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Trends in Pharmacological Sciences, ISSN 0165-6147, 04/2019, Volume 40, Issue 4, pp. 233 - 236
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e64905
Mosquito-borne diseases such as malaria and dengue fever take a large toll on global health. The primary chemical agents used for controlling mosquitoes are... 
MALPIGHIAN TUBULES | CELLS | TRANSPORT | YELLOW-FEVER MOSQUITO | KIR1.1 | MULTIDISCIPLINARY SCIENCES | URINE | INSECTS | MECHANISMS | AEDES-AEGYPTI | DIURESIS | Anopheles - metabolism | Potassium - metabolism | Anopheles - growth & development | Insecticides - chemistry | Hemolymph - drug effects | Humans | Culex - metabolism | Benzimidazoles - chemistry | Aedes - metabolism | Dose-Response Relationship, Drug | HEK293 Cells | Imines - chemistry | Culex - growth & development | Female | Potassium Channels, Inwardly Rectifying - antagonists & inhibitors | Molecular Structure | Malpighian Tubules - drug effects | Potassium Channel Blockers - pharmacology | Insecticides - pharmacology | Membrane Potentials - drug effects | Insect Proteins - physiology | Imines - metabolism | Hemolymph - metabolism | Insect Proteins - genetics | Potassium Channels, Inwardly Rectifying - genetics | Imines - pharmacology | Aedes - genetics | Insect Proteins - antagonists & inhibitors | Malpighian Tubules - metabolism | Patch-Clamp Techniques | Animals | Benzimidazoles - metabolism | Potassium Channels, Inwardly Rectifying - physiology | Benzimidazoles - pharmacology | Malpighian Tubules - pathology | Potassium Channel Blockers - chemistry | Aedes - growth & development | Insecticides | Chemical weapons | Usage | Mosquitoes | Kidney failure | Potassium channels | Neurosciences | Toxicity | Physicians | Viral diseases | Homeostasis | Nervous system | Aquatic insects | Channels | Tropical diseases | Insecticide resistance | Agrochemicals | Chemical agents | Physiology | Public health | Urine | Vector-borne diseases | Killing | Pathogens | Excretion | Kidneys | Potassium channels (inwardly-rectifying) | Malaria | Research & development--R&D | Dengue | Hemolymph | Tubules | Pharmacology | Fever | Medicine | Inhibitors | Insects | Renal failure | Anesthesiology | Potassium | Kidney transplantation | Research & development | R&D
Journal Article
Journal of Neuroimmune Pharmacology, ISSN 1557-1890, 6/2016, Volume 11, Issue 2, pp. 231 - 237
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 05/2018, Volume 365, Issue 2, pp. 291 - 300
Mutations in the MeCP2 gene are responsible for the neurodevelopmental disorder Rett syndrome (RTT). MeCP2 is a DNA-binding protein whose abundance and ability... 
Drug Discovery and Translational Medicine
Journal Article
Journal Article
Cerebral Cortex, ISSN 1047-3211, 12/2018, Volume 28, Issue 12, pp. 4291 - 4304
Abstract Dysregulated fear memory can lead to a broad spectrum of anxiety disorders. The brain systems underlying fear memory are manifold, with the... 
LTP | plasticity | mGlu5 | hippocampus | ALLOSTERIC MODULATORS | PROTEIN-SYNTHESIS | SYNAPTIC PLASTICITY | NEUROSCIENCES | PREFRONTAL CORTEX | MEMORY | MOUSE MODEL | MGLUR5 | LONG-TERM POTENTIATION | INTRINSIC PLASTICITY | Original
Journal Article
Neuropharmacology, ISSN 0028-3908, 01/2019, Volume 144, pp. 19 - 28
Stress can precipitate or worsen symptoms of many psychiatric illnesses. Dysregulation of the prefrontal cortex (PFC) glutamate system may underlie these... 
mGlu3 | mGlu5 | Reversal learning | Stress | Synaptic plasticity | Prelimbic prefrontal cortex | reversal learning | stress | synaptic plasticity | prelimbic prefrontal cortex
Journal Article
Neuropharmacology, ISSN 0028-3908, 01/2019, Volume 144, p. 19
Stress can precipitate or worsen symptoms of many psychiatric illnesses. Dysregulation of the prefrontal cortex (PFC) glutamate system may underlie these... 
Neurosciences | Synthesis | Glycogen | Physiological aspects | Glutamate | Mental illness
Journal Article
Science Translational Medicine, ISSN 1946-6234, 08/2017, Volume 9, Issue 403
Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the methyl-CpG binding protein 2 ( MECP2 ) gene. The cognitive impairments seen in... 
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 01/2020, Volume 63, Issue 2, pp. 656 - 675
WD repeat domain 5 (WDR5) is a member of the WD40-repeat protein family that plays a critical role in multiple chromatin-centric processes. Overexpression of... 
TARGET | COMPLEX | CHEMISTRY, MEDICINAL | RECOGNITION | MYC | REGULATES HOXA9 CHROMATIN | MLL | TUMORIGENESIS | EXPRESSION | BINDING | FAMILY
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 12/2017, Volume 9, Issue 9, pp. 2210 - 2217
Rett syndrome and MECP2 Duplication syndrome are neurodevelopmental disorders attributed to loss-of-function mutations in, or duplication of, the gene encoding... 
negative allosteric modulator | MECP2 Duplication syndrome | MeCP2 | mGlu | ADX71743 | Rett syndrome | mGlu7
Journal Article
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 1/2020, Volume 63, Issue 2, pp. 656 - 675
WD repeat domain 5 (WDR5) is a member of the WD40-repeat protein family that plays a critical role in multiple chromatin-centric processes. Overexpression of... 
WDR5 | mixed-lineage leukemia | WIN site inhibitor | structure-based design
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2018, Volume 61, Issue 13, pp. 5623 - 5642
WDR5 is a chromatin-regulatory scaffold protein overexpressed in various cancers and a potential epigenetic drug target for the treatment of mixed-lineage... 
COMPLEX | CHEMISTRY, MEDICINAL | WD REPEAT | HIGH-AFFINITY | LINEAGE | BINDING | LEUKEMIA MLL PROTEIN | WDR5 | mixed-lineage leukemia | fragment screening | structure-based design
Journal Article
Journal Article