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Journal of Experimental Medicine, ISSN 0022-1007, 01/2003, Volume 197, Issue 2, pp. 163 - 168
T lymphocytes expressing the T cell receptor (TCR)-γδ recognize unknown antigens on tumor cells. Here we identify metabolites of the mevalonate pathway as the... 
IPP | HMGR | Bisphosphonate drugs | Antigen recognition | Tumor antigen | antigen recognition | tumor antigen | bisphosphonate drugs
Journal Article
Science, ISSN 0036-8075, 2/2008, Volume 319, Issue 5863, pp. 624 - 627
Cathepsin K was originally identified as an osteoclast-specific lysosomal protease, the inhibitor of which has been considered might have therapeutic... 
T lymphocytes | Messenger RNA | Cytokines | Dendritic cells | DNA | Toll like receptors | Bones | Osteoclasts | Reports | Inflammation | Arthritis | ACTIVATION | BONE LOSS | DENDRITIC CELLS | AUTOIMMUNITY | MULTIDISCIPLINARY SCIENCES | PYCNODYSOSTOSIS | ADJUVANTS | ANTIGEN PRESENTATION | LYSOSOMAL CYSTEINE PROTEASES | T-CELLS | INNATE IMMUNITY | Arthritis, Experimental - drug therapy | Encephalomyelitis, Autoimmune, Experimental - metabolism | T-Lymphocytes - enzymology | Dendritic Cells - immunology | Dinucleoside Phosphates - immunology | Encephalomyelitis, Autoimmune, Experimental - immunology | Male | Osteoporosis - drug therapy | Endosomes - metabolism | Antigens, CD - metabolism | Arthritis, Experimental - metabolism | Freund's Adjuvant - immunology | Protease Inhibitors - pharmacology | T-Lymphocytes - drug effects | Dendritic Cells - drug effects | Autoimmune Diseases - metabolism | Autoimmune Diseases - drug therapy | Cathepsins - antagonists & inhibitors | Bone Resorption | Cathepsin K | Cytokines - metabolism | DNA - immunology | Signal Transduction | Autoimmune Diseases - immunology | Rats | Arthritis, Experimental - immunology | DNA - metabolism | Dinucleoside Phosphates - metabolism | Animals | Cathepsins - metabolism | Lymphocyte Activation - drug effects | T-Lymphocytes - immunology | Mice | Toll-Like Receptor 9 - metabolism | Cathepsins - deficiency | Autoimmunity | Care and treatment | Control | Physiological aspects | Cathepsins | Influence | Models | Properties | Biochemistry | Pharmacology | Cellular biology | Autoimmune diseases | Rodents
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2007, Volume 104, Issue 27, pp. 11394 - 11399
Abnormal T cell immune responses induce aberrant expression of inflammatory cytokines such as TNF-α, leading to osteoclast-mediated bone erosion and... 
T lymphocytes | Molecules | Pathology | Receptors | Stem cells | Osteoclasts | Bones | Ligands | Arthritis | Inflammation | Costimulatory | TNF-α | Paired immunoglobulin-like receptor | Rheumatoid arthritis | RHEUMATOID-ARTHRITIS | COLLAGEN-INDUCED ARTHRITIS | costimulatory | IMMUNOGLOBULIN-LIKE RECEPTORS | ADAPTER PROTEINS | TNF-alpha | MULTIDISCIPLINARY SCIENCES | INFLAMMATORY ARTHRITIS | DEFICIENT MICE | rheumatoid arthritis | FACTOR-ALPHA | TUMOR-NECROSIS-FACTOR | IMMUNE-SYSTEM | paired immunoglobulin-like receptor | TRANSGENIC MICE | Arthritis, Experimental - genetics | Receptors, Immunologic - physiology | Osteoporosis - therapy | Arthritis, Experimental - therapy | Tumor Necrosis Factor-alpha - genetics | Osteoclasts - cytology | Arthritis, Experimental - pathology | Cell Differentiation - genetics | Osteoclasts - immunology | Infliximab | Receptors, Immunologic - biosynthesis | Inflammation Mediators - metabolism | Tumor Necrosis Factor-alpha - immunology | Osteoporosis - genetics | Inflammation Mediators - physiology | Inflammation Mediators - immunology | Osteoclasts - pathology | Osteoporosis - immunology | Mice, Transgenic | Arthritis, Experimental - immunology | Mice, Knockout | Cell Differentiation - immunology | Gene Amplification - immunology | Animals | Osteoporosis - pathology | Antibodies, Monoclonal - administration & dosage | Tumor Necrosis Factor-alpha - physiology | Mice | Receptors, Immunologic - genetics | Tumor Necrosis Factor-alpha - biosynthesis | NFATC Transcription Factors - genetics | Cytokines | Tumor necrosis factor | Genetic aspects | Research | T cells | Gene expression | Biological Sciences
Journal Article
European Journal of Immunology, ISSN 0014-2980, 08/2008, Volume 38, Issue 8, pp. 2200 - 2209
Primates, but not rodents, have T cell receptor Vγ9‐Vδ2 T cells bridging innate and adaptive antimicrobial immunity. This T cell population is activated by... 
T cells | Antigen presentation | Hydroxymethylglutaryl‐coenzyme A reductase | Hydroxymethylglutaryl-coenzyme A reductase
Journal Article
Drug Design, Development and Therapy, ISSN 1177-8881, 07/2015, Volume 9, pp. 3755 - 3766
Introduction: Bu-Shen-Ning-Xin decoction (BSNXD) is a traditional Chinese medicinal composition that has been used as a remedy for postmenopausal osteoporosis,... 
Osteoclastogenesis | Estrogen receptor α | NF-κB | NFATc1 | Herbal formula | GLYCOSIDES | ACTIVATION | CHEMISTRY, MEDICINAL | estrogen receptor alpha | C-FMS | PROLIFERATION | BETA | NF-kappa B | BONE LOSS | herbal formula | PHARMACOLOGY & PHARMACY | SUPPRESSES | DIFFERENTIATION | osteoclastogenesis | UP-REGULATION | EXPRESSION | Estradiol - blood | Ovariectomy | Humans | NFATC Transcription Factors - metabolism | Bone Resorption - drug therapy | Drugs, Chinese Herbal - pharmacology | NF-kappa B - metabolism | Osteoclasts - metabolism | Immunoenzyme Techniques | Osteoporosis, Postmenopausal - drug therapy | Dose-Response Relationship, Drug | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Estrogen Receptor alpha - metabolism | Female | Mice | Mice, Inbred BALB C | Drugs, Chinese Herbal - administration & dosage | Osteoclasts - drug effects | Disease Models, Animal | Immunoassay | Downstream effects | Estrogens | Menopause | Osteoporosis | Signal transduction | Precursors | Acid resistance | Bone marrow | Biocompatibility | Inhibition | Drug dosages | Herbs | Enzymes | NF-κB protein | Gynecology | Bone turnover | Enzyme immunoassay | Metabolism | Sex hormones | Hospitals | Pharmacy | Ligands | Scientific imaging | Mass spectrometry | Endocrinology | Flow cytometry | Animal models | Transcription | Estrogen | 17β-Estradiol | Macrophages | Pyrazole | Western blotting | Bone resorption | Transfection | Pathways | TRANCE protein | Obstetrics | Chromatography | Post-menopause | Signaling | Monocytes | Womens health | Osteoclasts | Receptor mechanisms | Laboratory animals | Females | Acid phosphatase
Journal Article
BioScience Trends, ISSN 1881-7815, 2017, Volume 11, Issue 1, pp. 69 - 76
Ankylosing spondylitis (AS) is a spinal arthritic disease that is often associated with human leukocyte antigen (HLA)-B27, while only part of HLA-B27 carriers... 
CD4+ T cell | PD-1 | CD8+ T cell | IL-6 | IL-10 | Ankylosing spondylitis | Tim-3 | CD4 | T cell | CD8 | CD8(+) T cell | SUSCEPTIBILITY | INTERLEUKIN-10 | HLA-B27 | ADOPTIVE TRANSFER | BIOLOGY | REGULATORY T-CELLS | CD4(+) | UPDATE | CD4(+) T cell | EXPRESSION
Journal Article
BioScience Trends, ISSN 1881-7815, 2016, Volume 10, Issue 4, pp. 277 - 287
Recent studies have suggested that dehydroepiandrosterone (DHEA) might serve as a form of immunomodulatory therapy for postmenopausal osteoporosis (PMO). The... 
Dehydroepiandrosterone | CD4+ T cells | TNF-α | postmenopausal osteoporosis | CD4 | T cells | Postmenopausal osteoporosis | RHEUMATOID-ARTHRITIS | TNF-alpha | ESTROGEN DEFICIENCY | RECEPTOR | KEY MECHANISM | GERIATRIC SYNDROMES | OSTEOCLASTOGENESIS | METABOLISM | SIGNALING PATHWAY | BIOLOGY | CD4(+) T cells | EXPRESSION
Journal Article
BioScience Trends, ISSN 1881-7815, 2017, Volume 11, Issue 3, pp. 267 - 273
Human papillomavirus (HPV) infections are common and generally harmless, but persistent infections can bring health problems like cancer and genital warts. For... 
human papillomavirus (HPV) | genital warts | Traditional Chinese medicine | HPV infection | cervical cancer | Genital warts | Human papillomavirus (HPV) | Cervical cancer | APOPTOSIS | DISEASES | CERVICAL-CANCER CELLS | BIOLOGY | EXPRESSION | BURDEN
Journal Article