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Journal of cellular physiology, ISSN 0021-9541, 12/2019
Drug discovery is an onerous, extremely expensive, and time-consuming process. Instead, drug repurposing is an attractive strategy for exploiting novel... 
Index Medicus
Journal Article
Mini-Reviews in Medicinal Chemistry, ISSN 1389-5575, 2016, Volume 16, Issue 2, pp. 113 - 141
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, p. e89919
Background: The poor bioavailability of Berberine (BBR) and Betulinic acid (BA) limits the development of these promising anticancer agents for clinical use.... 
INTESTINAL-ABSORPTION | BREAST-CANCER CELLS | APOPTOSIS | IN-VITRO | ACTIVATED PROTEIN-KINASE | LIQUID-CHROMATOGRAPHY | EFFICACY | MULTIDISCIPLINARY SCIENCES | RATS | HUMAN-MELANOMA | MASS-SPECTROMETRY | Immunohistochemistry | Lung Neoplasms - drug therapy | Berberine - administration & dosage | Triterpenes - pharmacology | Humans | Triterpenes - therapeutic use | Biological Availability | Lung Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Vascular Endothelial Growth Factor A - metabolism | Antineoplastic Agents - administration & dosage | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Berberine - pharmacokinetics | Clone Cells | Cell Death - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Disease Models, Animal | In Situ Nick-End Labeling | Lung Neoplasms - genetics | Administration, Oral | Rats, Sprague-Dawley | Blotting, Western | Chemistry, Pharmaceutical | Berberine - pharmacology | Animals | Mice, Nude | Cell Membrane Permeability - drug effects | Cell Line, Tumor | Berberine - therapeutic use | Triterpenes - pharmacokinetics | Triterpenes - administration & dosage | Antimitotic agents | Usage | Analysis | Permeability | Metastasis | Lung cancer, Non-small cell | Antineoplastic agents | Tumor proteins | Vascular endothelial growth factor | Monomolecular films | Lung cancer | Melanoma | Non-small cell lung carcinoma | JNK protein | Breast cancer | Bioavailability | Kinases | Studies | Acids | Pharmacy | Rodents | Hypoxia | Drug dosages | Pharmaceutical sciences | Apoptosis
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, p. e53708
Background: Three-dimensional (3D) in-vitro cultures are recognized for recapitulating the physiological microenvironment and exhibiting high concordance with... 
THERAPY | 3RD-DIMENSION | SOLID TUMORS | SPHEROIDS | MULTIDISCIPLINARY SCIENCES | CANCER STEM-CELL | TISSUE | PENETRATION | EXTRACELLULAR-MATRIX | DRUG-RESISTANCE | SCAFFOLDS | Taxoids - pharmacology | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Humans | Caspase 3 - metabolism | Spheroids, Cellular - pathology | Lung Neoplasms - pathology | Taxoids - metabolism | Cell Culture Techniques - methods | Antineoplastic Agents - metabolism | Nanoparticles | Biological Transport | Neoplastic Stem Cells - metabolism | Biomarkers, Tumor - metabolism | Inhibitory Concentration 50 | Neoplastic Stem Cells - pathology | Antineoplastic Agents - pharmacology | Spheroids, Cellular - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Glucuronic Acid - chemistry | Drug Evaluation, Preclinical - methods | Spheroids, Cellular - metabolism | Docetaxel | Hexuronic Acids - chemistry | Alginates - chemistry | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - genetics | Immunohistochemistry | Anthracyclines | Analysis | Tumors | Drugs | Cell culture | Camptothecin | Size distribution | 5-Fluorouracil | Toxicity | Lung cancer | Two dimensional models | Cytotoxicity | Mesothelioma | Drug resistance | Drug development | Drug screening | Caspase-3 | Doxorubicin | Anticancer properties | Angiogenesis | Biomedical materials | Antitumor agents | Biocompatibility | Pharmaceutical sciences | Formulations | Evaluation | Caspase | Cultures | Gene expression | Spheroids | Penetration resistance | Studies | Polymerase chain reaction | Pharmacy | Stem cells | Hypoxia | Three dimensional models | Scaffolds | Apoptosis | Cancer
Journal Article
International Immunopharmacology, ISSN 1567-5769, 10/2019, Volume 75, p. 105755
Pulmonary fibrosis is an irreversible lung disorder with predictable decline in lung function leading to respiratory insufficiency. Incidence of pulmonary... 
Immunohistochemistry | Respiratory function | Mesenchyme | Lung diseases | Markers | Homeostasis | Confocal microscopy | Autophagy | Bleomycin | Pulmonary fibrosis | Lungs | Microscopy | Fibrosis | Attenuation | Neem | Phagocytosis
Journal Article
Biological Trace Element Research, ISSN 0163-4984, 5/2019, Volume 189, Issue 1, pp. 145 - 156
Journal Article
Phytotherapy Research, ISSN 0951-418X, 04/2017, Volume 31, Issue 4, pp. 591 - 623
Journal Article
Life Sciences, ISSN 0024-3205, 03/2019, Volume 220, pp. 8 - 20
Drug repurposing off late has been emerging as an inspiring alternative approach to conventional, exhaustive and arduous process of drug discovery. It is a... 
Niclosamide | Pulmonary fibrosis | EMT | Wnt/β-catenin | MEDICINE, RESEARCH & EXPERIMENTAL | LUNG | Wnt/beta-catenin | PHARMACOLOGY & PHARMACY | Wnt protein | Mesenchyme | Migration | Lung diseases | Proteins | β-catenin | Signaling | Scars | Bleomycin | Fibrosis | Attenuation | In vivo methods and tests | Drug discovery | Index Medicus
Journal Article
BioFactors, ISSN 0951-6433, 11/2018, Volume 44, Issue 6, pp. 507 - 517
Scleroderma is an inflammatory autoimmune disease which begins with inflammation due to tissue injury and advances to progressive accumulation of extracellular... 
Withaferin A | bleomycin | inflammation | EMT | scleroderma | Skin - metabolism | Humans | Scleroderma, Localized - chemically induced | Extracellular Matrix - metabolism | Male | NF-kappa B - metabolism | Smad2 Protein - genetics | Anti-Inflammatory Agents - isolation & purification | Proto-Oncogene Proteins c-akt - metabolism | Disease Models, Animal | Fibroblasts - metabolism | NF-kappa B - antagonists & inhibitors | Signal Transduction | Anti-Inflammatory Agents - pharmacology | Dermatologic Agents - isolation & purification | Scleroderma, Localized - pathology | Smad2 Protein - metabolism | Bleomycin - administration & dosage | Fibroblasts - pathology | Myofibroblasts - drug effects | Forkhead Box Protein O3 - metabolism | Withanolides - pharmacology | Fibroblasts - drug effects | Mice | Scleroderma, Localized - genetics | Extracellular Matrix - pathology | Withania - chemistry | Withanolides - isolation & purification | Smad3 Protein - metabolism | Proto-Oncogene Proteins c-akt - genetics | Forkhead Box Protein O3 - genetics | Myofibroblasts - metabolism | Smad3 Protein - genetics | I-kappa B Kinase - metabolism | Forkhead Box Protein O3 - antagonists & inhibitors | Skin - pathology | Dermatologic Agents - pharmacology | Myofibroblasts - pathology | Scleroderma, Localized - drug therapy | Extracellular Matrix - drug effects | Mice, Inbred C57BL | Gene Expression Regulation | I-kappa B Kinase - genetics | Animals | Transforming Growth Factor beta - genetics | NF-kappa B - genetics | Cell Differentiation - drug effects | Transforming Growth Factor beta - metabolism | Skin - drug effects
Journal Article
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