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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2012, Volume 109, Issue 33, pp. 13302 - 13307
In postmitotic mammalian cells, protein p53R2 substitutes for protein R2 as a subunit of ribonucleotide reductase. In human patients with mutations in RRM2B,... 
Ribonucleotides | DNA damage | DNA | Cell lines | Fibroblasts | Irradiation | Fluorescence | Mitochondrial DNA | DNA repair | Genetic mutation | Mitochondrial disease | Cell cycle | DNA precursors | dNTP de novo synthesis | cell cycle | MULTIDISCIPLINARY SCIENCES | DEPLETION | mitochondrial disease | DAMAGE | FIBROBLASTS | NUCLEOTIDE EXCISION-REPAIR | STRAND BREAKS | INHIBITION | HISTONE H2AX PHOSPHORYLATION | GENE | RRM2B | MUTATIONS | Hydroxyurea - pharmacology | Fibroblasts - enzymology | DNA Replication - drug effects | Humans | DNA Repair - radiation effects | Ethidium - metabolism | DNA Repair - genetics | Fluorometry | Protein Subunits - metabolism | DNA, Mitochondrial - genetics | Ultraviolet Rays | Mitochondria - genetics | DNA Replication - radiation effects | Nucleotides - pharmacology | Mitochondria - radiation effects | Phosphorylation - drug effects | Nucleic Acid Conformation | Mammals - metabolism | DNA Repair - drug effects | Cell Cycle Proteins - metabolism | Mitochondria - drug effects | Fibroblasts - pathology | Mutation - genetics | Phosphorylation - radiation effects | Animals | Fibroblasts - radiation effects | Fibroblasts - drug effects | Ribonucleotide Reductases - metabolism | DNA Replication - genetics | Histones - metabolism | Hydroxyurea - metabolism | DNA replication | Physiological aspects | Research | Health aspects | Biological Sciences
Journal Article
Journal Article
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, ISSN 1015-8987, 2019, Volume 53, Issue S1, pp. 63 - 78
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2008, Volume 105, Issue 46, pp. 17801 - 17806
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2011, Volume 286, Issue 13, pp. 11132 - 11140
Ribonucleotide reduction provides deoxynucleotides for nuclear and mitochondrial (mt) DNA replication and DNA repair. In cycling mammalian cells the reaction... 
THYMIDINE KINASE | NEUROGASTROINTESTINAL ENCEPHALOMYOPATHY | IN-VITRO | REPAIR | MITOCHONDRIAL-DNA DEPLETION | CANCER CELLS | GENE | DNTP POOLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RENAL-FAILURE | DAMAGE | Fibroblasts - enzymology | DNA, Mitochondrial - metabolism | Oxidation-Reduction | Thymidine Kinase - genetics | Humans | Cell Cycle Proteins - metabolism | Cells, Cultured | DNA Repair - physiology | Mutation, Missense | Deoxyribonucleotides - genetics | DNA, Mitochondrial - genetics | DNA Replication - physiology | Deoxyribonucleotides - metabolism | Ribonucleotide Reductases - metabolism | Thymidine Kinase - metabolism | Cell Cycle - physiology | Cell Cycle Proteins - genetics | Fibroblasts - cytology | Ribonucleotide Reductases - genetics | Enzymes | Thymidine kinase | Starvation | ribonucleotides | Muscles | Mitochondrial DNA | Energy requirements | Metabolism | DNA repair | deoxyribonucleotides | Mammalian cells | DNA biosynthesis | Mitochondria | Missense mutation | Ribonucleoside-triphosphate reductase | S phase | Fibroblasts | Replication | Substrate Cycles | Molecular Bases of Disease | mtDNA Depletion Syndromes | Genetic Diseases | Ribonucleotide Reductase | Metabolic Diseases | Nucleoside Nucleotide Metabolism | dNTP Pools | DNA Synthesis | Cell and Molecular Biology | Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci) | Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) | Cell- och molekylärbiologi
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2003, Volume 100, Issue 21, pp. 12159 - 12164
Journal Article
The FASEB Journal, ISSN 0892-6638, 01/2020, Volume 34, Issue 1, pp. 631 - 647
In mammalian cells, the catabolic activity of the dNTP triphosphohydrolase SAMHD1 sets the balance and concentration of the four dNTPs. Deficiency of SAMHD1... 
UV‐induced DNA repair | deoxynucleotide catabolism | deoxynucleotide pool imbalance | sterile alpha motif and HD domain containing protein 1 (SAMHD1)
Journal Article