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1. Full Text High Irisin levels in nondiabetic HIV‐infected males are associated with insulin resistance, nonalcoholic fatty liver disease, and subclinical atherosclerosis
by Moreno‐Perez, Oscar and Reyes‐Garcia, Rebeca and Muñoz‐Torres, Manuel and Merino, Esperanza and Boix, Vicente and Reus, Sergio and Giner, Livia and Alfayate, Rocío and Garcia‐Fontana, Beatriz and Sanchez‐Paya, Jose and Picó, Antonio and Portilla, Joaquín
Clinical Endocrinology, ISSN 0300-0664, 10/2018, Volume 89, Issue 4, pp. 414 - 423
Summary Objective HIV infection is associated with an increased risk of cardiovascular disease. Irisin is a miokyne secreted by skeletal muscle, which may... 
nonalcoholic fatty liver disease | HIV | insulin homeostasis | cardiovascular | carotid intima‐media thickness | irisin | subclinical atherosclerosis | carotid intima-media thickness | INDEPENDENT PREDICTOR | ADULTS | RISK | SERUM | PREVALENCE | DIABETES-MELLITUS | MYOKINE IRISIN | OBESITY | ENDOCRINOLOGY & METABOLISM | Antiviral agents | Enzymes | RNA | Muscles | HIV patients | Nuclear magnetic resonance spectroscopy | Triglycerides | HIV (Viruses) | Highly active antiretroviral therapy | Fatty liver | Analysis | Atherosclerosis | Insulin resistance | Hepatitis C | HIV infection | Liver diseases | Diabetes mellitus | Homeostasis | Multivariate analysis | Males | Ribonucleic acid--RNA | Insulin | Antiretroviral therapy | Hip | Skeletal muscle | CD4 antigen | Steatosis | Magnetic resonance spectroscopy | Disease resistance | Human immunodeficiency virus--HIV | Arteriosclerosis | Ultrasonography | Lipodystrophy | Diabetes | Cardiovascular diseases
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2. Full Text The Endosomal Protein Appl1 Mediates Akt Substrate Specificity and Cell Survival in Vertebrate Development
by Schenck, Annette and Goto-Silva, Livia and Collinet, Claudio and Rhinn, Muriel and Giner, Angelika and Habermann, Bianca and Brand, Michael and Zerial, Marino
Cell, ISSN 0092-8674, 2008, Volume 133, Issue 3, pp. 486 - 497
During development of multicellular organisms, cells respond to extracellular cues through nonlinear signal transduction cascades whose principal components... 
SIGNALING;CELLBIO | SIGNAL-TRANSDUCTION | RAB5 EFFECTORS | COMPLEX | TURNOVER | ENDOCYTIC PATHWAY | GIPC | INTERACTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEATH | DOMAINS | CANCER | CELL BIOLOGY | Signal Transduction | Cell Survival | Zebrafish Proteins - metabolism | Molecular Sequence Data | Substrate Specificity | Glycogen Synthase Kinase 3 beta | Embryonic Development | Glycogen Synthase Kinase 3 - metabolism | Organ Specificity | Zebrafish - embryology | Vertebrates | Animals | Gene Expression Regulation, Developmental | Zebrafish Proteins - analysis | Zebrafish - metabolism | Endosomes - chemistry | Zebrafish Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Apoptosis | Growth factors
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3. Full Text Subclinical atherosclerosis in low Framingham risk HIV patients
by León, Rafael and Reus, Sergio and López, Nicolás and Portilla, Irene and Sánchez‐Payá, José and Giner, Livia and Boix, Vicente and Merino, Esperanza and Torrús, Diego and Moreno‐Pérez, Óscar and Portilla, Joaquín
European Journal of Clinical Investigation, ISSN 0014-2972, 08/2017, Volume 47, Issue 8, pp. 591 - 599
Background Pathogenesis of atherosclerosis is complex, and differences between HIV‐infected patients and general population cannot be completely explained by... 
intima‐media thickness | microbial translocation | HIV | inflammation | subclinical atherosclerosis | intima-media thickness | MEDICINE, RESEARCH & EXPERIMENTAL | RATES | MEDICINE, GENERAL & INTERNAL | CARDIOVASCULAR-DISEASE | INFECTED PATIENTS | INTERVENTION | BACTERIAL-DNA | PROGRESSION | Biomarkers - metabolism | Body Mass Index | Age Factors | Carotid Intima-Media Thickness | Humans | Risk Factors | DNA, Ribosomal - metabolism | Male | Case-Control Studies | Viral Load | Lipopolysaccharide Receptors - metabolism | Carotid Artery Diseases - virology | Carotid Artery Diseases - diagnostic imaging | Adult | Anti-HIV Agents - therapeutic use | Female | HIV Infections - drug therapy | Interleukin-6 - metabolism | Hypertension | Highly active antiretroviral therapy | Medical research | Interleukins | Ultrasound imaging | Atherosclerosis | Medicine, Experimental | HIV patients | HIV (Viruses) | Risk factors | Control methods | Pathogenesis | Interleukin | Prophylaxis | Multivariate analysis | Inflammatory diseases | Interleukin 6 | Vascular diseases | Antiretroviral agents | Human immunodeficiency virus--HIV | Ultrasonography | Bacteria | Diagnosis | Statins | Age | Deoxyribonucleic acid--DNA | Receiving | Diabetes mellitus | Health risks | Cigarettes | Risk analysis | Cigarette smoking | Patients | Hip | CD4 antigen | Infectious diseases | Tumor necrosis factor | Arteriosclerosis | Health risk assessment | Cardiovascular diseases | Smoking
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4. Full Text Low-Level HIV Viremia Is Associated With Microbial Translocation and Inflammation
by Reus, Sergio and Portilla, Joaquín and Sánchez-Payá, José and Giner, Livia and Francés, Rubén and Such, José and Boix, Vicente and Merino, Esperanza and Gimeno, Adelina
JAIDS Journal of Acquired Immune Deficiency Syndromes, ISSN 1525-4135, 02/2013, Volume 62, Issue 2, pp. 129 - 134
BACKGROUND:Decrease in HIV viral load (VL) is accompanied by decrease in microbial translocation (MT) and chronic inflammation, but the behavior of these... 
microbial translocation | viral load | HIV | ribosomal bacterial DNA | antiretroviral treatment | INFECTIOUS DISEASES | GUT | IMMUNOLOGY | SUPPRESSION | PLASMA-LEVELS | CIRRHOSIS | ACTIVE ANTIRETROVIRAL THERAPY | IMMUNE ACTIVATION | INFECTION | BACTERIAL-DNA | DISEASE PROGRESSION | Humans | Middle Aged | Tumor Necrosis Factor-alpha - blood | Male | Inflammation - blood | Viral Load | Young Adult | HIV Infections - immunology | Inflammation - complications | Lipopolysaccharides - blood | Interleukin-6 - blood | DNA, Bacterial - blood | Statistics, Nonparametric | Adult | Female | DNA, Ribosomal - blood | Anti-Retroviral Agents - therapeutic use | Cross-Sectional Studies | Ribosomal Proteins - genetics | HIV Infections - virology | Risk Factors | Inflammation - virology | CD4 Lymphocyte Count | Biomarkers - blood | Chi-Square Distribution | Bacterial Translocation | Lipopolysaccharide Receptors - blood | Viremia - complications | Viremia - virology | HIV Infections - drug therapy | Aged | Chronic Disease
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5. Full Text Vitamin D insufficiency and subclinical atherosclerosis in non‐diabetic males living with HIV
by Portilla, Joaquín and Moreno‐Pérez, Óscar and Serna‐Candel, Carmen and Escoín, Corina and Alfayate, Rocio and Reus, Sergio and Merino, Esperanza and Boix, Vicente and Giner, Livia and Sánchez‐Payá, José and Picó, Antonio
Journal of the International AIDS Society, ISSN 1758-2652, 01/2014, Volume 17, Issue 1, pp. 18945 - n/a
Introduction Vitamin D insufficiency (VDI) has been associated with increased cardiovascular risk in the non‐HIV population. This study evaluates the... 
atherosclerosis | vitamin D insufficiency | carotid intima media thickness | adipokines | HIV | antiretroviral treatment | Carotid intima media thickness | Adipokines | Vitamin D insufficiency | Atherosclerosis | Antiretroviral treatment | INTIMA-MEDIA THICKNESS | INFECTIOUS DISEASES | MYOCARDIAL-INFARCTION | D DEFICIENCY | RISK | ANTIRETROVIRAL THERAPY | IMMUNOLOGY | REVERSE-TRANSCRIPTASE INHIBITORS | INFECTED PATIENTS | 1,25-DIHYDROXYVITAMIN D-3 | HIGH PREVALENCE | PROGRESSION | Blood Glucose - analysis | Cross-Sectional Studies | Vitamin D Deficiency - complications | Carotid Intima-Media Thickness - statistics & numerical data | Humans | Risk Factors | Tumor Necrosis Factor-alpha - blood | Asymptomatic Diseases - epidemiology | Logistic Models | Male | Plasminogen Activator Inhibitor 1 - blood | Vitamin D - blood | Atherosclerosis - etiology | Interleukin-6 - blood | Lipids - blood | HIV Infections - complications | Adult | Vitamin D - analogs & derivatives | C-Reactive Protein - analysis | Vitamin D deficiency | Complications and side effects | Physiological aspects | Diabetes | HIV infection | Risk factors | Studies | Vitamin D | Health risk assessment | Human immunodeficiency virus--HIV
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6. Full Text Reproductive history before and after HIV diagnosis: A cross-sectional study in HIV-positive women in Spain
by Hernando, Victoria and Alejos, Belen and Montero, Marta and Pérez-Elias, Mjesús and Blanco, José Ramón and Giner, Livia and Gómez-Sirvent, Juan Luis and Iribarren, Jose Antonio and Bernal, Enrique and Bolumar, Francisco and CoRIS and and CoRIS
Medicine (United States), ISSN 0025-7974, 02/2017, Volume 96, Issue 5, p. e5991
The aim of this study is to examine the reproductive history of human immunodeficiency virus (HIV)-positive women, before and after HIV diagnosis, to describe... 
HIV infection | abortions | pregnancy | UNITED-STATES | DECISION | INFECTED WOMEN | EUROPE | INTENTIONS | MEDICINE, GENERAL & INTERNAL | DESIRE | ABORTION | COHORT | TO-CHILD TRANSMISSION | Pregnancy Complications, Infectious - virology | Prevalence | Cross-Sectional Studies | HIV Seropositivity - complications | Pregnancy Complications, Infectious - epidemiology | HIV Infections - epidemiology | HIV Infections - virology | Humans | Middle Aged | Pregnancy | Young Adult | Spain - epidemiology | Adolescent | HIV Infections - complications | HIV Seropositivity - epidemiology | Reproductive History | Adult | Female | Infectious Disease Transmission, Vertical - statistics & numerical data | Odds Ratio | Pregnancy Outcome | HIV Seropositivity - virology | Disease transmission | Analysis | HIV patients | Diagnosis | Research | HIV (Viruses) | Health aspects | HIV infection in pregnancy
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7. Low-Level HIV Viremia Is Associated With Microbial Translocation and Inflammation
by Sergio Reus and Joaquín Portilla and José Sánchez-Payá and Livia Giner and Rubén Francés and José Such and Vicente Boix and Esperanza Merino and Adelina Gimeno
Journal of Acquired Immune Deficiency Syndromes, ISSN 1525-4135, 02/2013, Volume 62, Issue 2, p. 129
  Decrease in HIV viral load (VL) is accompanied by decrease in microbial translocation (MT) and chronic inflammation, but the behavior of these markers in... 
Antiretroviral drugs | Human immunodeficiency virus--HIV | Biomarkers | Drug therapy | Viral infections | Inflammatory diseases
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8. Low-Level HIV Viremia Is Associated With Microbial Translocation and Inflammation
by Reus, Sergio and Portilla, Joaquin and Sanchez-Paya, Jose and Giner, Livia and Frances, Ruben and Such, Jose and Boix, Vicente and Merino, Esperanza and Gimeno, Adelina
JAIDS Journal of Acquired Immune Deficiency Syndromes, ISSN 1525-4135, 02/2013, Volume 62, Issue 2, pp. 129 - 129
Decrease in HIV viral load (VL) is accompanied by decrease in microbial translocation (MT) and chronic inflammation, but the behavior of these markers in... 
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9. Full Text Prediction of recurrent clostridium difficile infection at the bedside: the GEIH-CDI score
by Cobo, Javier and Merino, Esperanza and Martínez, Cristina and Martínez, Rocío and Cózar-Llistó, Alberto and Shaw, Evelyn and Marrodán, Teresa and Calbo, Esther and Bereciartúa, Elena and Sánchez-Muñoz, Luis A and Salavert, Miguel and Pérez-Rodríguez, M. Teresa and García-Rosado, Dácil and Bravo-Ferrer, J. María and Gálvez-Acebal, Juan and Henríquez-Camacho, César and Cuquet, Jordi and Pino-Calm, Berta and Torres, Luis and Sánchez-Porto, Antonio and Fernández-Félix, Borja M and Romero, José and Muriel, Alfonso and Giner, Livia and Boix, Lucía and Boix, Vicente and Ramos-Martínez, Antonio and Martos, Purificación and Arch, Olga and Sardiña, Cristina and Aguirre, Elena and Badía, Cristina and Perales, Ildefonso and De Santos-Castro, Pedro A and Bratos-Pérez, Miguel Angel and Cuellar, Sandra and González, Eva and Soto, Adriana and Sousa, Adrián and Llinares, Pedro and Castelo, Laura and Morales, Isabel and Sojo, Jesús and Delgado-Iribarren, Alberto and Martí, Carmina and Vázquez, Rosa and Mairal, Pilar and Nosocomial Infect Study Grp
International Journal of Antimicrobial Agents, ISSN 0924-8579, 03/2018, Volume 51, Issue 3, pp. 393 - 398
Recurrence of infection (CDI) has major consequences for both patients and the health system. The ability to predict which patients are at increased risk of... 
Recurrence | Clinical prediction tool | Clostridium difficile | DERIVATION | INFECTIOUS DISEASES | RISK-FACTORS | TOXIN-B | METAANALYSIS | VALIDATION | MICROBIOLOGY | IMPACT | VANCOMYCIN | FIDAXOMICIN | PHARMACOLOGY & PHARMACY | CYCLE
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10. Full Text The effects of Maraviroc on liver fibrosis in HIV/HCV co‐infected patients
by Ortega Gonzalez, Enrique and Boix, Vicente and Garcia Deltoro, Miguel and Lopez Aldeguer, Jose and Portilla, Joaquin and Montero, Marta and Ballester Belda, Emilio and Abril, Vicente and Gutierrez, Felix and Minguez, Carlos and Galindo, Josefa and Benirto, Concepcion and Garcia Rodriguez, Magdalena and Giner, Livia and Rubio, Purificacion and Uso, Jorge and Llerena, Giovanna
Journal of the International AIDS Society, ISSN 1758-2652, 11/2014, Volume 17, Issue 4 Suppl 3, pp. 19643 - n/a
Introduction The fibrogenesis analysis in quimeric CCR1 and CCR5 mice revealed that CCR5 mediates its pro‐fibrogenic effects in hepatic cells and promoting... 
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11. Full Text Contemporary stroke prevention strategies in 11 096 European patients with atrial fibrillation: A report from the EURObservational Research Programme on Atrial Fibrillation (EORP-AF) Long-Term General Registry
by Boriani, Giuseppe and Proietti, Marco and Laroche, Cécile and Fauchier, Laurent and Marin, Francisco and Nabauer, Michael and Potpara, Tatjana and Dan, Gheorghe-Andrei and Kalarus, Zbigniew and Diemberger, Igor and Tavazzi, Luigi and Maggioni, Aldo P and Lip, Gregory Y. H and EORP-AF Long-Term Gen Registry Inv and EORP-AF Long-Term General Registry Investigators and Steering Committee (National Coordinators) and the EORP-AF Long-Term General Registry Investigators
Europace, ISSN 1099-5129, 05/2018, Volume 20, Issue 5, pp. 747 - 757
Aims Contemporary data regarding atrial fibrillation (AF) management and current use of oral anticoagulants (OACs) for stroke prevention are needed. Methods... 
Stroke | Registry | Epidemiology | Atrial fibrillation | Mortality | Thromboembolic risk | CARDIAC & CARDIOVASCULAR SYSTEMS | MANAGEMENT | GUIDELINES | FOLLOW-UP | RISK | ADHERENCE | SOCIETY | ANTITHROMBOTIC TREATMENT | ORAL ANTICOAGULANTS | OUTCOMES | Anticoagulants - administration & dosage | Humans | Middle Aged | Male | Hemorrhage - prevention & control | Secondary Prevention - methods | Registries - statistics & numerical data | Platelet Aggregation Inhibitors - administration & dosage | Female | Stroke - epidemiology | Platelet Aggregation Inhibitors - adverse effects | Stroke - prevention & control | Administration, Oral | Atrial Fibrillation - drug therapy | Comorbidity | Risk Factors | Atrial Fibrillation - complications | Europe - epidemiology | Anticoagulants - adverse effects | Outcome and Process Assessment (Health Care) | Stroke - etiology | Atrial Fibrillation - epidemiology | Survival Analysis | Aged | Hemorrhage - chemically induced
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12. Full Text High delayed mortality after the first episode of Clostridium difficile infection
by Cózar, Alberto and Ramos-Martínez, Antonio and Merino, Esperanza and Martínez -García, Cristina and Shaw, Evelyn and Marrodán, Teresa and Calbo, Esther and Bereciartúa, Elena and Sánchez- Muñoz, Luis A and Salavert, Miguel and Pérez-Rodríguez, M. Teresa and García, Dácil and Bravo-Ferrer, J. María and Gálvez-Acebal, Juan and Henríquez, César and Cuquet, Jordi and Gil-Campesino, Helena and Torres, Luis and Sánchez-Porto, Antonio and Royuela, Ana and Cobo, Javier and Romero, José and Muriel, Alfonso and Giner, Livia and Federico, Ferrere and Rocío, Martínez-Ruiz S and Martos, Purificación and Sardiña, Cristina and Elena, Aguirre and Badía, Cristina and Perales, Alfonso and De Santos-Castro, Pedro A and Miguel, AngelBratos-Pérez and Cuellar, Sandra and Eva, Gonzalez and llinares, Pedro and Laura, Castelo and Morales, Isabel and Delgado-Iribarren, Alberto and Mairal, Pilar and Study Grp and Study group
Anaerobe, ISSN 1075-9964, 06/2019, Volume 57, pp. 93 - 98
infection (CDI) is characterized by a high delayed and unrelated mortality. Predicting delayed mortality in CDI patients could allow the implementation of... 
Fecal incontinence | Immunosuppression | Aged | Comorbidity | Mortality | Clostridium difficile | HOSPITALIZED-PATIENTS | RISK-FACTORS | DIARRHEA | MICROBIOLOGY | ALL-CAUSE | VANCOMYCIN | MORBIDITY | PREDICTORS | DISEASE | RECURRENCE | METRONIDAZOLE | Medicine, Experimental | Medical research | Health aspects | Analysis
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