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1. Full Text Tracking the Evolution of Non–Small-Cell Lung Cancer
by Jamal-Hanjani, Mariam and Wilson, Gareth A and McGranahan, Nicholas and Birkbak, Nicolai J and Watkins, Thomas B.K and Veeriah, Selvaraju and Shafi, Seema and Johnson, Diana H and Mitter, Richard and Rosenthal, Rachel and Salm, Max and Horswell, Stuart and Escudero, Mickael and Matthews, Nik and Rowan, Andrew and Chambers, Tim and Moore, David A and Turajlic, Samra and Xu, Hang and Lee, Siow-Ming and Forster, Martin D and Ahmad, Tanya and Hiley, Crispin T and Abbosh, Christopher and Falzon, Mary and Borg, Elaine and Marafioti, Teresa and Lawrence, David and Hayward, Martin and Kolvekar, Shyam and Panagiotopoulos, Nikolaos and Janes, Sam M and Thakrar, Ricky and Ahmed, Asia and Blackhall, Fiona and Summers, Yvonne and Shah, Rajesh and Joseph, Leena and Quinn, Anne M and Crosbie, Phil A and Naidu, Babu and Middleton, Gary and Langman, Gerald and Trotter, Simon and Nicolson, Marianne and Remmen, Hardy and Kerr, Keith and Chetty, Mahendran and Gomersall, Lesley and Fennell, Dean A and Nakas, Apostolos and Rathinam, Sridhar and Anand, Girija and Khan, Sajid and Russell, Peter and Ezhil, Veni and Ismail, Babikir and Irvin-Sellers, Melanie and Prakash, Vineet and Lester, Jason F and Kornaszewska, Malgorzata and Attanoos, Richard and Adams, Haydn and Davies, Helen and Dentro, Stefan and Taniere, Philippe and O’Sullivan, Brendan and Lowe, Helen L and Hartley, John A and Iles, Natasha and Bell, Harriet and Ngai, Yenting and Shaw, Jacqui A and Herrero, Javier and Szallasi, Zoltan and Schwarz, Roland F and Stewart, Aengus and Quezada, Sergio A and Le Quesne, John and Van Loo, Peter and Dive, Caroline and Hackshaw, Allan and Swanton, Charles and TRACERx Consortium
The New England Journal of Medicine, ISSN 0028-4793, 06/2017, Volume 376, Issue 22, pp. 2109 - 2121
Distinct genes are mutated in different regions of a single patient’s tumor. Point mutations seem to have less adverse effect on relapse-free survival than... 
HETEROGENEITY | WIDESPREAD | MUTATIONAL PROCESSES | MEDICINE, GENERAL & INTERNAL | ADENOCARCINOMAS | PATTERNS | CHROMOSOMAL INSTABILITY | Lung Neoplasms - genetics | Prognosis | Prospective Studies | Carcinoma, Non-Small-Cell Lung - genetics | Lung Neoplasms - mortality | Humans | Risk Factors | Male | Phylogeny | Carcinoma, Non-Small-Cell Lung - mortality | Genetic Heterogeneity | DNA Copy Number Variations | Exome | Disease-Free Survival | Female | Neoplasm Recurrence, Local - genetics | Mutation | Chromosomal Instability | Sequence Analysis, DNA - methods | Evolution, Molecular | Lung cancer, Non-small cell | Chromosomes | Research | Medical research | Chromatin | Epidermal growth factor receptors | Transcription | p53 Protein | Lung cancer | DNA damage | Non-small cell lung carcinoma | Oncology | Genomes | Multivariate analysis | DNA repair | Survival | Cyclin-dependent kinase 4 | Genomic instability | Pathology | Census | Lungs | Evolution | Death | Tumors | Index Medicus | Abridged Index Medicus
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2. Full Text Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors
by Arce Vargas, Frederick and Furness, Andrew J.S and Solomon, Isabelle and Joshi, Kroopa and Mekkaoui, Leila and Lesko, Marta H and Miranda Rota, Enrique and Dahan, Rony and Georgiou, Andrew and Sledzinska, Anna and Ben Aissa, Assma and Franz, Dafne and Werner Sunderland, Mariana and Wong, Yien Ning Sophia and Henry, Jake Y and O’Brien, Tim and Nicol, David and Challacombe, Ben and Beers, Stephen A and Spain, Lavinia and Wotherspoon, Andrew and Francis, Nicholas and Smith, Amy and Smith, Sean and Smith, Myles and Smith, Elaine and Strauss, Dirk and Hayes, Andrew and Soultati, Aspasia and Stares, Mark and Lynch, Joanna and Fotiadis, Nicos and Fernando, Archana and Hazell, Steve and Chandra, Ashish and Pickering, Lisa and Rudman, Sarah and Chowdhury, Simon and Swanton, Charles and Jamal-Hanjani, Mariam and Veeriah, Selvaraju and Shafi, Seema and Czyzewska-Khan, Justyna and Johnson, Benjamin and Johnson, Diana and Laycock, Joanne and Bosshard-Carter, Leticia and Goh, Gerald and Rosenthal, Rachel and Gorman, Pat and Murugaesu, Nirupa and Hynds, Robert E and Wilson, Gareth and Birkbak, Nicolai J and Watkins, Thomas B.K and McGranahan, Nicholas and Horswell, Stuart and Mitter, Richard and Escudero, Mickael and Stewart, Aengus and Van Loo, Peter and Rowan, Andrew and Xu, Hang and Turajlic, Samra and Hiley, Crispin and Abbosh, Christopher and Goldman, Jacki and Stone, Richard Kevin and Denner, Tamara and Matthews, Nik and Matthews, Sue and Elgar, Greg and Ward, Sophia and Biggs, Jennifer and Costa, Marta and Begum, Sharmin and Phillimore, Ben and Chambers, Tim and Nye, Emma and Graca, Sofia and Al Bakir, Maise and Hartley, John A and Lowe, Helen L and Herrero, Javier and Lawrence, David and Hayward, Martin and Panagiotopoulos, Nikolaos and Kolvekar, Shyam and Falzon, Mary and Borg, Elaine and Simeon, Celia and Hector, Gemma and Aranda, Marie and Novelli, Marco and Oukrif, Dahmane and Janes, Sam M and Thakrar, Ricky and Forster, Martin and Ahmad, Tanya and Lee, Siow Ming and ... and Melanoma TRACERx Consortium and Renal TRACERx Consortium and Lung TRACERx Consortium
Immunity, ISSN 1074-7613, 04/2017, Volume 46, Issue 4, pp. 577 - 586
CD25 is expressed at high levels on regulatory T (Treg) cells and was initially proposed as a target for cancer immunotherapy. However, anti-CD25 antibodies... 
regulatory T cells | tumor immunotherapy | anti-CD25 | Treg depletion | inhibitory Fc receptor | CD25 | tumor microenvironment | Fc gamma receptors | anti-PD-1 | EFFECTOR | RESPONSES | LYMPHOCYTE-ASSOCIATED ANTIGEN-4 | CANCER-PATIENTS | MELANOMA | MONOCLONAL-ANTIBODY | ANTI-CTLA-4 ANTIBODIES | IMMUNOLOGY | ANTITUMOR-ACTIVITY | COMBINATION | GAMMA-RS | T-Lymphocytes, Regulatory - metabolism | Immunotherapy - methods | Humans | Antibodies, Monoclonal - therapeutic use | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Lymphocyte Depletion | Receptors, IgG - metabolism | T-Lymphocytes, Regulatory - immunology | Neoplasms - therapy | Flow Cytometry | Immunoglobulin Fc Fragments - immunology | Antibodies, Monoclonal - immunology | Interleukin-2 Receptor alpha Subunit - immunology | Kaplan-Meier Estimate | Programmed Cell Death 1 Receptor - metabolism | Receptors, IgG - immunology | Protein Binding - immunology | Animals | Neoplasms - immunology | K562 Cells | Cell Line, Tumor | Mice | Antibodies, Monoclonal - metabolism | Programmed Cell Death 1 Receptor - immunology | Neoplasms - pathology | Viral antibodies | Cell death | Analysis | Immunotherapy | Antibodies | T cells | Cancer | Fc receptors | Beer | Immunoglobulins | Lymphatic system | Immune response | Cytokines | Melanoma | Light emitting diodes | Lymphocytes T | Anticancer properties | Depletion | Lymphocytes | Tumors | Immune system | Report
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3. Full Text Appropriateness of fast track lung cancer referrals to the lung cancer clinic by radiologists: a re-audit
by Gomersall, Lesley and Mitchell-Hay, Rosalind N
Clinical Radiology, ISSN 0009-9260, 2015, Volume 70, pp. S12 - S12
Radiology | Lung cancer
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4. Full Text Degarelix for Treating Advanced Hormone-Dependent Prostate Cancer: An Evidence Review Group Perspective of a NICE Single Technology Appraisal
by Uttley, Lesley and Whyte, Sophie and Gomersall, Timothy and Ren, Shijie and Wong, Ruth and Chambers, Duncan and Tappenden, Paul
PharmacoEconomics, ISSN 1170-7690, 07/2017, Volume 35, Issue 7, pp. 717 - 726
As part of its Single Technology Appraisal Process, the National Institute for Health and Care Excellence (NICE) invited the manufacturer of degarelix (Ferring... 
THERAPY | FLARE | MEN | HEALTH CARE SCIENCES & SERVICES | PHARMACOLOGY & PHARMACY | HEALTH POLICY & SERVICES | ECONOMICS | RELIEF | Prostate cancer | Cancer patients | Care and treatment | Medical research | Antigens | Mortality | Committees | Metastasis | Medical screening | Quality of life | Studies | Mens health | Testosterone | Androgens | Surgery | Urogenital system
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5. Full Text Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution
by Abbosh, Christopher and Birkbak, Nicolai J and Wilson, Gareth A and Jamal-Hanjani, Mariam and Constantin, Tudor and Salari, Raheleh and Le Quesne, John and Moore, David A and Veeriah, Selvaraju and Rosenthal, Rachel and Marafioti, Teresa and Kirkizlar, Eser and Watkins, Thomas B. K and McGranahan, Nicholas and Ward, Sophia and Martinson, Luke and Riley, Joan and Fraioli, Francesco and Al Bakir, Maise and Grönroos, Eva and Zambrana, Francisco and Endozo, Raymondo and Bi, Wenya Linda and Fennessy, Fiona M and Sponer, Nicole and Johnson, Diana and Laycock, Joanne and Shafi, Seema and Czyzewska-Khan, Justyna and Rowan, Andrew and Chambers, Tim and Matthews, Nik and Turajlic, Samra and Hiley, Crispin and Lee, Siow Ming and Forster, Martin D and Ahmad, Tanya and Falzon, Mary and Borg, Elaine and Lawrence, David and Hayward, Martin and Kolvekar, Shyam and Panagiotopoulos, Nikolaos and Janes, Sam M and Thakrar, Ricky and Ahmed, Asia and Blackhall, Fiona and Summers, Yvonne and Hafez, Dina and Naik, Ashwini and Ganguly, Apratim and Kareht, Stephanie and Shah, Rajesh and Joseph, Leena and Quinn, Anne Marie and Crosbie, Phil A and Naidu, Babu and Middleton, Gary and Langman, Gerald and Trotter, Simon and Nicolson, Marianne and Remmen, Hardy and Kerr, Keith and Chetty, Mahendran and Gomersall, Lesley and Fennell, Dean A and Nakas, Apostolos and Rathinam, Sridhar and Anand, Girija and Khan, Sajid and Russell, Peter and Ezhil, Veni and Ismail, Babikir and Irvin-Sellers, Melanie and Prakash, Vineet and Lester, Jason F and Kornaszewska, Malgorzata and Attanoos, Richard and Adams, Haydn and Davies, Helen and Oukrif, Dahmane and Akarca, Ayse U and Hartley, John A and Lowe, Helen L and Lock, Sara and Iles, Natasha and Bell, Harriet and Ngai, Yenting and Elgar, Greg and Szallasi, Zoltan and Schwarz, Roland F and Herrero, Javier and Stewart, Aengus and Quezada, Sergio A and Peggs, Karl S and Van Loo, Peter and Dive, Caroline and Lin, C. Jimmy and Rabinowitz, Matthew and Aerts, Hugo J. W. L and ... and TRACERx Consortium and The PEACE Consortium and TRACERx consortium and PEACE consortium and The PEACE consortium and The TRACERx consortium
Nature, ISSN 0028-0836, 04/2017, Volume 545, Issue 7655, pp. 446 - 451
The early detection of relapse following primary surgery for non-small-cell lung cancer and the characterization of emerging subclones, which seed metastatic... 
IMPACT | MUTATIONS | CIRCULATING TUMOR DNA | UPTAKE RATIO | MULTIDISCIPLINARY SCIENCES | Biopsy - methods | Early Detection of Cancer - methods | Humans | Lung Neoplasms - pathology | Cell Tracking | Neoplasm Recurrence, Local - pathology | DNA, Neoplasm - blood | DNA Mutational Analysis | Cell Lineage - genetics | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Limit of Detection | Reproducibility of Results | Carcinoma, Non-Small-Cell Lung - surgery | Carcinoma, Non-Small-Cell Lung - genetics | Neoplasm Recurrence, Local - diagnosis | Tumor Burden | Multiplex Polymerase Chain Reaction | Postoperative Care - methods | Clone Cells - metabolism | Disease Progression | Neoplasm Metastasis - genetics | Drug Resistance, Neoplasm - genetics | Clone Cells - pathology | Neoplasm Metastasis - pathology | Neoplasm Metastasis - diagnosis | Carcinoma, Non-Small-Cell Lung - blood | Lung Neoplasms - surgery | Neoplasm Recurrence, Local - genetics | Lung Neoplasms - blood | DNA, Neoplasm - genetics | Evolution, Molecular | Lung cancer | Development and progression | Genetic aspects | Phylogeny | Nucleotide sequencing | Metastasis | Observations | Methods | DNA sequencing
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6. Full Text Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution
by McGranahan, Nicholas and Rosenthal, Rachel and Hiley, Crispin and Hiley, Crispin T and Rowan, Andrew and Rowan, Andrew J and Watkins, Thomas B.K and Wilson, Gareth and Wilson, Gareth A and Birkbak, Nicolai J and Veeriah, Selvaraju and Van Loo, Peter and Herrero, Javier and Swanton, Charles and Jamal-Hanjani, Mariam and Shafi, Seema and Czyzewska-Khan, Justyna and Johnson, Benjamin and Johnson, Diana and Laycock, Joanne and Bosshard-Carter, Leticia and Gorman, Pat and Hynds, Robert E and Horswell, Stuart and Mitter, Richard and Escudero, Mickael and Stewart, Aengus and Xu, Hang and Turajlic, Samra and Abbosh, Christopher and Goldman, Jacki and Stone, Richard Kevin and Denner, Tamara and Matthews, Nik and Matthews, Sue and Elgar, Greg and Ward, Sophia and Costa, Marta and Begum, Sharmin and Phillimore, Ben and Chambers, Tim and Nye, Emma and Graca, Sofia and Al Bakir, Maise and Joshi, Kroopa and Furness, Andrew and Ben Aissa, Assma and Wong, Yien Ning Sophia and Georgiou, Andy and Quezada, Sergio and Hartley, John A and Lowe, Helen L and Lawrence, David and Hayward, Martin and Panagiotopoulos, Nikolaos and Kolvekar, Shyam and Falzon, Mary and Borg, Elaine and Marafioti, Teresa and Simeon, Celia and Hector, Gemma and Smith, Amy and Smith, Sean and Smith, Elaine and Aranda, Marie and Novelli, Marco and Oukrif, Dahmane and Janes, Sam M and Thakrar, Ricky and Forster, Martin and Ahmad, Tanya and Lee, Siow Ming and Papadatos-Pastos, Dionysis and Carnell, Dawn and Mendes, Ruheena and George, Jeremy and Navani, Neal and Ahmed, Asia and Taylor, Paul and Taylor, Magali and Choudhary, Junaid and Summers, Yvonne and Califano, Raffaele and Shah, Rajesh and Krysiak, Piotr and Rammohan, Kendadai and Fontaine, Eustace and Booton, Richard and Evison, Matthew and Crosbie, Phil and Moss, Stuart and Idries, Faiza and Joseph, Leena and Bishop, Paul and Chaturved, Anshuman and Quinn, Anne Marie and Doran, Helen and Leek, Angela and Harrison, Phil and Moore, Katrina and ... and TRACERx Consortium
Cell, ISSN 0092-8674, 11/2017, Volume 171, Issue 6, pp. 1259 - 1271.e11
Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through human leukocyte antigen (HLA) loss may facilitate immune evasion.... 
neoantigen | lung cancer | chromosomal instability | bioinformatics | cancer evolution | immune-editing | copy number | loss of heterozygosity | immune-escape | heterogeneity | MUTATIONAL PROCESSES | CTLA-4 BLOCKADE | CELLS | PD-1 BLOCKADE | BIOCHEMISTRY & MOLECULAR BIOLOGY | COPY NUMBER | DOWN-REGULATION | SENSITIVITY | RESISTANCE | NEOANTIGENS | DISCOVERY | CELL BIOLOGY | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Tumor Escape | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Middle Aged | HLA Antigens - immunology | Lung Neoplasms - pathology | Male | Lung Neoplasms - therapy | HLA Antigens - genetics | Loss of Heterozygosity | Carcinoma, Non-Small-Cell Lung - immunology | Carcinoma, Non-Small-Cell Lung - therapy | Lung Neoplasms - immunology | Antigen Presentation | Aged, 80 and over | Adult | Female | Aged | Polymorphism, Single Nucleotide | Mutation | Cohort Studies | Histocompatibility antigens | Lung cancer, Non-small cell | Analysis | Immunotherapy | Tumor antigens | HLA histocompatibility antigens
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7. Full Text A multicenter randomized trial of continuous versus intermittent β-lactam infusion in severe sepsis
by Dulhunty, Joel M and Roberts, Jason A and Davis, Joshua S and Webb, Steven A. R and Bellomo, Rinaldo and Gomersall, Charles and Shirwadkar, Charudatt and Eastwood, Glenn M and Myburgh, John and Paterson, David L and Starr, Therese and Paul, Sanjoy K and Lipman, Jeffrey and Peck, Leah and Young, Helen and Boschert, Catherine and Fletcher, Jason and Smith, Julie and Nand, Kiran and Sara, Treena and Harney, Amy and Rodgers, Helen and Van Haren, Frank and Clarke, Sally and Durham, David and Hannan, Catherine and Matheson, Elisha and Schwartz, Kate and Thomas, Karen and Bone, Allison and Cattigan, Claire and Elderkin, Tania and Salerno, Tania and Cameron, Robert and Ellis, Katrina and Hatter, Sheridan and Sanap, Milind and Soar, Natalie and Wood, Josette and Chan, Karen and Heffernan, Aaron and Lai, Nai An and Moss, Catherine and Sheehy, Kate and Duroux, Maree and Ratcliffe, Megan and Shone, Samantha and Warhurst, Timothy and Dunlop, Rachel and Stuart, Janine and Udy, Andrew and Cooper, David and McAllister, Rick and Cheng, Andrew and Inskip, Deborah and Miller, Jennene and Knowles, Serena and Reynolds, Claire and Rudham, Sam and Baker, Stuart and Hepburn, Kristy and Roberts, Brigit and Woods, Paul and Chatterjee, Indranil and Cullen, Martin and Kong, Jing and Nayyar, Vineet and Whitehead, Christina and Leung, Patricia and Gilder, Eileen and McCarthy, Lianne and McGuiness, Shay and Parke, Rachael and Benefield, Kirsten and Chen, Yan and McArthur, Colin and Newby, Lynette and Henderson, Seton and Mehrtens, Jan and Noble, Sascha and Chadwick, Lesley and Freebain, Ross and Hogan, Chantal and Kazemi, Alex and Rust, Laura and Song, Rima and Tilsley, Anna and Williams, Anthony and Andrews, Lynn and Dinsdale, Richard and Hunt, Anna and Hurford, Sally and Mackle, Diane and Ongley, Jessica and Young, Paul and Durning, John and Frengley, Robert and La Pine, Mary and McCracken, Geoff and Sharma, Swarna Baskar and ... and BLING II Investigators and ANZICS Clinical Trials Grp and BLING II Investigators for the ANZICS Clinical Trials Group
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 12/2015, Volume 192, Issue 11, pp. 1298 - 1305
Rationale: Continuous infusion of beta-lactam antibiotics may improve outcomes because of time-dependent antibacterial activity compared with intermittent... 
Clinical outcome | Antibiotic | Intensive care | Pharmacodynamics | Pharmacokinetics | antibiotic | ANTIBIOTICS | METAANALYSIS | intensive care | PIPERACILLIN-TAZOBACTAM | pharmacodynamics | TISSUE | INTENSIVE-CARE UNITS | MEROPENEM | clinical outcome | RESPIRATORY SYSTEM | PSEUDOMONAS-AERUGINOSA | pharmacokinetics | BOLUS | CRITICALLY-ILL PATIENTS | CRITICAL CARE MEDICINE | Prospective Studies | Double-Blind Method | Drug Administration Schedule | Humans | Middle Aged | Male | Treatment Outcome | Anti-Bacterial Agents - therapeutic use | Sepsis - drug therapy | Survival Analysis | Female | Aged | Infusions, Intravenous | beta-Lactams - therapeutic use | Anti-Bacterial Agents - administration & dosage | Length of Stay - statistics & numerical data | beta-Lactams - administration & dosage
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8. Full Text Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies
by Arce Vargas, Frederick and Furness, Andrew J.S and Litchfield, Kevin and Joshi, Kroopa and Rosenthal, Rachel and Ghorani, Ehsan and Solomon, Isabelle and Lesko, Marta H and Ruef, Nora and Roddie, Claire and Henry, Jake Y and Spain, Lavinia and Ben Aissa, Assma and Georgiou, Andrew and Wong, Yien Ning Sophia and Smith, Myles and Smith, Elaine and Smith, Sean and Strauss, Dirk and Hayes, Andrew and Nicol, David and O'Brien, Tim and Mårtensson, Linda and Ljungars, Anne and Teige, Ingrid and Frendéus, Björn and Harrington, Kevin and Melcher, Alan and Wotherspoon, Andrew and Francis, Nicholas and Challacombe, Ben and Fernando, Archana and Hazell, Steve and Chandra, Ashish and Pickering, Lisa and Lynch, Joanna and Rudman, Sarah and Chowdhury, Simon and Harrison-Phipps, Karen and Varia, Mary and Horsfield, Catherine and Polson, Alexander and Stamp, Gordon and O'Donnell, Marie and Drake, William and Hill, Jennifer and Hill, Peter and Hrouda, David and Mayer, Eric and Olsburgh, Jonathan and Kooiman, Gordon and O'Connor, Kevin and Stewart, Grant and Stewart, Aengus and Aitchison, Michael and Tran, Maxine and Fotiadis, Nicos and Verma, Hema and Lopez, Jose and Lester, Jason and Morgan, Fiona and Kornaszewska, Malgorzata and Attanoos, Richard and Adams, Haydn and Davies, Helen and Fennell, Dean and Shaw, Emily and Shaw, Jacqui and Shaw, Penny and Le Quesne, John and Nakas, Apostolos and Rathinam, Sridhar and Monteiro, William and Marshall, Hilary and Nelson, Louise and Bennett, Jonathan and Riley, Joan and Primrose, Lindsay and Martinson, Luke and Anand, Girija and Khan, Sajid and Nicolson, Marianne and Kerr, Keith and Kerr, Amy and Palmer, Shirley and Remmen, Hardy and Miller, Joy and Buchan, Keith and Chetty, Mahendran and Gomersall, Lesley and Lock, Sara and Naidu, Babu and Langman, Gerald and Trotter, Simon and Bellamy, Mary and Bancroft, Hollie and Kadiri, Salma and Webb, Joanne and Middleton, Gary and Djearaman, Madava and ... and TRACERx Renal and TRACERx Melanoma and TRACERx Lung Consortia and TRACERx Lung consortia
Cancer Cell, ISSN 1535-6108, 04/2018, Volume 33, Issue 4, pp. 649 - 663.e4
With the use of a mouse model expressing human Fc-gamma receptors (FcγRs), we demonstrated that antibodies with isotypes equivalent to ipilimumab and... 
tremelimumab | IgG subclass | tumor immunotherapy | ipilimumab | antibody-dependent cell-mediated cytotoxicity | immune regulatory antibodies | CTLA-4 | Fc-gamma receptors | regulatory T cell depletion | immune checkpoints | regulatory T cell depletion | UNTREATED MELANOMA | BREAST-CANCER | METASTATIC MELANOMA | CTLA-4 BLOCKADE | CANCER-PATIENTS | ONCOLOGY | REGULATORY T-CELLS | ANTITUMOR-ACTIVITY | C-RECEPTOR POLYMORPHISMS | GAMMA RECEPTOR | IGG SUBCLASSES | CELL BIOLOGY | Antineoplastic Agents, Immunological - administration & dosage | Antibodies, Monoclonal - pharmacology | Humans | Treatment Outcome | Ipilimumab - pharmacology | Receptors, IgG - metabolism | Antineoplastic Agents, Immunological - pharmacology | T-Lymphocytes, Regulatory - immunology | Xenograft Model Antitumor Assays | Receptors, IgG - genetics | Animals | Antibodies, Monoclonal - administration & dosage | Melanoma - genetics | Melanoma - immunology | Melanoma - drug therapy | Cell Line, Tumor | Female | Mice | Polymorphism, Single Nucleotide | CTLA-4 Antigen - antagonists & inhibitors | Ipilimumab - administration & dosage | Viral antibodies | Fc receptors | Analysis | Immunotherapy | Melanoma | Antibodies | T cells
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