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by Coleman, Robert L and Coleman, R L and Oza, Amit M and Oza, A M and Lorusso, D and Lorusso, Domenica and Aghajanian, C and Aghajanian, Carol and Oaknin, A and Oaknin, Ana and Dean, A and Dean, Andrew and Colombo, N and Colombo, Nicoletta and Weberpals, Johanne I and Weberpals, J I and Clamp, Andrew and Clamp, A and Scambia, Giovanni and Scambia, G and Leary, A and Leary, Alexandra and Holloway, Robert W and Holloway, R W and Gancedo, M Amenedo and Gancedo, Margarita Amenedo and Fong, Peter C and Fong, P C and Goh, Jeffrey C and Goh, J C and O'Malley, David M and O'Malley, D M and Armstrong, Deborah K and Armstrong, D K and Garcia-Donas, Jesus and Garcia-Donas, J and Swisher, E M and Swisher, Elizabeth M and Floquet, A and Floquet, Anne and Konecny, Gottfried E and Konecny, G E and McNeish, I A and McNeish, Iain A and Scott, C L and Scott, Clare L and Cameron, Terri and Maloney, Lara and Isaacson, Jeff and Goble, Sandra and Grace, Caroline and Harding, Thomas C and Raponi, Mitch and Sun, James and Lin, Kevin K and Giordano, Heidi and Ledermann, J A and Ledermann, Jonathan A and Buck, M and Friedlander, M L and Harnett, P and Kichenadasse, G and Denys, H and Dirix, L and Vergote, I and Elit, L and Ghatage, P and Plante, M and Provencher, D and Welch, S and Gladieff, L and Joly, F and Lortholary, A and Lotz, J and Medioni, J and Tredan, O and You, B and El-Balat, A and Hänle, C and Krabisch, P and Neunhöffer, T and Pölcher, M and Wimberger, P and Amit, A and Kovel, S and Leviov, M and Safra, T and Shapira-Frommer, R and Stemmer, S and Bologna, A and Pignata, S and Sabbatini, R F and Tamberi, S and Zamagni, C and O'Donnell, A and Herraez, A Casado and Guerra, E M and Palacio, I and Romero, I and Sanchez, A and ... and ARIEL3 Investigators and ARIEL3 investigators
The Lancet, ISSN 0140-6736, 10/2017, Volume 390, Issue 10106, pp. 1949 - 1961
Rucaparib, a poly(ADP-ribose) polymerase inhibitor, has anticancer activity in recurrent ovarian carcinoma harbouring a mutation or high percentage of... 
MEDICINE, GENERAL & INTERNAL | MULTICENTER | SOLID TUMORS | BEVACIZUMAB | OPEN-LABEL | CANCER | HETEROZYGOSITY | EPITHELIAL OVARIAN | CHEMOTHERAPY | Double-Blind Method | Follow-Up Studies | Risk Assessment | Humans | Middle Aged | Ovarian Neoplasms - pathology | Neoplasm Recurrence, Local - drug therapy | Survival Rate | Treatment Outcome | Ovarian Neoplasms - mortality | Neoplasm Recurrence, Local - mortality | Indoles - administration & dosage | Poly(ADP-ribose) Polymerase Inhibitors - administration & dosage | Neoplasm Recurrence, Local - pathology | Disease-Free Survival | Maintenance Chemotherapy - methods | Internationality | Ovarian Neoplasms - therapy | Female | Aged | Molecular Targeted Therapy - methods | Clinical trials | Care and treatment | Carcinoma | Drug therapy | Ovarian cancer | Cancer | Analysis | Chemotherapy | Ovarian carcinoma | Platinum | Biomarkers | Mutation | Cancer therapies | Tumors | Homologous recombination | Central nervous system | Poly(ADP-ribose) | Homology | Genomes | Fallopian tube | ADP | Anticancer properties | Metastases | Homologous recombination repair | Randomization | Pain | Motivation | Ribose | Hemoglobin | Alanine | Anemia | Poly(ADP-ribose) polymerase | Breast cancer | Patients | Survival | Heterozygosity | Abdomen | Polymerase | Inhibitors | Point mutation | Loss of heterozygosity | Antitumor activity | Aspartate aminotransferase | Peritoneum
Journal Article
by Pivot, Xavier and Romieu, Gilles and Debled, Marc and Pierga, Jean-Yves and Kerbrat, Pierre and Bachelot, Thomas and Lortholary, Alain and Espié, Marc and Fumoleau, Pierre and Serin, Daniel and Jacquin, Jean-Philippe and Jouannaud, Christelle and Rios, Maria and Abadie-Lacourtoisie, Sophie and Venat-Bouvet, Laurence and Cany, Laurent and Catala, Stéphanie and Khayat, David and Gambotti, Laetitia and Pauporté, Iris and Faure-Mercier, Celine and Paget-Bailly, Sophie and Henriques, Julie and Grouin, Jean Marie and Piprot, C and Cals, L and Chaigneau, L and Demarchi, F and N'Guyen, T and Stein, U and Villanueva, C and Bréau, JL and Chouahnia, AK and Saintigny, P and Boué, F and deSaint-Hilaire, P and Guimont, I and Grossat, N and Valenza, B and Lévy, E and Médioni, J and Delbaldo, C and Grenier, J and Pouessel, D and Lavau-Denès, S and Falandry, C and Fournel-Fédérico, C and Freyer, G and Tartas, S and Trillet-Lenoir, V and Bons, F and Auclerc, G and Chièze, S and Raban, N and Tournigand, C and Trager-Maury, S and Bousquet, G and Cuvier, C and Giacchetti, S and Hocini, A and LeMaignan, C and Misset, JL and Avenin, D and Beerblock, C and Gligorov, J and Rivera, P and Roché, H and Bougnoux, P and Hajjaji, N and Capitain, O and Delva, R and Maillart, P and Soulié, P and Bonnefoi, H and Durand, M and Madranges, N and Mauriac, L and Chollet, P and Dillies, AF and Durando, X and Ferrière, JP and Mouret-Reynier, C and Nabholtz, JM and Van Praagh, I and Cottu, P and Diéras, V and Durieux, A and Galotte, M and Girre, V and Henry, S and Iurisci, I and Jouve, M and Laurence, V and Mignot, L and Piperno-Neumann, S and Tresca, P and Coudert, B and Ferrant, E and Mayer, F and Vanneuville, AC and ... and PHARE Trial Investigators and PHARE trial investigators
The Lancet, ISSN 0140-6736, 06/2019, Volume 393, Issue 10191, pp. 2591 - 2598
Journal Article
by Gaudet, Mia M and Kuchenbaecker, Karoline B and Vijai, Joseph and Klein, Robert J and Kirchhoff, Tomas and McGuffog, Lesley and Barrowdale, Daniel and Dunning, Alison M and Lee, Anew and Dennis, Joe and Healey, Sue and Dicks, Ed and Soucy, Penny and Sinilnikova, Olga M and Pankratz, Vernon S and Wang, Xianshu and Elidge, Ronald C and Tessier, Daniel C and Vincent, Daniel and Bacot, Francois and Hogervorst, Frans B. L and Peock, Susan and Stoppa-Lyonnet, Dominique and Peterlongo, Paolo and Schmutzler, Rita K and Nathanson, Katherine L and Piedmonte, Marion and Singer, Christian F and Thomassen, Mads and Hansen, Thomas v O and Neuhausen, Susan L and Blanco, Ignacio and Greene, Mark H and Garber, Judith and Weitzel, Jeffrey N and Anulis, Irene L and Goldgar, David E and D'Anea, Emma and Caldes, Trinidad and Nevanlinna, Heli and Osorio, Ana and van Rensburg, Elizabeth J and Arason, Adalgeir and Rennert, Gad and van den Ouweland, Ans M. W and van der Hout, Annemarie H and Kets, Carolien M and Aalfs, Cora M and Wijnen, Juul T and Ausems, Margreet G. E. M and Frost, Debra and Ellis, Steve and Fineberg, Elena and Platte, Radka and Evans, D. Gareth and Jacobs, Chris and Adlard, Julian and Tischkowitz, Marc and Porteous, Mary E and Damiola, Francesca and Golmard, Lisa and Barjhoux, Laure and Longy, Michel and Belotti, Muriel and Ferrer, Sana Fert and Mazoyer, Sylvie and Spurdle, Amanda B and Manoukian, Siranoush and Barile, Monica and Genuardi, Maurizio and Arnold, Norbert and Meindl, Alfons and Sutter, Christian and Wappenschmidt, Barbara and Domchek, Susan M and Pfeiler, Georg and Friedman, Eitan and Jensen, Uffe Birk and Robson, Mark and Shah, Sohela and Lazaro, Conxi and Mai, Phuong L and Benitez, Javier and Southey, Melissa C and Schmidt, Marjanka K and Fasching, Peter A and Peto, Julian and Humphreys, Manjeet K and Wang, Qin and Michailidou, Kyriaki and Sawyer, Elinor J and Burwinkel, Barbara and Guénel, Pascal and Bojesen, Stig E and Milne, Roger L and Brenner, Hermann and Lochmann, Magdalena and Aittomäki, Kristiina and Dörk, Thilo and Margolin, Sara and ... and KConFab Investigators and Ontario Canc Genetics Network and HEBON and EMBRACE and GEMO Study Collaborators and GENICA Network and Ontario Cancer Genetics Network and The GENICA Network
PLoS genetics, ISSN 1553-7390, 2013, Volume 9, Issue 3, p. e1003173
Journal Article
by Lawrenson, Kate and Kar, Siddhartha and McCue, Karen and Kuchenbaeker, K and Michailidou, Kyriaki and Tyrer, Jonathan and Beesley, Jonathan and Ramus, Susan and Li, Q and Delgado, M.K and Lee, Janet M and Aittomäki, Kristiina and Anulis, Irene and Anton-Culver, Hoda and Arndt, V and Arun, Banu and Arver, Brita Wasteson and Bandera, Elisa and Barile, Monica and Barkardottir, R.B and Barrowdale, Daniel and Beckmann, Matthias and Benítez, Javier and Berchuck, Anew and Bisogna, Maria and Bjorge, Line and Blomqvist, Carl and Blot, William and Bogdanova, Natalia and Bojesen, A and Bojesen, Stig and Bolla, Manjeet K and Bonnani, Bernardo and Borresen-Dale, Anne-Lise and Brauch, Hiltrud and Brennan, Paul and Brenner, Hermann and Bruinsma, Fiona and Brunet, Joan and Buhari, Shaik Ahmad Bin Syed and Burwinkel, Barbara and Butzow, Ralf and Buys, Sauna and Cai, Qiuyin and Caldes, Trinidad and Campbell, Ian and Canniotto, R and Chang-Claude, Jenny and Chiquette, J and Choi, J.-Y and Claes, Kathleen B.M and Cook, Linda S and Cox, Angela and Cramer, Daniel and Cross, Simon and Cybulski, Cezary and Czene, Kamila and Daly, Mary B and Damiola, Francesca and Dansonka-Mieszkowska, Agnieszka and Darabi, Hatef and Dennis, Joe and Devilee, Peter and Díez, Orland and Doherty, Jennifer A and Domchek, Susan and Dorfling, Cecilia and Dörk, Thilo and Dumont, Martine and Ehrencrona, Hans and Ejlertsen, Bent and Ellis, Steve and Engel, Christoph and Lee, Eunjung and Evans, D.G and Fasching, Peter and Feliubadaló, L and Figueroa, Jonine and Flesch-Janys, Dieter and Fletcher, Olivia and Flyger, Henrik and Foretova, Lenka and Fostira, Florentia and Foulkes, William and Fridley, Brooke and Friedman, Eitan and Frost, Debra and Gambino, G and Ganz, Patricia A and Garber, Judy and García-Closas, Montserrat and Gentry-Maharaj, Aleksana and Ghoussaini, Maya and Giles, Graham and Glasspool, Rosalind and Godwin, Anew K and Goldberg, Mark and Goldgar, David and González-Neira, Anna and Goode, Ellen and ... and KConFab Investigators and Australian Ovarian Canc Study Grp and GEMO Study Collaborators and EMBRACE and Hereditary Breast & Ovarian Canc R and Australian Ovarian Cancer Study Group and Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON) and The Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON) and Medicinska fakulteten and Region Östergötland and Linköpings universitet and Institutionen för klinisk och experimentell medicin and Diagnostikcentrum and Klinisk patologi och klinisk genetik and Avdelningen för cellbiologi
Nature Communications, ISSN 2041-1723, 09/2016, Volume 7, Issue 1, p. 12675
Journal Article
by Antoniou, Antonis C and Sinilnikova, Olga M and McGuffog, Lesley and Healey, Sue and Nevanlinna, Heli and Heikkinen, Tuomas and Simard, Jacques and Spurdle, Amanda B and Beesley, Jonathan and Chen, Xiaoqing and Neuhausen, Susan L and Ding, Yuan C and Couch, Fergus J and Wang, Xianshu and Fredericksen, Zachary and Peterlongo, Paolo and Peissel, Bernard and Bonanni, Bernardo and Viel, Alessana and Bernard, Loris and Radice, Paolo and Szabo, Csilla I and Foretova, Lenka and Zikan, Michal and Claes, Kathleen and Greene, Mark H and Mai, Phuong L and Rennert, Gad and Lejbkowicz, Flavio and Anulis, Irene L and Ozcelik, Hilmi and Glendon, Gord and Gerdes, Anne-Marie and Thomassen, Mads and Sunde, Lone and Caligo, Maria A and Laitman, Yael and Kontorovich, Tair and Cohen, Shimrit and Kaufman, Bella and Dagan, Efrat and Baruch, Ruth Gershoni and Friedman, Eitan and Harbst, Katja and Barbany-Bustinza, Gisela and Rantala, Johanna and Ehrencrona, Hans and Karlsson, Per and Domchek, Susan M and Nathanson, Katherine L and Osorio, Ana and Blanco, Ignacio and Lasa, Aiana and Beniez, Javier and Hamann, Ute and Hogervorst, Frans B. L and Rookus, Matti A and Collee, J. Margriet and Devilee, Peter and Ligtenberg, Marjolijn J and van der Luijt, Rob B and Aalfs, Cora M and Waisfisz, Quinten and Wijnen, Juul and van Roozendaal, Cornelis E. P and Peock, Susan and Cook, Margaret and Frost, Debra and Oliver, Clare and Platte, Radka and Evans, D. Gareth and Lalloo, Fiona and Eeles, Rosalind and Izatt, Louise and Davidson, Rosemarie and Chu, Carol and Eccles, Diana and Cole, Trevor and Hodgson, Shirley and Godwin, Anew K and Stoppa-Lyonnet, Dominique and Buecher, Bruno and Leone, Melanie and Bressac-de Paillerets, Brigitte and Remenieras, Auey and Caron, Olivier and Lenoir, Gilbert M and Sevenet, Nicolas and Longy, Michel and Ferrer, Sana Fert and Prieur, Fabienne and Goldgar, David and Miron, Alexander and John, Esther M and Buys, Sauna S and Daly, Mary B and Hopper, John L and Terry, Mary Beth and Yassin, Yosuf and Singer, Christian and ... and Kathleen Cuningham Fdn Consortium and EMBRACE and CIMBA and GEMO and HEBON and Breast Canc Family Registry and OCGN and Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer and Breast Cancer Family Registry
Human molecular genetics, ISSN 0964-6906, 2009, Volume 18, Issue 22, pp. 4442 - 4456
Genome-wide association studies of breast cancer have identified multiple single nucleotide polymorphisms (SNPs) that are associated with increased breast... 
POPULATION | ALLELES | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUSCEPTIBILITY | GENETICS & HEREDITY | OVARIAN-CANCER | EXPRESSION | ESTROGEN-RECEPTOR | GENOME-WIDE ASSOCIATION | Chromosomes, Human, Pair 8 - genetics | Genetics, Population | Genetic Predisposition to Disease | Genome-Wide Association Study | Follow-Up Studies | Humans | Middle Aged | Genetic Variation | Young Adult | BRCA1 Protein - genetics | Chromosomes, Human, Pair 2 - genetics | Breast Neoplasms - genetics | Aged, 80 and over | Adult | Female | Heterozygote | Aged | Polymorphism, Single Nucleotide | Mutation | Microfilament Proteins - genetics | BRCA2 Protein - genetics | Association Studies | Pair 2 | Medical and Health Sciences | single nucleotide polymorphism | genetic association | heterozygote | Breast Neoplasms | 80 and over | Biochemistry and Molecular Biology | Genetics | Chromosomes | Pair 8 | Biological Sciences | BRCA1 protein | article | Clinical Medicine | Naturvetenskap | adult | unclassified drug | Medicin och hälsovetenskap | Klinisk medicin | Single Nucleotide | Population | Natural Sciences | priority journal | human | BRCA2 protein | gene mutation | aged | breast cancer | protein LSP1 | controlled study | Biokemi och molekylärbiologi | Microfilament Proteins | Biologiska vetenskaper | allele | cancer risk | Cancer and Oncology | oncoprotein | Cancer och onkologi | Polymorphism
Journal Article
by Antoniou, Antonis C and Kartsonaki, Christiana and Sinilnikova, Olga M and Soucy, Penny and McGuffog, Lesley and Healey, Sue and Lee, Anew and Peterlongo, Paolo and Manoukian, Siranoush and Peissel, Bernard and Zaffaroni, Daniela and Cattaneo, Elisa and Barile, Monica and Pensotti, Valeria and Pasini, Barbara and Dolcetti, Riccardo and Giannini, Giuseppe and Putignano, Anna Laura and Varesco, Liliana and Radice, Paolo and Mai, Phuong L and Greene, Mark H and Anulis, Irene L and Glendon, Gord and Ozcelik, Hilmi and Thomassen, Mads and Gerdes, Anne-Marie and Kruse, Torben A and Birk Jensen, Uffe and Crüger, Dorthe G and Caligo, Maria A and Laitman, Yael and Milgrom, Roni and Kaufman, Bella and Paluch-Shimon, Shani and Friedman, Eitan and Loman, Niklas and Harbst, Katja and Lindblom, Annika and Arver, Brita and Ehrencrona, Hans and Melin, Beatrice and Nathanson, Katherine L and Domchek, Susan M and Rebbeck, Timothy and Jakubowska, Ania and Lubinski, Jan and Gronwald, Jacek and Huzarski, Tomasz and Byrski, Tomasz and Cybulski, Cezary and Gorski, Bohdan and Osorio, Ana and Ramón Y Cajal, Teresa and Fostira, Florentia and Anés, Raquel and Benitez, Javier and Hamann, Ute and Hogervorst, Frans B and Rookus, Matti A and Hooning, Maartje J and Nelen, Marcel R and van der Luijt, Rob B and van Os, Theo A. M and van Asperen, Christi J and Devilee, Peter and Meijers-Heijboer, Hanne E. J and Gómez Garcia, Encarna B and Peock, Susan and Cook, Margaret and Frost, Debra and Platte, Radka and Leyland, Jean and Evans, D. Gareth and Lalloo, Fiona and Eeles, Ros and Izatt, Louise and Adlard, Julian and Davidson, Rosemarie and Eccles, Diana and Ong, Kai-Ren and Cook, Jackie and Douglas, Fiona and Paterson, Joan and Kennedy, M. John and Miedzybrodzka, Zosia and Godwin, Anew and Stoppa-Lyonnet, Dominique and Buecher, Bruno and Belotti, Muriel and Tirapo, Carole and Mazoyer, Sylvie and Barjhoux, Laure and Lasset, Christine and Leroux, Dominique and Faivre, Laurence and Bronner, Myriam and Prieur, Fabienne and Nogues, Catherine and Rouleau, Etienne and ... and kConFab Investigators and EMBRACE and CEMO Study Collaborators and CIMBA and HEBON and Breast Canc Family Registry and SWE-BRCA and Breast Cancer Family Registry and kConFab investigators and on behalf of CIMBA and Medicinska fakulteten and Institutionen för strålningsvetenskaper and Onkologi and Umeå universitet
Human molecular genetics, ISSN 0964-6906, 2011, Volume 20, Issue 16, pp. 3304 - 3321
Journal Article