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by Dickinson, Mary E and Flenniken, Ann M and Ji, Xiao and Teboul, Lydia and Wong, Michael D and White, Jacqueline K and Meehan, Terrence F and Weninger, Wolfgang J and Westerberg, Henrik and Adissu, Hibret and Baker, Candice N and Bower, Lynette and Brown, James M and Brianna Caddle, L and Chiani, Francesco and Clary, Dave and Cleak, James and Daly, Mark J and Denegre, James M and Doe, Brendan and Dolan, Mary E and Edie, Sarah M and Fuchs, Helmut and Gailus-Durner, Valerie and Galli, Antonella and Gambadoro, Alessia and Gallegos, Juan and Guo, Shiying and Horner, Neil R and Hsu, Chih-wei and Johnson, Sara J and Kalaga, Sowmya and Keith, Lance C and Lanoue, Louise and Lawson, Thomas N and Lek, Monkol and Mark, Manuel and Marschall, Susan and Mason, Jeremy and McElwee, Melissa L and Newbigging, Susan and Nutter, Lauryl M.J and Peterson, Kevin A and Ramirez-Solis, Ramiro and Rowland, Douglas J and Ryder, Edward and Samocha, Kaitlin E and Seavitt, John R and Selloum, Mohammed and Szoke-Kovacs, Zsombor and Tamura, Masaru and Trainor, Amanda G and Tudose, Ilinca and Wakana, Shigeharu and Warren, Jonathan and Wendling, Olivia and West, David B and Wong, Leeyean and Yoshiki, Atsushi and MacArthur, Daniel G and Tocchini-Valentini, Glauco P and Gao, Xiang and Flicek, Paul and Bradley, Allan and Skarnes, William C and Justice, Monica J and Parkinson, Helen E and Moore, Mark and Wells, Sara and Braun, Robert E and Svenson, Karen L and Hrabe de Angelis, Martin and Herault, Yann and Mohun, Tim and Mallon, Ann-Marie and Mark Henkelman, R and Brown, Steve D.M and Adams, David J and Kent Lloyd, K.C and McKerlie, Colin and Beaudet, Arthur L and Bucan, Maja and Murray, Stephen A and McKay, Matthew and Urban, Barbara and Lund, Caroline and Froeter, Erin and LaCasse, Taylor and Mehalow, Adrienne and Gordon, Emily and Donahue, Leah Rae and Taft, Robert and Kutney, Peter and Dion, Stephanie and Goodwin, Leslie and Kales, Susan and Urban, Rachel and Palmer, Kristina and Pertuy, Fabien and Bitz, Deborah and ... and Int Mouse Phenotyping Consortium and The International Mouse Phenotyping Consortium
Nature, ISSN 0028-0836, 09/2016, Volume 537, Issue 7621, pp. 508 - 514
Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting from knockouts of these genes in mice have provided tremendous... 
MICRO-CT | MULTIDISCIPLINARY SCIENCES | DISEASE | GENOME-WIDE | MAMMALIAN GENE-FUNCTION | SCREENS | GLYCOGENIN-1 DEFICIENCY | IDENTIFICATION | EXPRESSION | MOUSE EMBRYO | RESOURCE | Genetic research | Phenotype | Research | High-throughput screening (Biochemical assaying) | Methods | Genotype & phenotype | Disease | Developmental biology | Genes | Genomes | Mutation | Embryos | Index Medicus | knockout | embryonic lethal | mouse | KOMP | IMPC | EUCOMM
Journal Article
by Mavaddat, Nasim and Michailidou, Kyriaki and Dennis, Joe and Lush, Michael and Fachal, Laura and Lee, Andrew and Lee, Eunjung and Tyrer, Jonathan P and Chen, Ting-Huei and Wang, Qin and Bolla, Manjeet K and Yang, Xin and Yang, Xiaohong R and Adank, Muriel A and Ahearn, Thomas and Aittomäki, Kristiina and Allen, Jamie and Andrulis, Irene L and Anton-Culver, Hoda and Antonenkova, Natalia N and Arndt, Volker and Aronson, Kristan J and Auer, Paul L and Auvinen, Päivi and Barrdahl, Myrto and Beane Freeman, Laura E and Beckmann, Matthias W and Behrens, Sabine and Benitez, Javier and Bermisheva, Marina and Bernstein, Leslie and Blomqvist, Carl and Bogdanova, Natalia V and Bojesen, Stig E and Bonanni, Bernardo and Børresen-Dale, Anne-Lise and Brauch, Hiltrud and Bremer, Michael and Brenner, Hermann and Brentnall, Adam and Brock, Ian W and Brooks-Wilson, Angela and Brucker, Sara Y and Brüning, Thomas and Burwinkel, Barbara and Campa, Daniele and Carter, Brian D and Castelao, Jose E and Chanock, Stephen J and Chlebowski, Rowan and Christiansen, Hans and Clarke, Christine L and Collée, J. Margriet and Cordina-Duverger, Emilie and Cornelissen, Sten and Couch, Fergus J and Cox, Angela and Cross, Simon S and Czene, Kamila and Daly, Mary B and Devilee, Peter and Dörk, Thilo and dos-Santos-Silva, Isabel and Dumont, Martine and Durcan, Lorraine and Dwek, Miriam and Eccles, Diana M and Ekici, Arif B and Eliassen, A. Heather and Ellberg, Carolina and Engel, Christoph and Eriksson, Mikael and Evans, D. Gareth and Fasching, Peter A and Figueroa, Jonine and Fletcher, Olivia and Flyger, Henrik and Försti, Asta and Fritschi, Lin and Gabrielson, Marike and Gago-Dominguez, Manuela and Gapstur, Susan M and García-Sáenz, José A and Gaudet, Mia M and Georgoulias, Vassilios and Giles, Graham G and Gilyazova, Irina R and Glendon, Gord and Goldberg, Mark S and Goldgar, David E and González-Neira, Anna and Grenaker Alnæs, Grethe I and Grip, Mervi and Gronwald, Jacek and Grundy, Anne and Guénel, Pascal and Haeberle, Lothar and Hahnen, Eric and Haiman, Christopher A and Håkansson, Niclas and ... and kConFab AOCS Investigators and ABCTB Investigators and NBCS Collaborators and kConFab/AOCS Investigators
The American Journal of Human Genetics, ISSN 0002-9297, 01/2019, Volume 104, Issue 1, pp. 21 - 34
Stratification of women according to their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and prevention strategies. Our... 
genetic | epidemiology | score | screening | stratification | polygenic | prediction | cancer | risk | breast | FUNCTIONAL VARIANTS | WOMEN | MODELS | SHRINKAGE | PROSTATE-CANCER | SUSCEPTIBILITY | GENETICS & HEREDITY | LOCUS | GENOME-WIDE ASSOCIATION | Prevention | Usage | Genetic susceptibility | Breast cancer | Genetic aspects | Research | Risk factors | Genetic screening
Journal Article
Lancet, The, ISSN 0140-6736, 2010, Volume 376, Issue 9747, pp. 1155 - 1163
Journal Article
by Mocroft, Amanda and Lundgren, Jens D and Ross, Michael and Law, Matthew and Reiss, Peter and Kirk, Ole and Smith, Colette and Wentworth, Deborah and Neuhaus, Jacqueline and Fux, Christoph A and Moranne, Olivier and Morlat, Phillipe and Johnson, Margaret A and Ryom, Lene and Lundgren, J. D and Powderly, B and Shortman, N and Moecklinghoff, C and Reilly, G and Franquet, X and Sabin, C. A and Phillips, A and Kirk, O and Weber, R and Pradier, C and Law, M and d'Arminio Monforte, A and Dabis, F and El-Sa, W. M and de Wit, S and Ryom, L and Kamara, D and Smith, C and Mocroft, A and Tverland, J and Mansfeld, M and Nielsen, J and Raben, D and Salbøl Brandt, R and Rickenbach, M and Fanti, I and Krum, E and Hillebregt, M and Geffard, S and Sundström, A and Delforge, M and Fontas, E and Torres, F and McManus, H and Wright, S and Kjær, J and Sjøl, A and Meidahl, P and Helweg-Larsen, J and Schmidt Iversen, J and Ross, M and Fux, C. A and Morlat, P and Moranne, O and Kesselring, A. M and Kamara, D. A and Friis-Møller, N and Kowalska, J and Sabin, C and Bruyand, M and Bower, M and Fätkenheuer, G and Donald, A and Grulich, A and Prins, J. M and Kuijpers, T. W and Scherpbier, H. J and van der Meer, J. T. M and Wit, F. W. M. N and Godfried, M. H and van der Poll, T and Nellen, F. J. B and Geerlings, S. E and van Vugt, M and Pajkrt, D and Bos, J. C and Wiersinga, W. J and van der Valk, M and Goorhuis, A and Hovius, J. W and van Eden, J and Henderiks, A and van Hes, A. M. H and Mutschelknauss, M and Nobel, H. E and Pijnappel, F. J. J and Westerman, A. M and Jurriaans, S and Back, N. K. T and Zaaijer, H. L and Berkhout, B and Cornelissen, M. T. E and Schinkel, C. J and Thomas, X. V and de Ruyter Ziekenhuis, Admiraal and ... and Royal Free Hosp Clin Cohort and INSIGHT Study Grp and DAD Study Grp and SMART Study Grp and ESPRIT Study Grp and D:A:D study group and Royal Free Hospital Clinic Cohort and SMART study group and INSIGHT study group and ESPRIT study group and D:A:D study group, the Royal Free Hospital Clinic Cohort, and the INSIGHT, SMART, and ESPRIT study groups
PLoS medicine, ISSN 1549-1277, 2015, Volume 12, Issue 3, pp. e1001809 - e1001809
Journal Article