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Journal Article
Journal Article
Annals of Oncology, ISSN 0923-7534, 10/2015, Volume 26, Issue suppl 6, pp. vi.140 - vi
Journal Article
European Journal of Human Genetics, ISSN 1018-4813, 11/2014, Volume 22, Issue 11, pp. 1314 - 1320
Primary mitochondrial disorders occur at a prevalence of one in 10000; similar to 50% of these demonstrate ocular pathology. Leber hereditary optic neuropathy... 
SURVIVAL | DISEASES | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | REGENERATIVE MEDICINE | MICE | DYSFUNCTION | GLAUCOMA | EXPRESSION | ASSOCIATION | TRANSPLANTATION | Cell- and Tissue-Based Therapy - methods | Dependovirus - genetics | Optic Nerve - pathology | Optic Atrophy, Hereditary, Leber - genetics | Stem Cells - cytology | Electron Transport Complex I - metabolism | Retinal Ganglion Cells - pathology | Stem Cell Transplantation | Retinal Ganglion Cells - cytology | Mitochondria - genetics | Retina - cytology | Electron Transport Complex I - genetics | Rotenone - toxicity | Disease Models, Animal | Cells, Cultured | Optic Atrophy, Hereditary, Leber - therapy | Genetic Markers | Saccharomyces cerevisiae Proteins - genetics | Magnetic Resonance Imaging | Animals | Optic Atrophy, Hereditary, Leber - chemically induced | Saccharomyces cerevisiae Proteins - metabolism | Mice | Mutation | Optic Nerve - drug effects | Retinal Ganglion Cells - drug effects | Glaucoma | Animal models | Nuclear magnetic resonance--NMR | Disease | Optic neuropathy | Stem cell transplantation | Retina | Mitochondrial DNA | Neuropathy | Visual perception | Electron transport chain | Mitochondria | Rodents | Degeneration | Optic nerve | Injection | Rotenone | N.M.R | Pathology | Magnetic resonance imaging | Cell death | Blindness | Stem cells | Neural stem cells | Photoreceptors | Gene therapy | Apoptosis | Manganese
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 6/2012, Volume 29, Issue 6, pp. 1425 - 1434
To investigate DSPE-PEG2000-based micellar formulations of salmon calcitonin (sCT) for their ability to improve pulmonary delivery.Micelles were characterised... 
Biomedical Engineering | Biochemistry, general | bone disorders | Biomedicine | DSPE-PEG | Pharmacy | pulmonary drug delivery | Medical Law | peptide delivery | Pharmacology/Toxicology | serine proteases | DESIGN | PHARMACEUTICALS | DRUG-DELIVERY | STABILITY | CHEMISTRY, MULTIDISCIPLINARY | PEPTIDE | BIOAVAILABILITY | PHARMACOLOGY & PHARMACY | ABSORPTION | POLYETHYLENE-GLYCOL | BOVINE SERUM-ALBUMIN | PEGYLATION | Leukocyte Elastase - metabolism | Rats, Wistar | Area Under Curve | Chymotrypsin - metabolism | Humans | Biological Availability | Male | Polyethylene Glycols - chemistry | Calcitonin - administration & dosage | Drug Carriers | Absorption | Light | Micelles | Drug Compounding | Scattering, Radiation | Bone Density Conservation Agents - chemistry | Bone Density Conservation Agents - pharmacokinetics | Cell Line | Calcitonin - blood | Magnetic Resonance Spectroscopy | Calcitonin - chemistry | Administration, Inhalation | Rats | Technology, Pharmaceutical - methods | Bone Density Conservation Agents - administration & dosage | Trypsin - metabolism | Chemistry, Pharmaceutical | Bone Density Conservation Agents - blood | Particle Size | Animals | Calcitonin - pharmacokinetics | Aerosols | Respiratory Mucosa - metabolism | Phosphatidylethanolamines - chemistry | Drugs | Chymotrypsin | Enzymes | Drug delivery systems | Trypsin | Peptides | Proteases | Analysis | Calcitonin | Respiratory agents | Hydrolases | Vehicles | Pharmacology | Bone diseases
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2009, Volume 106, Issue 42, pp. 17817 - 17822
Degenerative retinopathies, including age-related macular degeneration, diabetic retinopathy, and hereditary retinal disorders-major causes of world... 
Molecules | Cell death | Medical treatment | Small interfering RNA | Microvessels | Retina | Photoreceptors | Mice | Blood brain barrier | Endothelial cells | Claudin-5 | Blood-retina barrier | RNAi | Tight junctions | Retinitis pigmentosa | DIABETIC-RETINOPATHY | RNA INTERFERENCE | MOLECULAR-GENETICS | MULTIDISCIPLINARY SCIENCES | BLOOD-BRAIN-BARRIER | TIGHT JUNCTION | DEGENERATION | blood-retina barrier | ENDOTHELIAL-CELLS | IN-VIVO | retinitis pigmentosa | GENE-THERAPY | tight junctions | LEBERS CONGENITAL AMAUROSIS | claudin-5 | Retina - drug effects | RNA, Small Interfering - genetics | Retina - metabolism | Humans | Guanosine Triphosphate - metabolism | Blood-Retinal Barrier - drug effects | IMP Dehydrogenase - genetics | Drug Delivery Systems | Guanosine Triphosphate - administration & dosage | RNA Interference | Disease Models, Animal | Electroretinography | Membrane Proteins - genetics | Cysteine Proteinase Inhibitors - administration & dosage | IMP Dehydrogenase - deficiency | Mice, Inbred C57BL | Retinitis Pigmentosa - drug therapy | Retinitis Pigmentosa - genetics | Retinitis Pigmentosa - metabolism | Mice, Knockout | Blood-Retinal Barrier - metabolism | Magnetic Resonance Imaging | Animals | Membrane Proteins - antagonists & inhibitors | Mice, Inbred BALB C | Oligopeptides - administration & dosage | Calpain - antagonists & inhibitors | Junctional complexes (Epithelium) | Drugs | Drug delivery systems | Cell junctions | Design and construction | Properties | Drug therapy | Vehicles | Biological Sciences | blood–retina barrier
Journal Article