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Journal of the National Cancer Institute, ISSN 0027-8874, 11/2013, Volume 105, Issue 22, p. 1762
Journal Article
Nature, ISSN 0028-0836, 08/2017, Volume 548, Issue 7668, pp. 471 - 475
Cyclin-dependent kinases 4 and 6 (CDK4/6) are fundamental drivers of the cell cycle and are required for the initiation and progression of various... 
BREAST-CANCER | CELLS | METHYLATION | MULTIDISCIPLINARY SCIENCES | SENESCENCE | EXPRESSION | REQUIREMENT | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Viruses - genetics | Breast Neoplasms - immunology | Humans | Transcriptome | T-Lymphocytes, Regulatory - immunology | T-Lymphocytes, Regulatory - cytology | Female | Biological Mimicry - drug effects | Phosphorylation - drug effects | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Disease Models, Animal | Viruses - drug effects | Viruses - immunology | Antigen Presentation - immunology | Breast Neoplasms - drug therapy | T-Lymphocytes, Regulatory - drug effects | Animals | Breast Neoplasms - genetics | Repressor Proteins - biosynthesis | Signal Transduction - drug effects | Breast Neoplasms - pathology | Cell Cycle Checkpoints - drug effects | Protein Kinase Inhibitors - therapeutic use | RNA, Double-Stranded - genetics | Cell Line, Tumor | Interferons - metabolism | Antigen Presentation - drug effects | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Oncology, Experimental | Cancer cells | Physiological aspects | Research | Protein kinases | Immunity | Cyclins | Cancer | Cell proliferation | Flow cytometry | Animal models | Phosphorylation | Senescence | Peptides | Genomics | Immune clearance | Cytotoxicity | Lymphocytes T | Genomes | Kinases | Cancer therapies | Cyclin-dependent kinase 4 | E2F protein | Breast carcinoma | Cell growth | Lymphocytes | New combinations | Cell cycle | Inhibition | Deoxyribonucleic acid--DNA | Antigen presentation | Medical research | Immune response | Immunoregulation | Intracellular levels | Double-stranded RNA | Breast cancer | Pharmacology | Gene expression | Ribonucleic acid--RNA | Immune systems | Inhibitors | Immune checkpoint | Immunogenicity | Breast | DNA methyltransferase | Interferon | Retinoblastoma | Tumors | Apoptosis | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2012, Volume 109, Issue 41, pp. 16618 - 16623
Although the role of TGF-ß in tumor progression has been studied extensively, its impact on drug delivery in tumors remains far from understood. In this study,... 
Cell growth | Receptors | Perfusion | Collagens | Antineoplastics | Blood vessels | Metastasis | Tumors | Cancer | Apoptosis | Breast cancer | Drug delivery | Vessel normalization | CANCER-CELLS | COLLAGEN | METASTASIS | SOLID TUMORS | MULTIDISCIPLINARY SCIENCES | VESSEL MATURATION | breast cancer | drug delivery | DELIVERY | GROWTH-FACTOR-BETA | SOLUBLE BETAGLYCAN | vessel normalization | PROSTATE-CANCER | EXTRACELLULAR TRANSPORT | Antibodies, Neutralizing - administration & dosage | Doxorubicin - therapeutic use | Receptors, Transforming Growth Factor beta - genetics | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Breast Neoplasms - metabolism | Tissue Distribution | Antibodies, Neutralizing - immunology | Lung Neoplasms - secondary | Transforming Growth Factor beta - antagonists & inhibitors | Female | Antibiotics, Antineoplastic - pharmacokinetics | Protein-Serine-Threonine Kinases - metabolism | Transforming Growth Factor beta - immunology | Collagen Type I - metabolism | Protein-Serine-Threonine Kinases - genetics | Treatment Outcome | Signal Transduction - genetics | Breast Neoplasms - drug therapy | Blotting, Western | Doxorubicin - pharmacokinetics | Antibiotics, Antineoplastic - administration & dosage | Xenograft Model Antitumor Assays | Animals | Lung Neoplasms - prevention & control | Receptors, Transforming Growth Factor beta - metabolism | Signal Transduction - drug effects | Tumor Burden - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Mice, Nude | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Transforming Growth Factor beta - metabolism | Index Medicus | Biological Sciences | Physical Sciences
Journal Article
by Goel, S
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, ISSN 1743-7555, 11/2016, Volume 12, pp. 67 - 67
Conference Proceeding
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2015, Volume 112, Issue 46, pp. 14325 - 14330
Journal Article
Journal Article
Current Breast Cancer Reports, ISSN 1943-4588, 3/2017, Volume 9, Issue 1, pp. 26 - 33
The purpose of this review is to describe the role of D-type cyclins and cyclin-dependent kinases (CDKs) 4 and 6 in breast cancer and to discuss potential... 
Estrogen receptor | Medicine & Public Health | CDK4/6 | Cyclin | Internal Medicine | Oncology | Breast cancer | Drug resistance | Surgical Oncology | Prevention | Estrogen | Gene expression | Phosphotransferases | Cancer | breast cancer | cyclin | drug resistance | CDK4 | estrogen receptor
Journal Article
Current Breast Cancer Reports, ISSN 1943-4588, 12/2015, Volume 7, Issue 4, pp. 190 - 202
Over the last two decades, four novel agents have been approved for the management of patients with metastatic human epidermal growth factor receptor 2... 
Trastuzumab emtansine | Medicine & Public Health | Pertuzumab | Brain metastasis | Oncology | Internal Medicine | Breast cancer | Metastasis | Lapatinib | HER2 | Surgical Oncology | Trastuzumab
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 04/2015, Volume 107, Issue 4, p. 1
Background: Matrix metalloproteinase (MMP) 14 may mediate tumor progression through vascular and immune-modulatory effects. Methods: Orthotopic murine breast... 
VASCULAR NORMALIZATION | INVASION | CANCER CELLS | ANGIOGENESIS | ONCOLOGY | MATRIX-METALLOPROTEINASE INHIBITORS | DRUG-DELIVERY | NITRIC-OXIDE SYNTHASE | TUMOR-GROWTH | EXPRESSION | BETA | Up-Regulation | Immunoglobulin G - blood | Breast Neoplasms - immunology | Humans | Gene Expression Regulation, Neoplastic | Neovascularization, Pathologic | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents - therapeutic use | Smad3 Protein - metabolism | Breast Neoplasms - metabolism | Nitric Oxide Synthase Type II - antagonists & inhibitors | Dose Fractionation | Female | Antineoplastic Agents - pharmacology | Matrix Metalloproteinase 14 - drug effects | Antibodies, Monoclonal - pharmacology | Enzyme Inhibitors - pharmacology | Smad2 Protein - metabolism | Nitric Oxide Synthase Type II - drug effects | Breast Neoplasms - blood supply | Matrix Metalloproteinase 14 - metabolism | Breast Neoplasms - drug therapy | Enzyme Inhibitors - therapeutic use | Macrophages - enzymology | Gene Expression Regulation, Enzymologic | Breast Neoplasms - radiotherapy | Phenotype | Animals | Signal Transduction - drug effects | Mammary Neoplasms, Experimental | Cell Line, Tumor | Macrophages - drug effects | Amidines - pharmacology | Mice | Benzylamines - pharmacology | Transforming Growth Factor beta - metabolism | Nitric Oxide Synthase Type II - metabolism | Enzymes | Genotype & phenotype | Immunoglobulins | Immunology | Radiation therapy | Gene expression | Tumors | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2011, Volume 108, Issue 1, pp. 302 - 307
Journal Article
Nature Medicine, ISSN 1078-8956, 07/2016, Volume 22, Issue 7, pp. 723 - 726
Brain metastases represent the greatest clinical challenge in treating HER2-positive breast cancer. We report the development of orthotopic patient-derived... 
MEDICINE, RESEARCH & EXPERIMENTAL | PTEN LOSS | EVEROLIMUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Immunohistochemistry | Genomic Instability | Neoplasm Transplantation | Phosphoproteins - drug effects | Phosphorylation | Apoptosis - drug effects | Humans | Caspase 3 - metabolism | Receptor, ErbB-2 - metabolism | Ki-67 Antigen - metabolism | Gene Expression Profiling | DNA Repair - genetics | Carrier Proteins - drug effects | Molecular Targeted Therapy | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Phosphoproteins - metabolism | Breast Neoplasms - metabolism | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | Brain Neoplasms - secondary | Caspase 3 - drug effects | Female | Antineoplastic Agents - pharmacology | Drug Therapy, Combination | Everolimus - pharmacology | Brain Neoplasms - genetics | Morpholines - pharmacology | Brain Neoplasms - drug therapy | Mice, SCID | Breast Neoplasms - drug therapy | Remission Induction | Xenograft Model Antitumor Assays | Magnetic Resonance Imaging | Drug Resistance, Neoplasm - genetics | Animals | Breast Neoplasms - genetics | Carrier Proteins - metabolism | Breast Neoplasms - pathology | Aminopyridines - pharmacology | Mice | Ki-67 Antigen - drug effects | Complications and side effects | Care and treatment | Brain tumors | Development and progression | Breast cancer | Genetic aspects | Metastasis | Phosphotransferases | Health aspects | Brain cancer | Rodents | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 11/2012, Volume 109, Issue 45, pp. E3119 - E3127
Brain metastases are a serious obstacle in the treatment of patients with human epidermal growth factor receptor-2 ( HER2 )–amplified breast cancer. Although... 
targeted therapy | CELLS | TRASTUZUMAB | ANGIOGENESIS | BEVACIZUMAB | MULTIDISCIPLINARY SCIENCES | PHASE-II | COMBINATION | CAPECITABINE | NERVOUS-SYSTEM METASTASES | tumor-stroma interaction | tumor microenvironment | antiangiogenesis | LAPATINIB GW572016 | treatment resistance | ENDOTHELIAL GROWTH-FACTOR | Receptor, ErbB-2 - genetics | Blood Vessels - pathology | Humans | Brain Neoplasms - pathology | Receptor, ErbB-2 - metabolism | Antibodies, Monoclonal - therapeutic use | Brain Neoplasms - blood supply | Killer Cells, Natural - pathology | Molecular Targeted Therapy | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Necrosis | Brain Neoplasms - secondary | Receptors, Vascular Endothelial Growth Factor - metabolism | Antibodies, Monoclonal, Humanized - pharmacology | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Female | Receptor, ErbB-2 - antagonists & inhibitors | Cell Death - drug effects | Disease Models, Animal | Antibodies, Monoclonal, Humanized - therapeutic use | Antibodies, Monoclonal - pharmacology | Treatment Outcome | Brain Neoplasms - drug therapy | Breast Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Diagnostic Imaging | Animals | Gene Amplification | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Neovascularization, Pathologic - drug therapy | Quinazolines - therapeutic use | Blood Vessels - drug effects | Survival Analysis | Cell Proliferation - drug effects | Killer Cells, Natural - drug effects | Mice | Quinazolines - pharmacology | Trastuzumab | Brain | Breast cancer | Metastasis | Medical treatment | Tumors | Index Medicus | Biological Sciences | PNAS Plus | tumor–stroma interaction
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 08/2013, Volume 105, Issue 16, pp. 1188 - 1201
Journal Article
Journal Article