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Cellular and Molecular Life Sciences, ISSN 1420-682X, 7/2014, Volume 71, Issue 13, pp. 2403 - 2427
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2003, Volume 100, Issue 14, pp. 8247 - 8252
Recently, p53 was demonstrated to affect the expression of the insulin-like growth factor 1 receptor (IGF-1R), a receptor tyrosine kinase that plays a crucial... 
Biological Sciences | Receptors | Cell growth | Immunoprecipitation | Ubiquitins | Cell lines | Melanoma | Antibodies | Melanocytes | Cultured cells | Western blotting | P53 | SARCOMA-CELLS | WILD-TYPE | PROTEIN | GAIN-OF-FUNCTION | MULTIDISCIPLINARY SCIENCES | GROWTH | cell growth | MDM2 | TUMOR | FACTOR-I RECEPTOR | EXPRESSION | p53 | Ubiquitin | Receptor, IGF Type 1 - metabolism | Oligodeoxyribonucleotides, Antisense - pharmacology | Tumor Suppressor Protein p53 - antagonists & inhibitors | Humans | Neoplasm Proteins - antagonists & inhibitors | 3T3 Cells - metabolism | Down-Regulation - radiation effects | Neoplasm Proteins - metabolism | Proteasome Endopeptidase Complex | Recombinant Fusion Proteins - metabolism | Genes, p53 | Cell Nucleus - metabolism | Transfection | Ultraviolet Rays | Tumor Cells, Cultured - radiation effects | Peptide Hydrolases - metabolism | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Tumor Suppressor Protein p53 - metabolism | Tumor Cells, Cultured - metabolism | Melanoma - pathology | Protein Processing, Post-Translational - physiology | Nuclear Proteins | Protein Interaction Mapping | Down-Regulation - physiology | Proto-Oncogene Proteins c-mdm2 | Animals | Mice | Physiological aspects | Insulin-like growth factor 1 | Cell research
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2012, Volume 109, Issue 18, pp. 7055 - 7060
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2012, Volume 109, Issue 50, pp. 20620 - 20625
Journal Article
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 12/2012, Volume 109, Issue 50, pp. 20620 - 20625
Owing to its essential role in cancer, insulin-like growth factor type 1 receptor (IGF-1R)–targeted therapy is an exciting approach for cancer treatment.... 
Arrestin2 | RTK | GPCR | Functional selectivity | Internalization | Trafficking | Biological Sciences | arrestin2 | internalization | trafficking | functional selectivity
Journal Article
British Journal of Cancer, ISSN 0007-0920, 06/2005, Volume 92, Issue 12, pp. 2097 - 2101
Journal Article
Frontiers in Endocrinology, ISSN 1664-2392, 2015, Volume 6, p. 64
The insulin-like growth factor type 1 receptor (IGF-1R) plays a key role in the development and maintenance of cancer. Since the first links between growth... 
RTK | Biased signaling | GPCR | IGF-1R | Cancer | BETA-ARRESTIN | FACTOR 1 RECEPTOR | INSULIN | SIMIAN SARCOMA-VIRUS | BIASED AGONISM | PROTEIN-COUPLED RECEPTOR | SMALL-MOLECULE INHIBITORS | ENDOCRINOLOGY & METABOLISM | cancer | biased signaling | GROWTH-FACTOR-I | CANCER CELL-LINES | TYROSINE PHOSPHATASE SHP-2 | biased agonism
Journal Article
Oncogene, ISSN 0950-9232, 01/2012, Volume 31, Issue 3, pp. 352 - 365
The human cathelicidin antimicrobial protein-18 and its C terminal peptide, LL-37, displays broad antimicrobial activity that is mediated through direct... 
breast cancer | LL-37 | invasion | IGF-1R | metastasis | ANTIMICROBIAL PROTEIN HCAP18/LL-37 | INSULIN-LIKE-GROWTH-FACTOR-1 RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | INNATE IMMUNE-SYSTEM | BETA-ARRESTIN | CELL BIOLOGY | BREAST-CANCER CELLS | 7-TRANSMEMBRANE RECEPTORS | UVEAL MELANOMA | PICROPODOPHYLLIN | ONCOLOGY | GENETICS & HEREDITY | IGF-1 RECEPTOR | Cell Line | Receptor, IGF Type 1 - metabolism | Phosphorylation | Cell Proliferation | Antimicrobial Cationic Peptides - chemistry | Receptor, IGF Type 1 - agonists | Humans | Phosphatidylinositol 3-Kinases - metabolism | Antimicrobial Cationic Peptides - metabolism | Arrestins - metabolism | Cell Transformation, Neoplastic - metabolism | MAP Kinase Signaling System | Neoplasm Invasiveness - physiopathology | Ubiquitination | beta-Arrestin 1 | beta-Arrestins | Proto-Oncogene Proteins c-akt - metabolism | Cell Movement | Cellular signal transduction | Genetic aspects | Growth factor receptors | Cathelicidins | Properties | Proteins | Breast cancer | Insulin-like growth factors | Metastasis | Peptides | Apoptosis | Cell proliferation | Antimicrobial activity | Transformation | Wound healing | Immunomodulation | cathelicidins | Extracellular signal-regulated kinase | AKT protein | Antimicrobial agents | MAP kinase | Cell membranes | C-Terminus | Carcinogenesis | 1-Phosphatidylinositol 3-kinase | Angiogenesis | beta -Arrestin | ubiquitination | Cell migration | Insulin-like growth factor receptors | Tumors | Index Medicus | Original
Journal Article
Annals of Oncology, ISSN 0923-7534, 10/2019, Volume 30, Issue Supplement_5
Abstract Background IGF-1R, a member of the tyrosine receptor family, is well documented in various experimental models to be an important factor in cell... 
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 47, pp. 82256 - 82267
Due to its ability to compensate for signals lost following therapeutic MAPK-inhibition, insulin-like growth factor type 1 receptor (IGF-1R) co-targeting is a... 
Biased signaling | Targeted therapy | Rtks | Functional selectivity | Cancer | CANCER-CELLS | targeted therapy | ARRESTIN-BIASED AGONISM | BETA-ARRESTIN | PICROPODOPHYLLIN PPP | V600E B-RAF | CELL BIOLOGY | METASTATIC MELANOMA | 7-TRANSMEMBRANE RECEPTORS | GROWTH | cancer | biased signaling | FACTOR-I RECEPTOR | UP-REGULATION | functional selectivity | rtks
Journal Article
Journal Article