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mice (46) 46
dermatology (33) 33
female (32) 32
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adult (23) 23
alopecia areata - immunology (20) 20
cell biology (19) 19
abridged index medicus (18) 18
disease models, animal (18) 18
skin (18) 18
mice, nude (17) 17
mice, scid (16) 16
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transplantation, heterologous (16) 16
alopecia (15) 15
autoimmunity (15) 15
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nude-mice (14) 14
alopecia areata - pathology (13) 13
baldness (13) 13
dermatology & venereal diseases (13) 13
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biochemistry (12) 12
cells (11) 11
immunology (11) 11
skin transplantation (11) 11
alopecia areata (10) 10
lymphocytes (10) 10
adipose tissue - transplantation (9) 9
aged, 80 and over (8) 8
expression (8) 8
hair (8) 8
immune privilege (8) 8
psoriasis (8) 8
surgery (8) 8
analysis (7) 7
autoimmune diseases - immunology (7) 7
cells, cultured (7) 7
hair loss (7) 7
human (7) 7
skin - immunology (7) 7
t-cells (7) 7
graft survival (6) 6
grafts (6) 6
hair follicle - immunology (6) 6
hair follicle - pathology (6) 6
human hair follicle (6) 6
immunity (6) 6
interferon-gamma (6) 6
proliferation (6) 6
t-lymphocytes - immunology (6) 6
autoimmune diseases (5) 5
autoimmune diseases - pathology (5) 5
c3h/hej mice (5) 5
growth (5) 5
human scalp explants (5) 5
injections, intradermal (5) 5
keratinocytes - metabolism (5) 5
killer cells, natural - immunology (5) 5
lymphocytes t (5) 5
mouse model (5) 5
survival (5) 5
t cells (5) 5
adolescent (4) 4
age (4) 4
alopecia - drug therapy (4) 4
apoptosis (4) 4
hair follicles (4) 4
immunohistochemistry (4) 4
immunotherapy (4) 4
in-vivo (4) 4
inflammation (4) 4
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injections, subcutaneous (4) 4
integumentary system (4) 4
langerhans cells (4) 4
medicine, general & internal (4) 4
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adipose-tissue (3) 3
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alopecia areata - etiology (3) 3
alopecia areata - genetics (3) 3
alopecia areata - therapy (3) 3
alopecia-areata (3) 3
angiogenesis (3) 3
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1. Full Text Collapse of Immune Privilege in Alopecia Areata: Coincidental or Substantial?
by Gilhar, Amos
Journal of Investigative Dermatology, ISSN 0022-202X, 11/2010, Volume 130, Issue 11, pp. 2535 - 2537
Only indirect evidence supports the concept that a collapse of immune privilege (IP) in hair follicles leads to the development of alopecia areata (AA). In... 
MICE | LYMPHOCYTES | DERMATOLOGY | Animals | Immune Tolerance - immunology | Alopecia Areata - therapy | Humans | Alopecia Areata - pathology | Hair Follicle - immunology | Alopecia Areata - immunology | Hair Follicle - pathology | Index Medicus
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2. Full Text The Beneficial Effect of Blocking Kv1.3 in the Psoriasiform SCID Mouse Model
by Gilhar, Amos and Bergman, Reuven and Assay, Bedia and Ullmann, Yehuda and Etzioni, Amos
Journal of Investigative Dermatology, ISSN 0022-202X, 01/2011, Volume 131, Issue 1, pp. 118 - 124
The Kv1.3 channel is important in the activation and function of effector memory T cells. Recently, specific blockers of the Kv1.3 channel have been developed... 
TARGET | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | DISEASES | MULTIPLE-SCLEROSIS | GATED K+ CHANNELS | POTASSIUM CHANNELS | SELECTIVE BLOCKADE | MEMORY T-CELLS | SHK TOXIN | LYMPHOCYTES | DERMATOLOGY | Psoriasis - immunology | Psoriasis - drug therapy | Humans | Cells, Cultured | Transplantation, Heterologous | Kv1.3 Potassium Channel - antagonists & inhibitors | Immunologic Memory - drug effects | Mice, SCID | Cnidarian Venoms - pharmacology | Killer Cells, Natural - cytology | Animals | Psoriasis - metabolism | Killer Cells, Natural - immunology | Kv1.3 Potassium Channel - metabolism | Skin Transplantation | Mice | Immunologic Memory - immunology | Kv1.3 Potassium Channel - immunology | Disease Models, Animal | Index Medicus
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3. Full Text JAK inhibitors and alopecia areata
by Gilhar, Amos and Keren, Aviad and Paus, Ralf
The Lancet, ISSN 0140-6736, 01/2019, Volume 393, Issue 10169, pp. 318 - 319
[...]we call for a more cautionary approach to systemic therapy with JAK inhibitors, at a time when their long-term adverse effects remain insufficiently... 
IMMUNE | MEDICINE, GENERAL & INTERNAL | INFECTIONS | DISEASE | Therapy | Multiple sclerosis | Erythropoietin | Disease | Systematic review | Skin cancer | Signal transduction | Cell activation | Restoration | Urinary tract infections | Inhibition | Drug dosages | Neutropenia | Hair | Herpes zoster | Baldness | Anemia | Melanoma | Patients | Appendix | Urinary tract diseases | Side effects | Alopecia | Tuberculosis | Inhibitors | Interleukin 10 | Pneumonia | Inflammatory bowel diseases | Interleukin | Chicken pox | Clinical trials | Risk | Lymphocytes T | Infections | Malignancy | Immunosuppressive agents | Lymphocytes | Intestine | Urogenital system | Age | Psoriasis | Dendritic cells | Diabetes mellitus | Health risks | Exploration | Signaling | Immune privilege | Interferon | Autoimmune diseases | Hair loss | Viral infections | Tumors | Index Medicus | Abridged Index Medicus
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4. Full Text The authors reply
by Gilhar, Amos and Etzioni, Amos and Paus, Ralf
New England Journal of Medicine, ISSN 0028-4793, 07/2012, Volume 367, Issue 3, p. 280
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5. Full Text T-cell “induced-self” MHC class I/peptide complexes may enable “de novo” tolerance induction to neo-antigens occurring outside of the thymus: Lessons from the hair follicle
by Oelert, Thilo and Gilhar, Amos and Paus, Ralf
Experimental Dermatology, ISSN 0906-6705, 06/2017, Volume 26, Issue 6, pp. 529 - 531
immunity | autoimmunity | cytotoxic T cells | neo-antigen | immune regulation
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6. Full Text T-cell "induced-self" MHC class I/peptide complexes may enable "de novo" tolerance induction to neo-antigens occurring outside of the thymus
by Thilo Oelert and Amos Gilhar and Ralf Paus
Experimental Dermatology, ISSN 0906-6705, 06/2017, Volume 26, Issue 6, p. 529
The hair follicle (HF) epithelium can present self-antigens to cognate CD8+ T cells. These cells express periodically during the hair cycle arising or... 
Hair | Antigen presentation | Antigens | CD8 antigen | Autoantigens | Lymphocytes T | Self | Epitopes | Epithelium | Immunological tolerance | Thymus | Alopecia | Major histocompatibility complex | Immunogenicity | Lymphocytes | Immune privilege | Interferon | Hair loss | Age
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7. Full Text T‐cell “induced‐self” MHC class I/peptide complexes may enable “de novo” tolerance induction to neo‐antigens occurring outside of the thymus
by Oelert, Thilo and Gilhar, Amos and Paus, Ralf
Experimental Dermatology, ISSN 0906-6705, 06/2017, Volume 26, Issue 6, pp. 529 - 531
The hair follicle ( HF ) epithelium can present self‐antigens to cognate CD 8+ T cells. These cells express periodically during the hair cycle arising or... 
neo‐antigen | immunity | autoimmunity | cytotoxic T cells | immune regulation
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8. Full Text Autoimmune Disease Induction in a Healthy Human Organ: A Humanized Mouse Model of Alopecia Areata
by Gilhar, Amos and Keren, Aviad and Shemer, Avner and d'Ovidio, Roberto and Ullmann, Yehuda and Paus, Ralf
Journal of Investigative Dermatology, ISSN 0022-202X, 03/2013, Volume 133, Issue 3, pp. 844 - 847
CELLS | HUMAN HAIR FOLLICLE | IMMUNE PRIVILEGE | MICE | SUBSTANCE-P | BLOCKADE | DERMATOLOGY | CD56 Antigen - metabolism | Skin Transplantation - immunology | Humans | Autoimmune Diseases - immunology | Transplantation, Heterologous | Mice, SCID | Leukocytes, Mononuclear - pathology | Animals | Leukocytes, Mononuclear - immunology | Skin Transplantation - pathology | Alopecia Areata - pathology | Mice | Alopecia Areata - immunology | Autoimmune Diseases - pathology | Skin - pathology | Disease Models, Animal | Injections, Intradermal | Skin - immunology | Index Medicus
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9. Full Text Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles
by Hawkshaw, Nathan J and Hardman, Jonathan A and Haslam, Iain S and Shahmalak, Asim and Gilhar, Amos and Lim, Xinhong and Paus, Ralf
PLoS Biology, ISSN 1544-9173, 05/2018, Volume 16, Issue 5, pp. e2003705 - e2003705
Hair growth disorders often carry a major psychological burden. Therefore, more effective human hair growth-modulatory agents urgently need to be developed.... 
REGRESSION | GROWTH-CONTROL | STEM-CELLS | DEXAMETHASONE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | ORGAN-CULTURE | PROLIFERATION | DIFFERENTIATION | INDUCTION | BETA-CATENIN | EXPRESSION | Hair Follicle - drug effects | Cyclosporine - therapeutic use | Wnt Signaling Pathway - drug effects | Membrane Proteins - antagonists & inhibitors | Cyclosporine - pharmacology | Alopecia - drug therapy | Humans | Intercellular Signaling Peptides and Proteins | Male | Drug Evaluation, Preclinical | Organ Culture Techniques | Biomedical research | Wnt protein | Cyclosporins | Frizzled protein | Frizzled-related protein 1 | Disorders | Follicles | Proteins | β-catenin | Keratin | Cell cycle | Research centers | Supervision | Hair | Dermatology | Inhibition (psychology) | Pharmacology | RNA polymerase | Regression analysis | Investigations | Molecular chains | Signaling | Inhibitors | Scalp | Stem cells | Ligands | Skin | Hair loss | Index Medicus
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10. Full Text Erythropoietin improves the survival of fat tissue after its transplantation in nude mice
by Hamed, Saher and Egozi, Dana and Kruchevsky, Danny and Teot, Luc and Gilhar, Amos and Ullmann, Yehuda
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 11, pp. e13986 - e13986
Background: Autologous transplanted fat has a high resorption rate, providing a clinical challenge for the means to reduce it. Erythropoietin (EPO) has... 
PROGENITOR CELLS | STEM-CELLS | ANGIOGENESIS | GRAFTS | VEGF | IN-VIVO | BIOLOGY | NEOVASCULARIZATION | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | ADIPOSE-TISSUE | Erythropoietin - pharmacology | Neovascularization, Physiologic - drug effects | Apoptosis - drug effects | Humans | Transplantation, Heterologous | Vascular Endothelial Growth Factor A - metabolism | Dose-Response Relationship, Drug | Adipose Tissue - metabolism | Adult | Female | Vascular Endothelial Growth Factor A - pharmacology | Cell Line | Endothelial Cells - metabolism | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Blotting, Western | Animals | Adipose Tissue - blood supply | Endothelial Cells - cytology | Mice, Nude | Cell Proliferation - drug effects | Mice | Adipose Tissue - transplantation | Graft Survival - drug effects | Receptors, Erythropoietin - metabolism | Endothelial Cells - drug effects | Adipose tissues | Phosphates | Erythropoietin | Vascular endothelial growth factor | Apoptosis | Nervous system | Transplantation | Insulin-like growth factors | Adipocytes | Kinases | Beta blockers | Grafting | Cell adhesion & migration | Angiogenesis | Rodents | Drug dosages | Autografts | Cell survival | Cytokines | Transplants | Histology | Survival | Insulin | Hemopoiesis | Grafts | Stem cells | Microvasculature | Diabetes | Index Medicus
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11. Full Text Innate lymphoid cells 3 induce psoriasis in xenotransplanted healthy human skin
by Keren, Aviad and Shemer, Avner and Ginzburg, Alex and Ullmann, Yehuda and Schrum, Adam G and Paus, Ralf and Gilhar, Amos
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 07/2018, Volume 142, Issue 1, pp. 305 - 308.e6
To the Editor: Recent studies have demonstrated that the number of group 3 innate lymphoid cells (ILC3s) is increased in peripheral blood, lesional skin, and... 
ALLERGY | T-CELLS | IMMUNOLOGY | Cell culture | Lymphoid cells | Immunoglobulins | Psoriasis | Cytokines | Lymphocytes | Skin | Software
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12. Full Text Abnormal interactions between perifollicular mast cells and CD8+ T-cells may contribute to the pathogenesis of alopecia areata
by Bertolini, Marta and Zilio, Federica and Rossi, Alfredo and Kleditzsch, Patrick and Emelianov, Vladimir E and Gilhar, Amos and Keren, Aviad and Meyer, Katja C and Wang, Eddy and Funk, Wolfgang and McElwee, Kevin and Paus, Ralf
PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, pp. e94260 - e94260
Alopecia areata (AA) is a CD8+ T-cell dependent autoimmune disease of the hair follicle (HF) in which the collapse of HF immune privilege (IP) plays a key... 
GROWTH-FACTOR-BETA | MULTIDISCIPLINARY SCIENCES | IMMUNE PRIVILEGE | PERIPHERAL TOLERANCE | MOUSE MODEL | GENE-EXPRESSION | CLASS-I EXPRESSION | COSTIMULATORY MOLECULES | CD30 LIGAND | HUMAN HAIR-FOLLICLES | CD8(+) T-CELLS | CD8-Positive T-Lymphocytes - cytology | Mast Cells - immunology | Cell Proliferation | Skin - metabolism | Humans | Middle Aged | Transforming Growth Factor beta1 - metabolism | Interleukin-10 - blood | Inflammation | Alopecia Areata - blood | Mice, Inbred C3H | Hair Follicle - pathology | Phenotype | Animals | Biopsy | Mast Cells - cytology | Female | Mice | Alopecia Areata - immunology | CD8-Positive T-Lymphocytes - immunology | Autoimmunity | Alopecia | Baldness | Analysis | Autoantigens | Skin | T cells | Transforming growth factors | Multiple sclerosis | Laboratories | Pathogenesis | CD8 antigen | Lymphocytes T | Cell interactions | Immunity | Consent | Rodents | Skin diseases | Lesions | Hair | Collapse | Internal medicine | Intercellular adhesion molecule 1 | Dermatology | Immunomodulation | Histomorphometry | Medicine | Ox40L protein | Major histocompatibility complex | PD-L1 protein | Interleukin 10 | Tryptase | Degranulation | Immune privilege | Mast cells | Immunoreactivity | Hair loss | Autoimmune diseases | Index Medicus
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13. Full Text The PDE4 inhibitor, apremilast, suppresses experimentally induced alopecia areata in human skin in vivo
by Keren, Aviad and Shemer, Avner and Ullmann, Yehuda and Paus, Ralf and Gilhar, Amos
Journal of Dermatological Science, ISSN 0923-1811, 2014, Volume 77, Issue 1, pp. 74 - 76
Highlights • Alopecia areata (AA) is an autoimmune disease. • The disease is mediated by cooperation between CD8+/NKG2D+ CD4+ cells. • Genes coding for NKG2D... 
Dermatology | MODEL | DERMATOLOGY | Immunohistochemistry | CD8-Positive T-Lymphocytes - cytology | Phosphodiesterase 4 Inhibitors - chemistry | Skin - metabolism | CD4-Positive T-Lymphocytes - cytology | Humans | Thalidomide - chemistry | Mice, SCID | Thalidomide - analogs & derivatives | Pilot Projects | Animals | Alopecia Areata - drug therapy | NK Cell Lectin-Like Receptor Subfamily K - metabolism | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Leukocytes, Mononuclear - cytology | Ligands | Mice | Alopecia Areata - immunology | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Baldness | Skin | Alopecia | Index Medicus
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14. Full Text Blocking Potassium Channels (Kv1.3): A New Treatment Option for Alopecia Areata?
by Gilhar, Amos and Keren, Aviad and Shemer, Avner and Ullmann, Yehuda and Paus, Ralf
Journal of Investigative Dermatology, ISSN 0022-202X, 08/2013, Volume 133, Issue 8, pp. 2088 - 2091
IMMUNITY | AUTOIMMUNE-DISEASES | MOUSE MODEL | THERAPEUTIC TARGETS | MEMORY T-CELLS | K+ CHANNELS | DERMATOLOGY | Animals | Alopecia Areata - drug therapy | Humans | Skin Transplantation | Transplantation, Heterologous | Alopecia Areata - pathology | Mice | Kv1.3 Potassium Channel - antagonists & inhibitors | Mice, SCID | Potassium Channel Blockers - pharmacology | Index Medicus
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15. Full Text Alopecia Areata
by Dawe, Robert S and Gilhar, Amos and Etzioni, Amos and Paus, Ralf
The New England Journal of Medicine, ISSN 0028-4793, 07/2012, Volume 367, Issue 3, pp. 279 - 280
To the Editor: In their review article on alopecia areata, Gilhar et al. (April 19 issue) 1 do not mention psoralen–ultraviolet A (PUVA) photochemotherapy.... 
MEDICINE, GENERAL & INTERNAL | Alopecia Areata | Hair - growth & development | Humans | Immunosuppressive Agents - therapeutic use | Immunotherapy | Psoralen | Alopecia | Baldness | Scalp | Hair loss | Health risk assessment | Dermatitis | Photochemotherapy | Index Medicus | Abridged Index Medicus
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16. Full Text Fibronectin Potentiates Topical Erythropoietin-Induced Wound Repair in Diabetic Mice
by Hamed, Saher and Ullmann, Yehuda and Egozi, Dana and Daod, Essam and Hellou, Elias and Ashkar, Manal and Gilhar, Amos and Teot, Luc
Journal of Investigative Dermatology, ISSN 0022-202X, 06/2011, Volume 131, Issue 6, pp. 1365 - 1374
Diabetes mellitus disrupts all phases of the wound repair cascade and leads to development of chronic wounds. We previously showed that topical erythropoietin... 
STIMULATES ANGIOGENESIS | CELLS | TISSUE PROTECTION | SKIN WOUNDS | RAT | RECOMBINANT-HUMAN-ERYTHROPOIETIN | PROLIFERATION | MODEL | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | DERMATOLOGY | Erythropoietin - pharmacology | Fibronectins - pharmacology | Apoptosis - drug effects | Streptozocin | Mice, Hairless | Nitric Oxide Synthase Type III - analysis | Hydroxyproline - analysis | Integrin beta1 - analysis | Vascular Endothelial Growth Factor A - analysis | Drug Synergism | Animals | Female | Mice | Wound Healing - drug effects | Diabetes Mellitus, Experimental - physiopathology | Endothelial Cells - drug effects | Index Medicus
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17. Full Text T-cell "induced-self" MHC class I/peptide complexes may enable "de novo" tolerance induction to neo-antigens occurring outside of the thymus: Lessons from the hair follicle
by Oelert, T and Gilhar, A and Paus, R
EXPERIMENTAL DERMATOLOGY, ISSN 0906-6705, 06/2017, Volume 26, Issue 6, pp. 529 - 531
The hair follicle (HF) epithelium can present self-antigens to cognate CD8+ T cells. These cells express periodically during the hair cycle arising or... 
immunity | autoimmunity | cytotoxic T cells | neo-antigen | immune regulation | DERMATOLOGY | CD8-Positive T-Lymphocytes - cytology | Major Histocompatibility Complex | Lymphocyte Activation | Humans | Immune Tolerance | Inflammation | Hair Follicle - pathology | Epitopes - immunology | Animals | Autoantigens - immunology | Interferon-gamma - immunology | Antigens - immunology | Thymus Gland - immunology | Mice | Alopecia Areata - immunology | Autoimmunity | T cells | Analysis | Antigenic determinants | Index Medicus
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18. Full Text Alopecia areata as a model for T cell-dependent autoimmune diseases
: Meeting Report
by Bertolini, Marta and Gilhar, Amos and Paus, Ralf
Experimental Dermatology, ISSN 0906-6705, 06/2012, Volume 21, Issue 6, pp. 477 - 479
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19. Full Text Isothiocyanates inhibit psoriasis-related proinflammatory factors in human skin
by Yehuda, Hila and Soroka, Yoram and Zlotkin-Frušić, Marina and Gilhar, Amos and Milner, Yoram and Tamir, Snait
Inflammation Research, ISSN 1023-3830, 7/2012, Volume 61, Issue 7, pp. 735 - 742
4-Methylthiobutylisothiocyanate (MTBI), the main rocket (Eruca sativa) seed isothiocyanate (ITC), and its oxidized form, sulforaphane (SFN), were assessed for... 
Allergology | Neurology | Skin inflammation | Biomedicine | Immunology | Psoriasis | Dermatology | Sulforaphane | Rheumatology | Pharmacology/Toxicology | 4-Methylthiobutylisothiocyanate | Isothiocyanates | INTERLEUKIN-1 | ANTIINFLAMMATORY ACTIVITY | MACROPHAGES | NECROSIS-FACTOR-ALPHA | IMMUNOLOGY | CELL BIOLOGY | RESPONSES | IN-VITRO | INFLAMMATION | NITRIC-OXIDE | NF-KAPPA-B | Cell Line | Thiocyanates - therapeutic use | Psoriasis - drug therapy | Cytokines - metabolism | Monocytes - cytology | Humans | Middle Aged | Transplantation, Heterologous | Mice, SCID | RNA, Messenger - metabolism | Monocytes - drug effects | Young Adult | Animals | Isothiocyanates - therapeutic use | Intercellular Adhesion Molecule-1 - genetics | Adolescent | Psoriasis - metabolism | Thiocyanates - pharmacology | Adult | Female | Mice | Cytokines - genetics | Isothiocyanates - pharmacology | Skin - drug effects | Messenger RNA | RNA | Analysis | Formulae, receipts, prescriptions | Skin diseases | Dermatologic agents | Skin | Inflammation | Universities and colleges | Mitogens | Index Medicus
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