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Nature Chemical Biology, ISSN 1552-4450, 07/2019, Volume 15, Issue 7, pp. 672 - 680
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 08/2019, Volume 116, Issue 32, pp. 15823 - 15829
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2019, Volume 62, Issue 2, pp. 699 - 726
Developing PROTACs to redirect the ubiquitination activity of E3 ligases and potently degrade a target protein within cells can be a lengthy and unpredictable... 
INDUCED PROTEIN-DEGRADATION | CHEMISTRY, MEDICINAL | STRUCTURE-GUIDED DESIGN | RECOGNITION | SWI/SNF COMPLEXES | TUMOR-SUPPRESSOR GENE | ALPHA | BROMODOMAIN | DISCOVERY | E3 UBIQUITIN LIGASE | SUBUNIT
Journal Article
Cell Reports, ISSN 2211-1247, 09/2017, Volume 20, Issue 12, pp. 2860 - 2875
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 03/2019, Volume 62, Issue 5, pp. 2508 - 2520
Focal adhesion tyrosine kinase (PTK2) is often overexpressed in human hepatocellular carcinoma (HCC), and several reports have linked PTK2 depletion and/or... 
FAK | OVEREXPRESSION | HEPATOCELLULAR-CARCINOMA | COMPLEX | CHEMISTRY, MEDICINAL | STRUCTURE-GUIDED DESIGN | PROTEIN-DEGRADATION | INHIBITOR | PROTAC DESIGN | CANCER | E3 UBIQUITIN LIGASE
Journal Article
Proceedings of the National Academy of Sciences of the United States, ISSN 0027-8424, 08/2019, Volume 116, Issue 32, p. 15823
The 3 human RAS genes, KRAS, NRAS, and HRAS, encode 4 different RAS proteins which belong to the protein family of small GTPases that function as binary... 
Proteins | Drug discovery | G proteins | Health aspects | Drug approval
Journal Article
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