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Surgery: Official Journal of the Society of University Surgeons, Central Surgical Association, and the American Association of Endocrine Surgeons, ISSN 0039-6060, 2012, Volume 152, Issue 3, pp. 477 - 488
Journal Article
Respiratory Medicine, ISSN 0954-6111, 05/2018, Volume 138, pp. 13 - 20
Pulmonary hypertension (PH) is commonly observed in patients with advanced idiopathic pulmonary fibrosis (IPF). Despite the availability of therapies for both... 
Hypertension | Idiopathic pulmonary fibrosis | Phosphodiesterase-5 inhibitor | Clinical trial | Echocardiogram | Sildenafil | 6-Minute walk test | Pirfenidone | CONTROLLED-TRIAL | LUNG FIBROSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | MANAGEMENT | GUIDELINES | EXERCISE CAPACITY | THERAPY | RESPIRATORY SYSTEM | ARTERIAL-HYPERTENSION | QUALITY-OF-LIFE | WALK DISTANCE | CLINICAL-PRACTICE | Sildenafil Citrate - adverse effects | Vasodilator Agents - therapeutic use | Randomized Controlled Trials as Topic - methods | Sildenafil Citrate - therapeutic use | Humans | Middle Aged | Male | Multicenter Studies as Topic - methods | Aged, 80 and over | Adult | Female | Hypertension, Pulmonary - drug therapy | Idiopathic Pulmonary Fibrosis - complications | Drug Therapy, Combination | Double-Blind Method | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Aged | Pyridones - therapeutic use | Clinical Trials, Phase II as Topic - methods | Vasodilator Agents - adverse effects | Hypertension, Pulmonary - etiology | Research Design | Idiopathic Pulmonary Fibrosis - drug therapy | Pyridones - adverse effects | Medical research | Care and treatment | Pulmonary fibrosis | Clinical trials | Medicine, Experimental | Development and progression | Respiratory tract diseases | Respiratory agents | Risk factors | Pulmonary hypertension | Heart | Medical services | Life assessment | Risk | Evidence-based medicine | Randomization | Dyspnea | Safety engineering | Regurgitation | Blood pressure | Rheumatic heart disease | Carbon monoxide | Safety | Cardiology | Tricuspid valve | Echocardiography | Pulmonary arteries | Lung diseases | Medical treatment | Patients | Quality of life | Studies | Fibrosis | Mercury
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2016, Volume 59, Issue 22, pp. 10285 - 10290
In PubChem screening assays, 466 highly promiscuous compounds were identified that were examined for known pan-assay interference compounds (PAINS) and... 
CHEMISTRY, MEDICINAL | DISCOVERY | PAINS | Small Molecule Libraries - chemistry | Molecular Structure | Polypharmacology | Drug Evaluation, Preclinical
Journal Article
Journal Article
RSC Advances, 01/2017, Volume 7, Issue 57, pp. 35638 - 35647
Activity artifacts in assays present a major problem for biological screening and medicinal chemistry. Such artifacts are often caused by compounds that form... 
Substructures | Analogs | Organic chemistry | Artifacts | Screening | Pain | Liabilities | Interference | Assaying | Chemical compounds
Journal Article
European Respiratory Journal, ISSN 0903-1936, 08/2018, Volume 52, Issue 2
We assessed safety and tolerability of treatment with pirfenidone (1602-2403 mg.day(-1)) and nintedanib (200-300 mg.day(-1)) in patients with idiopathic... 
TRIALS | MANAGEMENT | RESPIRATORY SYSTEM | COMBINATION THERAPY
Journal Article
RSC Advances, ISSN 2046-2069, 07/2017, Volume 7, Issue 57, pp. 35638 - 35647
Activity artifacts in assays present a major problem for biological screening and medicinal chemistry. Such artifacts are often caused by compounds that form... 
MEDICINAL CHEMISTRY | MATCHED MOLECULAR PAIRS | PAINS | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2008, Volume 26, Issue 13, pp. 2118 - 2123
Purpose We conducted a retrospective analysis of safety data from randomized, single-agent fluoropyrimidine clinical trials ( bolus fluorouracil/leucovorin... 
TRIAL | ORAL CAPECITABINE | 5-FLUOROURACIL | III COLON-CANCER | ONCOLOGY | FLUOROURACIL PLUS LEUCOVORIN | PHASE-III | ADJUVANT TREATMENT | TOXICITY | CONTINUOUS-INFUSION | METASTATIC COLORECTAL-CANCER | Prodrugs - administration & dosage | Leucovorin - administration & dosage | Residence Characteristics | Capecitabine | United States | Humans | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Vitamin B Complex - administration & dosage | Antimetabolites, Antineoplastic - administration & dosage | Neoplasm Metastasis | Organoplatinum Compounds - administration & dosage | Fluorouracil - administration & dosage | Fluorouracil - adverse effects | Colorectal Neoplasms - drug therapy | Deoxycytidine - adverse effects | Retrospective Studies | Chemotherapy, Adjuvant | Far East | Neutropenia - chemically induced | Gastrointestinal Diseases - ethnology | Severity of Illness Index | Colorectal Neoplasms - ethnology | Fluorouracil - analogs & derivatives | Risk Assessment | Deoxycytidine - administration & dosage | Europe | Treatment Outcome | Withholding Treatment | Neutropenia - ethnology | Prodrugs - adverse effects | Antimetabolites, Antineoplastic - adverse effects | Colorectal Neoplasms - pathology | Deoxycytidine - analogs & derivatives | Gastrointestinal Diseases - chemically induced | Index Medicus | pathology | Organoplatinum Compounds | Leucovorin | administration & dosage | Surgery | Colorectal Neoplasms | Adjuvant | ethnology | Fluorouracil | Neutropenia | drug therapy | chemically induced | Prodrugs | Antineoplastic | Antineoplastic Combined Chemotherapy Protocols | Antimetabolites | Kirurgi | Gastrointestinal Diseases | Chemotherapy | Deoxycytidine | analogs & derivatives | adverse effects | Vitamin B Complex
Journal Article