X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (1739) 1739
Publication (122) 122
Patent (49) 49
Book Chapter (26) 26
Conference Proceeding (26) 26
Book Review (13) 13
Book / eBook (12) 12
Dissertation (7) 7
Magazine Article (6) 6
Data Set (3) 3
Paper (2) 2
Newspaper Article (1) 1
Report (1) 1
Trade Publication Article (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (492) 492
female (290) 290
male (289) 289
index medicus (242) 242
middle aged (205) 205
adult (193) 193
animals (174) 174
aged (132) 132
surgery (121) 121
analysis (83) 83
ophthalmology (67) 67
adolescent (66) 66
research (64) 64
gastroenterology & hepatology (53) 53
meteorology & atmospheric sciences (53) 53
multidisciplinary sciences (52) 52
transplantation (52) 52
time factors (48) 48
aged, 80 and over (47) 47
cats (47) 47
child (47) 47
electroencephalography (47) 47
microbiology (46) 46
chemistry (45) 45
treatment outcome (43) 43
environmental sciences (42) 42
follow-up studies (42) 42
mice (41) 41
biochemistry & molecular biology (40) 40
neurosciences (40) 40
retrospective studies (40) 40
geosciences, multidisciplinary (39) 39
clinical neurology (37) 37
microbiota (37) 37
further section (34) 34
kidney transplantation (34) 34
rats (34) 34
carbon (33) 33
medicine & public health (33) 33
research article (33) 33
management (32) 32
medicine (32) 32
diagnosis (31) 31
ecology (31) 31
forests (31) 31
prognosis (31) 31
article (30) 30
cancer (30) 30
climate (30) 30
emissions (30) 30
molecular sequence data (30) 30
mortality (30) 30
risk factors (30) 30
tropical forests (29) 29
amino acid sequence (28) 28
identification (28) 28
metallurgy (28) 28
organic chemistry (28) 28
human necessities (27) 27
carbon dioxide (26) 26
cell biology (26) 26
climate change (26) 26
heterocyclic compounds (26) 26
methods (26) 26
studies (26) 26
biochemistry (25) 25
expression (25) 25
models (25) 25
oncology (25) 25
probiotics (25) 25
proteins (25) 25
acute disease (24) 24
bacteria (24) 24
fluxes (24) 24
immunology (24) 24
science (24) 24
survival (24) 24
genetics & heredity (23) 23
model (23) 23
mutation (23) 23
switzerland (23) 23
trees (23) 23
genetic aspects (22) 22
health aspects (22) 22
phylogeny (22) 22
rabbits (22) 22
seizures - chemically induced (22) 22
co2 (21) 21
forestry (21) 21
genetics (21) 21
growth (21) 21
medical research (21) 21
physics (21) 21
young adult (21) 21
acute necrotizing pancreatitis (20) 20
agriculture (20) 20
biology (20) 20
biomass (20) 20
child, preschool (20) 20
kidney transplantation - immunology (20) 20
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
UTL at Downsview - May be requested (4) 4
Robarts - Stacks (3) 3
Gerstein Science - Stacks (2) 2
Architecture Landscape (Shore + Moffat) - Stacks (1) 1
Business (Joseph L Rotman) - Stacks (1) 1
Collection Dvlpm't (Acquisitions) - Closed Orders (1) 1
Mathematical Sciences - Stacks (1) 1
Online Resources - Online (1) 1
UofT at Mississauga - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (1448) 1448
German (391) 391
French (27) 27
Spanish (9) 9
Portuguese (6) 6
Danish (2) 2
Chinese (1) 1
Swedish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
Nature, ISSN 0028-0836, 03/2010, Volume 464, Issue 7287, pp. 431 - 435
Activating mutations in KRAS and BRAF are found in more than 30% of all human tumours and 40% of melanoma, respectively, thus targeting this pathway could have... 
SELECTIVE INHIBITOR | POTENT | EFFICACY | MECHANISM | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | KINASE | C-RAF | B-RAF | MUTATIONS | PROTEINS | Neoplasms - metabolism | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Diphenylamine - pharmacology | raf Kinases - antagonists & inhibitors | Humans | Protein Multimerization | ras Proteins - metabolism | Protein Transport - drug effects | Extracellular Signal-Regulated MAP Kinases - metabolism | raf Kinases - metabolism | Diphenylamine - analogs & derivatives | Mitogen-Activated Protein Kinase Kinases - metabolism | Adenosine Triphosphate - metabolism | Indoles - pharmacology | Benzamides - pharmacology | Cell Membrane - metabolism | raf Kinases - genetics | Cell Membrane - drug effects | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Pyrazoles - pharmacology | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Line | Indenes - pharmacology | raf Kinases - chemistry | Proto-Oncogene Proteins c-raf - genetics | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Neoplasms - enzymology | Proto-Oncogene Proteins - genetics | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Proto-Oncogene Proteins c-raf - metabolism | Neoplasms - drug therapy | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Proto-Oncogene Proteins c-raf - deficiency | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Neoplasms - pathology | Ras genes | Growth | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Mitogen-activated protein kinases | Competition | Clinical trials | Enzymes | Kinases | Proteins | Cellular | Inhibitors | Pathways | Tumours | Signalling | Dimerization
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2012, Volume 55, Issue 6, pp. 2869 - 2881
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 09/2011, Volume 21, Issue 18, pp. 5533 - 5537
Structure-activity relationships around a novel series of B-Raf(V600E) inhibitors are reported. The enzymatic and cellular potencies of inhibitors derived from... 
ACTIVATION | DESIGN | CHEMISTRY, MEDICINAL | Pyrrolopyridine | CHEMISTRY, ORGANIC | KINASE INHIBITORS | BRAF | Pyrazolopyridine | DISCOVERY | POTENT | B-Raf(V600E) | PATHWAY | Structure-activity relationship | B-RAF | MUTATIONS
Journal Article
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 09/2011, Volume 21, Issue 18, pp. 5533 - 5537
Structure-activity relationships around a novel series of B-Raf inhibitors are reported. The enzymatic and cellular potencies of inhibitors derived from two... 
Pyrrolopyridine | Structure-activity relationship | B-Raf | Pyrazolopyridine
Journal Article
Current Opinion in Organ Transplantation, ISSN 1087-2418, 08/2010, Volume 15, Issue 4, pp. 451 - 455
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 01/2012, Volume 22, Issue 2, pp. 912 - 915
A single crystal was obtained of a lead B-Raf inhibitor with low aqueous solubility. The X-ray crystal structure revealed hydrogen-bonded head-to-tail dimers... 
Single-crystal X-ray | Crystal packing | Aqueous solubility | Crystal lattice energy | B-Raf
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 05/2011, Volume 2, Issue 5, pp. 342 - 347
The V600E mutation of B-Raf kinase results in constitutive activation of the MAPK signaling pathway and is present in approximately 7% of all cancers. Using... 
MAPK pathway | targeted therapy | pyrazolopyridine | B-Raf | amorphous spray-dried dispersion
Journal Article
Biogeosciences, ISSN 1726-4170, 2012, Volume 9, Issue 8, pp. 3381 - 3403
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 05/2012, Volume 22, Issue 10, pp. 3387 - 3391
Herein we describe the discovery of a novel series of ATP competitive B-Raf inhibitors via structure based drug design (SBDD). These pyridopyrimidin-7-one... 
METASTATIC MELANOMA | ACTIVATION | CHEMISTRY, MEDICINAL | Kinase | PATHWAY | BRAF MUTATIONS | Pyridopyrimidin-7-one | CHEMISTRY, ORGANIC | PYRAZOLOPYRIDINE INHIBITORS | B-Raf | Drug discovery | Structure based drug design
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 10/2012, Volume 22, Issue 19, pp. 6237 - 6241
Cell potent inhibitors of B-Raf that bind to the kinase in the DFG-out conformation are reported. These compounds utilize the hinge-binding group and... 
Inactive conformation | Structure-based design | B-RafV600E | DFG-out | Kinase selectivity | B-Raf | Indexing in process
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 05/2012, Volume 22, Issue 10, pp. 3387 - 3391
Herein we describe the discovery of a novel series of ATP competitive B-Raf inhibitors via structure based drug design (SBDD). These pyridopyrimidin-7-one... 
Kinase | Pyridopyrimidin-7-one | B-Raf | Drug discovery | Structure based drug design
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 04/2014, Volume 24, Issue 8, pp. 1923 - 1927
Herein we describe the design of a novel series of ATP competitive B-Raf inhibitors via structure-based methods. These 3- -methylquinazoline-4( )-one based... 
Melonoma | Type IIB inhibitor | B-Raf inhibitors | Kinase drug discovery
Journal Article
No results were found for your search.

Cannot display more than 1000 results, please narrow the terms of your search.