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1. Full Text Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years
by Braak, Heiko and Thal, Dietmar R and Ghebremedhin, Estifanos and Del Tredici, Kelly
Journal of Neuropathology and Experimental Neurology, ISSN 0022-3069, 11/2011, Volume 70, Issue 11, pp. 960 - 969
Two thousand three hundred and thirty two nonselected brains from 1- to 100-year-old individuals were examined using immunocytochemistry (AT8) and Gallyas... 
A-amyloid | Pretangles/neurofibrillary tangles | Neuropil threads | Alzheimer disease | Brainstem | Locus coeruleus | Hyperphosphorylated tau protein | TAU-PROTEIN | NEUROFIBRILLARY CHANGES | DEPOSITION | BRAIN-STEM | COGNITIVE IMPAIRMENT | PATHOLOGY | NEUROSCIENCES | CLINICAL NEUROLOGY | DEGENERATION | beta-amyloid | NUCLEUS | TANGLES | LOCUS-COERULEUS | NEURONS | Neurofibrillary Tangles - pathology | Silver Staining - methods | Neurons - pathology | Humans | Middle Aged | Child, Preschool | tau Proteins - metabolism | Infant | Male | Disease Progression | Alzheimer Disease - pathology | Brain - metabolism | Young Adult | Adolescent | Amyloid beta-Peptides - metabolism | Statistics, Nonparametric | Aged, 80 and over | Brain - pathology | Adult | Female | Aged | Neurons - metabolism | Child | Cohort Studies | Brain | Medical research | Cloning
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2. Full Text Peripheral and central autonomic nervous system: does the sympathetic or parasympathetic nervous system bear the brunt of the pathology during the course of sporadic PD?
by Orimo, Satoshi and Ghebremedhin, Estifanos and Gelpi, Ellen
Cell and Tissue Research, ISSN 0302-766X, 7/2018, Volume 373, Issue 1, pp. 267 - 286
It is a well-established fact that the sympathetic, parasympathetic and enteric nervous systems are affected at early stages in Parkinson’s disease (PD).... 
Human Genetics | α-Synuclein | Parasympathetic | meta -Iodobenzylguanidine cardiac scintigraphy | Tyrosine hydroxylase | Sympathetic | Enteric nervous system | Biomedicine | Autonomic nervous system | Gastrointestinal system | Proteomics | Cardiovascular autonomic test | Molecular Medicine | Heart rate variability | Parkinson’s disease | Orthostatic hypotension | Lewy body | meta-Iodobenzylguanidine cardiac scintigraphy | LEWY-BODY DISEASE | GLAND NEEDLE-BIOPSY | Parkinson's disease | ALZHEIMERS-DISEASE | SPINAL-CORD | BRAIN-STEM | COLONIC BIOPSIES | EDINGER-WESTPHAL NUCLEUS | SLEEP BEHAVIOR DISORDER | CELL BIOLOGY | ALPHA-SYNUCLEIN PATHOLOGY | IDIOPATHIC PARKINSONS-DISEASE | alpha-Synuclein | Parasympathetic Nervous System - pathology | Parkinson Disease - pathology | Humans | Autonomic Nervous System - pathology | Sympathetic Nervous System - pathology | Organ Specificity | Motor Neurons - pathology | Neurophysiology | Pathology | Neurodegenerative diseases | Central nervous system | Nervous system | Gastrointestinal tract | Parasympathetic nervous system | Movement disorders
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3. Full Text Stages in the development of Parkinson's disease-related pathology
by Braak, Heiko and Ghebremedhin, Estifanos and Rüb, Udo and Bratzke, Hansjürgen and Del Tredici, Kelly
Cell and Tissue Research, ISSN 0302-766X, 10/2004, Volume 318, Issue 1, pp. 121 - 134
The synucleinopathy, idiopathic Parkinson's disease, is a multisystem disorder that involves only a few predisposed nerve cell types in specific regions of the... 
Parkinson's disease | Pathoarchitectonics | Staging | Alpha-synuclein | Lewy neurites | Lewy bodies | NERVOUS-SYSTEM | NEURODEGENERATIVE DISORDERS | ALZHEIMERS-DISEASE | BASAL GANGLIA | alpha-synuclein | SUBSTANTIA-NIGRA | PEDUNCULOPONTINE NUCLEUS | CELL BIOLOGY | HUMAN CEREBRAL-CORTEX | FUNCTIONAL-ANATOMY | BODY-CONTAINING NEURONS | staging | pathoarchitectonics | Brain - pathology | Parkinson Disease - pathology | Parkinson Disease - physiopathology | Brain - physiopathology | Humans
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4. Full Text Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic parkinson's disease
by Tredici, Kelly Del and Hawkes, Christopher H and Ghebremedhin, Estifanos and Braak, Heiko
Acta Neuropathologica, ISSN 0001-6322, 06/2010, Volume 119, Issue 6, pp. 703 - 713
A retrospective autopsy-based study of the human submandibular gland, one of the three major salivary glands, together with anatomically related peripheral... 
Peripheral nervous system | Parkinson's disease | Lewy body disease | Superior cervical ganglion | Submandibular gland | Lewy neuritis | Esophagus | Sialorrhea | Autonomic nervous system/ganglia | Sialopenia | Synucleinopathy | Dysphagia | Alpha-synuclein | ELDERLY SUBJECTS | PATHOLOGY | CARDIAC SYMPATHETIC-NERVE | CLINICAL NEUROLOGY | GASTROINTESTINAL DYSFUNCTION | OLFACTORY DYSFUNCTION | AUTONOMIC DYSFUNCTION | MULTIPLE-SYSTEM-ATROPHY | CONTAINING NEURONS | AMYOTROPHIC-LATERAL-SCLEROSIS | SALIVARY-GLANDS | NEUROSCIENCES | Lewy neurites | Immunohistochemistry | Parkinson Disease - pathology | Vagus Nerve - metabolism | Multiple System Atrophy - pathology | Superior Cervical Ganglion - pathology | Humans | Middle Aged | Lewy Body Disease - pathology | Submandibular Gland - metabolism | Male | Superior Cervical Ganglion - metabolism | Vagus Nerve - pathology | Lewy Body Disease - metabolism | Submandibular Gland - pathology | Multiple System Atrophy - metabolism | Aged, 80 and over | Female | Aged | Parkinson Disease - metabolism | Retrospective Studies | Lewy Bodies - metabolism | Lewy Bodies - pathology | alpha-Synuclein - metabolism | Cohort Studies | Medical colleges | Polyethylene | Neurosciences | Developmental biology | Polyethylene glycol
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5. Full Text Cerebral amyloid angiopathy and its relationship to Alzheimer's disease
by Thal, Dietmar Rudolf and Griffin, W. Sue T and de Vos, Rob A.I and Ghebremedhin, Estifanos
Acta Neuropathologica, ISSN 0001-6322, 06/2008, Volume 115, Issue 6, pp. 599 - 609
Cerebral amyloid angiopathy (CAA) is characterized by the deposition of the amyloid beta-protein (A beta) within cerebral vessels. The involvement of different... 
Drainage | Cerebral amyloid angiopathy | Amyloid β-protein | Cerebral blood flow | Alzheimer's disease | A-BETA DEPOSITS | FAMILIAL BRITISH DEMENTIA | PATHOLOGY | amyloid beta-protein | MILD COGNITIVE IMPAIRMENT | MENINGOCEREBROVASCULAR AMYLOIDOSIS | NEUROSCIENCES | CLINICAL NEUROLOGY | APOLIPOPROTEIN-E | cerebral amyloid angiopathy | DUTCH TYPE | cerebral blood flow | drainage | PRECURSOR PROTEIN | TRANSGENIC MOUSE MODEL | SMOOTH-MUSCLE CELLS | GIANT-CELL ARTERITIS | Cerebral Amyloid Angiopathy - complications | Cerebral Amyloid Angiopathy - pathology | Alzheimer Disease - complications | Apolipoprotein E4 - genetics | Amyloid - metabolism | Humans | Alzheimer Disease - metabolism | Alzheimer Disease - genetics | Cerebral Amyloid Angiopathy - genetics | Cerebral Amyloid Angiopathy - metabolism | Alzheimer Disease - pathology | Index Medicus
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6. Full Text Precortical Phase of Alzheimer's Disease (AD)-Related Tau Cytoskeletal Pathology
by Stratmann, Katharina and Heinsen, Helmut and Korf, Horst-Werner and Del Turco, Domenico and Ghebremedhin, Estifanos and Seidel, Kay and Bouzrou, Mohamed and Grinberg, Lea T and Bohl, Juergen and Wharton, Stephen B and den Dunnen, Wilfred and Rueb, Udo
BRAIN PATHOLOGY, ISSN 1015-6305, 05/2016, Volume 26, Issue 3, pp. 371 - 386
Alzheimer's disease (AD) represents the most frequent progressive neuropsychiatric disorder worldwide leading to dementia. We systematically investigated the... 
allocortex | prion-like diseases | AXONAL-TRANSPORT | NEUROANATOMICAL CONNECTIONS | MILD COGNITIVE IMPAIRMENT | HIPPOCAMPAL-FORMATION | NEURODEGENERATIVE DISEASES | entorhinal region | MIDBRAIN PERIAQUEDUCTAL GRAY | NEUROPATHOLOGICAL DIAGNOSIS | NEUROFIBRILLARY DEGENERATION | cytoskeletal pathology | subcortical nuclei | SUBCORTICAL AFFERENTS | DORSAL RAPHE NUCLEUS | Alzheimer's disease | tau protein | prion‐like diseases | PATHOLOGY | NEUROSCIENCES | CLINICAL NEUROLOGY | Cytoskeleton - pathology | Humans | Middle Aged | Brain - pathology | Female | Male | Aged | tau Proteins | Disease Progression | Alzheimer Disease - pathology | Alzheimers disease | Pathology | Rodents
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7. Full Text Vascular Pathology in Alzheimer Disease: Correlation of Cerebral Amyloid Angiopathy and Arteriosclerosis/Lipohyalinosis with Cognitive Decline
by THAL, DIETMAR RUDOLF and GHEBREMEDHIN, ESTIFANOS and ORANTES, MARIO and WIESTLER, OTMAR D
JNEN: Journal of Neuropathology & Experimental Neurology, ISSN 0022-3069, 12/2003, Volume 62, Issue 12, pp. 1287 - 1301
Sporadic, late-onset Alzheimer disease (AD) constitutes the most frequent cause of dementia in the elderly population. AD-related pathology is often... 
Arteriosclerosis/Lipohyalinosis | Cerebral amyloid angiopathy | Amyloid β-protein | Alzheimer disease | Apolipoprotein E | Dementia | HUMAN BRAIN | PROTEIN | RAT | DEPOSITION | INTERSTITIAL FLUID | PATHOLOGY | amyloid beta-protein | NEUROSCIENCES | LESIONS | CLINICAL NEUROLOGY | BETA | THRESHOLD | arteriosclerosis/lipohyalinosis | cerebral amyloid angiopathy | apolipoprotein e | dementia | SIMVASTATIN | Intracranial Arteriosclerosis - pathology | Alzheimer Disease - physiopathology | Cognition Disorders - physiopathology | Cerebral Amyloid Angiopathy - physiopathology | Humans | Middle Aged | Cognition Disorders - pathology | Male | Alzheimer Disease - pathology | Cerebral Amyloid Angiopathy - pathology | Analysis of Variance | Aged, 80 and over | Female | Aged | Intracranial Arteriosclerosis - physiopathology
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8. Full Text Diminished tyrosine hydroxylase immunoreactivity in the cardiac conduction system and myocardium in Parkinson's disease: An anatomical study
by Ghebremedhin, Estifanos and Del Tredici, Kelly and Langston, James W and Braak, Heiko
Acta Neuropathologica, ISSN 0001-6322, 12/2009, Volume 118, Issue 6, pp. 777 - 784
Clinical and autopsy studies have consistently reported cardiac sympathetic dysfunction in the left ventricular wall in patients with Parkinson's disease (PD).... 
Cardiac conduction system | Tyrosine hydroxylase | Parkinson's disease | Lewy body disease | Sympathetic dysfunction | NERVOUS-SYSTEM | SYMPATHETIC DENERVATION | AUTONOMIC DYSFUNCTION | MIBG | INNERVATION | DISORDERS | SYMPTOMS | PATHOLOGY | NEUROSCIENCES | CLINICAL NEUROLOGY | DEGENERATION | ORTHOSTATIC HYPOTENSION | Immunohistochemistry | Tyrosine 3-Monooxygenase - metabolism | Heart Conduction System - metabolism | Humans | Male | Myocardium - metabolism | Statistics, Nonparametric | Aged, 80 and over | Female | Aged | Neurons - metabolism | Parkinson Disease - metabolism | alpha-Synuclein - metabolism | Heart - innervation
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9. Full Text Inverse Relationship Between Cerebrovascular Lesions and Severity of Lewy Body Pathology in Patients With Lewy Body Diseases
by Ghebremedhin, Estifanos and Rosenberger, Albert and Rüb, Udo and Vuksic, Mario and Berhe, Tzeggai and Bickeböller, Heike and de Vos, Rob A.I and Thal, Dietmar R and Deller, Thomas
Journal of Neuropathology and Experimental Neurology, ISSN 0022-3069, 05/2010, Volume 69, Issue 5, pp. 442 - 448
Cerebrovascular pathology is a major cause of stroke and mortality. Studies on prevalence of cerebrovascular pathologies in dementia with Lewy bodies (DLBs)... 
Parkinson disease | Lewy body disease | Cerebrovascular disease | Dementia with Lewy bodies | MORTALITY | CEREBRAL AMYLOID ANGIOPATHY | DEMENTIA | ALZHEIMERS-DISEASE | ATHEROSCLEROSIS | PREVALENCE | PATHOLOGY | NEUROSCIENCES | CLINICAL NEUROLOGY | STROKE | BODIES | BRAIN | PARKINSONS-DISEASE | Neurofibrillary Tangles - pathology | Parkinson Disease - complications | Parkinson Disease - pathology | Humans | Middle Aged | Lewy Body Disease - complications | Lewy Body Disease - pathology | Brain Infarction - pathology | Male | Cerebral Angiography - methods | Chi-Square Distribution | Principal Component Analysis - methods | Case-Control Studies | Cerebrovascular Disorders - etiology | Brain Infarction - etiology | Circle of Willis - pathology | Hemorrhage - etiology | Amyloid beta-Peptides - metabolism | Aged, 80 and over | Female | Aged | Retrospective Studies | Neurologic Examination - methods | Lewy Bodies - pathology
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10. Full Text Two Types of Sporadic Cerebral Amyloid Angiopathy
by THAL, DIETMAR RUDOLF and GHEBREMEDHIN, ESTIFANOS and RÜB, UDO and YAMAGUCHI, HARUYASU and TREDICI, KELLY DEL and BRAAK, HEIKO
JNEN: Journal of Neuropathology & Experimental Neurology, ISSN 0022-3069, 03/2002, Volume 61, Issue 3, pp. 282 - 293
Cerebral amyloid angiopathy (CAA) is a type of β-amyloidosis that occurs in leptomeningeal and cortical vessels of the elderly. In a sample of 41 CAA cases... 
Cerebral amyloid angiopathy | Dyshoric angiopathy | Leptomeningeal vessels | Apolipoprotein E | Cortical capillaries | Aβ-Protein | cortical capillaries | HEMORRHAGE | ALZHEIMERS-DISEASE | dyshoric angiopathy | PATHOLOGY | APOLIPOPROTEIN-E GENOTYPE | leptomeningeal vessels | NEUROSCIENCES | A beta-protein | CLINICAL NEUROLOGY | cerebral amyloid angiopathy | MOUSE MODEL | apolipoprotein E | BETA-PROTEIN | SMOOTH-MUSCLE-CELLS | PRECURSOR PROTEIN | E-EPSILON 4 | BASEMENT-MEMBRANE | Alzheimer Disease - complications | Blood Vessels - metabolism | Humans | Middle Aged | Male | Reference Values | Cerebral Infarction - complications | Cerebral Amyloid Angiopathy - complications | Amyloid beta-Peptides - metabolism | Aged, 80 and over | Adult | Female | Amyloidosis - complications | Cerebral Amyloid Angiopathy - genetics | Capillaries - metabolism | Severity of Illness Index | Genetic Predisposition to Disease | Cerebral Amyloid Angiopathy - physiopathology | Gene Frequency | Genotype | Cerebrovascular Circulation | Cerebral Amyloid Angiopathy - classification | Aging - physiology | Apolipoproteins E - genetics | Brain Diseases - complications | Alleles | Aged
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11. Full Text Murine renal organic anion transporters mOAT1 and mOAT3 facilitate the transport of neuroactive tryptophan metabolites
by Andrew Bahn and Marija Ljubojević and Heiko Lorenz and Christian Schultz and Estifanos Ghebremedhin and Bernhard Ugele and Ivan Sabolić and Gerhard Burckhardt and Yohannes Hagos
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 11/2005, Volume 289, Issue 5, pp. 1075 - 1084
Tryptophan metabolites such as kynurenate (KYNA), xanthurenate (XA), and quinolinate are considered to have an important impact on many physiological... 
N-methyl-D-aspartate receptor | Brain | Kidneys | Macula densa | Transforming growth factor | ENZYME-ACTIVITIES | PHYSIOLOGY | KYNURENINE PATHWAY | macula densa | FUNCTIONAL-CHARACTERIZATION | kidneys | brain | BLOOD-BRAIN-BARRIER | CELL BIOLOGY | QUINOLINIC ACID | ABLUMINAL MEMBRANE | HOMOVANILLIC-ACID | AMINOHIPPURATE SECRETION | CHOROID-PLEXUS | transforming growth factor | RABBIT PROXIMAL TUBULES | Gene Expression | Cercopithecus aethiops | Tryptophan - metabolism | Brain - metabolism | Organic Anion Transport Protein 1 - physiology | Biological Transport, Active | Kidney - metabolism | Animals | Tryptophan - analogs & derivatives | Mice | Molecular Structure | COS Cells | Organic Anion Transporters, Sodium-Independent - physiology
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12. Full Text Determining minimal stimulus intensity for mechanomyographic analysis
by Tosovic, Danijel and Seidl, Laura and Ghebremedhin, Estifanos and Brown, Mark J
Journal of Electromyography and Kinesiology, ISSN 1050-6411, 2015, Volume 25, Issue 5, pp. 749 - 753
Abstract Introduction: Mechanomyography (MMG) has recently shown promise in monitoring recovery of injured muscles. However, delivering a maximal percutaneous... 
Physical Medicine and Rehabilitation | Mechanomyography | Stimulation | Contraction time | Muscle | Injury | SIGNAL | SPORT SCIENCES | PHYSIOLOGY | MUSCLE INJURIES | REHABILITATION | NEUROSCIENCES | Myography - methods | Muscle Contraction | Muscle, Skeletal - physiology | Humans | Myography - standards
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13. Full Text Capillary cerebral amyloid angiopathy identifies a distinct APOE ε4-associated subtype of sporadic Alzheimer's disease
by Thal, Dietmar Rudolf and Papassotiropoulos, Andreas and Saido, Takaomi C and Griffin, W.S.T and Mrak, Robert E and Kölsch, Heike and Tredici, Kelly Del and Attems, Johannes and Ghebremedhin, Estifanos
Acta Neuropathologica, ISSN 0001-6322, 08/2010, Volume 120, Issue 2, pp. 169 - 183
macroglobulin receptor/low-density lipoprotein receptor-related protein (lrp-1) | Cerebral amyloid angiopathy | EAAT-2 | Apolipoprotein e (apoe) | Alzheimer's disease
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14. Full Text Hierarchical Distribution of the Tau Cytoskeletal Pathology in the Thalamus of Alzheimer’s Disease Patients
by Rüb, Udo and Stratmann, Katharina and Heinsen, Helmut and Del Turco, Domenico and Ghebremedhin, Estifanos and Seidel, Kay and den Dunnen, Wilfred and Korf, Horst-Werner
Journal of Alzheimer's Disease, ISSN 1387-2877, 10/2015, Volume 49, Issue 4, pp. 905 - 915
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15. Full Text Hierarchical distribution of the tau cytoskeletal pathology in the thalamus of Alzheimer's disease patients
by Rüb, Udo and Stratmann, Katharina and Heinsen, Helmut and Del Turco, Domenico and Ghebremedhin, Estifanos and Seidel, Kay and Den Dunnen, Wilfred and Korf, Horst-Werner
Journal of Alzheimer's Disease, ISSN 1387-2877, 12/2015, Volume 49, Issue 4, pp. 905 - 915
In spite of considerable progress in neuropathological research on Alzheimer's disease (AD), knowledge regarding the exact pathoanatomical distribution of the... 
tau | cytoskeletal pathology | pathoanatomy | Alzheimer's disease | thalamus | SYSTEM | NEUROFIBRILLARY TANGLES | RETICULAR NUCLEUS | CONNECTIONS | NEUROSCIENCES | NEURODEGENERATIVE DISEASES | DEGENERATION | PROPAGATION | BRAIN | HISTORY | Thalamus - metabolism | Humans | Alzheimer Disease - metabolism | Cytoskeleton - metabolism | tau Proteins - metabolism | Thalamus - pathology | Alzheimer Disease - pathology
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16. Full Text Modified amyloid variants in pathological subgroups of β‐amyloidosis
by Gerth, Janina and Kumar, Sathish and Rijal Upadhaya, Ajeet and Ghebremedhin, Estifanos and Arnim, Christine A. F and Thal, Dietmar R and Walter, Jochen
Annals of Clinical and Translational Neurology, ISSN 2328-9503, 07/2018, Volume 5, Issue 7, pp. 815 - 831
Objective Amyloid β (Aβ) depositions in plaques and cerebral amyloid angiopathy (CAA) represent common features of Alzheimer's disease (AD). Sequential... 
MAJOR COMPONENT | ALZHEIMERS ASSOCIATION GUIDELINES | NATIONAL INSTITUTE | HUMAN BRAIN | CEREBRAL-HEMORRHAGE | A-BETA | TERMINAL HETEROGENEITY | NEUROSCIENCES | CLINICAL NEUROLOGY | NEUROPATHOLOGIC ASSESSMENT | SENILE PLAQUES | APOLIPOPROTEIN-E | Hypertension | Pathology | Alzheimers disease | Dementia
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