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Journal Article
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2013, Volume 123, Issue 12, pp. 5119 - 5134
A systems pharmacological approach that capitalizes on the characterization of intracellular signaling networks can transform our understanding of human... 
MEDICINE, RESEARCH & EXPERIMENTAL | VISUAL CYCLE | PHAGOCYTOSIS | OPTICAL COHERENCE TOMOGRAPHY | ABCA4 | RHODOPSIN | MECHANISMS | MICE | DOXAZOSIN | LONG-TERM TREATMENT | CLINICAL-EXPERIENCE | Receptors, Adrenergic, alpha-2 - genetics | Guanabenz - therapeutic use | Reactive Oxygen Species | Receptor, Serotonin, 5-HT2A - genetics | Doxazosin - pharmacology | Humans | Photoreceptor Cells, Vertebrate - drug effects | Adrenergic alpha-Antagonists - therapeutic use | Macaca fascicularis | Adrenergic alpha-Antagonists - pharmacology | Molecular Targeted Therapy | Photoreceptor Cells, Vertebrate - physiology | Macular Degeneration - drug therapy | Adenylyl Cyclase Inhibitors | Adrenergic alpha-Agonists - therapeutic use | Alcohol Oxidoreductases - genetics | ATP-Binding Cassette Transporters - deficiency | Photoreceptor Cells, Vertebrate - radiation effects | ATP-Binding Cassette Transporters - genetics | Adenine - therapeutic use | Doxazosin - therapeutic use | Nerve Tissue Proteins - biosynthesis | Receptors, Adrenergic, alpha-2 - biosynthesis | Drug Evaluation, Preclinical | Disease Models, Animal | Macular Degeneration - prevention & control | Receptor, Serotonin, 5-HT2A - biosynthesis | Adenine - analogs & derivatives | Signal Transduction | Cell Survival | Light - adverse effects | Serotonin Antagonists - therapeutic use | Receptors, G-Protein-Coupled - biosynthesis | Adenine - pharmacology | Serotonin Antagonists - pharmacology | Nerve Tissue Proteins - genetics | Mice, Knockout | Guanabenz - pharmacology | Animals | Macular Degeneration - congenital | Macular Degeneration - genetics | Adrenergic alpha-Agonists - pharmacology | Mice | Mice, Inbred BALB C | Receptors, G-Protein-Coupled - genetics | Photoreceptor Cells, Vertebrate - pathology | Alcohol Oxidoreductases - deficiency | Macular degeneration | Retinal degeneration | Research | Studies | Pathology | Signal transduction | Disease | Genes | Retina | Photoreceptors | Pharmacology | Index Medicus | Abridged Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2009, Volume 106, Issue 41, pp. 17325 - 17330
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 06/2015, Volume 11, Issue 6, pp. 409 - 415
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2015, Volume 125, Issue 7, pp. 2781 - 2794
Emixustat is a visual cycle modulator that has entered clinical trials as a treatment for age-related macular degeneration (AMD). This molecule has been... 
LIPOFUSCIN FLUOROPHORE | MEDICINE, RESEARCH & EXPERIMENTAL | LEBER CONGENITAL AMAUROSIS | DENSITY MAPS | CONE PHOTORECEPTORS | PROTEIN-COUPLED RECEPTOR | PIGMENT EPITHELIUM | CRYSTAL-STRUCTURE | STARGARDT DISEASE | MACULAR DEGENERATION | VISUAL CYCLE MODULATOR | Free Radical Scavengers - pharmacology | Propanolamines - metabolism | Free Radical Scavengers - chemistry | Stereoisomerism | Retinaldehyde - chemistry | Crystallography, X-Ray | Male | Retinaldehyde - metabolism | Retinal Degeneration - metabolism | Macular Degeneration - drug therapy | Retinal Degeneration - prevention & control | Alcohol Oxidoreductases - genetics | ATP-Binding Cassette Transporters - deficiency | Phenyl Ethers - chemistry | ATP-Binding Cassette Transporters - genetics | Cattle | cis-trans-Isomerases - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Female | cis-trans-Isomerases - metabolism | Catalytic Domain | Enzyme Inhibitors - metabolism | Free Radical Scavengers - metabolism | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Models, Molecular | Phenyl Ethers - pharmacology | Mice, Knockout | cis-trans-Isomerases - chemistry | Macular Degeneration - metabolism | Animals | Retinaldehyde - toxicity | Propanolamines - chemistry | Mice | Mice, Inbred BALB C | Schiff Bases - metabolism | Phenyl Ethers - metabolism | Propanolamines - pharmacology | Retinal Degeneration - pathology | Alcohol Oxidoreductases - deficiency | Macular degeneration | Vitamin A | Laboratories | Light | Pigments | Data collection | Retina | Cytotoxicity | Photoreceptors | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2012, Volume 287, Issue 7, pp. 5059 - 5069
Compromised clearance of all-trans-retinal (atRAL), a component of the retinoid cycle, increases the susceptibility of mouse retina to acute light-induced... 
VISUAL CYCLE | OXIDATIVE STRESS | ACTIVATED PROTEIN-KINASE | 5-HT1A RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHOLIPASE-C | IN-VIVO | RECESSIVE RETINITIS-PIGMENTOSA | GENE ABCR | BINDING-PROPERTIES | NEUTROPHIL NADPH-OXIDASE | Reactive Oxygen Species - metabolism | Receptor, Serotonin, 5-HT2A - genetics | Calcium - metabolism | Humans | NADPH Oxidases - metabolism | Corneal Dystrophies, Hereditary - genetics | Type C Phospholipases - metabolism | Retinaldehyde - metabolism | Alcohol Oxidoreductases - genetics | ATP-Binding Cassette Transporters - genetics | Corneal Dystrophies, Hereditary - pathology | ATP-Binding Cassette Transporters - metabolism | NADPH Oxidases - genetics | Signal Transduction | Light - adverse effects | Receptor, Muscarinic M3 - metabolism | Alcohol Oxidoreductases - metabolism | Corneal Dystrophies, Hereditary - metabolism | Receptor, Muscarinic M3 - genetics | Serotonin 5-HT2 Receptor Antagonists - pharmacology | Mice, Knockout | Macular Degeneration - metabolism | Animals | Macular Degeneration - genetics | Type C Phospholipases - genetics | Mice | Inositol 1,4,5-Trisphosphate - genetics | Photoreceptor Cells, Vertebrate - metabolism | Receptor, Serotonin, 5-HT2A - metabolism | Inositol 1,4,5-Trisphosphate - metabolism | Photoreceptor Cells, Vertebrate - pathology | Macular Degeneration - pathology | Index Medicus | Molecular Bases of Disease | Vitamin A | Retinal metabolism | Vision | Reactive oxygen species (ROS) | Retinoid
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1976 - 18
Rhodopsin homeostasis is tightly coupled to rod photoreceptor cell survival and vision. Mutations resulting in the misfolding of rhodopsin can lead to... 
RESCUE | MUTANT RHODOPSIN | PHARMACOLOGICAL CHAPERONES | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | DOMINANT | MUTATIONS | MONOCLONAL-ANTIBODIES | RETINITIS-PIGMENTOSA | STARGARDT-DISEASE | CELL-DEATH | Neuroprotective Agents - therapeutic use | NIH 3T3 Cells | Retinaldehyde - therapeutic use | Thiophenes - therapeutic use | Humans | Male | Retinal Degeneration - etiology | Protein Transport - drug effects | Retinal Rod Photoreceptor Cells - metabolism | Rhodopsin - metabolism | Alcohol Oxidoreductases - genetics | Neuroprotective Agents - pharmacology | Rhodopsin - agonists | ATP-Binding Cassette Transporters - genetics | Protein Folding - drug effects | HEK293 Cells | Female | Retinal Rod Photoreceptor Cells - drug effects | Disease Models, Animal | Retinal Rod Photoreceptor Cells - radiation effects | Retinal Degeneration - drug therapy | Light - adverse effects | Mice, Inbred C57BL | Thiophenes - pharmacology | Treatment Outcome | Protein Transport - genetics | Mice, Knockout | Animals | High-Throughput Screening Assays | Rhodopsin - genetics | Rhodopsin - antagonists & inhibitors | Retinaldehyde - pharmacology | Cell Line, Tumor | Mice | Mutation | Retinal Degeneration - pathology | Retinal Rod Photoreceptor Cells - pathology | Rhodopsin | Cell survival | Toxicity | Retinitis pigmentosa | Homeostasis | Cytotoxicity | Retina | Pharmacology | Light effects | Molecular chains | Mutants | Mammalian cells | Retinal degeneration | Photoreceptors |