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by Bailey, Peter and Chang, David K and Nones, Katia and Johns, Amber L and Patch, Ann-Marie and Gingras, Marie-Claude and Miller, David K and Christ, Angelika N and Bruxner, Tim J. C and Quinn, Michael C and Nourse, Craig and Murtaugh, L. Charles and Harliwong, Ivon and Idrisoglu, Senel and Manning, Suzanne and Nourbakhsh, Ehsan and Wani, Shivangi and Fink, Lynn and Holmes, Oliver and Chin, Venessa and Anderson, Matthew J and Kazakoff, Stephen and Leonard, Conrad and Newell, Felicity and Waddell, Nick and Wood, Scott and Xu, Qinying and Wilson, Peter J and Cloonan, Nicole and Kassahn, Karin S and Taylor, Darrin and Quek, Kelly and Robertson, Alan and Pantano, Lorena and Mincarelli, Laura and Sanchez, Luis N and Evers, Lisa and Wu, Jianmin and Pinese, Mark and Cowley, Mark J and Jones, Marc D and Colvin, Emily K and Nagrial, Adnan M and Humphrey, Emily S and Chantrill, Lorraine A and Mawson, Amanda and Humphris, Jeremy and Chou, Angela and Pajic, Marina and Scarlett, Christopher J and Pinho, Andreia V and Giry-Laterriere, Marc and Rooman, Ilse and Samra, Jaswinder S and Kench, James G and Lovell, Jessica A and Merrett, Neil D and Toon, Christopher W and Epari, Krishna and Nguyen, Nam Q and Barbour, Andrew and Zeps, Nikolajs and Moran-Jones, Kim and Jamieson, Nigel B and Graham, Janet S and Duthie, Fraser and Oien, Karin and Hair, Jane and Grützmann, Robert and Maitra, Anirban and Iacobuzio-Donahue, Christine A and Wolfgang, Christopher L and Morgan, Richard A and Lawlor, Rita T and Corbo, Vincenzo and Bassi, Claudio and Rusev, Borislav and Capelli, Paola and Salvia, Roberto and Tortora, Giampaolo and Mukhopadhyay, Debabrata and Petersen, Gloria M and Munzy, Donna M and Fisher, William E and Karim, Saadia A and Eshleman, James R and Hruban, Ralph H and Pilarsky, Christian and Morton, Jennifer P and Sansom, Owen J and Scarpa, Aldo and Musgrove, Elizabeth A and Bailey, Ulla-Maja Hagbo and Hofmann, Oliver and Sutherland, Robert L and Wheeler, David A and Gill, Anthony J and Gibbs, Richard A and Pearson, John V and Waddell, Nicola and ... and Australian Pancreatic Canc Genome and Australian Pancreatic Cancer Genome Initiative
Nature, ISSN 0028-0836, 03/2016, Volume 531, Issue 7592, pp. 47 - 52
Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32 recurrently mutated genes that aggregate into 10 pathways: KRAS, TGF-beta,... 
PATHWAYS | METASTASIS | DUCTAL ADENOCARCINOMA | PACKAGE | MULTIDISCIPLINARY SCIENCES | TUMOR | MUTATIONS | DIFFERENTIATION | Pancreatic Neoplasms - metabolism | Prognosis | Hepatocyte Nuclear Factor 3-beta - genetics | Genomics | Humans | Carcinoma, Pancreatic Ductal - metabolism | Gene Expression Regulation, Neoplastic | Transcriptome | Hepatocyte Nuclear Factor 3-gamma - genetics | Gene Regulatory Networks | Histone Demethylases - genetics | Tumor Suppressor Protein p53 - genetics | Carcinoma, Pancreatic Ductal - genetics | DNA Methylation | Tumor Suppressor Proteins - genetics | Carcinoma, Pancreatic Ductal - classification | Trans-Activators - genetics | Pancreatic Neoplasms - classification | Transcription, Genetic | Nuclear Proteins - genetics | Carcinoma, Pancreatic Ductal - immunology | Genes, Neoplasm - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Carcinoma, Pancreatic Ductal - pathology | Genome, Human - genetics | Homeodomain Proteins - genetics | Animals | Pancreatic Neoplasms - immunology | Survival Analysis | Cell Line, Tumor | Mice | Physiological aspects | Pancreatic cancer | Methods | Genes | Genomes | Mutation | Gene expression | Tumors
Journal Article
by Waddell, Nicola and Pajic, Marina and Patch, Ann-Marie and Chang, David K and Kassahn, Karin S and Bailey, Peter and Johns, Amber L and Miller, David and Nones, Katia and Quek, Kelly and Quinn, Michael C. J and Robertson, Alan J and Fadlullah, Muhammad Z. H and Bruxner, Tim J. C and Christ, Angelika N and Harliwong, Ivon and Idrisoglu, Senel and Manning, Suzanne and Nourse, Craig and Nourbakhsh, Ehsan and Wani, Shivangi and Wilson, Peter J and Markham, Emma and Cloonan, Nicole and Anderson, Matthew J and Fink, J. Lynn and Holmes, Oliver and Kazakoff, Stephen H and Leonard, Conrad and Newell, Felicity and Poudel, Barsha and Song, Sarah and Taylor, Darrin and Waddell, Nick and Wood, Scott and Xu, Qinying and Wu, Jianmin and Pinese, Mark and Cowley, Mark J and Lee, Hong C and Jones, Marc D and Nagrial, Adnan M and Humphris, Jeremy and Chantrill, Lorraine A and Chin, Venessa and Steinmann, Angela M and Mawson, Amanda and Humphrey, Emily S and Colvin, Emily K and Chou, Angela and Scarlett, Christopher J and Pinho, Andreia V and Giry-Laterriere, Marc and Rooman, Ilse and Samra, Jaswinder S and Kench, James G and Pettitt, Jessica A and Merrett, Neil D and Toon, Christopher and Epari, Krishna and Nguyen, Nam Q and Barbour, Andrew and Zeps, Nikolajs and Jamieson, Nigel B and Graham, Janet S and Niclou, Simone P and Bjerkvig, Rolf and Grützmann, Robert and Aust, Daniela and Hruban, Ralph H and Maitra, Anirban and Iacobuzio-Donahue, Christine A and Wolfgang, Christopher L and Morgan, Richard A and Lawlor, Rita T and Corbo, Vincenzo and Bassi, Claudio and Falconi, Massimo and Zamboni, Giuseppe and Tortora, Giampaolo and Tempero, Margaret A and Gill, Anthony J and Eshleman, James R and Pilarsky, Christian and Scarpa, Aldo and Musgrove, Elizabeth A and Pearson, John V and Biankin, Andrew V and Grimmond, Sean M and Australian Pancreatic Canc Genome and Australian Pancreatic Cancer Genome Initiative
Nature, ISSN 0028-0836, 02/2015, Volume 518, Issue 7540, pp. 495 - 501
Journal Article
by Humphris, Jeremy L and Patch, Ann-Marie and Nones, Katia and Bailey, Peter J and Johns, Amber L and McKay, Skye and Chang, David K and Miller, David K and Pajic, Marina and Kassahn, Karin S and Quinn, Michael C.J and Bruxner, Timothy J.C and Christ, Angelika N and Harliwong, Ivon and Idrisoglu, Senel and Manning, Suzanne and Nourse, Craig and Nourbakhsh, Ehsan and Stone, Andrew and Wilson, Peter J and Anderson, Matthew and Fink, J. Lynn and Holmes, Oliver and Kazakoff, Stephen and Leonard, Conrad and Newell, Felicity and Waddell, Nick and Wood, Scott and Mead, Ronald S and Xu, Qinying and Wu, Jianmin and Pinese, Mark and Cowley, Mark J and Jones, Marc D and Nagrial, Adnan M and Chin, Venessa T and Chantrill, Lorraine A and Mawson, Amanda and Chou, Angela and Scarlett, Christopher J and Pinho, Andreia V and Rooman, Ilse and Giry-Laterriere, Marc and Samra, Jaswinder S and Kench, James G and Merrett, Neil D and Toon, Christopher W and Epari, Krishna and Nguyen, Nam Q and Barbour, Andrew and Zeps, Nikolajs and Jamieson, Nigel B and McKay, Colin J and Carter, C. Ross and Dickson, Euan J and Graham, Janet S and Duthie, Fraser and Oien, Karin and Hair, Jane and Morton, Jennifer P and Sansom, Owen J and Grützmann, Robert and Hruban, Ralph H and Maitra, Anirban and Iacobuzio-Donahue, Christine A and Schulick, Richard D and Wolfgang, Christopher L and Morgan, Richard A and Lawlor, Rita T and Rusev, Borislav and Corbo, Vincenzo and Salvia, Roberto and Cataldo, Ivana and Tortora, Giampaolo and Tempero, Margaret A and Hofmann, Oliver and Eshleman, James R and Pilarsky, Christian and Scarpa, Aldo and Musgrove, Elizabeth A and Gill, Anthony J and Pearson, John V and Grimmond, Sean M and Waddell, Nicola and Biankin, Andrew V and Australian Pancreatic Canc Genome and Australian Pancreatic Cancer Genome Initiative
Gastroenterology, ISSN 0016-5085, 2016, Volume 152, Issue 1, pp. 68 - 74.e2
Journal Article
Gut, ISSN 0017-5749, 11/2015, Volume 64, Issue 11, pp. 1790 - 1799
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 5083 - 14
Journal Article
Current Cancer Drug Targets, ISSN 1568-0096, 08/2015, Volume 15, Issue 6, pp. 463 - 468
Sirtuin 1 is a protein deacetylase that regulates a large number of proteins often functionally implicated in tumor development and progression. Its... 
Chemotherapy | Deleted in breast cancer 1 | Sirtuin 1 | Mutation | Pancreas | Personalized medicine | Genomic | ANALYSIS REVEALS | CELLS | ACETYLATION | personalized medicine | EPITHELIAL-MESENCHYMAL TRANSITION | mutation | INHIBITION | ONCOLOGY | genomic | ENHANCES CHEMOSENSITIVITY | PATHWAY | pancreas | MUTANT P53 | UP-REGULATION | EXPRESSION
Journal Article
Science Translational Medicine, ISSN 1946-6234, 04/2017, Volume 9, Issue 384, pp. eaai8504 - eaai8504
The emerging standard of care for patients with inoperable pancreatic cancer is a combination of cytotoxic drugs gemcitabine and Abraxane, but patient response... 
MIGRATION | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | DUCTAL ADENOCARCINOMA | CELL INVASION | RHO-KINASE/ROCK | TUMOR | TENSION | EXTRACELLULAR-MATRIX | CLEAVAGE FURROW | REVEALS | CELL BIOLOGY | Liver - pathology | Humans | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Extracellular Matrix - metabolism | Deoxycytidine - pharmacology | Antineoplastic Agents - therapeutic use | rho-Associated Kinases - antagonists & inhibitors | CDC2 Protein Kinase - metabolism | Pancreatic Neoplasms - drug therapy | Deoxycytidine - therapeutic use | Neoplasm Metastasis | rho-Associated Kinases - metabolism | Actin Cytoskeleton - drug effects | src-Family Kinases - metabolism | Albumin-Bound Paclitaxel - therapeutic use | Antineoplastic Agents - pharmacology | Actin Cytoskeleton - metabolism | Neoplasm Invasiveness | Pancreatic Neoplasms - pathology | Albumin-Bound Paclitaxel - pharmacology | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - therapeutic use | Treatment Outcome | Disease Progression | Collagen - metabolism | Animals | Signal Transduction - drug effects | Protein Kinase Inhibitors - therapeutic use | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Biosensing Techniques | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Deoxycytidine - analogs & derivatives
Journal Article
Cell Reports, ISSN 2211-1247, 02/2016, Volume 14, Issue 4, pp. 907 - 919
Journal Article