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science & technology (11) 11
humans (9) 9
life sciences & biomedicine (9) 9
female (6) 6
lung cancer (6) 6
male (6) 6
carcinoma, non-small-cell lung - genetics (4) 4
lung neoplasms - genetics (4) 4
mutation (4) 4
tumors (4) 4
aged (3) 3
analysis (3) 3
cancer (3) 3
cohort studies (3) 3
evolution (3) 3
evolution, molecular (3) 3
genomes (3) 3
immunotherapy (3) 3
loss of heterozygosity (3) 3
lung cancer, non-small cell (3) 3
middle aged (3) 3
oncology (3) 3
prospective studies (3) 3
treatment outcome (3) 3
abridged index medicus (2) 2
adult (2) 2
animals (2) 2
anti-bacterial agents - administration & dosage (2) 2
anti-bacterial agents - therapeutic use (2) 2
antibodies (2) 2
antigens (2) 2
beta-lactams - administration & dosage (2) 2
beta-lactams - therapeutic use (2) 2
bioinformatics (2) 2
carcinoma, non-small-cell lung - immunology (2) 2
carcinoma, non-small-cell lung - pathology (2) 2
carcinoma, squamous cell - genetics (2) 2
cell biology (2) 2
cell line, tumor (2) 2
chromosomal instability (2) 2
chromosomes (2) 2
depletion (2) 2
disease-free survival (2) 2
dna copy number variations (2) 2
fc receptors (2) 2
general & internal medicine (2) 2
genetic aspects (2) 2
heterozygosity (2) 2
histocompatibility antigens (2) 2
hla histocompatibility antigens (2) 2
immune system (2) 2
infusions, intravenous (2) 2
lung neoplasms - immunology (2) 2
lung neoplasms - pathology (2) 2
lymphocytes (2) 2
medical research (2) 2
melanoma (2) 2
mice (2) 2
multidisciplinary sciences (2) 2
pathology (2) 2
pharmacology & pharmacy (2) 2
polymorphism, single nucleotide (2) 2
prognosis (2) 2
receptors, igg - metabolism (2) 2
science & technology - other topics (2) 2
sepsis - drug therapy (2) 2
t cells (2) 2
t-lymphocytes, regulatory - immunology (2) 2
tumor antigens (2) 2
tumor immunotherapy (2) 2
viral antibodies (2) 2
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accumulation (1) 1
activators (1) 1
adenocarcinoma - genetics (1) 1
adenocarcinoma - immunology (1) 1
adenocarcinoma - pathology (1) 1
adenocarcinoma of lung - genetics (1) 1
aged, 80 and over (1) 1
androgens (1) 1
anti-bacterial agents - pharmacokinetics (1) 1
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antibodies, monoclonal - immunology (1) 1
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antibodies, monoclonal - therapeutic use (1) 1
antibodies, monoclonal, humanized (1) 1
antibody-dependent cell-mediated cytotoxicity (1) 1
anticancer properties (1) 1
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antigen presentation - immunology (1) 1
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1. Full Text Tracking the Evolution of Non–Small-Cell Lung Cancer
by Jamal-Hanjani, Mariam and Wilson, Gareth A and McGranahan, Nicholas and Birkbak, Nicolai J and Watkins, Thomas B.K and Veeriah, Selvaraju and Shafi, Seema and Johnson, Diana H and Mitter, Richard and Rosenthal, Rachel and Salm, Max and Horswell, Stuart and Escudero, Mickael and Matthews, Nik and Rowan, Andrew and Chambers, Tim and Moore, David A and Turajlic, Samra and Xu, Hang and Lee, Siow-Ming and Forster, Martin D and Ahmad, Tanya and Hiley, Crispin T and Abbosh, Christopher and Falzon, Mary and Borg, Elaine and Marafioti, Teresa and Lawrence, David and Hayward, Martin and Kolvekar, Shyam and Panagiotopoulos, Nikolaos and Janes, Sam M and Thakrar, Ricky and Ahmed, Asia and Blackhall, Fiona and Summers, Yvonne and Shah, Rajesh and Joseph, Leena and Quinn, Anne M and Crosbie, Phil A and Naidu, Babu and Middleton, Gary and Langman, Gerald and Trotter, Simon and Nicolson, Marianne and Remmen, Hardy and Kerr, Keith and Chetty, Mahendran and Gomersall, Lesley and Fennell, Dean A and Nakas, Apostolos and Rathinam, Sridhar and Anand, Girija and Khan, Sajid and Russell, Peter and Ezhil, Veni and Ismail, Babikir and Irvin-Sellers, Melanie and Prakash, Vineet and Lester, Jason F and Kornaszewska, Malgorzata and Attanoos, Richard and Adams, Haydn and Davies, Helen and Dentro, Stefan and Taniere, Philippe and O’Sullivan, Brendan and Lowe, Helen L and Hartley, John A and Iles, Natasha and Bell, Harriet and Ngai, Yenting and Shaw, Jacqui A and Herrero, Javier and Szallasi, Zoltan and Schwarz, Roland F and Stewart, Aengus and Quezada, Sergio A and Le Quesne, John and Van Loo, Peter and Dive, Caroline and Hackshaw, Allan and Swanton, Charles and TRACERx Consortium
The New England journal of medicine, ISSN 0028-4793, 06/2017, Volume 376, Issue 22, pp. 2109 - 2121
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Lung Neoplasms - genetics | Prognosis | Prospective Studies | Carcinoma, Non-Small-Cell Lung - genetics | Lung Neoplasms - mortality | Humans | Risk Factors | Male | Phylogeny | Carcinoma, Non-Small-Cell Lung - mortality | Genetic Heterogeneity | DNA Copy Number Variations | Exome | Disease-Free Survival | Female | Neoplasm Recurrence, Local - genetics | Mutation | Chromosomal Instability | Sequence Analysis, DNA - methods | Evolution, Molecular | Lung cancer, Non-small cell | Chromosomes | Research | Medical research | Chromatin | Epidermal growth factor receptors | Transcription | p53 Protein | Lung cancer | DNA damage | Non-small cell lung carcinoma | Oncology | Genomes | Multivariate analysis | DNA repair | Survival | Cyclin-dependent kinase 4 | Genomic instability | Pathology | Census | Lungs | Evolution | Death | Tumors | Index Medicus | Abridged Index Medicus
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2. Full Text Degarelix for Treating Advanced Hormone-Dependent Prostate Cancer: An Evidence Review Group Perspective of a NICE Single Technology Appraisal
by Uttley, Lesley and Whyte, Sophie and Gomersall, Timothy and Ren, Shijie and Wong, Ruth and Chambers, Duncan and Tappenden, Paul
PharmacoEconomics, ISSN 1170-7690, 07/2017, Volume 35, Issue 7, pp. 717 - 726
Economics | Social Sciences | Life Sciences & Biomedicine | Health Care Sciences & Services | Pharmacology & Pharmacy | Business & Economics | Health Policy & Services | Science & Technology | Evidence-Based Practice | Cost-Benefit Analysis | Humans | Male | Neoplasms, Hormone-Dependent - drug therapy | Gonadotropin-Releasing Hormone - agonists | Prostatic Neoplasms - drug therapy | Oligopeptides - therapeutic use | Prostate cancer | Cancer patients | Care and treatment | Medical research | Antigens | Mortality | Committees | Metastasis | Medical screening | Quality of life | Studies | Mens health | Testosterone | Androgens | Surgery | Cost analysis | Urogenital system
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3. Full Text Appropriateness of fast track lung cancer referrals to the lung cancer clinic by radiologists: a re-audit
by Gomersall, Lesley and Mitchell-Hay, Rosalind N
Clinical radiology, ISSN 0009-9260, 2015, Volume 70, pp. S12 - S12
Radiology | Lung cancer
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4. Full Text Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution
by McGranahan, Nicholas and Rosenthal, Rachel and Hiley, Crispin T and Rowan, Andrew J and Watkins, Thomas B.K and Wilson, Gareth A and Birkbak, Nicolai J and Veeriah, Selvaraju and Van Loo, Peter and Herrero, Javier and Swanton, Charles and Swanton, Charles and Jamal-Hanjani, Mariam and Veeriah, Selvaraju and Shafi, Seema and Czyzewska-Khan, Justyna and Johnson, Diana and Laycock, Joanne and Bosshard-Carter, Leticia and Rosenthal, Rachel and Gorman, Pat and Hynds, Robert E and Wilson, Gareth and Birkbak, Nicolai J and Watkins, Thomas B.K and McGranahan, Nicholas and Horswell, Stuart and Mitter, Richard and Escudero, Mickael and Stewart, Aengus and Van Loo, Peter and Rowan, Andrew and Xu, Hang and Turajlic, Samra and Hiley, Crispin and Abbosh, Christopher and Goldman, Jacki and Stone, Richard Kevin and Denner, Tamara and Matthews, Nik and Elgar, Greg and Ward, Sophia and Costa, Marta and Begum, Sharmin and Phillimore, Ben and Chambers, Tim and Nye, Emma and Graca, Sofia and Al Bakir, Maise and Joshi, Kroopa and Furness, Andrew and Ben Aissa, Assma and Wong, Yien Ning Sophia and Georgiou, Andy and Quezada, Sergio and Hartley, John A and Lowe, Helen L and Herrero, Javier and Lawrence, David and Hayward, Martin and Panagiotopoulos, Nikolaos and Kolvekar, Shyam and Falzon, Mary and Borg, Elaine and Marafioti, Teresa and Simeon, Celia and Hector, Gemma and Smith, Amy and Aranda, Marie and Novelli, Marco and Oukrif, Dahmane and Janes, Sam M and Thakrar, Ricky and Forster, Martin and Ahmad, Tanya and Lee, Siow Ming and Papadatos-Pastos, Dionysis and Carnell, Dawn and Mendes, Ruheena and George, Jeremy and Navani, Neal and Ahmed, Asia and Taylor, Magali and Choudhary, Junaid and Summers, Yvonne and Califano, Raffaele and Taylor, Paul and Shah, Rajesh and Krysiak, Piotr and Rammohan, Kendadai and Fontaine, Eustace and Booton, Richard and Evison, Matthew and Crosbie, Phil and Moss, Stuart and Idries, Faiza and Joseph, Leena and Bishop, Paul and Chaturved, Anshuman and Quinn, Anne Marie and ... and the TRACERx Consortium and TRACERx Consortium
Cell (Cambridge), ISSN 0092-8674, 11/2017, Volume 171, Issue 6, pp. 1259 - 1271.e11
neoantigen | lung cancer | chromosomal instability | bioinformatics | cancer evolution | immune-editing | copy number | loss of heterozygosity | immune-escape | heterogeneity | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Tumor Escape | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Middle Aged | HLA Antigens - immunology | Lung Neoplasms - pathology | Male | Lung Neoplasms - therapy | HLA Antigens - genetics | Loss of Heterozygosity | Carcinoma, Non-Small-Cell Lung - immunology | Carcinoma, Non-Small-Cell Lung - therapy | Lung Neoplasms - immunology | Antigen Presentation | Aged, 80 and over | Adult | Female | Aged | Polymorphism, Single Nucleotide | Mutation | Cohort Studies | Histocompatibility antigens | Lung cancer, Non-small cell | Analysis | Immunotherapy | Tumor antigens | HLA histocompatibility antigens | Index Medicus
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5. Full Text Neoantigen-directed immune escape in lung cancer evolution
by Rosenthal, Rachel and Cadieux, Elizabeth Larose and Salgado, Roberto and Bakir, Maise Al and Moore, David A and Hiley, Crispin T and Lund, Tom and Tanić, Miljana and Reading, James L and Joshi, Kroopa and Henry, Jake Y and Ghorani, Ehsan and Wilson, Gareth A and Birkbak, Nicolai J and Jamal-Hanjani, Mariam and Veeriah, Selvaraju and Szallasi, Zoltan and Loi, Sherene and Hellmann, Matthew D and Feber, Andrew and Chain, Benny and Herrero, Javier and Quezada, Sergio A and Demeulemeester, Jonas and Van Loo, Peter and Beck, Stephan and McGranahan, Nicholas and Swanton, Charles and Swanton, Charles and Jamal-Hanjani, Mariam and Veeriah, Selvaraju and Czyzewska-Khan, Justyna and Johnson, Diana and Laycock, Joanne and Rosenthal, Rachel and Gorman, Pat and Hynds, Robert E and Wilson, Gareth and Birkbak, Nicolai J and Watkins, Thomas B. K and McGranahan, Nicholas and Escudero, Mickael and Stewart, Aengus and Van Loo, Peter and Rowan, Andrew and Hiley, Crispin T and Abbosh, Christopher and Goldman, Jacki and Stone, Richard Kevin and Denner, Tamara and Ward, Sophia and Nye, Emma and Joshi, Kroopa and Ben Aissa, Assma and Wong, Yien Ning Sophia and Georgiou, Andy and Quezada, Sergio and Hartley, John A and Lowe, Helen L and Herrero, Javier and Lawrence, David and Hayward, Martin and Panagiotopoulos, Nikolaos and Falzon, Mary and Borg, Elaine and Marafioti, Teresa and Janes, Sam M and Forster, Martin and Ahmad, Tanya and Lee, Siow Ming and Papadatos-Pastos, Dionysis and Carnell, Dawn and Mendes, Ruheena and George, Jeremy and Ahmed, Asia and Taylor, Magali and Choudhary, Junaid and Summers, Yvonne and Califano, Raffaele and Taylor, Paul and Shah, Rajesh and Krysiak, Piotr and Rammohan, Kendadai and Fontaine, Eustace and Booton, Richard and Evison, Matthew and Crosbie, Phil and Moss, Stuart and Joseph, Leena and Bishop, Paul and Quinn, Anne Marie and Doran, Helen and Leek, Angela and Harrison, Phil and Moore, Katrina and Waddington, Rachael and Novasio, Juliette and Blackhall, Fiona and Rogan, Jane and Smith, Elaine and ... and TRACERx Consortium and TRACERx consortium and The TRACERx consortium
Nature (London), ISSN 0028-0836, 03/2019, Volume 567, Issue 7749, pp. 479 - 485
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Adenocarcinoma - pathology | Prognosis | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Lung Neoplasms - pathology | Male | Female | Adenocarcinoma - genetics | Gene Expression Regulation, Neoplastic - genetics | Tumor Escape - immunology | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Antigens, Neoplasm - genetics | Antigens, Neoplasm - immunology | Carcinoma, Non-Small-Cell Lung - genetics | Adenocarcinoma - immunology | Antigen Presentation - immunology | Carcinoma, Squamous Cell - immunology | Carcinoma, Non-Small-Cell Lung - immunology | Tumor Microenvironment - immunology | Disease-Free Survival | Lung Neoplasms - immunology | Evolution, Molecular | Lymphocytes, Tumor-Infiltrating - immunology | Causes of | Development and progression | Genetic aspects | Cellular immunity | Lung cancer | RNA sequencing | Epigenetic inheritance | Medical colleges | Histocompatibility antigens | RNA | Tumor antigens | HLA histocompatibility antigens | Lung cancer, Non-small cell | Tumors | Working groups | Brain cancer | Editing | Genomes | Metastases | Gene sequencing | Histopathology | Lymphocytes | Evolution | Bioinformatics | Immune system | Antigens | T cell receptors | Ribonucleic acid--RNA | Estimates | Heterozygosity | White blood cells | Pathology | Depletion | Loss of heterozygosity | Epigenetics | Biomarkers | Ligands | Infiltration | Microenvironments | Mutation | Cancer | Index Medicus
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6. Full Text Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies
by Arce Vargas, Frederick and Furness, Andrew J.S and Litchfield, Kevin and Joshi, Kroopa and Rosenthal, Rachel and Ghorani, Ehsan and Solomon, Isabelle and Lesko, Marta H and Ruef, Nora and Roddie, Claire and Henry, Jake Y and Spain, Lavinia and Ben Aissa, Assma and Georgiou, Andrew and Wong, Yien Ning Sophia and Smith, Myles and Strauss, Dirk and Hayes, Andrew and Nicol, David and O'Brien, Tim and Mårtensson, Linda and Ljungars, Anne and Teige, Ingrid and Frendéus, Björn and Harrington, Kevin and Melcher, Alan and Wotherspoon, Andrew and Francis, Nicholas and Challacombe, Ben and Fernando, Archana and Hazell, Steve and Chandra, Ashish and Pickering, Lisa and Lynch, Joanna and Rudman, Sarah and Chowdhury, Simon and Harrison-Phipps, Karen and Varia, Mary and Horsfield, Catherine and Polson, Alexander and Stamp, Gordon and O'Donnell, Marie and Drake, William and Hill, Peter and Hrouda, David and Mayer, Eric and Olsburgh, Jonathan and Kooiman, Gordon and O'Connor, Kevin and Stewart, Grant and Aitchison, Michael and Tran, Maxine and Fotiadis, Nicos and Verma, Hema and Lopez, Jose and Lester, Jason and Morgan, Fiona and Kornaszewska, Malgorzata and Attanoos, Richard and Adams, Haydn and Davies, Helen and Fennell, Dean and Shaw, Jacqui and Le Quesne, John and Nakas, Apostolos and Rathinam, Sridhar and Monteiro, William and Marshall, Hilary and Nelson, Louise and Bennett, Jonathan and Riley, Joan and Primrose, Lindsay and Martinson, Luke and Anand, Girija and Khan, Sajid and Nicolson, Marianne and Kerr, Keith and Palmer, Shirley and Remmen, Hardy and Miller, Joy and Buchan, Keith and Chetty, Mahendran and Gomersall, Lesley and Lock, Sara and Naidu, Babu and Langman, Gerald and Trotter, Simon and Bellamy, Mary and Bancroft, Hollie and Kerr, Amy and Kadiri, Salma and Webb, Joanne and Middleton, Gary and Djearaman, Madava and Summers, Yvonne and Califano, Raffaele and Taylor, Paul and Shah, Rajesh and Krysiak, Piotr and Rammohan, Kendadai and ... and TRACERx Renal and TRACERx Lung consortia and TRACERx Melanoma and TRACERx Lung Consortia
Cancer cell, ISSN 1535-6108, 04/2018, Volume 33, Issue 4, pp. 649 - 663.e4
tremelimumab | IgG subclass | tumor immunotherapy | ipilimumab | antibody-dependent cell-mediated cytotoxicity | immune regulatory antibodies | CTLA-4 | Fc-gamma receptors | regulatory T cell depletion | immune checkpoints | regulatory T cell depletion | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Antineoplastic Agents, Immunological - administration & dosage | Antibodies, Monoclonal - pharmacology | Humans | Treatment Outcome | Ipilimumab - pharmacology | Receptors, IgG - metabolism | Antineoplastic Agents, Immunological - pharmacology | T-Lymphocytes, Regulatory - immunology | Xenograft Model Antitumor Assays | Antibodies, Monoclonal, Humanized | Receptors, IgG - genetics | Animals | Antibodies, Monoclonal - administration & dosage | Melanoma - genetics | Melanoma - immunology | Melanoma - drug therapy | Cell Line, Tumor | Female | Mice | Polymorphism, Single Nucleotide | CTLA-4 Antigen - antagonists & inhibitors | Ipilimumab - administration & dosage | Viral antibodies | Fc receptors | Analysis | Immunotherapy | Melanoma | Antibodies | T cells | Index Medicus
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7. Full Text A multicenter randomized trial of continuous versus intermittent β-lactam infusion in severe sepsis
by Dulhunty, Joel M and Roberts, Jason A and Davis, Joshua S and Webb, Steven A. R and Bellomo, Rinaldo and Gomersall, Charles and Shirwadkar, Charudatt and Eastwood, Glenn M and Myburgh, John and Paterson, David L and Starr, Therese and Paul, Sanjoy K and Lipman, Jeffrey and Peck, Leah and Young, Helen and Boschert, Catherine and Fletcher, Jason and Smith, Julie and Nand, Kiran and Sara, Treena and Harney, Amy and Rodgers, Helen and Van Haren, Frank and Clarke, Sally and Durham, David and Hannan, Catherine and Matheson, Elisha and Schwartz, Kate and Thomas, Karen and Bone, Allison and Cattigan, Claire and Elderkin, Tania and Salerno, Tania and Cameron, Robert and Ellis, Katrina and Hatter, Sheridan and Sanap, Milind and Soar, Natalie and Wood, Josette and Chan, Karen and Heffernan, Aaron and Lai, Nai An and Moss, Catherine and Sheehy, Kate and Duroux, Maree and Ratcliffe, Megan and Shone, Samantha and Warhurst, Timothy and Dunlop, Rachel and Stuart, Janine and Udy, Andrew and Cooper, David and McAllister, Rick and Cheng, Andrew and Inskip, Deborah and Miller, Jennene and Knowles, Serena and Reynolds, Claire and Rudham, Sam and Baker, Stuart and Hepburn, Kristy and Roberts, Brigit and Woods, Paul and Chatterjee, Indranil and Cullen, Martin and Kong, Jing and Nayyar, Vineet and Whitehead, Christina and Leung, Patricia and Gilder, Eileen and McCarthy, Lianne and McGuiness, Shay and Parke, Rachael and Benefield, Kirsten and Chen, Yan and McArthur, Colin and Newby, Lynette and Henderson, Seton and Mehrtens, Jan and Noble, Sascha and Chadwick, Lesley and Freebain, Ross and Hogan, Chantal and Kazemi, Alex and Rust, Laura and Song, Rima and Tilsley, Anna and Williams, Anthony and Andrews, Lynn and Dinsdale, Richard and Hunt, Anna and Hurford, Sally and Mackle, Diane and Ongley, Jessica and Young, Paul and Durning, John and Frengley, Robert and La Pine, Mary and McCracken, Geoff and Sharma, Swarna Baskar and ... and BLING II Investigators and ANZICS Clinical Trials Grp and BLING II Investigators for the ANZICS Clinical Trials Group
American journal of respiratory and critical care medicine, ISSN 1073-449X, 12/2015, Volume 192, Issue 11, pp. 1298 - 1305
Clinical outcome | Antibiotic | Intensive care | Pharmacodynamics | Pharmacokinetics | Respiratory System | Life Sciences & Biomedicine | Critical Care Medicine | General & Internal Medicine | Science & Technology | Prospective Studies | Double-Blind Method | Drug Administration Schedule | Humans | Middle Aged | Male | Treatment Outcome | Anti-Bacterial Agents - therapeutic use | Sepsis - drug therapy | Survival Analysis | Female | Aged | Infusions, Intravenous | beta-Lactams - therapeutic use | Anti-Bacterial Agents - administration & dosage | Length of Stay - statistics & numerical data | beta-Lactams - administration & dosage | Index Medicus | Abridged Index Medicus
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