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1. Full Text Eosinophilic Gastrointestinal Disorders
by Gonsalves, Nirmala
Clinical Reviews in Allergy & Immunology, ISSN 1080-0549, 10/2019, Volume 57, Issue 2, pp. 272 - 285
Eosinophilic gastrointestinal disorders (EGID) are a group of disorders characterized by pathologic eosinophilic infiltration of the esophagus, stomach, small... 
Allergology | Food allergy | Immunology | Medicine & Public Health | Eosinophilic esophagitis | Internal Medicine | Dysphagia | Food impaction | Eosinophilic gastritis | Eosinophilic gastroenteritis | Allergens | Gastrointestinal tract diseases | Gastroenteritis | Medical services | Disorders | Body weight loss | Small intestine | Pain | Vomiting | Satiety | Enteritis | Colon | Children | Food hypersensitivity | Food | Stomach | Signs and symptoms | Leukocytes (eosinophilic) | Weight loss | Esophagitis | Diarrhea | Nausea | Esophagus | Gastritis | Diet | Infiltration | Adults | Colitis
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2. Dietary Therapy in Eosinophilic Esophagitis
by Gonsalves, Nirmala
Gastrointestinal Endoscopy Clinics of North America, ISSN 1052-5157, 01/2018, Volume 28, Issue 1, pp. 89 - 96
Eosinophilic esophagitis is characterized by dense mucosal eosinophilia with symptoms of esophageal dysfunction. Because the incidence and prevalence are... 
Eosinophilic esophagitis | Dysphagia | Dietary therapy | Food Hypersensitivity - complications | Food Hypersensitivity - immunology | Eosinophilic Esophagitis - immunology | Eosinophilic Esophagitis - diet therapy | Humans | Immune Tolerance | Food, Formulated | Food
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3. Full Text Clinical presentation and approach to dietary management of eosinophilic esophagitis
by Gonsalves, Nirmala
Gastroenterology and Hepatology, ISSN 1554-7914, 12/2018, Volume 14, Issue 12, pp. 706 - 712
Eosinophilic gastrointestinal disorders are a group of disorders that are characterized by chronic eosinophilic inflammation in the gastrointestinal tract,... 
Food allergy | Dysphagia | Food impaction | Eosinophilic esophagitis | dysphagia | food impaction | Column | food allergy
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4. ACG clinical guideline: Evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EoE)
by Dellon, Evan S and Gonsalves, Nirmala and Hirano, Ikuo and Furuta, Glenn T and Liacouras, Chris A and Katzka, David A and American College of Gastroenterology
American Journal of Gastroenterology, ISSN 0002-9270, 05/2013, Volume 108, Issue 5, pp. 679 - 692
Esophageal eosinophilia and eosinophilic esophagitis (EoE) are increasingly recognized and prevalent conditions, which now represent common clinical problems... 
FLUTICASONE PROPIONATE | ELIMINATION DIET | GASTROESOPHAGEAL-REFLUX DISEASE | ENDOSCOPIC-FINDINGS | TOPICAL CORTICOSTEROID TREATMENT | ORAL VISCOUS BUDESONIDE | DOUBLE-BLIND | PROTON PUMP INHIBITORS | PLACEBO-CONTROLLED TRIAL | NATURAL-HISTORY | GASTROENTEROLOGY & HEPATOLOGY | Gastroesophageal Reflux - therapy | Diagnosis, Differential | Gastroesophageal Reflux - diagnosis | Eosinophilic Esophagitis - diagnosis | Humans | Eosinophilic Esophagitis - pathology | Clinical Trials as Topic | Fluticasone | Evidence-Based Medicine | Proton Pump Inhibitors - therapeutic use | Esophagoscopy | Eosinophilia - pathology | Eosinophilic Esophagitis - therapy | Eosinophilic Esophagitis - complications | Esophagus - pathology | Algorithms | Biopsy | Endpoint Determination | Anti-Inflammatory Agents - therapeutic use | Adult | Androstadienes - therapeutic use | Eosinophilia - diagnosis | Prednisone - therapeutic use
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5. Full Text Eosinophilic esophagitis: Updated consensus recommendations for children and adults
by Liacouras, Chris A., MD and Furuta, Glenn T., MD and Hirano, Ikuo, MD and Atkins, Dan, MD and Attwood, Stephen E., MD, FRCS, FRCSI, MCh and Bonis, Peter A., MD and Burks, A. Wesley, MD and Chehade, Mirna, MD and Collins, Margaret H., MD and Dellon, Evan S., MD, MPH and Dohil, Ranjan, MD and Falk, Gary W., MD, MS and Gonsalves, Nirmala, MD and Gupta, Sandeep K., MD and Katzka, David A., MD and Lucendo, Alfredo J., MD, PhD and Markowitz, Jonathan E., MD, MSCE and Noel, Richard J., MD and Odze, Robert D., MD, FRCP and Putnam, Philip E., MD, FAAP and Richter, Joel E., MD, FACP, MACG and Romero, Yvonne, MD and Ruchelli, Eduardo, MD and Sampson, Hugh A., MD and Schoepfer, Alain, MD and Shaheen, Nicholas J., MD, MPH and Sicherer, Scott H., MD and Spechler, Stuart, MD and Spergel, Jonathan M., MD, PhD and Straumann, Alex, MD and Wershil, Barry K., MD and Rothenberg, Marc E., MD, PhD and Aceves, Seema S., MD, PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2011, Volume 128, Issue 1, pp. 3 - 20.e6
Eosinophilic esophagitis (EoE) is a clinicopathologic condition of increasing recognition and prevalence. In 2007, a consensus recommendation provided clinical... 
Allergy and Immunology | esophageal | eosinophilic | food allergy | esophagitis | Eosinophils | HISTOPATHOLOGIC VARIABILITY | FOOD IMPACTION | TOPICAL CORTICOSTEROID TREATMENT | MAST-CELLS | MUCOSAL BIOPSIES | BARRETTS-ESOPHAGUS | IMMUNOLOGY | ALLERGY | GASTROESOPHAGEAL-REFLUX DISEASE | PEDIATRIC-PATIENTS | GENE-EXPRESSION | DIAGNOSTIC-CRITERIA | Eosinophilic Esophagitis - therapy | Guidelines as Topic | Eosinophilic Esophagitis - immunology | Eosinophilic Esophagitis - diagnosis | Humans | Adult | Child | Consensus Development Conferences as Topic | Gastroesophageal reflux | Esophagitis | Allergy | Disease susceptibility | Allergic reaction | Health aspects | Food allergies | Expert witness testimony | Disease | Advisors | Allergies | Proteins | Pain | Biopsy | Gastroenterology | Minority stockholders | Accreditation | Pharmaceuticals | Food
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6. Full Text Endoscopic assessment of the oesophageal features of eosinophilic oesophagitis: validation of a novel classification and grading system
by Hirano, Ikuo and Moy, Nelson and Heckman, Michael G and Thomas, Colleen S and Gonsalves, Nirmala and Achem, Sami R
Gut, ISSN 0017-5749, 04/2013, Volume 62, Issue 4, pp. 489 - 495
Objective Abnormalities are commonly identified during endoscopy in eosinophilic oesophagitis (EoE). There is no standardised classification to describe these... 
VARIABILITY | DYSPHAGIA | MUCOSA | ADULT PATIENTS | WHITE | FELINE ESOPHAGUS | BUDESONIDE | PREVALENCE | GASTROENTEROLOGY & HEPATOLOGY | CONSENSUS RECOMMENDATIONS | CHILDREN | Severity of Illness Index | Clinical Competence | Reproducibility of Results | Videotape Recording | Eosinophilic Esophagitis - classification | Humans | Middle Aged | Eosinophilic Esophagitis - pathology | Female | Male | Esophagoscopy - methods | Endoscopic surgery | Esophagitis | Research | Endoscopy | Diagnosis | Methods | Eosinophil disorders | Studies | Video recordings | Gastroenterology | Classification | Adults | Agreements | Clinical medicine
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7. Full Text Distinct Features in the Clinical Presentations of Eosinophilic Esophagitis in Children and Adults: Is This the Same Disease?
by Gonsalves, Nirmala
Digestive Diseases, ISSN 0257-2753, 03/2014, Volume 32, Issue 1-2, pp. 89 - 92
Recent consensus guidelines define eosinophilic esophagitis (EoE) as a chronic, immune/antigen-mediated esophageal disease characterized clinically by symptoms... 
EoE-Phenotypes and Assessment of Disease Activity | Dysphagia | Food impaction | Eosinophil | Esophagus | EOTAXIN-3 | GASTROESOPHAGEAL-REFLUX DISEASE | GENE-EXPRESSION | GASTROENTEROLOGY & HEPATOLOGY | 6-FOOD ELIMINATION DIET | Eosinophilic Esophagitis - physiopathology | Allergens - adverse effects | Humans | Eosinophilic Esophagitis - pathology | Adult | Environment | Child | Disease Progression | Eosinophilic Esophagitis - genetics
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8. Full Text Steroids versus dietary therapy for the treatment of eosinophilic esophagitis
by Gonsalves, Nirmala
Current Opinion in Gastroenterology, ISSN 0267-1379, 07/2014, Volume 30, Issue 4, pp. 396 - 401
PURPOSE OF REVIEWEosinophilic esophagitis (EoE) is a condition characterized by dense mucosal eosinophilia in conjunction with symptoms of esophageal... 
Topical corticosteroids | Dysphagia | Eosinophilic esophagitis | Dietary therapy | CONTROLLED-TRIAL | topical corticosteroids | ELIMINATION DIET | ELEMENTAL DIET | SWALLOWED FLUTICASONE | dysphagia | ADULTS | IDENTIFICATION | CHILDREN | FLUTICASONE PROPIONATE | INFLAMMATION | eosinophilic esophagitis | dietary therapy | GASTROENTEROLOGY & HEPATOLOGY | MILK | Glucocorticoids - therapeutic use | Prevalence | Eosinophilic Esophagitis - diet therapy | Deglutition Disorders - diet therapy | Humans | Eosinophilic Esophagitis - epidemiology | Proton Pump Inhibitors - therapeutic use | Drug Delivery Systems | Incidence | Patient Selection | Eosinophilic Esophagitis - drug therapy | Deglutition Disorders - drug therapy | Diet - methods | Immunologic Factors - therapeutic use
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9. Esophageal dilation in eosinophilic esophagitis: Effectiveness, safety, and impact on the underlying inflammation
by Schoepfer, Alain M and Gonsalves, Nirmala and Bussmann, Christian and Conus, Sébastien and Simon, Hans-Uwe and Straumann, Alex and Hirano, Ikuo
American Journal of Gastroenterology, ISSN 0002-9270, 05/2010, Volume 105, Issue 5, pp. 1062 - 1070
OBJECTIVES: Esophageal dilation often leads to long-lasting relief of dysphagia in eosinophilic esophagitis (EoE). The aim of this study was to define the... 
RINGED ESOPHAGUS | DYSPHAGIA | ADULT PATIENTS | CONTROLLED TRIAL | FLUTICASONE PROPIONATE | FOOD IMPACTION | CORTICOSTEROIDS | GASTROENTEROLOGY & HEPATOLOGY | CHILDREN | FEATURES | PERFORATION | Immunohistochemistry | Eosinophilia - therapy | Inflammation - pathology | Humans | Middle Aged | Male | Reference Values | Deglutition Disorders - therapy | Esophagitis - pathology | Patient Satisfaction | Eosinophilia - pathology | Deglutition Disorders - diagnosis | Statistics, Nonparametric | Adult | Female | Esophagoscopy - methods | Databases, Factual | Esophagitis - therapy | Severity of Illness Index | Risk Assessment | Catheterization - methods | Probability | Safety Management | Treatment Outcome | Quality of Life | Aged | Cohort Studies
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10. Full Text Oncostatin M promotes mucosal epithelial barrier dysfunction, and its expression is increased in patients with eosinophilic mucosal disease
by Pothoven, Kathryn L., MSc and Norton, James E., MSc and Hulse, Kathryn E., PhD and Suh, Lydia A., BSc and Carter, Roderick G., BSc and Rocci, Erin, BSc and Harris, Kathleen E., BSc and Shintani-Smith, Stephanie, MD and Conley, David B., MD and Chandra, Rakesh K., MD and Liu, Mark C., MD and Kato, Atsushi, PhD and Gonsalves, Nirmala, MD and Grammer, Leslie C., MD and Peters, Anju T., MD and Kern, Robert C., MD and Bryce, Paul J., PhD and Tan, Bruce K., MD, MS and Schleimer, Robert P., PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 136, Issue 3, pp. 737 - 746.e4
Background Epithelial barrier dysfunction is thought to play a role in many mucosal diseases, including asthma, chronic rhinosinusitis (CRS), and eosinophilic... 
Allergy and Immunology | atopic asthma | epithelial barrier | transepithelial electrical resistance | eosinophilic esophagitis | chronic rhinosinusitis | tight junctions | Oncostatin M | CELLS | PROTEIN | ION-TRANSPORT | NASAL POLYPS | MONOCLONAL-ANTIBODY | IMMUNOLOGY | LEUKEMIA-INHIBITORY FACTOR | INTERFERON-GAMMA | ALLERGY | AIRWAY HYPERRESPONSIVENESS | M OSM | Humans | Middle Aged | Eosinophilic Esophagitis - pathology | Bronchoalveolar Lavage Fluid - immunology | Fluorescein-5-isothiocyanate - metabolism | Male | Sinusitis - genetics | Eosinophilic Esophagitis - immunology | Asthma - immunology | Sinusitis - pathology | Nasal Polyps - metabolism | Dextrans - metabolism | Tight Junctions - metabolism | Gene Expression | Sinusitis - metabolism | Epithelial Cells - pathology | Fluorescein-5-isothiocyanate - analogs & derivatives | Tight Junctions - immunology | Bronchoalveolar Lavage Fluid - chemistry | Oncostatin M - immunology | Rhinitis - pathology | Asthma - pathology | Chronic Disease | RNA, Messenger - immunology | Asthma - metabolism | Epithelial Cells - metabolism | Nasal Mucosa - pathology | Case-Control Studies | Sinusitis - immunology | Nasal Polyps - genetics | Adult | Female | Nasal Mucosa - metabolism | Eosinophilic Esophagitis - genetics | Eosinophilic Esophagitis - metabolism | Nasal Polyps - immunology | Rhinitis - immunology | Nasal Polyps - pathology | RNA, Messenger - genetics | Permeability | Asthma - genetics | Rhinitis - genetics | Rhinitis - metabolism | Nasal Mucosa - immunology | Epithelial Cells - immunology | Aged | Primary Cell Culture | Oncostatin M - genetics | Tight Junctions - pathology | Medical colleges | Studies | Sinuses | Disease | Biopsy | Otolaryngology | Polyvinyl alcohol | Endoscopy | Gene expression | Small intestine | Age
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11. Full Text Expression of mast cell–associated genes is upregulated in adult eosinophilic esophagitis and responds to steroid or dietary therapy
by Hsu Blatman, Karen S., MD and Gonsalves, Nirmala, MD and Hirano, Ikuo, MD and Bryce, Paul J., PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2011, Volume 127, Issue 5, pp. 1307 - 1308.e3
  Biopsy specimens from 7 patients without EoE (3 male and 4 female patients; median age, 54 years; age range, 27-80 years; average peak eosinophil count, 0)... 
Allergy and Immunology | ALLERGY | IMMUNOLOGY | Up-Regulation | Gene Expression - drug effects | Humans | Middle Aged | Male | Fluticasone | Chemokine CCL26 | Eosinophilic Esophagitis - physiopathology | Eosinophilic Esophagitis - immunology | Mast Cells - metabolism | Aged, 80 and over | Anti-Inflammatory Agents - therapeutic use | Adult | Female | Steroids - pharmacology | Steroids - therapeutic use | Mast Cells - immunology | Anti-Inflammatory Agents - pharmacology | Eosinophilic Esophagitis - diet therapy | Carboxypeptidases A - metabolism | Treatment Outcome | Androstadienes - pharmacology | Chemokines, CC - genetics | Eosinophilic Esophagitis - drug therapy | Aged | Androstadienes - therapeutic use | Carboxypeptidases A - genetics | Chemokines, CC - metabolism | Medical colleges | Studies | Pediatrics | Pathogenesis | Biopsy | Dysphagia | Endoscopy | Gene expression | Allergies | Age | Food
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12. Full Text GWAS identifies four novel eosinophilic esophagitis loci
by Sleiman, Patrick M. A and Wang, Mei-Lun and Cianferoni, Antonella and Aceves, Seema and Gonsalves, Nirmala and Nadeau, Kari and Bredenoord, Albert J and Furuta, Glenn T and Spergel, Jonathan M and Hakonarson, Hakon
Nature communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, p. 5593
Eosinophilic esophagitis (EoE) is an allergic disorder characterized by infiltration of the oesophagus with eosinophils. We had previously reported association... 
ATOPIC-DERMATITIS | RISK LOCI | METAANALYSIS | PROTEIN | CALPAIN | ALLERGY | JAPANESE POPULATION | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY LOCI | ASTHMA | GENOME-WIDE ASSOCIATION | Genetic Predisposition to Disease | Genome-Wide Association Study | Guanine Nucleotide Exchange Factors - genetics | Humans | Repressor Proteins - genetics | Male | STAT6 Transcription Factor - genetics | Calpain - genetics | Case-Control Studies | Adult | Female | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Eosinophilic Esophagitis - genetics
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13. Full Text Histopathologic variability and endoscopic correlates in adults with eosinophilic esophagitis
by Gonsalves, Nirmala, MD and Policarpio-Nicolas, Maria, MD and Zhang, Qing, MD and Rao, M. Sambasiva, MD and Hirano, Ikuo, MD
Gastrointestinal Endoscopy, ISSN 0016-5107, 2006, Volume 64, Issue 3, pp. 313 - 319
Background Recently recognized as an important cause of dysphagia and food impaction in adults, eosinophilic esophagitis (EE) is diagnosed by histologic... 
Gastroenterology and Hepatology | GASTROESOPHAGEAL-REFLUX | THERAPY | GASTROENTEROLOGY & HEPATOLOGY | FEATURES | CHILDREN | Biopsy - methods | Humans | Middle Aged | Male | Esophagitis - etiology | Esophagitis - pathology | Eosinophilia - pathology | Esophagus - pathology | Mucous Membrane - pathology | Mucous Membrane - immunology | Sensitivity and Specificity | Adolescent | Adult | Deglutition Disorders - etiology | Female | Aged | Eosinophilia - complications | Esophagus - immunology | Eosinophils | Esophagitis | Adults
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14. Food Allergies and Eosinophilic Gastrointestinal Illness
by Gonsalves, Nirmala
Gastroenterology Clinics of North America, ISSN 0889-8553, 03/2007, Volume 36, Issue 1, pp. 75 - 91
Eosinophilic gastrointestinal disorders are characterized by eosinophilic infiltration and inflammation of the gastrointestinal tract in the absence of... 
GASTROESOPHAGEAL-REFLUX | ADULTS | FOLLOW-UP | EXPERIENCE | ESOPHAGEAL EOSINOPHILIA | GASTROENTEROLOGY & HEPATOLOGY | GASTROENTERITIS | FLUTICASONE | ASSOCIATION | CHILDREN | FEATURES | Esophagitis - therapy | Environmental Illness - physiopathology | Eosinophilia - therapy | Eosinophilia - etiology | Environmental Illness - complications | Humans | Endoscopy, Gastrointestinal | Gastrointestinal Diseases - complications | Eosinophilia - epidemiology | Food Hypersensitivity - complications | Esophagitis - complications | Esophagitis - epidemiology | Esophagitis - diagnosis | Esophagitis - physiopathology | Eosinophilia - diagnosis | Eosinophilia - physiopathology | Food Hypersensitivity - physiopathology
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15. Full Text Elimination Diet Effectively Treats Eosinophilic Esophagitis in Adults; Food Reintroduction Identifies Causative Factors
by Gonsalves, Nirmala and Yang, Guang–Yu and Doerfler, Bethany and Ritz, Sally and Ditto, Anne M and Hirano, Ikuo
Gastroenterology, ISSN 0016-5085, 2012, Volume 142, Issue 7, pp. 1451 - 1459.e1
Background & Aims Adults with eosinophilic esophagitis (EoE) typically present with dysphagia and food impaction. A 6-food elimination diet (SFED) is effective... 
Gastroenterology and Hepatology | Food Allergy | Stricture | Inflammation | Esophagus | REFLUX | GASTROENTEROLOGY & HEPATOLOGY | CHILDREN | Skin Tests | Eosinophilic Esophagitis - diagnosis | Eosinophilic Esophagitis - diet therapy | Humans | Middle Aged | Endoscopy, Gastrointestinal | Male | Eosinophilic Esophagitis - etiology | Food Hypersensitivity - complications | Young Adult | Esophagus - pathology | Eosinophilic Esophagitis - immunology | Quality of Life | Adult | Female | Aged | Eosinophils - pathology | Biopsy, Needle | Food Hypersensitivity - diagnosis | Food allergy | Allergy | Medical colleges | Esophagitis | Adults | Food and nutrition | Allergic reaction
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