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Journal Article
CANCER, ISSN 0008-543X, 02/2006, Volume 106, Issue 3, pp. 631 - 635
BACKGROUND. Several studies have recently reported on the occurrence of a JAK2(V617F) mutation in myeloid cells from the majority of patients with polycythemia... 
MYELOFIBROSIS | JAK2(V617F) | mutant allele | myeloid cells | ONCOLOGY | polycythemia vera | CHRONIC MYELOPROLIFERATIVE DISORDERS | MUTATION | TYROSINE KINASE JAK2 | heterozygotes | homozygotes | MYELOID METAPLASIA | Phenotype | Gene mutations | Analysis | Protein tyrosine kinase | Polycythemia vera | Genetic aspects | Research
Journal Article
Journal Article
Nature, ISSN 0028-0836, 11/2009, Volume 462, Issue 7270, pp. 182 - 188
Direct inhibition of transcription factor complexes remains a central challenge in the discipline of ligand discovery. In general, these proteins lack surface... 
PROGENITOR CELLS | ACTIVATION | GENE | MULTIDISCIPLINARY SCIENCES | ACUTE LYMPHOBLASTIC-LEUKEMIA | T-CELL LEUKEMIA | C-MYC | GAMMA-SECRETASE INHIBITORS | MUTATIONS | HUMAN HOMOLOG | MASTERMIND | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Transcription Factors - chemistry | Humans | Transcriptional Activation - drug effects | Genome - genetics | Receptor, Notch1 - chemistry | Cell Membrane Permeability | Substrate Specificity | DNA-Binding Proteins - metabolism | Peptides - chemical synthesis | Peptides - metabolism | Protein Binding - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Disease Models, Animal | Binding, Competitive | Protein Structure, Tertiary | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Peptides - chemistry | Protein Structure, Secondary | Models, Molecular | Drosophila Proteins - chemistry | Receptor, Notch1 - metabolism | Genome - drug effects | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Peptides - pharmacology | Transcription Factors - metabolism | Animals | Signal Transduction - drug effects | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Receptor, Notch1 - antagonists & inhibitors | Transcription factors | Research | Ligands (Biochemistry) | Peptide bonds | Index Medicus
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 03/2011, Volume 29, Issue 7, pp. 789 - 796
Journal Article
Nature, ISSN 0028-0836, 11/2009, Volume 462, Issue 7269, pp. 108 - 112
Journal Article
Journal Article
Science Signaling, ISSN 1945-0877, 11/2009, Volume 2, Issue 97, pp. ra73 - ra73
Journal Article
PLoS Medicine, ISSN 1549-1277, 2006, Volume 3, Issue 7, pp. 1140 - 1151
The JAK2V617F allele has recently been identified in patients with polycythemia vera (PV), essential thrombocytosis (ET), and myelofibrosis with myeloid... 
Recombinant Fusion Proteins - adverse effects | Humans | Myeloproliferative Disorders - pathology | Mutation, Missense | Primary Myelofibrosis - pathology | Receptors, Cytokine - physiology | Janus Kinases - physiology | Bone Marrow Transplantation | Hematopoiesis - physiology | Myeloid Cells - drug effects | Transcription, Genetic | Colony-Forming Units Assay | Phosphorylation - drug effects | mRNA Cleavage and Polyadenylation Factors - genetics | Hematologic Neoplasms - physiopathology | Disease Models, Animal | Cells, Cultured - drug effects | Bone Marrow Cells - pathology | Hematopoiesis - genetics | Signal Transduction - genetics | Thrombocytosis - etiology | Sequence Analysis, DNA | Cell Division - drug effects | mRNA Cleavage and Polyadenylation Factors - physiology | Receptor, Platelet-Derived Growth Factor alpha - physiology | Hematologic Neoplasms - drug therapy | Mice | Mice, Inbred BALB C | Myeloid Cells - pathology | Protein Processing, Post-Translational - genetics | Myeloproliferative Disorders - genetics | Oncogene Proteins, Fusion - physiology | STAT Transcription Factors - physiology | Protein Processing, Post-Translational - drug effects | Cells, Cultured - pathology | Bone Marrow Cells - drug effects | Spleen - pathology | Thrombocytosis - pathology | Gene Expression Regulation | Janus Kinases - antagonists & inhibitors | Point Mutation | Megakaryocytes - pathology | Primary Myelofibrosis - genetics | Animals | Oncogene Proteins, Fusion - genetics | Protein Kinase Inhibitors - therapeutic use | Receptor, Platelet-Derived Growth Factor alpha - genetics | Myeloproliferative Disorders - etiology | Signal Transduction - physiology | Protein Kinase Inhibitors - pharmacology | Genetic Vectors | Megakaryocytes - drug effects | Cytokines - pharmacology | Amino Acid Substitution | Thrombocytosis - genetics | Genetic aspects | Myelofibrosis | Research | Index Medicus | Hematology | Gene Therapy | Genomics | Genetics | Oncology | Cancer Biology | Hematology (including Blood Transfusion)
Journal Article
Journal Article