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Nature, ISSN 0028-0836, 10/2011, Volume 478, Issue 7370, pp. 529 - 533
Journal Article
Nature, ISSN 0028-0836, 09/2015, Volume 525, Issue 7570, pp. 538 - 542
Bromodomain and extra terminal protein (BET) inhibitors are first-in-class targeted therapies that deliver a newtherapeutic opportunity by directly targeting... 
SELECTIVE-INHIBITION | ACCURATE | CHROMATIN | MECHANISM | MULTIDISCIPLINARY SCIENCES | ACUTE MYELOID-LEUKEMIA | DRUG-RESISTANCE | MUTATIONS | SEQUENCING DATA | CANCER | DISCOVERY | Chromatin - metabolism | Transcription, Genetic - drug effects | Clone Cells - drug effects | Neoplastic Stem Cells - drug effects | Epigenesis, Genetic | Humans | Leukemia, Myeloid, Acute - metabolism | Molecular Targeted Therapy | Neoplastic Stem Cells - metabolism | Leukemia, Myeloid, Acute - drug therapy | Neoplastic Stem Cells - pathology | Gene Expression Regulation, Neoplastic - drug effects | Hematopoietic Stem Cells - drug effects | Benzodiazepines - pharmacology | Leukemia, Myeloid, Acute - pathology | Cells, Cultured | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Hematopoietic Stem Cells - metabolism | Clone Cells - metabolism | beta Catenin - metabolism | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Clone Cells - pathology | Wnt Signaling Pathway - drug effects | Genes, myc - genetics | Hematopoietic Stem Cells - cytology | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Mice | Drug Resistance, Neoplasm - drug effects | Leukemia, Myeloid, Acute - genetics | Proteins | Leukemia | Cloning | Cell cycle | Stem cells | Epigenetics | Apoptosis | Index Medicus
Journal Article
ISSN 1535-6108, 2018
Journal Article
Cancer Cell, ISSN 1535-6108, 10/2018, Volume 34, Issue 4, pp. 533 - 535
In this issue of , de Boer et al. refine a set of acute myeloid leukemia (AML)-enriched plasma membrane markers that can be used to identify, prospectively... 
ONCOLOGY | ACUTE MYELOID-LEUKEMIA | CELL BIOLOGY | Prospective Studies | Mutation | Leukemia, Myeloid, Acute | Humans | Cells, Cultured | Cloning | Leukemia | Stem cells | Index Medicus
Journal Article
Nature Cell Biology, ISSN 1465-7392, 09/2017, Volume 19, Issue 9, pp. 1093 - 1104
Loss-of-function mutations of cyclic-AMP response element binding protein, binding protein (CREBBP) are prevalent in lymphoid malignancies. However, the tumour... 
PATHOGENESIS | TRANSFORMATION | EVOLUTION | GENE | ALIGNMENT | ACETYLATION | DNA-DAMAGE | THERAPEUTIC TARGETS | BINDING PROTEIN | SOMATIC MUTATIONS | CELL BIOLOGY | Lymphopoiesis | Cell Proliferation | Epigenesis, Genetic | Gene Expression Regulation, Neoplastic | Tumor Suppressor Protein p53 - genetics | CREB-Binding Protein - genetics | Lymphoma - metabolism | CREB-Binding Protein - metabolism | Cell Self Renewal | Neoplastic Stem Cells - metabolism | Time Factors | Cell Transformation, Neoplastic - genetics | Neoplastic Stem Cells - pathology | Lymphoma - pathology | Transcription, Genetic | Acetylation | CREB-Binding Protein - deficiency | Lymphangiogenesis | Genetic Predisposition to Disease | Signal Transduction | Lymphoid Progenitor Cells - metabolism | Mice, Inbred C57BL | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Lymphoma - genetics | Cell Transformation, Neoplastic - metabolism | Mice, Knockout | Phenotype | Animals | Mice | DNA Damage | Histones - metabolism | Mutation | Cell Transformation, Neoplastic - pathology | Methylation | Lymphoid Progenitor Cells - pathology | Binding | Transformation | AMP | Transcription | p53 Protein | Abnormalities | Biological evolution | DNA damage | Lymphoma | Damage detection | Lymphocytes B | Cells (biology) | Stem cells | Lymphomas | Damage accumulation | Evolution & development | Deoxyribonucleic acid--DNA | Tumors | B-cell lymphoma | Index Medicus
Journal Article
JOURNAL OF EXPERIMENTAL MEDICINE, ISSN 0022-1007, 04/2019, Volume 216, Issue 4, pp. 966 - 981
Epigenetic regulators, such as EZH2, are frequently mutated in cancer, and loss-of-function EZH2 mutations are common in myeloid malignancies. We have examined... 
EPIGENETIC REGULATORS | INITIATING CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | STEM-CELLS | PROTEIN | METHYLTRANSFERASE GENE EZH2 | MOUSE MODEL | SELF-RENEWAL | ACUTE MYELOID-LEUKEMIA | IMMUNOLOGY | BINDING | SOMATIC MUTATIONS | 304 | 315
Journal Article
BMC Cancer, ISSN 1471-2407, 08/2015, Volume 15, Issue 1, pp. 585 - 585
Background: B-cell precursor acute lymphoblastic leukemia (B-ALL) is amongst the leading causes of childhood cancer-related mortality. Its most common... 
Trp53 | B-cell precursor | Leukemia | Insertional mutagenesis | JAK/STAT | Pax5 | ETV6-RUNX1 | ACTIVATION | TWINS | RELAPSE | ONCOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | CELL DIFFERENTIATION | COMMON | MICE | MUTATIONS | JAK3 | GENETIC ALTERATIONS | Anopheles | Transposons | Translocation (Genetics) | Genes | B cells | Gene expression | Health aspects | Index Medicus
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2015, Volume 212, Issue 10, pp. 1551 - 1569
Journal Article
Blood, ISSN 0006-4971, 04/2018, Volume 131, Issue 15, pp. 1639 - 1653
FLT3 internal tandem duplication (FLT3ITD) mutations are common in acute myeloid leukemia (AML) associated with poor patient prognosis. Although new-generation... 
Index Medicus | Abridged Index Medicus
Journal Article
ISSN 0006-4971, 2018
FLT3 internal tandem duplication (FLT3ITD) are common mutations in acute myeloid leukemia (AML) associated with poor patient prognosis. Although new generation... 
Journal Article
Cancer Cell, ISSN 1535-6108, 02/2018, Volume 33, Issue 2, pp. 274 - 291.e8
Journal Article