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1. Full Text The epidemiology of sepsis in Brazilian intensive care units (the Sepsis PREvalence Assessment Database, SPREAD): an observational study
by Machado, E C and Machado, D and Machado, F R and Machado, Flavia R and Machado, R S and Cavalcanti, Alexandre Biasi and Bozza, Fernando Augusto and Ferreira, R and Ferreira, I and Ferreira, P and Ferreira, E L A and Ferreira, C S and Ferreira, Elaine M and Angotti Carrara, Fernanda Sousa and Sousa, Juliana Lubarino and Sousa, R K and Caixeta, Noemi and Salomao, Reinaldo and Angus, Derek C and Pontes Azevedo, Luciano Cesar and Zajac, S R and Bley, M V and Scazufca, A and Rosateli, P and Reis, T and Junior, H A O and Junior, J M M and Junior, A D F and Junior, S M D and Junior, A Nogueira and Junior, E A and Neto, P A Nunes and Neto, E Eberhart and Neto, M L and Neto, J S A and Filho, W H and Filho, C M F and Filho, E Thomé and Filho, J Mugait and Filho, I L S and Filho, G T Henriques and Filho, H Carvalho and Filho, M C and Filho, W O and Lima, G S and Lima, R and Lima, M F A and Lima, M A M and Lima, H and Vieira, M and Vieira, S and Vieira, P C B and Vieira, E and Zanchet, M and Miguita, R and Petisco, G M and Westphal, G A and Santos, J R P and Santos, J C and Santos, V and Santos, L and Santos, A P G and Damasceno, M and Damasceno, V and dos Santos, J T and dos Santos, R Perreira and Fernandes, F and Fernandes, L and Fernandes, R and Fernandes, S S and Almeida, E P and Almeida, R and Almeida, EP and Lemos, M and Camacho, R and Ribeiro, A G and Ribeiro, A and Douglas, M O G and Mattei, G A and Rabelo, H R M P and Pinto, V G S and Pinto, E M and Pinto, S P S and Fontes, L E and Guitzel, M and Lucio, M and Conceição, C N P and Barros, A and Salgado, D and Veiga, V C and Rojas, S S O and de Paula, KM and Hatum, R and Fraenkel, L and Viana, W N and Rabello, L and Tanaka, L and Uchoa, M and Moura, M D and Moura, E M F and ... and Latin American Sepsis Institute Ne and SPREAD Investigators and Latin American Sepsis Institute Network
The Lancet Infectious Diseases, ISSN 1473-3099, 11/2017, Volume 17, Issue 11, pp. 1180 - 1189
The sepsis burden on acute care services in middle-income countries is a cause for concern. We estimated incidence, prevalence, and mortality of sepsis in... 
MORTALITY | INFECTIOUS DISEASES | MULTICENTER | AMERICA | COUNTRY | GUIDELINES | SEPTIC SHOCK | CRITICALLY-ILL | Length of Stay | Intensive Care Units | Prevalence | Humans | Risk Factors | Sepsis - epidemiology | Survival Analysis | Random Allocation | Brazil - epidemiology | Incidence | Sepsis - mortality | Epidemiology | Questions and answers | Databases | Analysis | Studies | Intensive care units | Economic models | Intensive care | Hospitals | Mortality | Sepsis
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2. Full Text The After-Hours Mutant Reveals a Role for Fbxl3 in Determining Mammalian Circadian Period
by Sofia I. H. Godinho and Elizabeth S. Maywood and Linda Shaw and Valter Tucci and Alun R. Barnard and Luca Busino and Michele Pagano and Rachel Kendall and Mohamed M. Quwailid and M. Rosario Romero and John O'Neill and Johanna E. Chesham and Debra Brooker and Zuzanna Lalanne and Michael H. Hastings and Patrick M. Nolan
Science, ISSN 0036-8075, 5/2007, Volume 316, Issue 5826, pp. 897 - 900
By screening N-ethyl-N-nitrosourea--mutagenized animals for alterations in rhythms of wheel-running activity, we identified a mouse mutation, after hours... 
Homozygotes | Proteins | Animal genetics | Phenotypes | Messenger RNA | Chronometry | Liver | Reports | Mice | Mammals | Genetic mutation | GENE | SUPRACHIASMATIC NUCLEUS | MULTIDISCIPLINARY SCIENCES | F-BOX PROTEINS | DEGRADATION | RHYTHM | ARABIDOPSIS | CLOCK | FAMILY | Cercopithecus aethiops | Molecular Sequence Data | Male | Basic Helix-Loop-Helix Transcription Factors - metabolism | Trans-Activators - genetics | Cell Cycle Proteins - genetics | Female | Suprachiasmatic Nucleus - metabolism | Transcription, Genetic | Lung - metabolism | Nuclear Proteins - genetics | ARNTL Transcription Factors | Amino Acid Sequence | Basic Helix-Loop-Helix Transcription Factors - genetics | Flavoproteins - metabolism | Flavoproteins - genetics | Liver - metabolism | Cell Cycle Proteins - metabolism | Circadian Rhythm - genetics | Gene Expression Regulation | Nuclear Proteins - metabolism | Transcription Factors - genetics | Period Circadian Proteins | Mice, Inbred C3H | Transcription Factors - metabolism | Point Mutation | Animals | CLOCK Proteins | F-Box Proteins - physiology | Cryptochromes | Trans-Activators - metabolism | Mice, Inbred BALB C | COS Cells | F-Box Proteins - genetics | Amino Acid Substitution | Crosses, Genetic | Circadian rhythms | Physiological aspects | Influence | Research | Mutation | Circadian rhythm | Gene expression | Rodents
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3. Full Text Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing
by Didiot, Marie-Cécile and Hall, Lauren M and Coles, Andrew H and Haraszti, Reka A and Godinho, Bruno MDC and Chase, Kathryn and Sapp, Ellen and Ly, Socheata and Alterman, Julia F and Hassler, Matthew R and Echeverria, Dimas and Raj, Lakshmi and Morrissey, David V and DiFiglia, Marian and Aronin, Neil and Khvorova, Anastasia
Molecular Therapy, ISSN 1525-0016, 10/2016, Volume 24, Issue 10, pp. 1836 - 1847
Delivery represents a significant barrier to the clinical advancement of oligonucleotide therapeutics for the treatment of neurological disorders, such as... 
CANCER-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | PROTEIN | EFFICACY | MICRORNAS | IN-VITRO | EXTRACELLULAR VESICLES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DISEASE | GENETICS & HEREDITY | MICE | BRAIN | COMMUNICATION | Genetic Therapy | Humans | Huntingtin Protein - metabolism | RNA, Small Interfering - pharmacology | Cells, Cultured | Gene Expression Regulation | Gene Silencing | Exosomes - genetics | RNA, Small Interfering - chemistry | Animals | Hydrophobic and Hydrophilic Interactions | Mice | Neurons - metabolism | Huntingtin Protein - genetics | RNA, Small Interfering - administration & dosage | Original
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4. Full Text RNAi modulation of placental sFLT1 for the treatment of preeclampsia
by Turanov, Anton A and Lo, Agnes and Hassler, Matthew R and Makris, Angela and Ashar-Patel, Ami and Alterman, Julia F and Coles, Andrew H and Haraszti, Reka A and Roux, Loic and Godinho, Bruno M. D. C and Echeverria, Dimas and Pears, Suzanne and Iliopoulos, Jim and Shanmugalingam, Renuka and Ogle, Robert and Zsengeller, Zsuzsanna K and Hennessy, Annemarie and Karumanchi, S. Ananth and Moore, Melissa J and Khvorova, Anastasia
Nature Biotechnology, ISSN 1087-0156, 12/2018, Volume 36, Issue 12, pp. 1164 - 1173
Preeclampsia is a placentally induced hypertensive disorder of pregnancy that is associated with substantial morbidity and mortality to mothers and fetuses.... 
MODIFIED SIRNA | GENE | EFFICACY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IN-VIVO | OLIGONUCLEOTIDE | MOUSE | HIGH-THROUGHPUT METHOD | GROWTH-FACTOR RECEPTOR-1 | TYROSINE KINASE 1 | ANGIOGENIC FACTORS | Pregnancy | Care and treatment | Endothelial growth factors | Placental diseases | Analysis | Mortality | Patient outcomes | Preeclampsia | Research | Health aspects | Fetuses | RNA-mediated interference | siRNA | Pre-eclampsia | Hydrophobicity | Gene expression | Morbidity | Organic chemistry | Placenta | Modulation | Isoforms | Primates | Vascular endothelial growth factor | Growth factors
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5. Full Text Growth kinetics and morphology of barite crystals derived from face-specific growth rates
by Godinho, Jose R.A and Stack, Andrew G and Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Crystal Growth and Design, ISSN 1528-7483, 05/2015, Volume 15, Issue 5, pp. 2064 - 2071
We investigate the growth kinetics and morphology of barite (BaSO4) crystals by measuring the growth rates of the (001), (210), (010), and (100) surfaces using... 
MOLECULAR-SCALE | SURFACE-PROPERTIES | DISSOLUTION RATES | MATERIALS SCIENCE, MULTIDISCIPLINARY | CRYSTALLOGRAPHY | WATER INTERFACE | CHEMISTRY, MULTIDISCIPLINARY | AQUEOUS-SOLUTION | STEP-GROWTH | ATOMIC-FORCE MICROSCOPY | SOLID-SOLUTION | CALCITE GROWTH | WASTE-WATER | INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY | morphology | crystal | surface orientation | growth rate | MATERIALS SCIENCE | kinetics
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6. Full Text Physicians' guideline adherence is associated with long‐term heart failure mortality in outpatients with heart failure with reduced ejection fraction: the QUALIFY international registry
by Komajda, Michel and Schöpe, Jakob and Wagenpfeil, Stefan and Tavazzi, Luigi and Böhm, Michael and Ponikowski, Piotr and Anker, Stefan D and Filippatos, Gerasimos S and Cowie, Martin R and Aleksanyan, A and Atayan, L and Avetisyan, A and Davtyan, N and Drambyan, M and Gevorgyan, K and Grigoryan, M and Hakobyan, Z and Hayrapetyan, H and Kocharyan, L and Kramarevskaya, T and Melqonyan, A and Muradyan, F and Nanyan, R and Ordyan, A and Ordyan, M and Piruzyan, A and Podosyan, G and Safaryan, K and Sargsyan, T and Sarkisyan, A and Sisakyan, H and Ter‐Grigoryan, V and Ustyan, T and Alexopoulos, C and Amerena, J and Arstall, M and Ayres, B and Barron, G and Beltrame, J and Bou‐Samra, J and Brown, M and Cross, D and Dwyer, N and Eccleston, N and Hare, D and Ho, B and Hopper, I and Jackson, B and Korczyk, D and Lattimore, J.D and Levendel, A and Macfadyen, R and Pandeli, V and Playford, D and Richardson, M and Senior, J. A and Shah, A and Shetty, P and Soward, A and Srivastava, P and Swale, M and Vogl, E and Wai, B and William, M and Worthington, A and Wright, S and Brunner, B and Fuhrmann, W and Horer, L and Maca, T and Nahler, A and Ortner, H and Racz, G and Scheibner, P and Sebald, C and Abdullayev, A and Abdullayev, R and Ahmadov, A and Alakbarov, E and Aliyev, Farid and Aliyev, Fuad and Bakhshaliyev, A and Bakhshiyev, M and Dadashova, G and Dashdamirov, R and Faradjova, N and Guliyev, Akif and Guliyev, Faig and Guliyeva, S and Hajiyev, G and Ibrahimov, F and Imanov, G and Isayeva, A and Isayeva, M and Jabrailova, U and Jafarov, R and Jahangirov, T and Khalilov, A and Khalilov, S and Mehdiyev, S and ... and QUALIFY Investigators and on behalf of the QUALIFY Investigators
European Journal of Heart Failure, ISSN 1388-9842, 07/2019, Volume 21, Issue 7, pp. 921 - 929
Background Physicians' adherence to guideline‐recommended therapy is associated with short‐term clinical outcomes in heart failure (HF) with reduced ejection... 
Heart failure | Adherence | Medication | Dosage | Outcomes | Guidelines | DIAGNOSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | MANAGEMENT | TASK-FORCE | ESC | EUROPEAN-SOCIETY
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7. Full Text Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways
by Osborn, Maire F and Coles, Andrew H and Biscans, Annabelle and Haraszti, Reka A and Roux, Loic and Davis, Sarah and Ly, Socheata and Echeverria, Dimas and Hassler, Matthew R and Godinho, Bruno M D C and Nikan, Mehran and Khvorova, Anastasia
Nucleic Acids Research, ISSN 0305-1048, 02/2019, Volume 47, Issue 3, pp. 1070 - 1081
Abstract Efficient delivery of therapeutic RNA beyond the liver is the fundamental obstacle preventing its clinical utility. Lipid conjugation increases plasma... 
PHOSPHOROTHIOATE | GALNAC | NANOPARTICLES | IN-VIVO DELIVERY | RNA | LDL RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIVER | BIODISTRIBUTION | 5'-VINYLPHOSPHONATE | ANTISENSE OLIGONUCLEOTIDES | Chemical Biology and Nucleic Acid Chemistry
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8. Full Text Importance of surface structure on dissolution of fluorite: Implications for surface dynamics and dissolution rates
by Godinho, J.R.A and Piazolo, S and Balic-Zunic, T and Stockholms universitet and Naturvetenskapliga fakulteten and Institutionen för geologiska vetenskaper
Geochimica et Cosmochimica Acta, ISSN 0016-7037, 02/2014, Volume 126, pp. 398 - 410
Dissolution rates are usually calculated as a function of surface area, which is assumed to remain constant ignoring the changes occurring on the surface... 
GEOCHEMISTRY & GEOPHYSICS | MINERAL DISSOLUTION | ORIENTATION | STABILITY | KINETICS | Analysis | Fluorine compounds | Fluorite | Dynamics | Mathematical analysis | Topography | Orientation | Surface area | Dissolution | Surface structure | Naturvetenskap | Geokemi | Geophysics | Geochemistry | Geofysik | Natural Sciences | Earth and Related Environmental Sciences | Geovetenskap och miljövetenskap
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9. Full Text Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo
by Hassler, Matthew R and Turanov, Anton A and Alterman, Julia F and Haraszti, Reka A and Coles, Andrew H and Osborn, Maire F and Echeverria, Dimas and Nikan, Mehran and Salomon, William E and Roux, Loïc and Godinho, Bruno M D C and Davis, Sarah M and Morrissey, David V and Zamore, Phillip D and Karumanchi, S Ananth and Moore, Melissa J and Aronin, Neil and Khvorova, Anastasia
Nucleic Acids Research, ISSN 0305-1048, 03/2018, Volume 46, Issue 5, pp. 2185 - 2196
Abstract Small interfering RNA (siRNA)-based drugs require chemical modifications or formulation to promote stability, minimize innate immunity, and enable... 
IMPROVE | RNAI | GENE | EFFICACY | POTENCY | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | 5'-VINYLPHOSPHONATE | HIGH-THROUGHPUT METHOD | RNA, Small Interfering - genetics | Peptides - chemistry | RNA Processing, Post-Transcriptional | RNA, Small Interfering - pharmacokinetics | Humans | Mice, Inbred C57BL | Cells, Cultured | Aptamers, Nucleotide - chemistry | Genetic Vectors - genetics | RNA, Small Interfering - chemistry | Tissue Distribution | Lipids - chemistry | Animals | RNA Interference | Female | HeLa Cells | Drug Delivery Systems - methods | Chemical Biology and Nucleic Acid Chemistry
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10. Full Text A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system
by Alterman, JF and Godinho, BMDC and Hassler, MR and Ferguson, CM and Echeverria, D and Sapp, E and Haraszti, RA and Coles, AH and Conroy, F and Miller, R and Roux, L and Yan, P and Knox, EG and Turanov, AA and King, RM and Gernoux, G and Mueller, C and Gray-Edwards, HL and Moser, RP and Bishop, NC and Jaber, SM and Gounis, MJ and Sena-Esteves, M and Pai, AA and DiFiglia, M and Aronin, N and Khvorova, A
NATURE BIOTECHNOLOGY, ISSN 1087-0156, 08/2019, Volume 37, Issue 8, pp. 884 - 884
Sustained silencing of gene expression throughout the brain using small interfering RNAs (siRNAs) has not been achieved. Here we describe an siRNA... 
TARGET | CELLS | PROTEIN | MESSENGER-RNA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | NEURONAL MARKER NEUN | IN-VIVO | DISEASE | MECHANISMS | HUNTINGTIN | DELIVERY | Physiological aspects | Genetic aspects | Gene expression | Central nervous system | Brain | Spinal cord | Drug delivery systems | Huntingtin | Toxicity | RNA-mediated interference | Nervous system | mRNA | siRNA | Cerebrospinal fluid | Injection | Ribonucleic acid--RNA | Neurological diseases | Gene silencing | Organic chemistry | Bioaccumulation | Primates | Mice | Phosphorothioate | Index Medicus
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