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Molecular Therapy - Oncolytics, ISSN 2372-7705, 06/2019, Volume 13, pp. 7 - 13
A network of pattern recognition receptors (PRRs) is responsible for the detection of invading viruses and acts as the trigger for the host antiviral response.... 
IFI16 | immunotherapy | cGAS | oncolytic virotherapy | STING | HSV | cancer | interferon | MEDICINE, RESEARCH & EXPERIMENTAL | CYCLIC GMP-AMP | ACTIVATION | RNA | ONCOLOGY | PATHWAY | ADAPTER | INNATE IMMUNE SENSOR | DOUBLE-STRANDED DNA | CYTOSOLIC-DNA | I INTERFERON | Immunotherapy | Oncolysis | Viruses | Adaptive immunity | Interferon | Pattern recognition | Sensors | Kinases | Viral infections
Journal Article
Molecular Therapy - Oncolytics, ISSN 2372-7705, 12/2019, Volume 15, pp. 91 - 100
Malignant peripheral nerve sheath tumors (MPNSTs) are an aggressive soft-tissue sarcoma amenable only to surgical resection. Oncolytic herpes simplex viruses... 
sarcoma | oncolytic virus | Neurofibromatosis | cGAS | STING | ISG | MPNST | pattern recognition receptor | oHSV
Journal Article
Translational oncology, ISSN 1936-5233, 02/2018, Volume 11, Issue 1, pp. 86 - 93
Malignant gliomas are the most common primary brain tumor and are characterized by rapid and highly invasive growth. Because of their poor prognosis, new... 
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, p. e0127278
Journal Article
PLoS ONE, 05/2015, Volume 10, Issue 5
Inflammasome activation is a two-step process where step one, priming, prepares the inflammasome for its subsequent activation, by step two. Classically step... 
Journal Article
Translational Oncology, ISSN 1936-5233, 02/2018, Volume 11, Issue 1, pp. 86 - 93
Malignant gliomas are the most common primary brain tumor and are characterized by rapid and highly invasive growth. Because of their poor prognosis, new... 
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 4/2014, Volume 192, Issue 8, pp. 3881 - 3888
Caspase-1 activation is a central event in innate immune responses to many pathogenic infections and tissue damage. The NLRP3 inflammasome, a multi-protein... 
monocytes | macrophages | inflammation | cell activation | cytokines | lipopolysaccharide | bacterial infections | human
Journal Article
Cancer Immunology Research, ISSN 2326-6066, 12/2018, Volume 6, Issue 12, pp. 1499 - 1510
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft-tissue sarcomas resistant to most cancer treatments. Surgical resection remains the... 
CELLS | HERPES-SIMPLEX-VIRUS | INTERFERON | PROTEIN | ONCOLOGY | STAT1 | IRS1 | GENE-EXPRESSION | INFECTION | TRS1 | IMMUNOLOGY | CHRONIC INFLAMMATION
Journal Article
Molecular Therapy - Oncolytics, ISSN 2372-7705, 12/2019, Volume 15, pp. 38 - 48
Solid tumors contain a mixture of malignant cells and non-malignant infiltrating cells that often create a chronic inflammatory and immunosuppressive... 
natural killer cells | sarcoma | dendritic cell vaccine | immunotherapy | oncolytic virotherapy | brain tumor | immunosuppression | neo-antigen | CAR T cells | metabolic antagonism
Journal Article
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