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Neuropharmacology, ISSN 0028-3908, 05/2011, Volume 60, Issue 6, pp. 937 - 943
Although great advances have recently been made in the study of signal transduction, the pathogenesis of affective disorders is still unknown. There is... 
Antidepressant | Forced swimming test | Depression | Protein kinase C | Phospholipase C
Journal Article
International Journal of Neuropsychopharmacology, ISSN 1461-1457, 07/2012, Volume 15, Issue 6, pp. 781 - 793
A growing body of evidence indicates that the extracellular signal-regulated kinase (ERK) pathway may participate in the neuronal modulation of depression.... 
Antidepressant | tail suspension test | depression | MAPK | protein kinase C | forced swim test | JUN | DEPRESSED-PATIENTS | PHOSPHORYLATION | PSYCHIATRY | BIPOLAR AFFECTIVE-DISORDER | ANTIDEPRESSANT TREATMENT | ELEMENT-BINDING PROTEIN | SYNAPTIC PLASTICITY | NEUROSCIENCES | CLINICAL NEUROLOGY | HIPPOCAMPUS | PHARMACOLOGY & PHARMACY | RAT-BRAIN | STRESS | Gene Expression Regulation, Enzymologic - drug effects | Affect - drug effects | MAP Kinase Signaling System - physiology | Affect - physiology | Enzyme Inhibitors - pharmacology | Motor Activity - drug effects | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Gene Expression Regulation, Enzymologic - physiology | Enzyme Activation - drug effects | Hindlimb Suspension - methods | Dose-Response Relationship, Drug | CREB-Binding Protein - metabolism | Hindlimb Suspension - psychology | Animals | MAP Kinase Kinase 4 - metabolism | MAP Kinase Signaling System - drug effects | Protein Isoforms - metabolism | Analysis of Variance | Swimming - psychology | Protein Kinase C - metabolism | Mice | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Phosphorylation | Protein kinase C | MEK inhibitors | Extracellular signal-regulated kinase | Depression | Immunoblotting | MAP kinase | Cyclic AMP response element-binding protein | Neuromodulation | Stress | Signal transduction | Mood | c-Jun amino-terminal kinase | Antidepressants | Cortex (frontal) | Hippocampus | Locomotor activity
Journal Article
Neuropharmacology, ISSN 0028-3908, 08/2013, Volume 71, pp. 141 - 147
The histamine H4 receptor (H4R) is expressed primarily on cells involved in inflammation and immune responses. Recently, it has been reported the functional... 
Anxiety | Pain | Histamine H4 receptors | Memory | Central nervous system | Feeding | Histamine | H4 receptors | ACTIVATION | RAT | FOOD-INTAKE | PHARMACOLOGICAL CHARACTERIZATION | MOUSE | NEUROSCIENCES | NEURONAL HISTAMINE | PHARMACOLOGY & PHARMACY | H-4 RECEPTOR | MOLECULAR-CLONING | ANTAGONISTS | Central Nervous System - metabolism | Receptors, G-Protein-Coupled - metabolism | Motor Activity - drug effects | Guanidines - pharmacology | Male | Receptors, G-Protein-Coupled - agonists | Thiourea - pharmacology | Appetite Depressants - therapeutic use | Histamine Agonists - administration & dosage | Analgesics - agonists | Dose-Response Relationship, Drug | Benzimidazoles - administration & dosage | Nootropic Agents - antagonists & inhibitors | Histamine Antagonists - pharmacology | Behavior, Animal - drug effects | Neurons - metabolism | Anti-Anxiety Agents - therapeutic use | Receptors, Histamine H4 | Neurons - drug effects | Appetite Depressants - chemistry | Guanidines - administration & dosage | Histamine Agonists - therapeutic use | Analgesics - therapeutic use | Nerve Tissue Proteins - antagonists & inhibitors | Nootropic Agents - agonists | Anti-Anxiety Agents - agonists | Nerve Tissue Proteins - agonists | Histamine Antagonists - administration & dosage | Nootropic Agents - therapeutic use | Random Allocation | Thiourea - administration & dosage | Antidepressive Agents - therapeutic use | Nerve Tissue Proteins - metabolism | Receptors, Histamine - metabolism | Animals | Anti-Anxiety Agents - antagonists & inhibitors | Analgesics - antagonists & inhibitors | Receptors, G-Protein-Coupled - antagonists & inhibitors | Central Nervous System - drug effects | Benzimidazoles - pharmacology | Mice | Histamine Agonists - pharmacology | Thiourea - analogs & derivatives | Histamine Agonists - chemistry | Analysis | Diazepam
Journal Article
Neurotherapeutics, ISSN 1933-7213, 04/2013, Volume 10, Issue 2, p. 329
  Issue Title: Mitochondrial Mechanisms and Neurological Disorders There is convincing evidence that nitric oxide (NO) may be a causative factor in the... 
Journal Article
Psychopharmacology, ISSN 0033-3158, 05/2013, Volume 227, Issue 1, p. 149
  Hypericum perforatum, popularly called St. John's wort (SJW), is a medicinal plant mainly used as antidepressant with a favorable safety profile than... 
Nitric oxide | Medicine, Botanic | Physiological aspects | Medicine, Herbal | Properties | Antidepressants, Tricyclic | St. John's wort | Proteins | Signal transduction | Psychopharmacology | Dietary supplements
Journal Article
Psychopharmacology, ISSN 0033-3158, 5/2013, Volume 227, Issue 1, pp. 149 - 163
Hypericum perforatum, popularly called St. John’s wort (SJW), is a medicinal plant mainly used as antidepressant with a favorable safety profile than standard... 
NF-κB | Neurosciences | St. John’s wort | Protein kinase C | Biomedicine | Pain | CREB | STAT1 | Pharmacology/Toxicology | Psychiatry
Journal Article
Neurotherapeutics, ISSN 1933-7213, 04/2013, Volume 10, Issue 2, p. 329
There is convincing evidence that nitric oxide (NO) may be a causative factor in the pathogenesis of migraine. We investigated the consequences of NO donors'... 
Nitric oxide | Analysis | Migraine | Nitrogen compounds | Sodium nitroferricyanide | Protein binding
Journal Article
Pain Medicine, ISSN 1526-2375, 07/2017, Volume 18, Issue 7, pp. 1334 - 1343
Abstract Objective. In this study, we compared the efficacy of a combination of PKC-blocker St. John’s Wort (SJW) and morphine in mice with painful... 
Morphine | St. John’s wort | Hypericin | PKCγ | Neuropathic pain
Journal Article
Neuropharmacology, ISSN 0028-3908, 01/2012, Volume 62, Issue 1, pp. 289 - 296
We investigated the involvement of extracellular signal-regulated kinase (ERK), c-Jun-N-terminal kinase/stress-activated protein kinase (JNK/SAPK), p38MAPK... 
Journal Article
Pain Medicine, ISSN 1526-2375, 07/2017, Volume 18, Issue 7, p. 1334
Abstract Objective. In this study, we compared the efficacy of a combination of PKC-blocker St. John's Wort (SJW) and morphine in mice with painful... 
Potentiation | Protein kinase C | Animal models | Pain perception | Narcotics | Morphine | Neuropathy | Analgesia | Flavonoids | Hypericin | Pain | Oxaliplatin | Opioids
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2014, Volume 9, Issue 7, pp. e102758 - e102758
The development of neuropathic syndromes is an important, dose limiting side effect of anticancer agents like platinum derivates, taxanes and vinca alkaloids.... 
NERVOUS-SYSTEM | 1ST-LINE TREATMENT | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | DOPAMINERGIC NEURODEGENERATION | INDUCED OXIDATIVE STRESS | ALZHEIMERS-DISEASE | COLORECTAL-CANCER | MULTIDISCIPLINARY SCIENCES | ACTIVATED-RECEPTOR-GAMMA | 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J | PERIPHERAL NEUROPATHY | Catalase - pharmacology | Spinal Cord - drug effects | Spinal Cord - metabolism | Antioxidants - metabolism | Humans | Neuralgia - metabolism | Male | PPAR gamma - metabolism | Neurotoxicity Syndromes - drug therapy | Peroxisomes - drug effects | Antineoplastic Agents - adverse effects | Oxidation-Reduction - drug effects | Neuralgia - chemically induced | Thiazolidinediones - pharmacology | Astrocytes - drug effects | Cells, Cultured | Rats | Mitochondria - metabolism | Mitochondria - drug effects | Rats, Sprague-Dawley | Peroxisomes - metabolism | HT29 Cells | Animals | PPAR gamma - agonists | Cell Line, Tumor | Neurotoxicity Syndromes - metabolism | Ganglia, Spinal - drug effects | Organoplatinum Compounds - adverse effects | Astrocytes - metabolism | Ganglia, Spinal - metabolism | Cell culture | Oxidative stress | Spinal cord | Neurosciences | Impairment | Childrens health | Nervous system | Glucose | Neuropathy | Peripheral neuropathy | Experiments | Cancer therapies | Anticancer properties | Antioxidants | Alkaloids | Neurotoxicity | Toxicology | Mitochondria | Oxaliplatin | Pain | Antitumor agents | Colon cancer | Dorsal root ganglia | Catalase | Metabolites | Neurodegeneration | Platinum | Rodents | Colon | Cold pressing | Incubation | Pharmacology | Metabolism | Organelles | Ganglia | Signaling | Chemotherapy | Peroxisomes | Brain research | Rosiglitazone | In vivo methods and tests | Peroxisome proliferator-activated receptors | Laboratory animals | Taxanes | Endocrinology | Cancer | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2015, Volume 10, Issue 6, pp. e0128080 - e0128080
Neurotoxicity is a main side effect of the anticancer drug oxaliplatin. The development of a neuropathic syndrome impairs quality of life and potentially... 
1ST-LINE TREATMENT | NERVOUS-SYSTEM | OXIDATIVE STRESS | CHRONIC PAIN | CISPLATIN | ACID AMIDE HYDROLASE | MULTIDISCIPLINARY SCIENCES | INDUCED PERIPHERAL NEUROPATHY | DIFFERENT SCHEDULES | ADJUVANT TREATMENT | CHEMOTHERAPY | Ethanolamines - pharmacology | Neurons - pathology | Neuralgia - complications | Neuroglia - pathology | Humans | Palmitic Acids - therapeutic use | Male | Neurotoxicity Syndromes - drug therapy | Neuroglia - drug effects | Nervous System - pathology | Neurotoxicity Syndromes - pathology | Inflammation Mediators - metabolism | Behavior, Animal - drug effects | Neurons - metabolism | Palmitic Acids - pharmacology | Neurons - drug effects | Disease Models, Animal | Neurotoxicity Syndromes - complications | Activating Transcription Factor 3 - metabolism | Rats, Sprague-Dawley | Neuralgia - drug therapy | HT29 Cells | Animals | Nervous System - drug effects | Ganglia, Spinal - pathology | Ethanolamines - therapeutic use | Neuroglia - metabolism | Ganglia, Spinal - drug effects | Organoplatinum Compounds - adverse effects | Development and progression | Research | Peripheral nerve diseases | Risk factors | Oxidative stress | Neuroprotection | Spinal cord | Heat treatment | Neurosciences | Animal models | Childrens health | Peripheral nerves | Nervous system | Diabetic neuropathy | Activation | Neuropathy | Glial cells | Peripheral neuropathy | Experiments | Cancer therapies | Neuronal-glial interactions | Anticancer properties | Neurotoxicity | Toxicology | Oxaliplatin | Pain | Colon cancer | Dorsal root ganglia | Rodents | Nerves | Colon | Thermal stimuli | Drug dosages | Hypertension | Pain perception | Pharmacology | Fatty acids | Ganglia | Molecular chains | Quality of life | Medicine | Chemotherapy | Side effects | Environmental science | Morphology | Laboratory animals | Cancer | Index Medicus
Journal Article
Neuropharmacology, ISSN 0028-3908, 05/2011, Volume 60, Issue 6, pp. 937 - 943
Although great advances have recently been made in the study of signal transduction, the pathogenesis of affective disorders is still unknown. There is... 
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 01/2017, Volume 174, Issue 1, pp. 28 - 40
Background and Purpose Neuropathic pain is under‐treated, with a detrimental effect on quality of life, partly because of low treatment efficacy, but also... 
Oxidative stress | Histamine | Enzymes | Care and treatment | Pain | Analysis | Research Papers | Research Paper
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 03/2015, Volume 750, pp. 27 - 31
Behavioral responses to food deprivation are a fundamental aspect of nervous system function in all animals. Several signaling molecules in the mammalian brain... 
Antisense oligodeoxynucleotides | Gi/o-proteins | Food deprivation | GTP-Binding Protein alpha Subunits, Gi-Go - genetics | Eating | Animals | Fasting | Oligonucleotides, Antisense - genetics | Feeding Behavior | Food Deprivation | Male | Mice | Motor Activity | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 03/2015, Volume 750, p. 27
Behavioral responses to food deprivation are a fundamental aspect of nervous system function in all animals. Several signaling molecules in the mammalian brain... 
Oligodeoxynucleotides | Animal behavior | G proteins | Membrane proteins
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 02/2019, Volume 62, Issue 4, pp. 1887 - 1901
A three-dimensional database search has been applied to design a series of endo- and exo-3-(pyridin-3-yl)bicyclo[2.2.1]heptan-2-amines as nicotinic receptor... 
Journal Article
中国神经再生研究:英文版, ISSN 1673-5374, 2017, Volume 12, Issue 3, pp. 403 - 404
Neuropathic pain originates from damages to the somatosensory nervous system(IASP-International Association for the Study of... 
疼痛 | 治疗 | 神经系统 | 植物修复 | 心肌缺血 | 周围神经病 | 药用 | 躯体感觉 | NICOTINIC RECEPTOR | PREVENTS | GLIA | NEUROSCIENCES | CELL BIOLOGY
Journal Article
Journal of Pharmacy and Pharmacology, ISSN 0022-3573, 06/2019, Volume 71, Issue 6, pp. 971 - 981
Journal Article