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Nature, ISSN 0028-0836, 08/2016, Volume 537, Issue 7619, pp. 185 - 190
Journal Article
Immunity, ISSN 1074-7613, 06/2012, Volume 36, Issue 6, pp. 933 - 946
The mitochondrial protein MAVS (also known as IPS-1, VISA, and CARDIF) interacts with RIG-I-like receptors (RLRs) to induce type I interferon (IFN-I). NLRX1 is... 
ELONGATION-FACTOR TU | HEPATITIS-C VIRUS | RNA | RIG-I | LEUCINE-RICH REPEAT | NUCLEOTIDE-BINDING | ANTIVIRAL IMMUNE-RESPONSES | IMMUNOLOGY | NF-KAPPA-B | ADAPTER PROTEIN | INNATE IMMUNITY | Humans | Recombinant Fusion Proteins - physiology | Molecular Sequence Data | Autophagy - physiology | Mitochondrial Proteins - genetics | Macrophages, Peritoneal - cytology | Interferon Type I - biosynthesis | DEAD-box RNA Helicases - physiology | HEK293 Cells | Microtubule-Associated Proteins - deficiency | Mitochondrial Proteins - deficiency | Cytokines - genetics | Fibroblasts - metabolism | Autophagy-Related Protein 12 | Carrier Proteins - physiology | Amino Acid Sequence | DEAD Box Protein 58 | Proteins - physiology | Peptide Elongation Factor Tu - physiology | Specific Pathogen-Free Organisms | Gene Expression Regulation - immunology | Macrophages, Peritoneal - immunology | Mitochondrial Proteins - physiology | Peptide Elongation Factor Tu - chemistry | Recombinant Fusion Proteins - chemistry | Microtubule-Associated Proteins - physiology | Multiprotein Complexes - physiology | Protein Interaction Mapping | Sequence Homology, Amino Acid | Adaptor Proteins, Signal Transducing - physiology | Sequence Alignment | Animals | Autophagy-Related Protein 5 | Mitochondrial Proteins - chemistry | Interferon Type I - genetics | Mice | Vesiculovirus - physiology | Cytokines - biosynthesis | Virus diseases | Proteins | Magneto-electric machines | Physiological aspects | Interferon | Biological response modifiers | Health aspects | Machinery | Mass spectrometry | Cells | Infections | Plasmids | Autophagy | Rodents | Viral infections
Journal Article
Journal Article
PLoS Pathogens, ISSN 1553-7366, 11/2012, Volume 8, Issue 11, p. e1003040
Heterotrimeric G-protein signaling pathways are vital components of physiology, and many are amenable to pharmacologic manipulation. Here, we identify... 
ALPHA-SUBUNITS | CYSTEINE PROTEASE | PHAGOCYTOSIS | CRYSTAL-STRUCTURE | MICROBIOLOGY | NUCLEOTIDE-BINDING | TRANSMEMBRANE KINASE FAMILY | VIROLOGY | COUPLED RECEPTORS | LIVER-ABSCESS | PARASITE | EXPRESSION | PARASITOLOGY | Entamoeba histolytica - immunology | Cricetulus | Entamoebiasis - enzymology | GTP-Binding Protein alpha Subunits - chemistry | Humans | Crystallography, X-Ray | Virulence Factors - immunology | Protozoan Proteins - genetics | Entamoebiasis - immunology | Entamoeba histolytica - genetics | GTP-Binding Protein alpha Subunits - immunology | Entamoeba histolytica - enzymology | Protozoan Proteins - chemistry | CHO Cells | Protein Structure, Tertiary | Cricetinae | Guanine Nucleotide Exchange Factors - genetics | Gene Expression Regulation - immunology | Jurkat Cells | GTP-Binding Protein alpha Subunits - genetics | Virulence Factors - chemistry | Rho Guanine Nucleotide Exchange Factors | Animals | Guanine Nucleotide Exchange Factors - immunology | Transcription, Genetic - immunology | Entamoebiasis - genetics | Protozoan Proteins - immunology | Guanine Nucleotide Exchange Factors - chemistry | Virulence Factors - biosynthesis | Physiological aspects | Entamoeba histolytica | G proteins | Research | Virulence (Microbiology) | Health aspects | Protein binding | Proteins | Inflammatory bowel disease | Pathogenesis | Cytotoxicity | Infections | Kinases | Experiments | Binding sites | Crystal structure
Journal Article
CHEMISTRY-A EUROPEAN JOURNAL, ISSN 0947-6539, 04/2017, Volume 23, Issue 19, pp. 4615 - 4624
Allosteric sodium in the helix bundle of a G protein-coupled receptor (GPCR) can modulate the receptor activation on the intracellular side. This phenomenon... 
G protein-coupled receptor | opioid receptors | RHODOPSIN ACTIVATION | GPCR activation | CRYSTAL-STRUCTURE | MEMBRANES | molecular dynamics | CHEMISTRY, MULTIDISCIPLINARY | allosteric effects | MOLECULES | PROTEIN-COUPLED RECEPTOR | STRUCTURAL BASIS | ION BINDING | GPCR | AGONIST | INSIGHTS | Proteins | Sodium | Narcotics | Naturvetenskap | Kemi | Natural Sciences | Chemical Sciences
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2015, Volume 58, Issue 4, pp. 1992 - 2002
Journal Article
Journal Article