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index medicus (57) 57
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1. Full Text Inhibition of lysyl oxidase ameliorates renal injury by inhibiting CD44-mediated pericyte detachment and loss of peritubular capillaries
by Saifi, Mohd Aslam and Godugu, Chandraiah
Life Sciences, ISSN 0024-3205, 01/2020, p. 117294
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2. Full Text Algimatrix™-based 3d cell culture system as an in vitro tumor model: An important tool in cancer research
by Godugu, Chandraiah and Singh, Mandip
Methods in Molecular Biology, ISSN 1064-3745, 2016, Volume 1379, pp. 117 - 128
Routinely used two-dimensional cell culture-based models often fail while translating the observations into in vivo models. This setback is more common in... 
AlgiMatrix | Nanoparticles | 2D cell cultures | In vivo environment | Cytotoxicity | Extracellular matrix | Alginate | Cell-to-cell interaction | 3D culture models | AlamarBlue | Nanostructured lipid carries | Spheroids | Carcinoma, Non-Small-Cell Lung - pathology | Immunohistochemistry | Humans | Spheroids, Cellular - metabolism | Spheroids, Cellular - pathology | Lung Neoplasms - pathology | Reverse Transcriptase Polymerase Chain Reaction | Cell Culture Techniques - methods | Blotting, Western | Biological Transport | Neoplastic Stem Cells - metabolism | Nanoparticles - metabolism | Cell Line, Tumor | Neoplastic Stem Cells - pathology | Index Medicus
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3. Full Text Repurposing an old drug for new use: Niclosamide in psoriasis-like skin inflammation
by Thatikonda, Sowjanya and Pooladanda, Venkatesh and Godugu, Chandraiah
Journal of cellular physiology, ISSN 0021-9541, 12/2019
Drug discovery is an onerous, extremely expensive, and time-consuming process. Instead, drug repurposing is an attractive strategy for exploiting novel... 
Index Medicus
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4. A review on pharmacological properties of coumarins
by Srikrishna, Devulapally and Godugu, Chandraiah and Kumar Dubey, Pramod
Mini-Reviews in Medicinal Chemistry, ISSN 1389-5575, 2016, Volume 16, Issue 2, pp. 113 - 141
The coumarin (benzopyran-2-one, or chromen-2-one) ring system, present in many natural products, displays diverse pharmacological properties. It has attracted... 
Antimicrobial | Pharmacological properties | Anticonvulsant | Anticancer | Antioxidant | Anti-inflammatory | Coumarin | MAO inhibitory | ANTIOXIDANT ACTIVITY | antimicrobial | antioxidant | 3-ARYLCOUMARINS SYNTHESIS | ANTIINFLAMMATORY ACTIVITY | CHEMISTRY, MEDICINAL | anticonvulsant | coumarin | INHIBITORY-ACTIVITY | pharmacological properties | ANTICONVULSANT AGENTS | IN-VITRO | anti-inflammatory | BIOLOGICAL EVALUATION | DERIVATIVES | HYBRIDS
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5. Full Text Approaches to improve the oral bioavailability and effects of novel anticancer drugs berberine and betulinic acid
by Godugu, Chandraiah and Patel, Apurva R and Doddapaneni, Ravi and Somagoni, Jaganmohan and Singh, Mandip
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, p. e89919
Background: The poor bioavailability of Berberine (BBR) and Betulinic acid (BA) limits the development of these promising anticancer agents for clinical use.... 
INTESTINAL-ABSORPTION | BREAST-CANCER CELLS | APOPTOSIS | IN-VITRO | ACTIVATED PROTEIN-KINASE | LIQUID-CHROMATOGRAPHY | EFFICACY | MULTIDISCIPLINARY SCIENCES | RATS | HUMAN-MELANOMA | MASS-SPECTROMETRY | Immunohistochemistry | Lung Neoplasms - drug therapy | Berberine - administration & dosage | Triterpenes - pharmacology | Humans | Triterpenes - therapeutic use | Biological Availability | Lung Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Vascular Endothelial Growth Factor A - metabolism | Antineoplastic Agents - administration & dosage | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Berberine - pharmacokinetics | Clone Cells | Cell Death - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Disease Models, Animal | In Situ Nick-End Labeling | Lung Neoplasms - genetics | Administration, Oral | Rats, Sprague-Dawley | Blotting, Western | Chemistry, Pharmaceutical | Berberine - pharmacology | Animals | Mice, Nude | Cell Membrane Permeability - drug effects | Cell Line, Tumor | Berberine - therapeutic use | Triterpenes - pharmacokinetics | Triterpenes - administration & dosage | Antimitotic agents | Usage | Analysis | Permeability | Metastasis | Lung cancer, Non-small cell | Antineoplastic agents | Tumor proteins | Vascular endothelial growth factor | Monomolecular films | Lung cancer | Melanoma | Non-small cell lung carcinoma | JNK protein | Breast cancer | Bioavailability | Kinases | Studies | Acids | Pharmacy | Rodents | Hypoxia | Drug dosages | Pharmaceutical sciences | Apoptosis
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6. Full Text AlgiMatrix™ Based 3D Cell Culture System as an In-Vitro Tumor Model for Anticancer Studies
by Godugu, Chandraiah and Patel, Apurva R and Desai, Utkarsh and Andey, Terrick and Sams, Alexandria and Singh, Mandip
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, p. e53708
Background: Three-dimensional (3D) in-vitro cultures are recognized for recapitulating the physiological microenvironment and exhibiting high concordance with... 
THERAPY | 3RD-DIMENSION | SOLID TUMORS | SPHEROIDS | MULTIDISCIPLINARY SCIENCES | CANCER STEM-CELL | TISSUE | PENETRATION | EXTRACELLULAR-MATRIX | DRUG-RESISTANCE | SCAFFOLDS | Taxoids - pharmacology | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Humans | Caspase 3 - metabolism | Spheroids, Cellular - pathology | Lung Neoplasms - pathology | Taxoids - metabolism | Cell Culture Techniques - methods | Antineoplastic Agents - metabolism | Nanoparticles | Biological Transport | Neoplastic Stem Cells - metabolism | Biomarkers, Tumor - metabolism | Inhibitory Concentration 50 | Neoplastic Stem Cells - pathology | Antineoplastic Agents - pharmacology | Spheroids, Cellular - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Glucuronic Acid - chemistry | Drug Evaluation, Preclinical - methods | Spheroids, Cellular - metabolism | Docetaxel | Hexuronic Acids - chemistry | Alginates - chemistry | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - genetics | Immunohistochemistry | Anthracyclines | Analysis | Tumors | Drugs | Cell culture | Camptothecin | Size distribution | 5-Fluorouracil | Toxicity | Lung cancer | Two dimensional models | Cytotoxicity | Mesothelioma | Drug resistance | Drug development | Drug screening | Caspase-3 | Doxorubicin | Anticancer properties | Angiogenesis | Biomedical materials | Antitumor agents | Biocompatibility | Pharmaceutical sciences | Formulations | Evaluation | Caspase | Cultures | Gene expression | Spheroids | Penetration resistance | Studies | Polymerase chain reaction | Pharmacy | Stem cells | Hypoxia | Three dimensional models | Scaffolds | Apoptosis | Cancer
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7. Full Text Therapeutic effects of Nimbolide, an autophagy regulator, in ameliorating pulmonary fibrosis through attenuation of TGF-β1 driven epithelial-to-mesenchymal transition
by Prashanth Goud, M and Bale, Swarna and Pulivendala, Gauthami and Godugu, Chandraiah
International Immunopharmacology, ISSN 1567-5769, 10/2019, Volume 75, p. 105755
Pulmonary fibrosis is an irreversible lung disorder with predictable decline in lung function leading to respiratory insufficiency. Incidence of pulmonary... 
Immunohistochemistry | Respiratory function | Mesenchyme | Lung diseases | Markers | Homeostasis | Confocal microscopy | Autophagy | Bleomycin | Pulmonary fibrosis | Lungs | Microscopy | Fibrosis | Attenuation | Neem | Phagocytosis
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8. Full Text Protective Effect of Nanoceria on Cisplatin-Induced Nephrotoxicity by Amelioration of Oxidative Stress and Pro-inflammatory Mechanisms
by Saifi, Mohd Aslam and Saifi, Mohd Aslam and Sangomla, Swetha and Sangomla, Swetha and Khurana, Amit and Khurana, Amit and Godugu, Chandraiah and Godugu, Chandraiah
Biological Trace Element Research, ISSN 0163-4984, 5/2019, Volume 189, Issue 1, pp. 145 - 156
Cisplatin (CP) is one of the most important anticancer compounds with its therapeutic usefulness in diverse types of solid cancer. However, its use is limited... 
Life Sciences | Biochemistry, general | Biotechnology | Nanoceria | Oxidative stress | Nutrition | Oncology | Inflammation | Nephrotoxicity | Cisplatin | LIPID-PEROXIDATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | COMBINATION | CHEMOTHERAPY | MURINE MODEL | INHIBITION | INDUCED TOXICITIES | AMIFOSTINE | CERIUM OXIDE NANOPARTICLES | ENDOCRINOLOGY & METABOLISM | CYTOTOXICITY | Nitrogen - metabolism | Kidney - drug effects | Enzyme-Linked Immunosorbent Assay | Antioxidants - metabolism | Body Weight - drug effects | Male | Spectroscopy, Fourier Transform Infrared | Cerium - therapeutic use | Nanoparticles | Inflammation - metabolism | Kidney - metabolism | Organ Size - drug effects | Animals | Cisplatin - toxicity | Mice | Oxidative Stress - drug effects | Antioxidants | Cerium | Urea | Rare earth metals | Pathogenesis | Metals | Body weight | Tissues | Chronic exposure | Interleukin 6 | Earth | Reduction | Histopathology | Catalase | Rare earths | Injuries | Glutathione | Creatinine | Kidneys | Antiinflammatory agents | Cytokines | Histology | Pharmacology | Tumor necrosis factor-α | Chemical compounds | Malondialdehyde | Injury prevention | Weight reduction | Levels | Cancer
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9. Full Text Withaferin A, a novel compound of Indian ginseng (Withania somnifera), ameliorates Cerulein‐induced acute pancreatitis: Possible role of oxidative stress and inflammation
by Tiruveedi, Vijaya Lakshmi and Bale, Swarna and Khurana, Amit and Godugu, Chandraiah
Phytotherapy Research, ISSN 0951-418X, 12/2018, Volume 32, Issue 12, pp. 2586 - 2596
Acute pancreatitis is an inflammatory disorder of the pancreas that may precipitate due to various reasons such as chronic alcoholism, gall stone obstruction,... 
Withaferin A | Cerulein | inflammation | oxidative stress | acute pancreatitis | LUNG | ACTIVATION | CHEMISTRY, MEDICINAL | KAPPA-B | MODEL | PHARMACOLOGY & PHARMACY | ACINAR-CELLS | MICE | SEVERITY | MODULATION | NANOCERIA | Inflammation - pathology | Panax | Acute Disease | Male | Pancreatitis - drug therapy | Pancreatitis - chemically induced | Animals | Withanolides - pharmacology | Inflammation - drug therapy | Pancreatitis - pathology | Mice | Oxidative Stress - drug effects | Ceruletide | Withanolides - therapeutic use | Withania - chemistry | Immunohistochemistry | Oxidative stress | Amylases | Analysis | Liver | Pancreatitis | Gallstones | Inflammation | Drug abuse | Parameter estimation | Alcoholism | Dietary supplements | Lipase | Malondialdehyde | Diet | Lungs | Calculi | Nitrotyrosine | Peroxidase | Pretreatment | Gall | Pancreas | Ginseng | Glutathione
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10. Full Text The Role of Plant‐derived Products in Pancreatitis: Experimental and Clinical Evidence
by Anchi, Pratibha and Khurana, Amit and Bale, Swarna and Godugu, Chandraiah
Phytotherapy Research, ISSN 0951-418X, 04/2017, Volume 31, Issue 4, pp. 591 - 623
Pancreatitis is a gastrointestinal disease with a worldwide sharp surge during the past decade. Pancreatitis includes acute and chronic subtypes, which are... 
pancreatitis | phytomedicine | inflammation | cerulein | oxidative stress | PRO-INFLAMMATORY CYTOKINES | KAPPA-B ACTIVATION | NARDOSTACHYS-JATAMANSI | CHEMISTRY, MEDICINAL | HEREDITARY PANCREATITIS | LUNG INJURY | ALPHA-LIPOIC ACID | RAT MODEL | KOREAN RED GINSENG | PHARMACOLOGY & PHARMACY | CHENG-QI DECOCTION | Female | Male | Pancreatitis - drug therapy | Phytotherapy - methods | Humans | Pancreatitis | B cells | Index Medicus
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11. Full Text Niclosamide alleviates pulmonary fibrosis in vitro and in vivo by attenuation of epithelial-to-mesenchymal transition, matrix proteins & Wnt/β-catenin signaling: A drug repurposing study
by Boyapally, Raju and Pulivendala, Gauthami and Bale, Swarna and Godugu, Chandraiah
Life Sciences, ISSN 0024-3205, 03/2019, Volume 220, pp. 8 - 20
Drug repurposing off late has been emerging as an inspiring alternative approach to conventional, exhaustive and arduous process of drug discovery. It is a... 
Niclosamide | Pulmonary fibrosis | EMT | Wnt/β-catenin | MEDICINE, RESEARCH & EXPERIMENTAL | LUNG | Wnt/beta-catenin | PHARMACOLOGY & PHARMACY | Wnt protein | Mesenchyme | Migration | Lung diseases | Proteins | β-catenin | Signaling | Scars | Bleomycin | Fibrosis | Attenuation | In vivo methods and tests | Drug discovery | Index Medicus
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12. Full Text Withaferin A attenuates bleomycin‐induced scleroderma by targeting FoxO3a and NF‐κβ signaling: Connecting fibrosis and inflammation
by Bale, Swarna and Pulivendala, Gauthami and Godugu, Chandraiah
BioFactors, ISSN 0951-6433, 11/2018, Volume 44, Issue 6, pp. 507 - 517
Scleroderma is an inflammatory autoimmune disease which begins with inflammation due to tissue injury and advances to progressive accumulation of extracellular... 
Withaferin A | bleomycin | inflammation | EMT | scleroderma | Skin - metabolism | Humans | Scleroderma, Localized - chemically induced | Extracellular Matrix - metabolism | Male | NF-kappa B - metabolism | Smad2 Protein - genetics | Anti-Inflammatory Agents - isolation & purification | Proto-Oncogene Proteins c-akt - metabolism | Disease Models, Animal | Fibroblasts - metabolism | NF-kappa B - antagonists & inhibitors | Signal Transduction | Anti-Inflammatory Agents - pharmacology | Dermatologic Agents - isolation & purification | Scleroderma, Localized - pathology | Smad2 Protein - metabolism | Bleomycin - administration & dosage | Fibroblasts - pathology | Myofibroblasts - drug effects | Forkhead Box Protein O3 - metabolism | Withanolides - pharmacology | Fibroblasts - drug effects | Mice | Scleroderma, Localized - genetics | Extracellular Matrix - pathology | Withania - chemistry | Withanolides - isolation & purification | Smad3 Protein - metabolism | Proto-Oncogene Proteins c-akt - genetics | Forkhead Box Protein O3 - genetics | Myofibroblasts - metabolism | Smad3 Protein - genetics | I-kappa B Kinase - metabolism | Forkhead Box Protein O3 - antagonists & inhibitors | Skin - pathology | Dermatologic Agents - pharmacology | Myofibroblasts - pathology | Scleroderma, Localized - drug therapy | Extracellular Matrix - drug effects | Mice, Inbred C57BL | Gene Expression Regulation | I-kappa B Kinase - genetics | Animals | Transforming Growth Factor beta - genetics | NF-kappa B - genetics | Cell Differentiation - drug effects | Transforming Growth Factor beta - metabolism | Skin - drug effects
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13. Folate-decorated PLGA nanoparticles as a rationally designed vehicle for the oral delivery of insulin
by Jain, Sanyog and Rathi, Vishal V and Jain, Amit K and Das, Manasmita and Godugu, Chandraiah
Nanomedicine, ISSN 1743-5889, 09/2012, Volume 7, Issue 9, pp. 1311 - 1337
The present study reports a novel approach for enhancing the oral absorption and hypoglycemic activity of insulin via encapsulation in folate-(FA) coupled... 
polylactide-co-glycolide nanoparticle | cumulative hypoglycemia | folic acid | oral insulin delivery | insulin stability | EFFICACY | STABILITY | CHITOSAN | NANOSCIENCE & NANOTECHNOLOGY | NANOCAPSULES | FORMULATION | CARRIERS | POLYMERIC NANOPARTICLES | PEG | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ABSORPTION | LIPOSOMES | Hypoglycemic Agents - therapeutic use | Diabetes Mellitus, Experimental - drug therapy | Hypoglycemic Agents - pharmacokinetics | Lactic Acid - chemistry | Blood Glucose - analysis | Nanoparticles - chemistry | Administration, Oral | Folic Acid - chemistry | Nanoparticles - ultrastructure | Rats | Insulin - administration & dosage | Male | Rats, Sprague-Dawley | Drug Carriers - chemistry | Animals | Hypoglycemic Agents - administration & dosage | Polyglycolic Acid - chemistry | Insulin - pharmacokinetics | Insulin - therapeutic use | Bioavailability
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14. Full Text An adaptogen: Withaferin a ameliorates in vitro and in vivo pulmonary fibrosis by modulating the interplay of fibrotic, matricelluar proteins, and cytokines
by Bale, Swarna and Venkatesh, Pooladanda and Sunkoju, Manoj and Godugu, Chandraiah
Frontiers in Pharmacology, ISSN 1663-9812, 03/2018, Volume 9
Pulmonary fibrosis (PF) is chronic lung disease with only two FDA approved clinically available drugs, with limited safety profile. Inadequate therapy... 
Epithelial to mesenchymal transition | Angiogenesis | Withaferin A | Extracellular matrix | Inflammation | Pulmonary fibrosis | ENDOTHELIAL-GROWTH-FACTOR | angiogenesis | MAST-CELLS | NEGATIVE BREAST-CANCER | BETA | EPITHELIAL-MESENCHYMAL TRANSITION | inflammation | SIGNALING PATHWAY | CELL-MIGRATION | pulmonary fibrosis | ORAL BIOAVAILABILITY | epithelial to mesenchymal transition | PHARMACOLOGY & PHARMACY | EXTRACELLULAR-MATRIX | FOCAL ADHESION KINASE | extracellular matrix | Development and progression | Care and treatment | Health aspects | Lactones
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