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1. Full Text A split intein T7 RNA polymerase for transcriptional AND-logic
by Schaerli, Yolanda and Schaerli, Yolanda and Gili, Magüi and Gili, Magüi and Isalan, Mark and Isalan, Mark
Nucleic acids research, ISSN 0305-1048, 10/2014, Volume 42, Issue 19, pp. 12322 - 12328
Synthetic biology has developed numerous parts for building synthetic gene circuits. However, few parts have been described for prokaryotes to integrate two... 
DNAE INTEIN | CELLS | GREEN FLUORESCENT PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | P-BAD PROMOTER | NETWORKS | SYNTHETIC BIOLOGY | COMPUTATION | EXPRESSION | GATES | Escherichia coli - genetics | Viral Proteins - chemistry | Inteins | Molecular Sequence Data | Transcription, Genetic | DNA-Directed RNA Polymerases - chemistry | Trans-Splicing | DNA-Directed RNA Polymerases - metabolism | Viral Proteins - metabolism | Index Medicus | Synthetic Biology and Bioengineering
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2. Full Text A unified design space of synthetic stripe-forming networks
by Schaerli, Yolanda and Munteanu, Andreea and Gili, Magüi and Cotterell, James and Sharpe, James and Isalan, Mark
Nature Communications, ISSN 2041-1723, 09/2014, Volume 5, Issue 1, pp. 4905 - 4905
Synthetic biology is a promising tool to study the function and properties of gene regulatory networks. Gene circuits with predefined behaviours have been... 
GENE NETWORKS | CIRCUITS | MORPHOGEN GRADIENTS | PATTERN-FORMATION | GREEN FLUORESCENT PROTEIN | LOGIC GATES | POSITIVE FEEDBACK | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | P-BAD PROMOTER | LIVING CELLS | Index Medicus
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3. Full Text USP15 stabilizes TGF-β2 receptor I and promotes oncogenesis through the activation of TGF-β2 signaling in glioblastoma
by Eichhorn, Pieter J. A and Rodón, Laura and Gonzàlez-Juncà, Alba and Dirac, Annette and Gili, Magüi and Martínez-Sáez, Elena and Aura, Claudia and Barba, Ignasi and Peg, Vicente and Prat, Aleix and Cuartas, Isabel and Jimenez, Jose and García-Dorado, David and Sahuquillo, Juan and Bernards, Réné and Baselga, José and Seoane, Joan
Nature Medicine, ISSN 1078-8956, 03/2012, Volume 18, Issue 3, pp. 429 - 435
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4. Full Text USP15 stabilizes TGF-beta receptor I and promotes oncogenesis through the activation of TGF-beta signaling in glioblastoma
by Eichhorn, PJA and Rodon, L and Gonzalez-Junca, A and Dirac, A and Gili, M and Martinez-Saez, E and Aura, C and Barba, I and Peg, V and Prat, A and Cuartas, I and Jimenez, J and Garcia-Dorado, D and Sahuquillo, J and Bernards, R and Baselga, J and Seoane, J
NATURE MEDICINE, ISSN 1078-8956, 03/2012, Volume 18, Issue 3, pp. 429 - U192
In advanced cancer, including glioblastoma, the transforming growth factor beta (TGF-beta) pathway acts as an oncogenic factor and is considered to be a... 
MEDICINE, RESEARCH & EXPERIMENTAL | SMURF2 | GLIOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | SMAD7 | CELL BIOLOGY | GROWTH-FACTOR-BETA | PATHWAY | GENETICS | BIOLOGY | DEGRADATION | TARGETS | E3 UBIQUITIN LIGASE | Ubiquitin | Phosphorylation | Receptors, Transforming Growth Factor beta - genetics | Prognosis | Humans | Gene Expression Regulation, Neoplastic | Brain Neoplasms - metabolism | Glioblastoma - genetics | RNA Interference | Cell Transformation, Neoplastic - genetics | Smad2 Protein - genetics | HEK293 Cells | Glioblastoma - metabolism | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Smad7 Protein - metabolism | Endopeptidases - metabolism | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | Smad2 Protein - metabolism | Ubiquitin-Protein Ligases - metabolism | Brain Neoplasms - genetics | Cell Transformation, Neoplastic - metabolism | Ubiquitin-Specific Proteases | Magnetic Resonance Imaging | Animals | Endopeptidases - genetics | Transforming Growth Factor beta - genetics | Receptors, Transforming Growth Factor beta - metabolism | Cell Line, Tumor | Mice | Transforming Growth Factor beta - metabolism | Index Medicus
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5. Full Text Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235
by Eichhorn, Pieter J. A and Gili, Magüi and Scaltriti, Maurizio and Serra, Violeta and Guzman, Marta and Nijkamp, Wouter and Beijersbergen, Roderick L and Valero, Vanesa and Seoane, Joan and Bernards, René and Baselga, José
Cancer Research, ISSN 0008-5472, 11/2008, Volume 68, Issue 22, pp. 9221 - 9230
Small molecule inhibitors of HER2 are clinically active in women with advanced HER2-positive breast cancer who have progressed on trastuzumab treatment.... 
BREAST-CANCER CELLS | PIK3CA MUTATIONS | ONCOLOGY | IN-VIVO | TYROSINE KINASE INHIBITOR | MONOCLONAL-ANTIBODY | ANTITUMOR-ACTIVITY | PHOSPHOINOSITIDE 3-KINASE | TRASTUZUMAB RESISTANCE | MAMMARY EPITHELIAL-CELLS | METASTATIC BREAST | Phosphorylation | Humans | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Quinolines - pharmacology | Antibodies, Monoclonal, Humanized | PTEN Phosphohydrolase - antagonists & inhibitors | Female | Proto-Oncogene Proteins c-akt - metabolism | Drug Resistance | PTEN Phosphohydrolase - genetics | Signal Transduction | Antibodies, Monoclonal - pharmacology | Carrier Proteins - antagonists & inhibitors | Imidazoles - pharmacology | Phosphatidylinositol 3-Kinases - genetics | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Animals | Cell Line, Tumor | Phosphatidylinositol 3-Kinases - physiology | Mice | Mice, Inbred BALB C | Protein Kinase Inhibitors - pharmacology | TOR Serine-Threonine Kinases | Mutation | Quinazolines - pharmacology | Trastuzumab | Index Medicus
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6. Full Text A unified design space of synthetic stripe-forming networks
by Schaerli, Yolanda and Munteanu, Andreea and Gili, Magüi and Cotterell, James and Sharpe, James and Isalan, Mark
Nature communications, 09/2014, Volume 5, p. 4905
Synthetic biology is a promising tool to study the function and properties of gene regulatory networks. Gene circuits with predefined behaviours have been... 
Genetic Engineering - methods | Gene Regulatory Networks - genetics | Synthetic Biology - methods | Base Sequence | Escherichia coli | Cloning, Molecular | Plasmids - genetics | Fluorescence | Molecular Sequence Data | Models, Genetic | Reverse Transcriptase Polymerase Chain Reaction | Sequence Analysis, DNA
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7. Full Text PI3K Hyperactivation Results in Lapatinib Resistance that is Reversed by the mTOR/PI3K Inhibitor NVP-BEZ235
by Eichhorn, Pieter J.A and Gili, Magüi and Scaltriti, Maurizio and Serra, Violeta and Guzman, Marta and Nijkamp, Wouter and Beijersbergen, Roderick L and Valero, Vanesa and Seoane, Joan and Bernards, René and Baselga, José
Cancer research, ISSN 0008-5472, 11/2008, Volume 68, Issue 22, pp. 9221 - 9230
Small molecule inhibitors of HER2 are clinically active in women with advanced HER2 positive breast cancer who have progressed on trastuzumab treatment.... 
lapatinib | PI3K pathway | Breast cancer | barcode screen | PI3K inhibitors
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8. Full Text Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2⁺ breast cancer patients
by Maurizio Scaltriti and Pieter J. Eichhorn and Javier Cortés and Ludmila Prudkin and Claudia Aura and José Jiménez and Sarat Chandarlapaty and Violeta Serra and Aleix Prat and Yasir H. Ibrahim and Marta Guzmán and Magui Gili and Olga Rodríguez and Sonia Rodríguez and José Pérez and Simon R. Green and Sabine Mai and Neal Rosen and Clifford Hudis and José Baselga and Carlos L. Arteaga
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2011, Volume 108, Issue 9, pp. 3761 - 3766
Clinical benefits from trastuzumab and other anti-HER2 therapies in patients with HER2 amplified breast cancer remain limited by primary or acquired... 
Tumor cell line | Receptors | Phosphorylation | Cell lines | Cell cycle | Breast cancer | Cyclins | Tumors | Cancer | Resistance mechanisms | ADJUVANT CHEMOTHERAPY | SURVIVAL | CELLS | AMPLIFICATION | PI3K PATHWAY | MULTIDISCIPLINARY SCIENCES | GROWTH-FACTOR | E OVEREXPRESSION | FACTOR-I RECEPTOR | E EXPRESSION | P27(KIP1) | Cyclin-Dependent Kinase 2 - metabolism | Oncogene Proteins - genetics | Antibodies, Monoclonal - pharmacology | Humans | Receptor, ErbB-2 - metabolism | Cyclin E - genetics | Gene Amplification - drug effects | Antibodies, Monoclonal, Humanized | Breast Neoplasms - enzymology | Drug Resistance, Neoplasm - genetics | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Models, Biological | Cell Line, Tumor | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Female | Protein Kinase Inhibitors - pharmacology | Trastuzumab | Drug Resistance, Neoplasm - drug effects | Medical treatment | Cloning | Genomes | Effects | Drug resistance | Cells | Index Medicus | Biological Sciences
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9. Full Text USP15 stabilizes TGF-[beta] receptor I and promotes oncogenesis through the activation of TGF-[beta] signaling in glioblastoma
by Pieter J and A Eichhorn and Rodon, Laura and Gonzalez-Junca, Alba and Dirac, Annette and Gili, Magui and Martinez-Saez, Elena and Aura, Claudia and Barba, Ignasi and Peg, Vicente and Prat, Aleix and Cuartas, Isabel and Jimenez, Jose and Garcia-Dorado, David and Sahuquillo, Juan and Bernards, Rene and Baselga, Jose and Seoane, Joan
Nature Medicine, ISSN 1078-8956, 03/2012, Volume 18, Issue 3, p. 429
  In advanced cancer, including glioblastoma, the transforming growth factor β (TGF-β) pathway acts as an oncogenic factor and is considered to be a... 
Care and treatment | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Transforming growth factors | Glioblastoma multiforme | Risk factors | Proteins | Signal transduction | Cellular biology | Gene expression | Pathogenesis | Brain cancer
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10. Full Text Abstract 22: Cyclin E amplification, a novel mechanism of resistance to trastuzumab in HER2 amplified breast cancer
by Scaltriti, Maurizio and Eichhorn, Pieter and Gili, Magui and Guzman, Marta and Aura, Claudia and Jimenez, José and Prudkin, Ludmila and Green, Simon R and Cortés, Javier and Chandarlapaty, Sarat and Mai, Sabine and Hudis, Clifford A and Rosen, Neal and Baselga, José
Cancer Research, ISSN 0008-5472, 04/2010, Volume 70, Issue 8 Supplement, pp. 22 - 22
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11. Full Text Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER[2.sup.+] breast cancer patients
by Scaltriti, Maurizio and Eichhorn, Pieter J and Cortes, Javier and Prudkin, Ludmila and Aura, Claudia and Jimenez, Jose and Chandarlapaty, Sarat and Serra, Violeta and Prat, Aleix and Ibrahim, Yasir H and Guzman, Marta and Gili, Magui and Rodriguez, Olga and Rodriguez, Sonia and Perez, Jose and Green, Simon R and Mai, Sabine and Rosen, Neal and Hudis, Clifford and Baselga, Jose
Proceedings of the National Academy of Sciences of the United States, ISSN 0027-8424, 03/2011, Volume 108, Issue 9, p. 3761
Care and treatment | Breast cancer | Genetic aspects | Research | Gene expression | Cyclin E proteins | Health aspects | Cancer
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