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Current Opinion in Oncology, ISSN 1040-8746, 09/2019, Volume 31, Issue 5, pp. 424 - 429
PURPOSE OF REVIEWEstrogen receptor-positive breast cancer accounts for 70% of all breast cancers. Sequential endocrine treatment in monotherapy or in... 
Journal Article
by Colleoni, Marco and Luo, Weixiu and Karlsson, Per and Chirgwin, Jacquie and Aebi, Stefan and Jerusalem, Guy and Neven, Patrick and Hitre, Erika and Graas, Marie-Pascale and Simoncini, Edda and Kamby, Claus and Thompson, Alastair and Loibl, Sibylle and Gavilá, Joaquín and Kuroi, Katsumasa and Marth, Christian and Müller, Bettina and O'Reilly, Seamus and Di Lauro, Vincenzo and Gombos, Andrea and Ruhstaller, Thomas and Burstein, Harold and Ribi, Karin and Bernhard, Jürg and Viale, Giuseppe and Maibach, Rudolf and Rabaglio-Poretti, Manuela and Gelber, Richard D and Coates, Alan S and Di Leo, Angelo and Regan, Meredith M and Goldhirsch, Aron and Vandebroek, An and Berliere, Martine and Mitine, Carine and Vuylsteke, Peter and Borms, Marleen and D'Hondt, Randal and Glorieux, Philippe and Mebis, Jeroen and Verhoeven, Didier and Coibion, Michael and Forget, Frederic and Duck, Lionel and Wyendaele, Wim and Barbeaux, Annelore and Salmon, Jean-Paul and Berteloot, Patrick and Vermeij, Joanna and Richard, Vincent and Cinieri, Saverio and Gianni, Lorenzo and Clerico, Mario and Pinotti, Graziella and Bernardo, Antonio and Biganzoli, Leo and Gennari, Alessandra and Graiff, Claudio and Amadori, Dino and Passalacqua, Rodolfo and Forbes, John and Francis, Prudence and Foo, Serene and Boyle, Frances and Redfern, Andrew and van der Westhuizen, Andre and Lewis, Craig and Sharma, Ravi and Sharma, Sharad and Beale, Philip and Byard, Ian and Begbie, Stephen and Sardelic, Frank and Abdi, Ehtesham and Clark, David and Chindewere, Aaron and Della-Fiorentina, Stephen and Asghari, Ray and Islam, Mohammed and Na Teo, Lee and White, Shane and Gilbert, Linda and Gardner, Katherine and Uhlmann, Catarina and Rauch, Daniel and Mannhart, Meinrad and Buser, Katharina and Dedes, Konstantin and Mueller, Andreas and Rageth, Christoph and Von Orelli, Stephanie and Senn, Hans Joerg and Pagani, Olivia and Pedrazzini, Augusto and Rochlitz, Christoph and Bodmer, Alexandre and Anchisi, Sandro and Zaman, Khalil and von Moos, Roger and Betticher, Daniel and ... and SOLE Investigators and Institute of Clinical Sciences, Department of Oncology and Sahlgrenska akademin and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy and Institutionen för kliniska vetenskaper, Avdelningen för onkologi
The Lancet Oncology, ISSN 1470-2045, 01/2018, Volume 19, Issue 1, pp. 127 - 138
Journal Article
The Lancet Oncology, ISSN 1470-2045, 03/2019, Volume 20, Issue 3, pp. 371 - 382
HER2-positive breast cancers usually contain large amounts of T-cell infiltrate. We hypothesised that trastuzumab resistance in HER2-positive breast cancer... 
TUMOR-INFILTRATING LYMPHOCYTES | SOLID TUMORS | ONCOLOGY | ANTIBODY | PROPOSAL | TILS | ANTI-PD-1 | CARCINOMA | STANDARDIZED METHOD | PATHOLOGISTS | Antimitotic agents | Breast cancer | Antineoplastic agents | Analysis
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 16759 - 9
There are two basic stages of fine motor learning: performance gain might occur during practice (online learning), and improvement might take place without any... 
INTELLIGENCE | SKILL ACQUISITION | IMPACT | MEMORY CONSOLIDATION | PERFORMANCE | MULTIDISCIPLINARY SCIENCES | SEQUENCE | SLOW SLEEP SPINDLE | SCHIZOPHRENIA | ELECTROENCEPHALOGRAPHIC FINGERPRINT | CHILDREN | Learning | Accuracy | Sleep | Distance learning | Sleep (NREM) | Motor skill learning | EEG | Internet | Neurodevelopmental disorders | Motor task performance | Williams syndrome
Journal Article
Expert Opinion on Investigational Drugs, ISSN 1354-3784, 07/2019, Volume 28, Issue 7, pp. 617 - 627
Introduction: Despite improvements in the management of HER2+ breast cancer, metastatic disease is still fatal. Usually, these patients receive several lines... 
HER2+ breast cancer | bispecific antibodies | ADCs | TKIs | HER2 MUTATIONS | OPEN-LABEL | MONOCLONAL-ANTIBODY | PHASE-1 DOSE-ESCALATION | ADJUVANT THERAPY | PLUS TRASTUZUMAB | PHYSICIANS CHOICE | TRASTUZUMAB-BASED THERAPY | METASTATIC BREAST-CANCER | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | HER2+breast cancer
Journal Article
Expert Opinion on Pharmacotherapy, ISSN 1465-6566, 01/2017, Volume 18, Issue 1, pp. 95 - 103
Journal Article
BREAST CANCER RESEARCH, ISSN 1465-542X, 05/2019, Volume 21, Issue 1, pp. 65 - 14
BackgroundHeterogeneity and lack of targeted therapies represent the two main impediments to precision treatment of triple-negative breast cancer (TNBC), and... 
IMMUNE CELLS | Immunome | LANDSCAPE | PROGNOSIS | Tertiary lymphoid structures | MACROPHAGES | TISSUE | RECEPTOR | Breast cancer | Neurogenesis | CROSS-TALK | Molecular subtypes | ONCOLOGY | Transcriptomics | Triple-negative | SCHWANN-CELLS | EXPRESSION | TUMOR MICROENVIRONMENT | Care and treatment | Genetic aspects | Immune response | Research | Cell differentiation | Life Sciences | Cancer
Journal Article
Expert opinion on investigational drugs, 06/2019, p. 1
: Despite improvements in the management of HER2+ breast cancer, metastatic disease is still fatal. Usually, these patients receive several lines of... 
Journal Article
BioMed Research International, ISSN 2314-6133, 2019, Volume 2019, pp. 8670398 - 12
Tyrosine kinases play crucial roles in cellular development and tumorigenesis. Tyrosine kinase inhibitors (TKIs) are effective and widely used drug molecules... 
CELL LUNG-CANCER | PHASE-III TRIAL | FACTOR B-CHAIN | TARGETED THERAPY | BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | GROWTH-FACTOR RECEPTOR | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BCR-ABL | PROTEIN-KINASES | CHRONIC MYELOMONOCYTIC LEUKEMIA | P53 | Organ Specificity - drug effects | Piperidines - toxicity | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Tumor Suppressor Protein p53 - genetics | Neoplasms - drug therapy | Protein Kinase Inhibitors - administration & dosage | Animals | Neoplasms - chemically induced | Anticarcinogenic Agents - administration & dosage | Imatinib Mesylate - administration & dosage | Anthracenes - toxicity | Mice | Proto-Oncogene Proteins c-myc - genetics | Gene Expression Regulation, Neoplastic - drug effects | Neoplasms - pathology | Brain | Liver | Leukemia | Genes | Lung cancer | Colorectal cancer | Metastasis | Myc protein | Kinases | Tissues | Cancer therapies | Lymph nodes | Thymus | Proteins | Signal transduction | Cell growth | Cell cycle | Bone marrow | Tumorigenesis | Growth factors | Protein-tyrosine kinase | Tyrosine | Spleen | Medical research | Anthracene | Imatinib | Kidneys | Breast cancer | Gene expression | Nodes | Lungs | Kidney cancer | Ligands | Tumor suppressor genes | 9,10-Dimethyl-1,2-benzanthracene | Mutation | Tumors | Lymph | Cancer | Apoptosis
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2018, Volume 13, Issue 4, pp. e0191926 - e0191926
CTLA-4 and CD28 exemplify a co-inhibitory and co-stimulatory signaling axis that dynamically sculpts the interaction of antigen-specific T cells with... 
UNTREATED MELANOMA | CYTOKINE RELEASE ASSAYS | LUNG-CANCER | IN-VITRO | MEDIATED CYTOTOXICITY | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | REGULATORY T-CELLS | CTLA-4 | ANTITUMOR ACTIVITIES | NIVOLUMAB PLUS IPILIMUMAB | Antineoplastic Agents, Immunological - toxicity | Epitope Mapping | Adjuvants, Immunologic - pharmacology | Antineoplastic Agents, Immunological - pharmacokinetics | Cricetulus | Cancer Vaccines - pharmacology | Humans | Immunoglobulin G - toxicity | Macaca fascicularis | Antineoplastic Agents, Immunological - chemistry | T-Lymphocytes, Regulatory - immunology | Adjuvants, Immunologic - pharmacokinetics | Neoplasms - therapy | Immunity, Cellular - drug effects | Adjuvants, Immunologic - chemistry | Immunoglobulin G - pharmacology | CHO Cells | Amino Acid Sequence | Immunoglobulin G - chemistry | Cells, Cultured | Models, Molecular | Adjuvants, Immunologic - toxicity | CTLA-4 Antigen - immunology | Antineoplastic Agents, Immunological - pharmacology | T-Lymphocytes, Regulatory - drug effects | Animals | Lymphocyte Activation - drug effects | Neoplasms - immunology | Antibody Formation - drug effects | CTLA-4 Antigen - antagonists & inhibitors | Toxicology | Pharmacology, Experimental | Research | Immunoglobulin G | Analysis | CD86 antigen | PD-1 protein | Lung cancer | Antibodies | Biochemistry | Lymphocytes T | CD28 antigen | Immunity | CTLA-4 protein | Lymphocytes | Immunotherapy | Combined vaccines | Primates | Repressing | Medical research | Immunoglobulins | Cytokines | Immunoregulation | Immunomodulation | Research & development--R&D | CD80 antigen | Pharmacology | T cell receptors | Chemical compounds | Signaling | Antigen-presenting cells | Biomarkers | Index Medicus | Research & development | R&D
Journal Article