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1. Full Text Cholesterol burden in the liver induces mitochondrial dynamic changes and resistance to apoptosis
by Domínguez‐Pérez, Mayra and Simoni‐Nieves, Arturo and Rosales, Patricia and Nuño‐Lámbarri, Natalia and Rosas‐Lemus, Mónica and Souza, Verónica and Miranda, Roxana U and Bucio, Leticia and Uribe Carvajal, Salvador and Marquardt, Jens U and Seo, Daekwan and Gomez‐Quiroz, Luis E and Gutiérrez‐Ruiz, María Concepción
Journal of cellular physiology, ISSN 0021-9541, 05/2019, Volume 234, Issue 5, pp. 7213 - 7223
apoptosis | cholesterol | oxidative stress | mitochondrial dynamics | Physiology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Non-alcoholic Fatty Liver Disease - pathology | Liver - pathology | Cell Proliferation | Mitochondria, Liver - pathology | Mitochondrial Dynamics - genetics | Non-alcoholic Fatty Liver Disease - genetics | Oxidative Stress | Mitochondria, Liver - metabolism | Liver - metabolism | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation | Transcriptome | Apoptosis - genetics | Hepatocytes - pathology | Male | Non-alcoholic Fatty Liver Disease - metabolism | Hepatocytes - metabolism | Animals | Time Factors | Diet, High-Fat | Cholesterol, Dietary | Disease Models, Animal | Cell culture | Oxidative stress | Liver diseases | High cholesterol diet | Pathogenesis | Liver | Homeostasis | Hepatocellular carcinoma | Triglycerides | Inflammation | Cholesterol | Steatosis | Cirrhosis | Mitochondria | Fatty liver | Hypercholesterolemia | Diet | Hepatocytes | Cell death | Rodents | Fibrosis | Membrane potential | Glutathione | Apoptosis | Index Medicus
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2. Full Text Antitumor effects in hepatocarcinoma of isoform-selective inhibition of HDAC2
by Lee, Yun-Han and Seo, Daekwan and Choi, Kyung-Ju and Andersen, Jesper B and Won, Min-Ah and Kitade, Mitsuteru and Gómez-Quiroz, Luis E and Judge, Adam D and Marquardt, Jens U and Raggi, Chiara and Conner, Elizabeth A and MacLachlan, Ian and Factor, Valentina M and Thorgeirsson, Snorri S
Cancer research (Chicago, Ill.), ISSN 0008-5472, 09/2014, Volume 74, Issue 17, pp. 4752 - 4761
Gastroenterology. Liver. Pancreas. Abdomen | Liver. Biliary tract. Portal circulation. Exocrine pancreas | Pharmacology. Drug treatments | Biological and medical sciences | Multiple tumors. Solid tumors. Tumors in childhood (general aspects) | Medical sciences | Antineoplastic agents | Tumors | Cell Cycle - genetics | Humans | Apoptosis - genetics | Male | Tumor Suppressor Protein p53 - genetics | Glycolysis - genetics | Proliferating Cell Nuclear Antigen - genetics | Lipogenesis - genetics | Carcinoma, Hepatocellular - genetics | Lipid Metabolism - genetics | Liver Neoplasms - pathology | Gene Expression Regulation, Neoplastic - genetics | bcl-2-Associated X Protein - genetics | PPAR gamma - genetics | Histone Deacetylase 2 - genetics | Liver Neoplasms - genetics | Cyclin-Dependent Kinase 6 - genetics | Up-Regulation - genetics | Signal Transduction - genetics | Mice, SCID | Disease Progression | Down-Regulation - genetics | Hep G2 Cells | Animals | Carcinoma, Hepatocellular - pathology | Cell Line, Tumor | Mice | Protein Isoforms - genetics | Index Medicus | HDAC2 | targeted siRNA therapeutics | cancer lipid metabolism | isoform selectivity | p53 acetylation | hepatocellular carcinoma
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3. Full Text Cholangiocyte death in ductopenic cholestatic cholangiopathies: Mechanistic basis and emerging therapeutic strategies
by Salas-Silva, Soraya and Simoni-Nieves, Arturo and Lopez-Ramirez, Jocelyn and Bucio, Leticia and Gómez-Quiroz, Luis E and Gutiérrez-Ruiz, María Concepción and Roma, Marcelo G
Life sciences (1973), ISSN 0024-3205, 02/2019, Volume 218, pp. 324 - 339
Cholangiocyte death | Cholangiopathies | Liver | Cholestasis | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Liver diseases | Cell death | Transplantation of organs, tissues, etc | Cystic fibrosis | Development and progression | Health aspects | Syngeneic grafts | Pathogenesis | Transplantation | Phospholipids | Autophagy | Necrosis | Allografts | Etiology | Replenishment | Therapeutic applications | Ducts | Mortality | Cholangitis | Epithelium | Bile duct | Molecular modelling | Fibrosis | Phagocytosis | Liver transplantation | Bile | Apoptosis | Index Medicus
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4. Full Text Hepatocyte-specific c-Met Deletion Disrupts Redox Homeostasis and Sensitizes to Fas-mediated Apoptosis
by Luis E. Gómez-Quiroz and Valentina M. Factor and Pal Kaposi-Novak and Cedric Coulouarn and Elizabeth A. Conner and Snorri S. Thorgeirsson
The Journal of biological chemistry, ISSN 0021-9258, 05/2008, Volume 283, Issue 21, pp. 14581 - 14589
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Proto-Oncogene Proteins c-met - metabolism | Oxidation-Reduction | Oxidative Stress | Signal Transduction | Cells, Cultured | Homeostasis | Substrate Specificity | NF-kappa B - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Hepatocytes - metabolism | fas Receptor - metabolism | Mice, Knockout | Proto-Oncogene Proteins c-met - genetics | Glutathione - biosynthesis | Hepatocytes - cytology | Animals | NF-kappa B - genetics | Proto-Oncogene Proteins c-met - deficiency | Mice | Proto-Oncogene Proteins c-akt - metabolism | Apoptosis | Index Medicus | Mechanisms of Signal Transduction
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5. Full Text Cell proliferation arrest and redox state status as part of different stages during senescence establishment in mouse fibroblasts
by Triana-Martínez, Francisco and Triana-Martínez, Francisco and López-Diazguerrero, Norma E and López-Diazguerrero, Norma E and Maciel-Barón, Luis A and Maciel-Barón, Luis A and Morales-Rosales, Sandra L and Morales-Rosales, Sandra L and Galván-Arzate, Sonia and Galván-Arzate, Sonia and Fernandez-Perrino, Francisco J and Fernandez-Perrino, Francisco J and Zentella, Alejandro and Zentella, Alejandro and Pérez, Viviana I and Pérez, Viviana I and Gomez-Quiroz, Luis E and Gomez-Quiroz, Luis E and Königsberg, Mina and Königsberg, Mina
Biogerontology (Dordrecht), ISSN 1389-5729, 4/2014, Volume 15, Issue 2, pp. 165 - 176
Life Sciences | Oxidative stress | Senescence | P16 | P27 | Geriatrics/Gerontology | Cell cycle | Developmental Biology | P21 | Cell Biology | Life Sciences & Biomedicine | Geriatrics & Gerontology | Science & Technology | Protein Carbonylation | Cell Proliferation | Oxidation-Reduction | Glutathione - metabolism | Cells, Cultured | Cellular Senescence - drug effects | Cellular Senescence - physiology | Cell Cycle Checkpoints - physiology | Glutathione Disulfide - metabolism | Antioxidants - pharmacology | Phenotype | Animals | Chromans - pharmacology | Fibroblasts - drug effects | DNA - biosynthesis | Fibroblasts - cytology | Mice | Fibroblasts - metabolism | Index Medicus
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6. Full Text Liver Cholesterol Overload Aggravates Obstructive Cholestasis by Inducing Oxidative Stress and Premature Death in Mice
by Nuño-Lámbarri, Natalia and Domínguez-Pérez, Mayra and Baulies-Domenech, Anna and Monte, Maria J and Marin, Jose J. G and Rosales-Cruz, Patricia and Souza, Verónica and Miranda, Roxana U and Bucio, Leticia and Montalvo-Jave, Eduardo E and Concepción Gutiérrez-Ruiz, María and García-Ruiz, Carmen and Fernández-Checa, José C and Gomez-Quiroz, Luis Enrique
Oxidative medicine and cellular longevity, ISSN 1942-0900, 8/2016, Volume 2016, pp. 9895176 - 13
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Immunohistochemistry | Liver Function Tests | Liver - pathology | Cholesterol, Dietary - toxicity | Liver - enzymology | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Mice, Inbred C57BL | Caspase 3 - metabolism | Bilirubin - analysis | Ki-67 Antigen - metabolism | Bile Ducts - surgery | Cholestasis - pathology | Mortality, Premature | Triglycerides - analysis | Animals | Liver - drug effects | Cholestasis - etiology | Glutathione - analysis | Cholesterol - analysis | Mice | Oxidative Stress - drug effects | Jaundice - etiology | Fatty Liver - etiology | Oxidative stress | Medical research | Jaundice, Obstructive | Liver diseases | Analysis | Medicine, Experimental | Health aspects | Risk factors | Investigations | Cholestasis | Cholesterol | Laboratories | Liver | Rodents | Bile | Apoptosis | Index Medicus
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7. Full Text Reactive oxygen species regulate lovastatin biosynthesis in Aspergillus terreus during submerged and solid-state fermentations
by Miranda, Roxana U and Gómez-Quiroz, Luis E and Mendoza, Mariel and Pérez-Sánchez, Ailed and Fierro, Francisco and Barrios-González, Javier
Fungal biology, ISSN 1878-6146, 12/2014, Volume 118, Issue 12, pp. 979 - 989
Submerged and solid-state fermentation | Lovastatin | Regulation of secondary metabolites | ROS in lovastatin biosynthesis | ROS | Life Sciences & Biomedicine | Mycology | Science & Technology | Gene Expression Regulation, Fungal | Transcription Factors - metabolism | Reactive Oxygen Species - metabolism | Culture Media | Acetylcysteine - metabolism | Lovastatin - biosynthesis | Aspergillus - genetics | Genes, Fungal | Transcription Factors - genetics | Aspergillus - metabolism | Fermentation | Hydrogen Peroxide - metabolism | Antioxidants | Cysteine | Analysis | Physiological aspects | Gene expression | Antilipemic agents | Index Medicus
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8. Full Text Biphasic regulation of the NADPH oxidase by HGF/c-Met signaling pathway in primary mouse hepatocytes
by Clavijo-Cornejo, Denise and Enriquez-Cortina, Cristina and López-Reyes, Alberto and Domínguez-Pérez, Mayra and Nuño, Natalia and Domínguez-Meraz, Marcela and Bucio, Leticia and Souza, Verónica and Factor, Valentina M and Thorgeirsson, Snorri S and Gutiérrez-Ruiz, María Concepción and Gómez-Quiroz, Luis E
Biochimie, ISSN 0300-9084, 06/2013, Volume 95, Issue 6, pp. 1177 - 1184
c-Met | Hepatocytes | HGF | NADPH oxidase | ROS | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Proto-Oncogene Proteins c-met - metabolism | Immunoprecipitation | Reactive Oxygen Species - metabolism | Mice, Inbred C57BL | NADPH Oxidases - metabolism | Hepatocytes - metabolism | Blotting, Western | Hepatocyte Growth Factor - metabolism | Mice, Knockout | Animals | NF-E2-Related Factor 2 - metabolism | Signal Transduction - physiology | Electrophoretic Mobility Shift Assay | Mice | Real-Time Polymerase Chain Reaction | Oxidases | Antioxidants | Transforming growth factors | Ligases | Quinone | Index Medicus | hepatocytes
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