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British Journal of Cancer, ISSN 0007-0920, 12/2019
Journal Article
Nature, ISSN 0028-0836, 09/2015, Volume 525, Issue 7570, pp. 538 - 542
Bromodomain and extra terminal protein (BET) inhibitors are first-in-class targeted therapies that deliver a newtherapeutic opportunity by directly targeting... 
SELECTIVE-INHIBITION | ACCURATE | CHROMATIN | MECHANISM | MULTIDISCIPLINARY SCIENCES | ACUTE MYELOID-LEUKEMIA | DRUG-RESISTANCE | MUTATIONS | SEQUENCING DATA | CANCER | DISCOVERY | Chromatin - metabolism | Transcription, Genetic - drug effects | Clone Cells - drug effects | Neoplastic Stem Cells - drug effects | Epigenesis, Genetic | Humans | Leukemia, Myeloid, Acute - metabolism | Molecular Targeted Therapy | Neoplastic Stem Cells - metabolism | Leukemia, Myeloid, Acute - drug therapy | Neoplastic Stem Cells - pathology | Gene Expression Regulation, Neoplastic - drug effects | Hematopoietic Stem Cells - drug effects | Benzodiazepines - pharmacology | Leukemia, Myeloid, Acute - pathology | Cells, Cultured | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Hematopoietic Stem Cells - metabolism | Clone Cells - metabolism | beta Catenin - metabolism | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Clone Cells - pathology | Wnt Signaling Pathway - drug effects | Genes, myc - genetics | Hematopoietic Stem Cells - cytology | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Mice | Drug Resistance, Neoplasm - drug effects | Leukemia, Myeloid, Acute - genetics | Proteins | Leukemia | Cloning | Cell cycle | Stem cells | Epigenetics | Apoptosis
Journal Article
Nature, ISSN 0028-0836, 09/2017, Volume 549, Issue 7670, pp. 101 - 105
Journal Article
Science, ISSN 0036-8075, 06/2017, Volume 356, Issue 6345, pp. 1397 - 1401
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 07/2016, Volume 23, Issue 7, pp. 673 - 681
Targeted therapies against disruptor of telomeric silencing 1-like (DOT1 L) and bromodomain-containing protein 4 (BRD4) are currently being evaluated in... 
CELLS | METHYLTRANSFERASE | CHROMATIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | ACUTE MYELOID-LEUKEMIA | MYELODYSPLASTIC SYNDROME | CELL BIOLOGY | INHIBITION | BIOPHYSICS | EXPRESSION | TRANSCRIPTIONAL ELONGATION | FUSION PROTEINS | Chromatin - metabolism | RNA, Small Interfering - genetics | Cell Proliferation | Humans | Methyltransferases - metabolism | Methyltransferases - genetics | Male | T-Lymphocytes - metabolism | Female | Transcription, Genetic | Acetylation | B-Lymphocytes - pathology | Proteomics - methods | T-Lymphocytes - pathology | Nuclear Proteins - genetics | B-Lymphocytes - metabolism | Chromatin - chemistry | Disease Models, Animal | Leukemia, Biphenotypic, Acute - pathology | Signal Transduction | Mice, Inbred C57BL | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Clinical Trials as Topic | Gene Expression Regulation, Leukemic | Transcription Factors - genetics | Transcription Factors - metabolism | Animals | Histones - genetics | Methyltransferases - antagonists & inhibitors | Nuclear Proteins - antagonists & inhibitors | Leukemia, Biphenotypic, Acute - metabolism | Protein Binding | Mice | Histones - metabolism | Primary Cell Culture | Leukemia, Biphenotypic, Acute - genetics | RNA, Small Interfering - metabolism | Epigenetic inheritance | Genetic transcription | Analysis | Leukemia | Protein expression | Molecular biology | Medical prognosis | Stem cells
Journal Article
Journal Article
Journal Article
EMBO reports, ISSN 1469-221X, 10/2017, Volume 18, Issue 10, pp. 1775 - 1785
Journal Article
Journal Article
Journal Article