The Lancet, ISSN 0140-6736, 02/2018, Volume 391, Issue 10121, pp. 668 - 678
bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would...
MEDICINE, GENERAL & INTERNAL | INFECTIONS | THERAPY | CLINICAL MANAGEMENT | Staphylococcal Infections - drug therapy | Double-Blind Method | Drug Administration Schedule | Administration, Oral | Humans | Middle Aged | Bacteremia - drug therapy | Male | Antibiotics, Antitubercular - pharmacology | Cross Infection - drug therapy | Bacteremia - microbiology | Administration, Intravenous | Community-Acquired Infections - drug therapy | Treatment Failure | Female | Aged | Rifampin - administration & dosage | Rifampin - pharmacology | Antibiotics, Antitubercular - administration & dosage | Bacterial infections | Mortality | Clinical trials | Staphylococcus infections | Systematic review | Metastasis | Bacteremia | Studies | Antibiotics | Technology assessment | Endocarditis | Nosocomial infections | Rifampin
MEDICINE, GENERAL & INTERNAL | INFECTIONS | THERAPY | CLINICAL MANAGEMENT | Staphylococcal Infections - drug therapy | Double-Blind Method | Drug Administration Schedule | Administration, Oral | Humans | Middle Aged | Bacteremia - drug therapy | Male | Antibiotics, Antitubercular - pharmacology | Cross Infection - drug therapy | Bacteremia - microbiology | Administration, Intravenous | Community-Acquired Infections - drug therapy | Treatment Failure | Female | Aged | Rifampin - administration & dosage | Rifampin - pharmacology | Antibiotics, Antitubercular - administration & dosage | Bacterial infections | Mortality | Clinical trials | Staphylococcus infections | Systematic review | Metastasis | Bacteremia | Studies | Antibiotics | Technology assessment | Endocarditis | Nosocomial infections | Rifampin
Journal Article
Lancet, The, ISSN 0140-6736, 2012, Volume 379, Issue 9827, pp. 1705 - 1711
Summary Background Prospective assessment of pharmacogenetic strategies has been limited by an inability to undertake bedside genetic testing. The CYP2C19*2...
Internal Medicine | MEDICINE, GENERAL & INTERNAL | CYP2C19 GENOTYPE | POLYMORPHISMS | RESIDUAL PLATELET REACTIVITY | CARDIOVASCULAR EVENTS | STENT THROMBOSIS | ACUTE CORONARY SYNDROMES | PRASUGREL | CLOPIDOGREL-TREATED PATIENTS | INTERVENTION | CLINICAL-OUTCOMES | Prasugrel Hydrochloride | Thiophenes - therapeutic use | Genetic Testing | Ticlopidine - therapeutic use | Humans | Middle Aged | Aryl Hydrocarbon Hydroxylases - genetics | Male | Loss of Heterozygosity | Angioplasty, Balloon, Coronary | Ticlopidine - adverse effects | Female | Platelet Aggregation - drug effects | Platelet Aggregation Inhibitors - therapeutic use | Purinergic P2Y Receptor Antagonists - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Precision Medicine | Pharmacogenetics | Genotype | Piperazines - therapeutic use | Ticlopidine - analogs & derivatives | Point-of-Care Systems | Cytochrome P-450 CYP2C19 | Acute Coronary Syndrome - therapy | Aged | Genetic Carrier Screening | Aggregation | Usage | Dosage and administration | Research | Blood platelets | Genetic screening | Studies | Medical research | Cardiovascular disease | Genetics | Heart attacks
Internal Medicine | MEDICINE, GENERAL & INTERNAL | CYP2C19 GENOTYPE | POLYMORPHISMS | RESIDUAL PLATELET REACTIVITY | CARDIOVASCULAR EVENTS | STENT THROMBOSIS | ACUTE CORONARY SYNDROMES | PRASUGREL | CLOPIDOGREL-TREATED PATIENTS | INTERVENTION | CLINICAL-OUTCOMES | Prasugrel Hydrochloride | Thiophenes - therapeutic use | Genetic Testing | Ticlopidine - therapeutic use | Humans | Middle Aged | Aryl Hydrocarbon Hydroxylases - genetics | Male | Loss of Heterozygosity | Angioplasty, Balloon, Coronary | Ticlopidine - adverse effects | Female | Platelet Aggregation - drug effects | Platelet Aggregation Inhibitors - therapeutic use | Purinergic P2Y Receptor Antagonists - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Precision Medicine | Pharmacogenetics | Genotype | Piperazines - therapeutic use | Ticlopidine - analogs & derivatives | Point-of-Care Systems | Cytochrome P-450 CYP2C19 | Acute Coronary Syndrome - therapy | Aged | Genetic Carrier Screening | Aggregation | Usage | Dosage and administration | Research | Blood platelets | Genetic screening | Studies | Medical research | Cardiovascular disease | Genetics | Heart attacks
Journal Article
Cancer Research, ISSN 0008-5472, 01/2013, Volume 73, Issue 1, pp. 285 - 296
textabstractKinases are dysregulated in most cancers, but the frequency of specific kinase mutations is low, indicating a complex etiology in kinase...
ACTIVATING MUTATION | POLYCYTHEMIA-VERA | MYELOPROLIFERATIVE DISORDERS | ONCOLOGY | TYROSINE KINASE | ACUTE LYMPHOBLASTIC-LEUKEMIA | CHRONIC LYMPHOCYTIC-LEUKEMIA | FOLLOW-UP | ACUTE MYELOID-LEUKEMIA | MYELODYSPLASTIC SYNDROME | CHRONIC MYELOMONOCYTIC LEUKEMIA | Drug Resistance, Neoplasm - genetics | Protein-Tyrosine Kinases - genetics | Algorithms | Humans | Leukemia - enzymology | Gene Expression Profiling - methods | Signal Transduction - genetics | Leukemia - genetics | Cluster Analysis | AML | ALL | CLL | CML | CMML | MPN | molecular diagnosis | personalized medicine
ACTIVATING MUTATION | POLYCYTHEMIA-VERA | MYELOPROLIFERATIVE DISORDERS | ONCOLOGY | TYROSINE KINASE | ACUTE LYMPHOBLASTIC-LEUKEMIA | CHRONIC LYMPHOCYTIC-LEUKEMIA | FOLLOW-UP | ACUTE MYELOID-LEUKEMIA | MYELODYSPLASTIC SYNDROME | CHRONIC MYELOMONOCYTIC LEUKEMIA | Drug Resistance, Neoplasm - genetics | Protein-Tyrosine Kinases - genetics | Algorithms | Humans | Leukemia - enzymology | Gene Expression Profiling - methods | Signal Transduction - genetics | Leukemia - genetics | Cluster Analysis | AML | ALL | CLL | CML | CMML | MPN | molecular diagnosis | personalized medicine
Journal Article
Nature, ISSN 0028-0836, 10/2018, Volume 562, Issue 7728, pp. 526 - 531
The implementation of targeted therapies for acute myeloid leukaemia (AML) has been challenging because of the complex mutational patterns within and across...
AML | INTERNAL TANDEM DUPLICATION | PHARMACOKINETICS | TET2 MUTATIONS | CLONAL HEMATOPOIESIS | FLT3 INHIBITOR | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | TRANS-RETINOIC ACID | MYELODYSPLASTIC SYNDROME | CANCER | Datasets as Topic | Genomics | Humans | Leukemia, Myeloid, Acute - metabolism | Repressor Proteins - genetics | Male | Proto-Oncogene Proteins - genetics | Molecular Targeted Therapy | Serine-Arginine Splicing Factors - genetics | Genome, Human - genetics | DNA (Cytosine-5-)-Methyltransferases - genetics | Exome - genetics | Sequence Analysis, RNA | Leukemia, Myeloid, Acute - drug therapy | Female | Nuclear Proteins - genetics | Core Binding Factor Alpha 2 Subunit - genetics | Gene Expression Regulation, Neoplastic - genetics | Leukemia, Myeloid, Acute - genetics | RNA sequencing | Medical research | Usage | Gene mutations | Myelocytic leukemia | Medicine, Experimental | Genetic aspects | Nonlymphoid leukemia | Research | Discriminant analysis | Sensitivity analysis | Leukemia | Principal components analysis | Pharmacology | Genomes | Gene expression | Kinases | Ribonucleic acid--RNA | Patients | Generalized linear models | Gene sequencing | Sensitivity | Mutation | Bioinformatics | Combinatorial analysis | Cancer | Tumors
AML | INTERNAL TANDEM DUPLICATION | PHARMACOKINETICS | TET2 MUTATIONS | CLONAL HEMATOPOIESIS | FLT3 INHIBITOR | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | TRANS-RETINOIC ACID | MYELODYSPLASTIC SYNDROME | CANCER | Datasets as Topic | Genomics | Humans | Leukemia, Myeloid, Acute - metabolism | Repressor Proteins - genetics | Male | Proto-Oncogene Proteins - genetics | Molecular Targeted Therapy | Serine-Arginine Splicing Factors - genetics | Genome, Human - genetics | DNA (Cytosine-5-)-Methyltransferases - genetics | Exome - genetics | Sequence Analysis, RNA | Leukemia, Myeloid, Acute - drug therapy | Female | Nuclear Proteins - genetics | Core Binding Factor Alpha 2 Subunit - genetics | Gene Expression Regulation, Neoplastic - genetics | Leukemia, Myeloid, Acute - genetics | RNA sequencing | Medical research | Usage | Gene mutations | Myelocytic leukemia | Medicine, Experimental | Genetic aspects | Nonlymphoid leukemia | Research | Discriminant analysis | Sensitivity analysis | Leukemia | Principal components analysis | Pharmacology | Genomes | Gene expression | Kinases | Ribonucleic acid--RNA | Patients | Generalized linear models | Gene sequencing | Sensitivity | Mutation | Bioinformatics | Combinatorial analysis | Cancer | Tumors
Journal Article
2014, ISBN 1849285802
Web Resource
2014, ISBN 1849285802
Web Resource
Journal of Physician Assistant Education, ISSN 1941-9430, 2018, Volume 29, Issue 2, pp. 129 - 131
Journal Article
The Journal of Physiology, ISSN 0022-3751, 12/2008, Volume 586, Issue 24, pp. 6049 - 6061
We tested the hypothesis that increasing blood amino acid (AA) availability would counter the physical inactivity-induced reduction in muscle protein...
DISUSE ATROPHY | PROLONGED INACTIVITY | PHYSIOLOGY | LENGTHENING CONTRACTIONS | GENE-EXPRESSION | HUMAN QUADRICEPS MUSCLE | ATROPHY INVOLVE | BED REST | NEUROSCIENCES | HUMAN SKELETAL-MUSCLE | NUTRITION COUNTERMEASURES | TRANSLATIONAL CONTROL | Protein Kinases - metabolism | Humans | Elongation Factor 2 Kinase - metabolism | Glycogen Synthase Kinase 3 beta | Male | Amino Acids - administration & dosage | Amino Acids, Essential - metabolism | Insulin - blood | Amino Acids - pharmacology | Muscle Proteins - biosynthesis | Dose-Response Relationship, Drug | Young Adult | Amino Acids - metabolism | Ubiquitination - drug effects | Quadriceps Muscle - drug effects | Adult | Female | Immobilization - methods | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Myofibrils - drug effects | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Glycogen Synthase Kinase 3 - metabolism | Myofibrils - physiology | Quadriceps Muscle - physiology | Amino Acids, Essential - blood | Muscle Strength - drug effects | Myofibrils - metabolism | TOR Serine-Threonine Kinases | Infusions, Intravenous | Quadriceps Muscle - metabolism | Muscle Strength - physiology | Physiological aspects | Protein biosynthesis | Amino acids | Skeletal Muscle and Exercise
DISUSE ATROPHY | PROLONGED INACTIVITY | PHYSIOLOGY | LENGTHENING CONTRACTIONS | GENE-EXPRESSION | HUMAN QUADRICEPS MUSCLE | ATROPHY INVOLVE | BED REST | NEUROSCIENCES | HUMAN SKELETAL-MUSCLE | NUTRITION COUNTERMEASURES | TRANSLATIONAL CONTROL | Protein Kinases - metabolism | Humans | Elongation Factor 2 Kinase - metabolism | Glycogen Synthase Kinase 3 beta | Male | Amino Acids - administration & dosage | Amino Acids, Essential - metabolism | Insulin - blood | Amino Acids - pharmacology | Muscle Proteins - biosynthesis | Dose-Response Relationship, Drug | Young Adult | Amino Acids - metabolism | Ubiquitination - drug effects | Quadriceps Muscle - drug effects | Adult | Female | Immobilization - methods | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Myofibrils - drug effects | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Glycogen Synthase Kinase 3 - metabolism | Myofibrils - physiology | Quadriceps Muscle - physiology | Amino Acids, Essential - blood | Muscle Strength - drug effects | Myofibrils - metabolism | TOR Serine-Threonine Kinases | Infusions, Intravenous | Quadriceps Muscle - metabolism | Muscle Strength - physiology | Physiological aspects | Protein biosynthesis | Amino acids | Skeletal Muscle and Exercise
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 06/2009, Volume 360, Issue 26, pp. 2719 - 2729
Somatically acquired mutations, which contribute to tumorigenesis, are usually specific to tumor tissue. Sequencing of the whole transcriptome — the entire set...
MEDICINE, GENERAL & INTERNAL | GENE | TRANSCRIPTION FACTOR FOXL2 | IDENTIFICATION | EXPRESSION | CORD-STROMAL TUMORS | GENOME | BREAST | P53 | Granulosa Cell Tumor - diagnosis | Immunohistochemistry | Taq Polymerase | Ovarian Neoplasms - diagnosis | Granulosa Cell Tumor - genetics | Humans | Ovarian Neoplasms - pathology | Genotype | Gene Expression Profiling | Granulosa Cell Tumor - pathology | Genetic Markers | Mutation, Missense | Forkhead Transcription Factors - genetics | Ovarian Neoplasms - genetics | Point Mutation | Sequence Analysis, RNA | Base Sequence | Female | Forkhead Box Protein L2 | Causes of | Genetic aspects | Granulosa cell tumor | Research | Studies | Medical research | Data analysis | Ovarian cancer | Tumors
MEDICINE, GENERAL & INTERNAL | GENE | TRANSCRIPTION FACTOR FOXL2 | IDENTIFICATION | EXPRESSION | CORD-STROMAL TUMORS | GENOME | BREAST | P53 | Granulosa Cell Tumor - diagnosis | Immunohistochemistry | Taq Polymerase | Ovarian Neoplasms - diagnosis | Granulosa Cell Tumor - genetics | Humans | Ovarian Neoplasms - pathology | Genotype | Gene Expression Profiling | Granulosa Cell Tumor - pathology | Genetic Markers | Mutation, Missense | Forkhead Transcription Factors - genetics | Ovarian Neoplasms - genetics | Point Mutation | Sequence Analysis, RNA | Base Sequence | Female | Forkhead Box Protein L2 | Causes of | Genetic aspects | Granulosa cell tumor | Research | Studies | Medical research | Data analysis | Ovarian cancer | Tumors
Journal Article
Journal of General Internal Medicine, ISSN 0884-8734, 7/2019, Volume 34, Issue 7, pp. 1110 - 1112
Journal Article
Beilstein Journal of Nanotechnology, ISSN 2190-4286, 03/2018, Volume 9, Issue 1, pp. 945 - 952
This work presents data confirming the existence of a scan speed related phenomenon in contact-mode atomic force microscopy (AFM). Specifically,...
Liquid | Phenomenon | Contact resonance | Atomic force microscope | Scan speed | FRICTION | PHYSICS, APPLIED | FILM | MATERIALS SCIENCE, MULTIDISCIPLINARY | SILICON | AFM | NANOSCIENCE & NANOTECHNOLOGY | phenomenon | contact resonance | ACOUSTIC MICROSCOPY | liquid | SPECTROSCOPY | atomic force microscope | SURFACE | SCALE | scan speed | WATER | Viscoelasticity | Atomic force microscopy | Researchers | Atomic beam spectroscopy | Microscopy | Spectrum analysis | Humidity | Research | Microscopes | Velocity
Liquid | Phenomenon | Contact resonance | Atomic force microscope | Scan speed | FRICTION | PHYSICS, APPLIED | FILM | MATERIALS SCIENCE, MULTIDISCIPLINARY | SILICON | AFM | NANOSCIENCE & NANOTECHNOLOGY | phenomenon | contact resonance | ACOUSTIC MICROSCOPY | liquid | SPECTROSCOPY | atomic force microscope | SURFACE | SCALE | scan speed | WATER | Viscoelasticity | Atomic force microscopy | Researchers | Atomic beam spectroscopy | Microscopy | Spectrum analysis | Humidity | Research | Microscopes | Velocity
Journal Article
Nature Genetics, ISSN 1061-4036, 12/2016, Volume 48, Issue 12, pp. 1564 - 1569
Elevated basal serum tryptase levels are present in 4-6% of the general population, but the cause and relevance of such increases are unknown(1,2). Previously,...
JOINT HYPERMOBILITY | EPIDEMIOLOGY | GENETICS & HEREDITY | Connective Tissue Diseases - enzymology | Skin Diseases - genetics | Tryptases - blood | Dysautonomia, Familial - enzymology | Humans | Middle Aged | Male | Pruritus - genetics | Pruritus - enzymology | Skin Diseases - blood | Young Adult | Adult | Chronic Pain - enzymology | Female | Child | Tryptases - genetics | Chronic Pain - genetics | DNA Copy Number Variations - genetics | Gastrointestinal Diseases - enzymology | Dysautonomia, Familial - blood | Chronic Pain - blood | Pruritus - blood | Gastrointestinal Diseases - genetics | Adolescent | Gastrointestinal Diseases - blood | Aged | Connective Tissue Diseases - genetics | Connective Tissue Diseases - blood | Skin Diseases - enzymology | Dysautonomia, Familial - genetics | Studies | Genomes | Comorbidity | Genes | Genomics | Irritable bowel syndrome
JOINT HYPERMOBILITY | EPIDEMIOLOGY | GENETICS & HEREDITY | Connective Tissue Diseases - enzymology | Skin Diseases - genetics | Tryptases - blood | Dysautonomia, Familial - enzymology | Humans | Middle Aged | Male | Pruritus - genetics | Pruritus - enzymology | Skin Diseases - blood | Young Adult | Adult | Chronic Pain - enzymology | Female | Child | Tryptases - genetics | Chronic Pain - genetics | DNA Copy Number Variations - genetics | Gastrointestinal Diseases - enzymology | Dysautonomia, Familial - blood | Chronic Pain - blood | Pruritus - blood | Gastrointestinal Diseases - genetics | Adolescent | Gastrointestinal Diseases - blood | Aged | Connective Tissue Diseases - genetics | Connective Tissue Diseases - blood | Skin Diseases - enzymology | Dysautonomia, Familial - genetics | Studies | Genomes | Comorbidity | Genes | Genomics | Irritable bowel syndrome
Journal Article