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The Journal of general virology, ISSN 0022-1317, 01/2019, Volume 100, Issue 1, pp. 89 - 98
Herpesviruses are known to manipulate autophagy to optimize their replication, counteract immune response and probably to promote tumourigenesis. This study... 
BIP | ER stress | CHOP | autophagy | UPR | HHV-6 | CELLS | HUMAN HERPESVIRUS-6 | CELLULAR RECEPTOR | MONOCYTES | HUMAN-HERPESVIRUS-6 | VIROLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Journal Article
Oncotarget, ISSN 1949-2553, 07/2019, Volume 10, Issue 45, p. 4691
Resistance to chemotherapy represents a major obstacle to successful treatment. The generation of reactive oxygen species (ROS) has been directly linked to the... 
Journal Article
Journal Article
BBA - Molecular Basis of Disease, ISSN 0925-4439, 03/2020, Volume 1866, Issue 3, p. 165647
HHV-6A and HHV-6B are neurotropic viruses able to dysregulate autophagy and activate ER stress/UPR in several cell types. The appropriate functioning of these... 
Tau phosphorylation | | HHV-6A | Autophagy/UPR | Neurons | Alzheimer's disease
Journal Article
Virus Research, ISSN 0168-1702, 11/2019, Volume 273, p. 197757
HHV-6A and HHV-6B are ubiquitous human betaherpesviruses sharing more than 80% homology. HHV-6B is the most common cause of encephalitis in transplant patients... 
ER stress | Monocytes | Dendritic cells | Autophagy | UPR | HHV-6 | HUMAN-HERPESVIRUS 6A | ENDOPLASMIC-RETICULUM STRESS | INDUCTION | HUMAN-HERPESVIRUS-6 | CD4 | TROPISM | REPLICATION | VIROLOGY | INFECTION | MACROPHAGE DIFFERENTIATION
Journal Article
Viruses, ISSN 1999-4915, 01/2019, Volume 11, Issue 1, p. 8
Previous studies have indicated that cytotoxic treatments may induce or not activate viral lytic cycle activation in cancer cells latently infected by Kaposi's... 
Bortezomib | NRF2 | TPA | KSHV lytic cycle | HSF1 | P62/SQSTM1 | ROS | Butyrate | APOPTOSIS | OXIDATIVE STRESS | PI3K/AKT/MTOR | butyrate | p62 | REPLICATION | INHIBITION | VIROLOGY | GENE | BLOCKS | LYMPHOMA | SQSTM1 | EXPRESSION | AUTOPHAGIC FLUX | p62/SQSTM1
Journal Article
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 09/2019, Volume 114, p. 105560
Kaposi Sarcoma Herpes Virus (KSHV) is an oncovirus belonging to the human gammaherpesvirus family, able to infect several immune cell types including B cells,... 
Monocytes | Reactive oxygen species | KHSV | Autophagy | p62 | CATALASE | CELLS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IMPAIRS | SERA | ALPHA | CELL BIOLOGY | BLOCKS | DIFFERENTIATION | STRESS
Journal Article
CANCERS, ISSN 2072-6694, 05/2019, Volume 11, Issue 5, p. 703
Pancreatic cancer is one of the most aggressive cancers whose prognosis is worsened by the poor response to the current chemotherapies. In this study, we... 
SURVIVAL | HSP90 | autophagy | mutp53 | P62/SQSTM1 | apigenin | SOD | p62 | pancreatic cancer | NRF2 | ONCOLOGY | ROS | EXPRESSION | PROMOTES | catalase
Journal Article
BIOMOLECULES, ISSN 2218-273X, 09/2019, Volume 9, Issue 9, p. 482
The oncogenic gammaherpesvirus Epstein-Barr virus (EBV) immortalizes in vitro B lymphocytes into lymphoblastoid cell lines (LCLs), a model that gives the... 
SURVIVAL | APOPTOSIS | OXIDATIVE STRESS | PI3K/AKT/MTOR | autophagy | BIOCHEMISTRY & MOLECULAR BIOLOGY | STAT3 | IL-6 | SQSTM1/p62 | LYMPHOMA-CELLS | ROS | GROWTH | quercetin | Epstein-Barr virus (EBV) | LCLs | EPSTEIN-BARR-VIRUS | LYMPHOCYTES | Epstein–Barr virus (EBV), STAT3
Journal Article
BBA - Molecular Basis of Disease, ISSN 0925-4439, 04/2016, Volume 1862, Issue 4, p. 805
Type 2 is the type of diabetes with higher prevalence in contemporary time, representing about 90% of the global cases of diabetes. In the course of diabetes,... 
Diabetics | Flavonoids | Hyperglycemia | Care and treatment | Flavones | Bioflavonoids | Disease susceptibility | Glucose | Health aspects | Dextrose | Type 2 diabetes | Medical research | Dendritic cells | Medicine, Experimental
Journal Article
Journal Article
The Journal of Nutritional Biochemistry, ISSN 0955-2863, 03/2017, Volume 41, pp. 124 - 136
Quercetin, a bioflavonoid contained in several vegetables daily consumed, has been studied for long time for its antiinflammatory and anticancer properties.... 
mTOR/PI3K/AKT | KSHV | PEL | Il-6 | Quercetin | STAT3 | CANCER-CELLS | RAPAMYCIN | mTOR/PI3K/AKF | ACTIVATION | SURVIVIN EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEATH | II-6 | MAJOR HISTOCOMPATIBILITY COMPLEX | KINASE INHIBITOR | KAPPA-B | NUTRITION & DIETETICS | WNT/BETA-CATENIN | GROWTH | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Humans | Proteasome Inhibitors - chemistry | Neoplasm Proteins - antagonists & inhibitors | Bortezomib - pharmacology | Neoplasm Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Autophagy - drug effects | Interleukins - metabolism | Drug Agonism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Antineoplastic Agents, Phytogenic - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | B-Lymphocytes - metabolism | STAT3 Transcription Factor - metabolism | Antineoplastic Agents, Phytogenic - adverse effects | Lymphoma, Primary Effusion - metabolism | B-Lymphocytes - cytology | Proteasome Inhibitors - pharmacology | Cells, Cultured | Lymphoma, Primary Effusion - pathology | Recombinant Fusion Proteins - chemistry | Antineoplastic Agents - chemistry | Down-Regulation - drug effects | Interleukins - antagonists & inhibitors | B-Lymphocytes - drug effects | B-Lymphocytes - immunology | Lymphoma, Primary Effusion - immunology | Signal Transduction - drug effects | Lymphoma, Primary Effusion - drug therapy | Quercetin - adverse effects | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | STAT3 Transcription Factor - antagonists & inhibitors | Bortezomib - agonists | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Quercetin - metabolism | Cellular proteins | Flavonoids | Flavones | Sarcoma | Bioflavonoids | Lymphomas | B cells | Apoptosis
Journal Article
Journal Article
Journal Article
Nutrition, ISSN 0899-9007, 2015, Volume 31, Issue 4, pp. 578 - 581
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2017, Volume 112, pp. 327 - 335
KSHV is a gammaherpesvirus strongly associated to human cancers such as Primary Effusion Lymphoma (PEL) and Kaposi's Sarcoma. The naturally virus-infected... 
ERK1/2 | KSHV | PEL | PKC δ | ROS | Oxidant species | TPA/Butyrate | P21 | P53 | Lytic cycle | CANCER-CELLS | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | SARCOMA-ASSOCIATED HERPESVIRUS | KINASE | PKC delta | PRIMARY INFECTION | LYMPHOMA-CELLS | KAPOSIS-SARCOMA | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | EPSTEIN-BARR-VIRUS | Herpesvirus 8, Human - drug effects | RNA, Small Interfering - genetics | Phosphorylation | Tetradecanoylphorbol Acetate - pharmacology | Oxidative Stress | Tumor Suppressor Protein p53 - antagonists & inhibitors | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Tumor Suppressor Protein p53 - genetics | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Herpesvirus 8, Human - pathogenicity | Lymphocytes - virology | Mitogen-Activated Protein Kinase 1 - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Butyric Acid - pharmacology | Flavonoids - pharmacology | Herpesvirus 8, Human - physiology | Lymphocytes - metabolism | Virus Replication - drug effects | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Gene Expression Regulation | Tumor Suppressor Protein p53 - metabolism | Antioxidants - pharmacology | Hydrogen Peroxide - metabolism | Host-Pathogen Interactions | Virus Activation - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Quercetin - pharmacology | Cell Line, Tumor | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Lymphomas | Sarcoma | Tumor proteins | Cell death | Antigens
Journal Article