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Journal Article
CANCERS, ISSN 2072-6694, 10/2019, Volume 11, Issue 10, p. 1518
Pharmacological Hedgehog (Hh) pathway inhibition has emerged as a valuable anticancer strategy. A number of small molecules able to block the pathway at the... 
TARGET | Hedgehog | ITCH | Smo | ONCOLOGY | GLI CODE | RESISTANCE | NUMB | cancer | Gli1 | MEDULLOBLASTOMA | multitarget | hedgehog | smo | gli1
Journal Article
The EMBO Journal, ISSN 0261-4189, 01/2015, Volume 34, Issue 2, pp. 200 - 217
Hedgehog signaling is essential for tissue development and stemness, and its deregulation has been observed in many tumors. Aberrant activation of Hedgehog... 
Gli inhibitors | Hedgehog | cancer | Gli1–DNA interaction | Gli1-DNA interaction | Cancer | CANCER-CELLS | STEM-CELLS | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | HUMAN GLIOMA | CELL BIOLOGY | PATHWAY BLOCKADE | INHIBITION | GROWTH | SCORING FUNCTIONS | MEDULLOBLASTOMA | Embryo, Mammalian - drug effects | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Receptors, G-Protein-Coupled - metabolism | Isoflavones - pharmacology | Cerebellum - drug effects | Embryo, Mammalian - metabolism | Kruppel-Like Transcription Factors - metabolism | Smoothened Receptor | Female | Glioblastoma - metabolism | Receptors, Cell Surface - physiology | Patched Receptors | DNA - drug effects | Fibroblasts - metabolism | Mutagenesis, Site-Directed | Cerebellum - metabolism | DNA - metabolism | Mice, SCID | Mutation - genetics | Kruppel-Like Transcription Factors - chemistry | Molecular Dynamics Simulation | Mice, Knockout | Animals | Embryonic Stem Cells - drug effects | Signal Transduction - drug effects | Embryo, Mammalian - cytology | Fibroblasts - drug effects | Glioblastoma - pathology | Cerebellum - cytology | Mice, Inbred NOD | Fibroblasts - cytology | Mice | Mice, Inbred BALB C | Zinc Finger Protein GLI1 | Glioblastoma - drug therapy | Kruppel-Like Transcription Factors - genetics | Medical research | Amino acids | Molecular biology | Deoxyribonucleic acid--DNA | Stem cells | Tumors
Journal Article
Beilstein Journal of Organic Chemistry, ISSN 1860-5397, 09/2018, Volume 14, Issue 1, pp. 2411 - 2417
An efficient strategy for the synthesis of 6-unsubstituted indolo[1,2-c]quinazolines is described. The Pd-catalyzed reaction of o-(o-aminophenylethynyl)... 
Indoles | Quinazolines | DMFDMA | Indoloquinazolines | Arylboronic acids | indoloquinazolines | FUSED HETEROCYCLES | ACIDS | CHEMISTRY, ORGANIC | indoles | arylboronic acids | CHEMISTRY | HINCKDENTINE-A | AGENTS | ARYL | quinazolines | CYCLIZATION | TRYPTANTHRIN | Aniline | Indole | Dimethylformamide
Journal Article
ISSN 1477-0520, 12/2019, Volume 17, Issue 47, pp. 165 - 172
Regioselective access to 10-substituted-2 H ,8 H -pyrano[2,3- f ]chromen-2-ones through the gold-catalyzed intramolecular hydroarylation of readily available... 
Journal Article
Current medicinal chemistry, 07/2019
Antimicrobial peptides (AMPs) are key effectors of the innate immunity and represent promising molecules for the development of new antibacterial drugs.... 
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 05/2017, Volume 2017, Issue 17, pp. 2385 - 2385
The cover picture shows the mechanistic pathway involved in the ring‐opening cross‐metathesis (ROM‐CM) reaction of resorc[4]arene macrocycles. The red... 
Ruthenium
Journal Article
ISSN 1477-0520, 1/2019, Volume 17, Issue 3, pp. 527 - 532
The gold-catalyzed hydroamination of 2-(arylethynyl)pyridines with anilines affords stereoselectively Z -enamine products with excellent regioselectivity. The... 
Journal Article
Organic Chemistry Frontiers, ISSN 2052-4110, 10/2018, Volume 5, Issue 20, pp. 3022 - 3055
Journal Article
Organic & Biomolecular Chemistry, ISSN 1477-0520, 01/2019, Volume 17, Issue 3, pp. 527 - 532
The gold-catalyzed hydroamination of 2-(arylethynyl)pyridines with anilines affords stereoselectively Z-enamine products with excellent regioselectivity. The... 
Pyridines | Gold | Nuclear magnetic resonance--NMR | Regioselectivity | Selectivity | Stereochemistry | Functional groups | Alkynes
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 05/2017, Volume 2017, Issue 17, pp. 2407 - 2415
For the first time we describe the detection of a ruthenium‐carbene‐resorc[4]arene complex produced, as a key intermediate, during an olefin metathesis... 
Carbene ligands | Ruthenium | NMR spectroscopy | Reaction mechanisms | Grubbs catalyst | Metathesis | MECHANISM | CHEMISTRY, ORGANIC | OLEFIN METATHESIS | POLYMERIZATION | OPENING-CROSS-METATHESIS | RING-CLOSING METATHESIS | THEORETICAL PERSPECTIVE | CARBENE COMPLEXES | INITIATORS | CATALYSTS | ELECTROSPRAY-IONIZATION | Oligomers | Nuclear magnetic resonance spectroscopy
Journal Article
Journal Article
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 01/2018, Volume 33, Issue 1, pp. 349 - 358
This work aims at elucidating the mechanism and kinetics of hydrolysis of GANT61, the first and most-widely used inhibitor of the Hedgehog (Hh) signalling... 
chemical stability | GANT61 | Gli inhibitor | bioactive form | Hedgehog pathway