRESSION | FACTOR-KAPPA-B | HODGKIN LYMPHOMA | T-CELL | MUTATIONS | SUBGROUPS | IMMUNOLOGY | A20 | Cell Survival - drug effects | Lymphoma, Large B-Cell, Diffuse - pathology | DNA, Neoplasm - metabolism | Humans | Lymphoma, Large B-Cell, Diffuse - enzymology | Guanylate Cyclase - metabolism | NF-kappa B - metabolism | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Caspase Inhibitors | Protease Inhibitors - pharmacology | CARD Signaling Adaptor Proteins - metabolism | Caspases - metabolism | Lymphocyte Activation - drug effects | B-Cell CLL-Lymphoma 10 Protein | Protein Binding - drug effects | Cell Line, Tumor | Lymphoma, Large B-Cell, Diffuse - immunology | Cell Proliferation - drug effects | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein | Adaptor Proteins, Signal Transducing - metabolism | Cytotoxicity, Immunologic - drug effects | Index Medicus | Brief Definitive Report
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11. Full Text The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma
by Pechloff, Konstanze and Holch, Julian and Ferch, Uta and Schweneker, Marc and Brunner, Kristina and Kremer, Markus and Sparwasser, Tim and Quintanilla-Martinez, Leticia and Zimber-Strobl, Ursula and Streubel, Berthold and Gewies, Andreas and Peschel, Christian and Ruland, Jürgen
Journal of Experimental Medicine, ISSN 0022-1007, 05/2010, Volume 207, Issue 5, pp. 1031 - 1044
Peripheral T cell lymphomas (PTCLs) are highly aggressive malignancies with poor prognosis. Their molecular pathogenesis is not well understood and small... 
SH2 DOMAIN | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | ADAPTER PROTEINS | TYROSINE KINASE | ANTIGEN-RECEPTOR | NON-HODGKIN-LYMPHOMA | IMMUNOLOGY | NF-KAPPA-B | CANCER | TEC FAMILY KINASES | Translocation, Genetic | Protein-Tyrosine Kinases - metabolism | Humans | Gene Expression Regulation, Neoplastic | Intracellular Signaling Peptides and Proteins - metabolism | Lectins, C-Type - genetics | Antigens, CD - genetics | Recombinant Fusion Proteins - metabolism | Chromosomes, Human, Pair 9 - genetics | Protein-Tyrosine Kinases - genetics | Spleen - enzymology | Receptors, Antigen, T-Cell - immunology | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Chromosomes, Human, Pair 5 - genetics | Disease Models, Animal | Signal Transduction | Lymphoma, T-Cell, Peripheral - genetics | Lymphoproliferative Disorders - genetics | Lymphoproliferative Disorders - pathology | Embryonic Stem Cells - physiology | Interleukin-2 - genetics | Animals | Lymphoma, T-Cell, Peripheral - pathology | Antigens, Differentiation, T-Lymphocyte - genetics | Mice | Receptors, Antigen, T-Cell - genetics
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12. Full Text Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-κB pathway and promotes lymphomagenesis
by Hömig-Hölzel, Cornelia and Hojer, Caroline and Rastelli, Julia and Casola, Stefano and Strobl, Lothar J and Müller, Werner and Quintanilla-Martinez, Leticia and Gewies, Andreas and Ruland, Jürgen and Rajewsky, Klaus and Zimber-Strobl, Ursula
Journal of Experimental Medicine, ISSN 0022-1007, 06/2008, Volume 205, Issue 6, pp. 1317 - 1329
CD40, a member of the tumor necrosis factor (TNF) receptor family, plays an essential role in T cell-dependent immune responses. Because CD40 is widely... 
MULTIPLE-MYELOMA | MEDICINE, RESEARCH & EXPERIMENTAL | PROTEIN-KINASE | IMMUNE-RESPONSES | IN-VIVO | GENE-EXPRESSION | X-LINKED IMMUNODEFICIENCY | T-CELL | LIGAND | IMMUNOLOGY | ANTIGEN RECEPTOR | HYPER-IGM
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13. Full Text Prdm6 is essential for cardiovascular development In Vivo
by Gewies, Andreas and Castineiras-Vilarino, Mercedes and Ferch, Uta and Jährling, Nina and Heinrich, Katja and Hoeckendorf, Ulrike and Przemeck, Gerhard K. H and Munding, Matthias and Groß, Olaf and Schroeder, Timm and Horsch, Marion and Karran, E. Loraine and Majid, Aneela and Antonowicz, Stefan and Beckers, Johannes and Hrabé De Angelis, Martin and Dodt, Hans-Ulrich and Peschel, Christian and Förster, Irmgard and Dyer, Martin J. S and Ruland, Jürgen
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, p. e81833
Members of the PRDM protein family have been shown to play important roles during embryonic development. Previous in vitro and in situ analyses indicated a... 
VASCULAR DEVELOPMENT | BREAST-CANCER | SMOOTH-MUSCLE | ANGIOGENESIS | GENE | T-CELL HOMEOSTASIS | YOLK-SAC | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | TRANSCRIPTIONAL REPRESSOR BLIMP-1 | MICE LACKING | Blotting, Southern | Cell Proliferation | Oligonucleotide Array Sequence Analysis | Repressor Proteins - genetics | DNA Primers | Mice, Knockout | Repressor Proteins - physiology | Blotting, Northern | Animals | Base Sequence | Body Patterning | Polymerase Chain Reaction | Cell Differentiation | Mice | Muscle, Smooth - cytology | Cardiovascular System - embryology | Neovascularization, Physiologic | Embryonic stem cells | Embryonic development | Pattern formation | Neurosciences | Physiological effects | Laboratories | Embryo cells | Stem cell transplantation | Smooth muscle | Lethality | Hemorrhage | Defects | Proteins | Consortia | Angiogenesis | Embryogenesis | Toxicology | Allografts | Immunology | Clonal deletion | Cell cycle | Deletion