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Lancet, The, ISSN 0140-6736, 2014, Volume 383, Issue 9911, pp. 60 - 68
Summary Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to LDL receptors, leading to their degradation. Genetics studies have shown that... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | DENSITY-LIPOPROTEIN CHOLESTEROL | DOUBLE-STRANDED-RNA | PLASMA-CHOLESTEROL | METAANALYSIS | CARDIOVASCULAR-DISEASE | MONOCLONAL-ANTIBODY | HYPERCHOLESTEROLEMIA | STATINS | AMG 145 | ATORVASTATIN | Single-Blind Method | Serine Endopeptidases - biosynthesis | Humans | Middle Aged | RNA, Small Interfering - pharmacology | RNA, Small Interfering - adverse effects | Cholesterol, LDL - drug effects | Male | Healthy Volunteers | Proprotein Convertases - genetics | Dose-Response Relationship, Drug | Proprotein Convertases - biosynthesis | RNA Interference | Serine Endopeptidases - blood | Serine Endopeptidases - genetics | Adult | Cholesterol, LDL - blood | Female | Proprotein Convertases - blood | RNA, Small Interfering - administration & dosage | Genetic Therapy - adverse effects | Genetic Therapy - methods | Proprotein Convertase 9 | Enzymes | Research | Gene mutations | Properties | Gene expression | Identification and classification | Medical research | RNA | Low density lipoproteins | Anticholesteremic agents | Clinical trials | Aluminum compounds | Coronary heart disease | Cholesterol | Hypercholesterolemia | Analysis | Medicine, Experimental | Product development | Trans fatty acids | Blood proteins | Studies | Heart | Nanoparticles | Plasma | Nutrition research | Cardiovascular disease | Lipids | Mutation | Drug dosages | Statins | Index Medicus | Abridged Index Medicus
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 07/2018, Volume 379, Issue 1, pp. 11 - 21
Hereditary transthyretin amyloidosis is caused by the deposition of misfolded transthyretin proteins in peripheral nerves and other tissues. This phase 3 trial... 
MEDICINE, GENERAL & INTERNAL | POLYNEUROPATHY | EFFICACY | TAFAMIDIS | SAFETY | LATE-ONSET | NATURAL-HISTORY | PROGRESSION | Prealbumin - genetics | Humans | Middle Aged | Male | Amyloid Neuropathies, Familial - therapy | Infusions, Intravenous - adverse effects | Aged, 80 and over | Adult | Female | Prealbumin - analysis | Severity of Illness Index | Double-Blind Method | Amyloid Neuropathies, Familial - complications | RNA, Small Interfering - adverse effects | Polyneuropathies - therapy | Disease Progression | Administration, Intravenous | Polyneuropathies - etiology | RNA, Small Interfering - therapeutic use | Least-Squares Analysis | Quality of Life | Aged | RNAi Therapeutics | Amyloid Neuropathies, Familial - blood | Edema - chemically induced | Walk Test | Gait Disorders, Neurologic - etiology | Care and treatment | Amyloidosis | Genetic aspects | Intravenous administration | Gait | Cardiomyopathy | RNA-mediated interference | Liver | Diabetes mellitus | Body weight | Transthyretin | Diabetic neuropathy | Neuropathy | Gene expression | Polyneuropathy | Quality of life | Medicine | Neurology | Hospitals | Nutritional status | Pharmaceuticals | Index Medicus | Abridged Index Medicus | Assaigs clínics | Clinical trials | RNA | Amiloïdosi | Clinical Medicine | Neurologi | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 08/2013, Volume 369, Issue 9, pp. 819 - 829
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 02/2011, Volume 183, Issue 4, pp. 531 - 538
Journal Article
Cancer Discovery, ISSN 2159-8274, 04/2013, Volume 3, Issue 4, pp. 406 - 417
Journal Article
by Fox, BA and Schendel, D.J and Butterfield, L.H and Aamdal, S and Allison, J.P and Ascierto, P.A and Atkins, M.B and Bartunkova, J and Bergmann, L and Berinstein, N and Bonorino, C.C and Borden, E and Bramson, J.L and Britten, C.M and Cao, X and Carson, W.E and Chang, A.E and Characiejus, D and Choudhury, A.R and Coukos, G and Gruijl, de, T.D and Dillman, R.O and Dolstra, H and noff, G and Durrant, L.G and Finke, J.H and Galon, J and Gollob, J.A and Gouttefangeas, C and Grizzi, F and Guida, M and Hakansson, L and Hege, K and Herberman, R.B and Hodi, F.S and Hoos, A and Huber, C and Hwu, P and Imai, K and Jaffee, E.M and Janetzki, S and June, C.H and Kalinski, P and Kaufmann, H.L and Kawakami, K and Kawakami, Y and Keilholtz, U and Khleif, S.N and Kiessling, R and Kotlan, B and Kroemer, G and Lapointe, R and Levitsky, H.I and Lotze, M.T and Maio, M. Di and Marschner, J.P and Mastrangelo, M.J and Masucci, G and Melero, I and Nelief, C and Murphy, W.J and Nelson, B and Nicolini, A and Nishimura, M.I and Odunsi, K and Ohashi, P.S and O'Donnell-Tormey, J and Old, L.J and Ottensmeier, C and Papamichail, M and Parmiani, G and Pawelec, G and Proietti, E and Qin, S and Rees, R and Ribas, A and Ridolfi, R and Ritter, G and Rivoltini, L and Romero, P.J and Salem, M.L and Scheper, R.J and Seliger, B and Sharma, P and Shiku, H and Singh-Jasuja, H and Song, W and Straten, P.T and Tahara, H and Tian, Z and Burg, van der, S.H and Hoegen, von, P and Wang, E and Welters, M.J and Winter, H and Withington, T and Wolchok, J.D and Xiao, W and Zitvogel, L and Zwierzina, H and ...
Journal of Translational Medicine, ISSN 1479-5876, 2011, Volume 9, Issue 1, pp. 214 - 214
Journal Article
Journal Article
Journal Article
Circulation, 09/2018
Hereditary transthyretin-mediated (hATTR) amyloidosis is a rapidly progressive, multisystem disease that presents with cardiomyopathy and/or polyneuropathy.... 
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 08/2006, Volume 12, Issue 15, pp. 4619 - 4627
Journal Article