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Drug Metabolism and Disposition, ISSN 0090-9556, 03/2013, Volume 41, Issue 3, pp. 668 - 681
Journal Article
Bioanalysis, ISSN 1757-6180, 2018, Volume 10, Issue 9, pp. 659 - 672
Aim: Evaluation of HPLC-high-resolution mass spectrometry (HPLC-HRMS) full scan with polarity switching for increasing throughput of human in vitro cocktail... 
loratadine | CYP inhibition | cocktail assay | drug-drug interaction | LC-HRMS full scan | CHEMISTRY, ANALYTICAL | METABOLITES | HUMAN PLASMA | PERSPECTIVE | BIOCHEMICAL RESEARCH METHODS | GUIDANCE | ASPIRIN | LC-MS/MS | PHARMACOKINETICS | ENZYMES | SIMVASTATIN
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 03/2011, Volume 39, Issue 3, pp. 510 - 521
Boceprevir (SCH 503034), a protease inhibitor, is under clinical development for the treatment of human hepatitis C virus infections. In human liver... 
METABOLISM | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | NS3 PROTEASE | ALDO-KETO REDUCTASES | CARBONYL REDUCTION | NEUROSTEROIDS | SUPERFAMILY | PHARMACOLOGY & PHARMACY | AGENTS | DEHYDROGENASE | HIV-INTEGRASE INHIBITOR | Liver - enzymology | Proline - metabolism | Stereoisomerism | Humans | Drugs, Investigational - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Urea - chemistry | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Drugs, Investigational - chemistry | Serine Proteinase Inhibitors - chemistry | Cytochrome P-450 CYP3A - genetics | Urea - analogs & derivatives | 3-Hydroxysteroid Dehydrogenases - metabolism | Hydroxysteroid Dehydrogenases - metabolism | Urea - metabolism | Molecular Structure | Oligopeptides - chemistry | Recombinant Proteins - metabolism | Oxidation-Reduction | Proline - analogs & derivatives | Subcellular Fractions - drug effects | Enzyme Inhibitors - pharmacology | Serine Proteinase Inhibitors - metabolism | Hydroxysteroid Dehydrogenases - genetics | Oligopeptides - metabolism | Subcellular Fractions - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Proline - chemistry | Hepacivirus - enzymology | Hydroxyprostaglandin Dehydrogenases - antagonists & inhibitors | Cytochrome P-450 CYP3A Inhibitors | Aldo-Keto Reductase Family 1 Member C3 | Cytochrome P-450 CYP3A - metabolism | Biotransformation - drug effects | Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Kinetics | 3-Hydroxysteroid Dehydrogenases - genetics | Viral Nonstructural Proteins - antagonists & inhibitors | Subcellular Fractions - enzymology | Index Medicus
Journal Article
Bioanalysis, 05/2018
Evaluation of HPLC-high-resolution mass spectrometry (HPLC-HRMS) full scan with polarity switching for increasing throughput of human in vitro cocktail... 
Journal Article
DRUG METABOLISM AND DISPOSITION, ISSN 0090-9556, 03/2013, Volume 41, Issue 3, pp. 668 - 681
The inhibitory effect of boceprevir (BOC), an inhibitor of hepatitis C virus nonstructural protein 3 protease was evaluated in vitro against a panel of... 
TELMISARTAN | UDP-GLUCURONOSYLTRANSFERASES | TELAPREVIR | HIV PROTEASE INHIBITORS | PHARMACOKINETICS | GLUCURONIDATION | GENOTYPE 1 INFECTION | PHARMACOLOGY & PHARMACY | HEALTHY-VOLUNTEERS | HEPATITIS-C | ATORVASTATIN | Liver - enzymology | Cricetulus | Antiviral Agents - toxicity | Proline - metabolism | Humans | Membrane Transport Modulators - toxicity | Membrane Transport Proteins - drug effects | Male | Antiviral Agents - metabolism | Organic Anion Transporters - metabolism | Dose-Response Relationship, Drug | LLC-PK1 Cells | Drug Interactions | Transfection | Liver - drug effects | Membrane Transport Proteins - genetics | Swine | Biotransformation | Enzyme Inhibitors - toxicity | Enzymes - genetics | Madin Darby Canine Kidney Cells | Female | Membrane Transport Proteins - metabolism | Microsomes, Liver - enzymology | Enzymes - metabolism | CHO Cells | Recombinant Proteins - metabolism | Cricetinae | Organic Anion Transporters - antagonists & inhibitors | Proline - toxicity | Enzyme Inhibitors - metabolism | Oxidoreductases - metabolism | Proline - analogs & derivatives | Membrane Transport Modulators - metabolism | Animals | Cytochrome P-450 CYP3A Inhibitors | Glucuronosyltransferase - metabolism | Cytochrome P-450 CYP3A - metabolism | Dogs | Kinetics | Solute Carrier Organic Anion Transporter Family Member 1b1 | Index Medicus
Journal Article
Journal Article
Separations, ISSN 2297-8739, 07/2019, Volume 6, Issue 3, p. 37
The development of antibiotic resistance by microbials has long been acknowledged. The major challenge worldwide is to develop novel, natural, and potent... 
antibacterial activity | medicinal plant | UHPLC-HRMS | Aechmea magdalenae | MIC
Journal Article
Archives of Toxicology, ISSN 0340-5761, 10/2003, Volume 77, Issue 10, pp. 547 - 554
Journal Article
Drug Metabolism Letters, ISSN 1872-3128, 08/2009, Volume 3, Issue 3, pp. 162 - 170
Journal Article
RETROVIROLOGY, ISSN 1742-4690, 2005, Volume 2, Issue Suppl 1, pp. P116 - P116
Conference Proceeding
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