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Gut, ISSN 0017-5749, 05/2012, Volume 61, Issue 5, pp. 673 - 684
ObjectiveGastric cancer is a major gastrointestinal malignancy for which targeted therapies are emerging as treatment options. This study sought to identify... 
GROWTH-FACTOR RECEPTOR | LUNG | AMPLIFICATION | COPY-NUMBER | ACQUIRED-RESISTANCE | TYROSINE KINASE INHIBITOR | GASTROENTEROLOGY & HEPATOLOGY | TRASTUZUMAB RESISTANCE | EXPRESSION | LINEAGE-SURVIVAL ONCOGENE | GENETIC ALTERATIONS | Stomach Neoplasms - genetics | Receptor, Epidermal Growth Factor - genetics | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Oligonucleotide Array Sequence Analysis | Receptor, ErbB-2 - genetics | Proportional Hazards Models | Proto-Oncogene Proteins - genetics | Antineoplastic Agents - therapeutic use | Genetic Markers | Stomach Neoplasms - drug therapy | Molecular Targeted Therapy | Proto-Oncogene Proteins c-met - genetics | Gene Amplification | Gene Deletion | Polymorphism, Single Nucleotide | Stomach Neoplasms - mortality | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Development and progression | Drug targeting | Genetic aspects | Research | Demographic aspects | Stomach cancer | Proteins | Studies | Chemotherapy | Medical prognosis | Mortality | Clinical trials | Breast cancer | Mutation | Cancer therapies | Patients | Tumors | Index Medicus | Abridged Index Medicus | Stomach | gastroscopy | Barrett's metaplasia | gastric cancer | targeted therapies | gene mutation | gastric pre-cancer | chemotherapy | oesophageal cancer | Barrett's carcinoma | receptor tyrosine kinases | cell signalling | gastrointestinal cancer | cancer | colorectal cancer screening | gastrointesinal endoscopy | gastric carcinoma | 1506 | molecular pathology | copy number alterations | gene expression
Journal Article
Gastroenterology, ISSN 0016-5085, 2013, Volume 145, Issue 3, pp. 554 - 565
Background & Aims Almost all gastric cancers are adenocarcinomas, which have considerable heterogeneity among patients. We sought to identify subtypes of... 
Gastroenterology and Hepatology | Stomach Cancer | Personalized Cancer Treatment | Cancer Classification | PI3K | GC-Class | Keywords Stomach Cancer GC-Class Personalized Cancer Treatment Cancer Classification PI3K | STEM-CELLS | DNA HYPOMETHYLATION | ADENOCARCINOMA | STOMACH-CANCER | TUMORS | CHEMOTHERAPY | CLASS DISCOVERY | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | CARCINOMA | REVEALS | Adenocarcinoma - classification | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Stomach Neoplasms - metabolism | Antineoplastic Agents - therapeutic use | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | Fluorouracil - therapeutic use | Adenocarcinoma - metabolism | Biomarkers, Tumor - metabolism | Adenocarcinoma - genetics | Retrospective Studies | Stomach Neoplasms - classification | Stomach Neoplasms - genetics | Genetic Association Studies | Treatment Outcome | Models, Statistical | Stomach Neoplasms - drug therapy | Adenocarcinoma - drug therapy | Regression Analysis | Bayes Theorem | Survival Analysis | Cell Line, Tumor | Aged | Biomarkers, Tumor - genetics | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Cluster Analysis | Medical colleges | Chemotherapy | College graduates | Stem cells | Stomach cancer | Cancer | Fluorouracil | Index Medicus | Abridged Index Medicus
Journal Article
by Horikoshi, Momoko and Yaghootkar, Hanieh and Mook-Kanamori, Dennis O and Sovio, Ulla and Taal, H. Rob and Hennig, Branwen J and Bradfield, Jonathan P and St Pourcain, Beate and Evans, David M and Charoen, Pimphen and Kaakinen, Marika and Cousminer, Diana L and Lehtimaki, Terho and Kreiner-Moller, Eskil and Warrington, Nicole M and Bustamante, Mariona and Feenstra, Bjarke and Berry, Diane J and Thiering, Elisabeth and Pfab, Thiemo and Barton, Sheila J and Shields, Beverley M and Kerkhof, Marjan and van Leeuwen, Elisa and Fulford, Anthony J and Kutalik, Zoltan and Zhao, Jing Hua and den Hoed, Marcel and Mahajan, Anubha and Lindi, Virpi and Goh, Liang-Kee and Hottenga, Jouke-Jan and Wu, Ying and Raitakari, Olli T and Harder, Marie N and Meirhaeghe, Aline and Ntalla, Ioanna and Salem, Rany M and Jameson, Karen A and Zhou, Kaixin and Monies, Dorota M and Lagou, Vasiliki and Kirin, Mirna and Heikkinen, Jani and Adair, Linda S and Alkuraya, Fowzan S and Al-Odaib, Ali and Amouyel, Philippe and Andersson, Ehm Astrid and Bennett, Amanda J and Blakemore, Alexana I. F and Buxton, Jessica L and Dallongeville, Jean and Das, Shikta and de Geus, Eco J. C and Estivill, Xavier and Flexeder, Claudia and Froguel, Philippe and Geller, Frank and Godfrey, Keith M and Gottrand, Frederic and Groves, Christopher J and Hansen, Torben and Hirschhorn, Joel N and Hofman, Albert and Hollegaard, Mads V and Hougaard, David M and Hyppoenen, Elina and Inskip, Hazel M and Isaacs, Aaron and Jorgensen, Torben and Kanaka-Gantenbein, Christina and Kemp, John P and Kiess, Wieland and Kilpelainen, Tuomas O and Klopp, Norman and Knight, Bridget A and Kuzawa, Christopher W and McMahon, George and Newnham, John P and Niinikoski, Harri and Oostra, Ben A and Pedersen, Louise and Postma, Dirkje S and Ring, Susan M and Rivadeneira, Fernando and Robertson, Neil R and Sebert, Sylvain and Simell, Olli and Slowinski, Torsten and Tiesler, Carla M. T and Toenjes, Anke and Vaag, Allan and Viikari, Jorma S and Vink, Jacqueline M and Vissing, Nadja Hawwa and Wareham, Nicholas J and Willemsen, Gonneke and Witte, Daniel R and Zhang, Haitao and ... and Early Growth Genetics EGG and MAGIC and Early Growth Genetics (EGG) Consortium and Meta-Analyses of Glucose- and Insulin-related traits Consortium (MAGIC) and The Meta-Analyses of Glucose- and Insulin-related traits Consortium (MAGIC)
Nature Genetics, ISSN 1061-4036, 01/2013, Volume 45, Issue 1, pp. 76 - 82
Journal Article
Gut, ISSN 0017-5749, 05/2015, Volume 64, Issue 5, pp. 707 - 719
Journal Article
Nature Cell Biology, ISSN 1465-7392, 04/2015, Volume 17, Issue 4, pp. 511 - 523
The functional significance of the overexpression of unmutated TAp73, a homologue of the tumour suppressor p53, in multiple human cancers is unclear, but... 
APOPTOTIC RESPONSE | FACTOR 1-ALPHA | WILD-TYPE P73 | IN-VITRO | KINASE C-ABL | DNA-DAMAGE | TUMOR ANGIOGENESIS | MAMMALIAN-CELLS | EXPRESSION | CANCER-THERAPY | CELL BIOLOGY | Vascular Endothelial Growth Factor A - biosynthesis | Humans | Gene Expression Regulation, Neoplastic | Ubiquitin-Protein Ligases - antagonists & inhibitors | Cell Hypoxia | DNA-Binding Proteins - metabolism | Ubiquitination | Nuclear Proteins - biosynthesis | Cell Transformation, Neoplastic - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Tumor Suppressor Proteins - genetics | Female | Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis | Nuclear Proteins - genetics | Tumor Suppressor Proteins - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | HCT116 Cells | Mice, Inbred C57BL | Neoplasms - blood supply | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Mice, SCID | Mice, Knockout | Tumor Protein p73 | Animals | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Protein Binding | Neovascularization, Pathologic - genetics | Mice | Tumor Suppressor Proteins - biosynthesis | Ubiquitin-Protein Ligases - genetics | DNA-Binding Proteins - biosynthesis | Oncology, Experimental | Genetic research | Tumor suppressor genes | Genetic aspects | Research | Properties | Genetic regulation | Carcinogenesis | Cancer | Index Medicus
Journal Article
by Ikram, Arfan and Fornage, Myriam and Smith, G.D and Seshai, Sudha and Schmidt, Reinhold and Debette, Stéphanie and Vrooman, Henri and Sigurdsson, Stefan and Ropele, Stefan and Taal, Rob and Mook-Kanamori, Dennis and Coker, Laura and Longstreth, W.T and Niessen, Wiro and DeStefano, Anita and Beiser, Alexa and Zijdenbos, A.P and Struchalin, Maksim and Jack Jr., Clifford and Rivadeneira Ramirez, Fernando and Uitterlinden, Ané and Knopman, David and Hartikainen, A.L and Pennell, Craig and Thiering, Eelisabeth and Steegers, Eric and Hakonarson, Hakon and Heinrich, Joachim and Palmer, Cameron and Jarvelin, Marjo-Riitta and McCarthy, Mark and Grant, Struan and Pourcain, Beate and Timpson, Nicholas and Sovio, Ulla and Nalls, Michael and Au, Rhoda and Hofman, Albert and Gudnason, Haukur and Lugt, Aad and Harris, Tamara and Meeks, William and Vernooij, Meike and Buchem, Mark and Catellier, Diane and Jaddoe, Vincent and Gudnason, Vilmundur and Windham, B Gwen and Wolf, Philip and Duijn, Cornelia and Mosley, Thomas and Launer, Lenore and Breteler, Monique and DeCarli, Charles and Adair, Linda and Ang, Wei and Atalay, Mustafa and Beijsterveldt, Toos and Bergen, Nienke and Benke, Paul and Berry, Diane and Coin, Lachlan and Davis, Oliver S and Elliott, Paul and Flexeder, Claudia and Frayling, Timothy and Gaillard, Romy and Groen-Blokhuis, Maria and Goh, L.-K and Haworth, Claire M and Hadley, David and Hedebrand, Johannes and Hinney, Anke and Hirschhorn, Joel and Holloway, John and Holst, J.J and Hottenga, Jouke Jan and Horikoshi, Momoko and Huikari, Ville and Hypponen, Elina and Kilpeläinen, Tuomas and Kirin, Mirna and Kowgier, Matthew and Lakka, Timo and Lange, Leslie and Lawlor, Debbie and Lehtimäki, Terho and Lewin, Alex and Lindgren, Cecilia and Lindi, Virpi and Maggi, Reedik and Marsh, Julie and Middeldorp, Christel and Millwood, Iona and Murray, Jeffrey and Nivard, Michel and Nohr, Christian and Ntalla, Ioanna and Oken, Emily and Panoutsopoulou, Kalliope and ... and Cohorts Heart Aging Res Genomic Ep and Early Growth Genetics EGG Consorti and Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium and Early Growth Genetics Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium and Early Growth Genetics (EGG) Consortium and Mittuniversitetet and Institutionen för samhällsvetenskap and Fakulteten för humanvetenskap
Nature Genetics, ISSN 1061-4036, 05/2012, Volume 44, Issue 5, pp. 539 - 544
Journal Article